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Chemical degradation of platinum oncolytics in urine and speciation of the inorganic contaminants cisplatin and carboplatin relevant in waste water

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Emerging Contaminants 2024年第1期10卷 47-53页

作者： karel Folens Janis Baeten karen Couvreur Gijs Du Laing Laboratory of Analytical Chemistry and Applied Ecochemistry(ECOCHEM) Department of Green Chemistry and TechnologyGhent UniversityFrieda Saeystraat 19052ZwijnaardeBelgium Center for Microbial Ecology and Technology(CMET) Department of BiotechnologyGhent UniversityCoupure Links 6539000GentBelgium Medical Oncology AZ GlorieuxGlorieuxlaan 559600RonseBelgium

Understanding the prevalent form of platinum(Pt)based antineoplastic agents,used in chemotherapy,is of importance to develop a remediation strategy that restricts aquatic *** speciation of Pt-based compounds was measured in actual patients’urine using hydrophobic interaction liquid chromatography(HILIC)equipped with an ICP-MS *** showed poor metabolization and intact excretion 11 h after administration,whereas cisplatin underwent a rapid aquation in the first 7 *** compare,the in vitro degradation rate of cisplatin,carboplatin and oxaliplatin was determined in synthetic human urine,mimicking true environmental *** fraction of intact molecules was measured at regular intervals following incubation at 37°C,resulting in degradation rate *** chemical stability was highest for carboplatin(k=0.0143±0.0012 min−1),versus faster degradation of oxaliplatin and cisplatin by exponential decay with k1 of 0.0026±0.0001 min−1 and k_(2)=5.59±0.46×10^(−6) min−1,*** kinetic parameters can serve as input to further expand modelling databases and improve the predictive power of speciation software to estimate eco-toxicity *** the strong residual cytotoxicity of the platinum antineoplastic molecules following renal clearance and human excretion,the contaminants are of high environmental concern and offer potential for metal recovery using advanced treatment *** such water treatment processes,especially carboplatin,above all cancerostatic platinum compounds,should be addressed since it is more persistent in the aquatic environment.

关键词： Pharmaceuticals Inorganic contaminants Speciation analysis Ecotoxicity

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth V.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.krosch Francesca Strutt karen F.Armstrong Hamish Patrick Mark k.Schutze Mark J.Blacket Department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

Depositional condition of Paleoproterozoic Francevillian carbonate rocks revisited from rare earth element contents

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Geoscience Frontiers 2024年第3期15卷 31-49页

作者： Satoshi Yoshida karen Bakakas Mayika Yuki Ishihara Mathieu Moussavou Hisashi Asanuma Tomohiko Sato Takafumi Hirata Cédric Ligna Yusuke Sawaki Amboise Edou-Minko Department of Earth Science and Astronomy The University of Tokyo3-8-1 Komaba Meguro-kuTokyo 153-8902Japan Center for Northeast Asian Studies Tohoku University41 KawauchiAoba-kuSendai 980-8576Japan Department of Geology Universitédes Sciences et Techniques de MasukuBP:90190025 FrancevilleGabon Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Geochemical Research Center The University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-nihonmatsuSakyo-kuKyoto 606-8501Japan Center for Fundamental Education Okayama University of Science1-1Ridai-choKita-kuOkayama CityOkayama 700-0005Japan

The Paleoproterozoic Francevillian Group in the eastern Gabonese Republic has been recently attracting increasing attention because it includes distinctive macroscopic structures interpreted as eukaryotic ***,its depositional setting and associated redox conditions need to be clearly *** clarify these,petrological studies and rare earth element(REE)abundances of carbonate rocks of the Francevillian Group in the Lastoursville basin were determined with ICP-MS coupled with a laser ablation sampling *** microscopic observations indicate that dolostones in this basin underwent the complicated diagenetic history,including sparitization,decomposition of organic matter,reduction of ferromanganese oxides,silicification,and later *** dolostones of lower Francevillian B(FB)Formation show heterogeneous textures formed by alterations during *** the alterations,changes of REE abundances and degrees of positive Y anomalies appear to have *** indicates that REE signatures in carbonate rocks can vary during *** high Mn contents in the dolostones of upper FB Formation were derived from the reduction of ferromanganese oxides in *** signatures of REE abundance in dolostones can be explained by the mixing of seawater and ferromanganese oxide *** that sense,the dolostones inherited the trace element characteristics of precursor ferromanganese oxides even after the diagenesis.Y/Ho values of the most primary parts of each sample exceed 33,the newly determined threshold value for marine carbonate rocks based on our *** magnitude of the La anomaly values also falls within the range of that of Holocene reefal *** indicate that a precursor of the dolostone of the Francevillian Group was deposited in a marine *** addition,presence of Ce anomalies in the upper FB Formation suggests that the Paleoproterozoic ocean was oxidized to such an ex

关键词： Carbonate diagenesis Francevillian Group LA-ICP-MS Seawater composition Y/Ho fractionation

Pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2006年第20期12卷 3204-3212页

作者： karen A Diefenbach Christopher k Breuer Department of Surgery Yale University School of Medicine Division of Pediatric Surgery330 Cedar StreetRm. 132 FMBNorth HavenCT 06520United States

Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, radiology studies, and endoscopic procedures are helpful in diagnosing inflammatory bowel disease and differentiating between Crohn＇s disease and ulcerative colitis. Once diagnosed, the goal of medical management is to induce remission of disease while minimizing the side effects of the medication. Specific attention needs to be paid to achieving normal growth in this susceptible population. Surgical management is usually indicated for failure of medical management, complication, or malignancy. Algorithms for diagnostic evaluation and treatment of pediatric inflammatory bowel disease are presented. The specific psychosocial issues facing these patients are also discussed in this review as are the future goals of research in the complex problem of pediatric inflammatory bowel disease.

关键词： Pediatric Inflammatory bowel Ulcerative colitis Crohn's disease

Solvent-Less Vapor-Phase Fabrication of Membranes for Sustainable Separation Processes

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Engineering 2020年第12期6卷 1432-1442页

作者： Junjie Zhao karen k.Gleason State key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University–Quzhou Quzhou 324000China Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Sustainable processes for purifying water,capturing carbon,producing biofuels,operating fuel cells,and performing energy-efficient industrial separations will require next-generation ***-less fabrication for membranes not only eliminates potential environmental issues with organic solvents,but also solves the swelling problems that occur with delicate polymer ***,the activation procedures often required for synthesizing microporous materials such as metal–organic frameworks(MOFs)can be reduced when solvent-less vapor-phase approaches are *** perspective covers several vacuum deposition processes,including initiated chemical vapor deposition(iCVD),initiated plasma-enhanced chemical vapor deposition(iPECVD),solvent-less vapor deposition followed by in situ polymerization(SLIP),atomic layer deposition(ALD),and molecular layer deposition(MLD).These solvent-less vapor-phase methods are powerful in creating ultrathin selective layers for thin-film composite membranes and advantageous in conformally coating nanoscale pores for the precise modification of pore size and internal *** resulting membranes have shown promising performance for gas separation,nanofiltration,desalination,and water/oil *** development of novel membrane materials and the scaling up of high-throughput reactors for solvent-less vapor-phase processes are necessary in order to make a real impact on the chemical industry in the future.

关键词： Membrane separation Chemical vapor deposition Atomic layer deposition Molecular layer deposition Thin films Metal-organic frameworks Polymers Advanced manufacturing

Dyeing of Polypropylene Fibers with Vat Dyes

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Journal of Donghua University(English Edition) 2006年第5期23卷 15-19页

作者：刘航 ETTERS J . Nolan LEONAS karen k Department of Textiles Merchandising & Interiors University of Georgia Athens Georgia 30605 USA

Polypropylene fibers have been extensively used in a variety of/products, including carpets and upholstery, due to their non-absorbency, good weather resistance, good resistance to macroorgamsms and so on. Because of their hydrophobic and highly crystalline nature, those well-established conventionai dyeing processes are difficult to apply to unmodified polypropylene. Colors of polypropylene fibers are primarily obtained by mass coloration which has the disadvantages of limited number of colors available and difficulties in inventory control due to the rapidly changing color needs of the market. In this paper, the use of vat dyes to dye polypropylene fabrics is investigated. Seventeen vat dyes were screened and factors influencing uptake of dyes by polypropylene fabrics were studied.

关键词： pol ypropylene vat dye leuco acid vat dye.

Taxonomy of Pseudolagarobasidium(Polyporales,Basidiomycota)

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Fungal Diversity 2012年第4期55卷 155-169页

作者： karen k.Nakasone Daniel L.Lindner Center for Forest Mycology Research Northern Research StationU.S.Forest ServiceOne Gifford Pinchot DriveMadisonWI 53726-2398USA

Pseudolagarobasidium(Polyporales,Basidiomycota)is a small,monophyletic genus of crustose,wood-inhabiting fungi with spines and a saprobic,endophytic,or parasitic *** species are accepted in the genus including two new species,*** from Belize and *** from *** analysis of the internal transcribed spacer of the ribosomal RNA gene places *** in a monophyletic clade with *** and an undescribed foliar *** combinations proposed include *** for Irpex modestus Berk.,*** for Hydnum pronum Berk.&Broome which is an earlier name for ***,and *** for Radulodon venustus Hjortstam&*** colliculosum Berk.&Broome from Sri Lanka is conspecific with *** species,Sistotrema ochroleucum and Radulum concentricum are not accepted in *** is compared with Radulodon and similar genera.A key to the species of Pseudolagarobasidium is provided.

关键词： Pirex concentricum Pseudolagarobasidium acaciicola P.leguminicola Hydnum ayresii Microbinding hyphae

Upper gastrointestinal function and glycemic control in diabetes mellitus

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World Journal of Gastroenterology 2006年第35期12卷 5611-5621页

作者： Reawika Chaikomin Christopher k Rayner karen L Jones Michael Horowitz University of Adelaide Department of Medi-cine Royal Adelaide Hospital North Terrace Adelaide South Australia 5000 Australia

Recent evidence has highlighted the impact of glycemic control on the incidence and progression of diabetic micro- and macrovascular complications, and on cardiovascular risk in the non-diabetic population. Postprandial blood glucose concentrations make a major contribution to overall glycemic control, and are determined in part by upper gastrointestinal function. Conversely, poor glycemic control has an acute, reversible effect on gastrointestinal motility. Insights into the mechanisms by which the gut contributes to glycemia have given rise to a number of novel dietary and pharmacological strategies designed to lower postprandial blood glucose concentrations.

关键词： Blood glucose Diabetes mellitus Gastric Emptying Gastrointestinal motility Hyperglycemia

Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

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World Journal of Gastrointestinal Oncology 2016年第12期8卷 826-834页

作者： Audrey H Calderwood karen E Lasser Hemant k Roy Section of Gastroenterology Depart-ment of MedicineDartmouth-Hitchcock Medical Center Section of General Internal Medicine Depart-ment of MedicineBoston University School of Medicine Section of Gastroenterology Department of MedicineBoston University School of Medicine

AIMTo review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer (CRC)]. METHODSWe performed a literature search using the National Library of Medicine through PubMed from 1/1/2003 to 5/30/2015. Specific Medical Subject Headings terms (colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CRC) were used in conjunction with subject headings/key words (surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma). We defined non-advanced adenomas as 1-2 adenomas each 25% villous histology or high-grade dysplasia. A combined endpoint of advanced neoplasia included advanced adenomas and invasive CRC. RESULTSOur search strategy identified 592 candidate articles of which 8 met inclusion criteria and were relevant for assessment of histology (low grade vs high grade dysplasia, villous features) and adenoma size. Six of these studies met the accepted quality indicator threshold for overall adenoma detection rate > 25% among study patients. We found 254 articles of which 7 met inclusion criteria for the evaluation of multiple adenomas. Lastly, our search revealed 222 candidate articles of which 6 met inclusion criteria for evaluation of serrated polyps. Our review found that villous features, high grade dysplasia, larger adenoma size, and having ≥ 3 adenomas at baseline are associated with an increased risk of future colonic neoplasia in some but not all studies. Serrated polyps in the proximal colon are associated with an increased risk of future colonic neoplasia, comparable to having a baseline advanced adenoma. CONCLUSIONData on adenoma features and risk of future adenomas and CRC are compelling yet modest in absolute effect size. Future research should refine this risk stratification.

关键词： Colon adenoma Colorectal cancer screening Surveillance Colonoscopy