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Current advances in using tolerogenic dendritic cells as a therapeutic alternative in the treatment of type 1 diabetes

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World Journal of Diabetes 2021年第5期12卷 603-615页

作者： William de Jesús Ríos-Ríos sorely adelina sosa-luis Honorio Torres-Aguilar Department of Biochemical Sciences Faculty Universidad Autónoma“Benito Juárez”de OaxacaOaxaca 68120Mexico Department of Molecular Biomedicine Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360Mexico

Type 1 diabetes(T1D)is an autoimmune disease characterized by the destruction of insulin-producingβ-cells of the pancreatic islets by autoreactive T cells,leading to high blood glucose levels and severe long-term *** typical treatment indicated in T1D is exogenous insulin administration,which controls glucose levels;however,it does not stop the autoimmune *** strategies have been implemented aimed at stoppingβ-cell destruction,such as cellular *** cells(DCs)as an alternative in cellular therapy have gained great interest for autoimmune disease therapy due to their plasticity to acquire immunoregulatory properties both in vivo and in vitro,performing functions such as anti-inflammatory cytokine secretion and suppression of autoreactive lymphocytes,which are dependent of their tolerogenic phenotype,displayed by features such as semimature phenotype,low surface expression of stimulatory molecules to prime T cells,as well as the elevated expression of inhibitory *** may be obtained and propagated easily in optimal amounts from peripheral blood or bone marrow precursors,such as monocytes or hematopoietic stem cells,respectively;therefore,various protocols have been established for tolerogenic(tol)DCs manufacturing for therapeutic research in the treatment of *** this review,we address the current advances in the use of tolDCs for T1D therapy,encompassing protocols for their manufacturing,the data obtained from preclinical studies carried out,and the status of clinical research evaluating the safety,feasibility,and effectiveness of tolDCs.

关键词： Type 1 diabetes Dendritic cells Autoimmunity Immune tolerance Cell therapy Immunotherapy.

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