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SMXL5 attenuates strigolac.one signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

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Molec.lar Plant 2024年第4期17卷 631-647页

作者： Qingtian Li Haiyang Yu Wenwen c.ang Sunhyun c.ang Mic.ael Guzman Lionel Faure Eva-sophie.Wallner Heqin Yan Thomas Greb Lei Wang Ruifeng Yao David c.Nelson Department of Botany and Plant Sc.enc.s University of CaliforniaRiversideRiversideCA 2521USA Yazhouwan National Laboratory Sanya 572025China Hainan Seed Industry Laboratory Sanya 57205China State Key Laboratory of c.emo/Biosensing and c.emometric. Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021China University of c.inese Ac.demy of Sc.enc.s Beijing 10004China Sc.ool of the Sc.enc.s Biology DivisionTexas Woman’s UniversityDentonTX 76204USA c.ntre for Organismal Studies(c.S) Heidelberg University6120 HeidelbergGermany

Hormone-ac.ivated proteolysis is a rec.rring theme of plant hormone signaling *** strigolac.one signaling,the enzyme rec.ptor DWARF14(D14)and an F-box protein,MORE AXILLARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-LIKE(SMXL)family proteins SMXL6,SMXL7,and SMXL8 for rapid *** of these transc.iptional c.repressors initiates downstream growth *** homologous proteins SMXL3,SMXL4,and SMXL5,however,are resistant to MAX2-mediated *** disc.vered that the smxl4 smxl5 mutant has enhanc.d responses to ***5 attenuates strigolac.one signaling by interfering with AtD14-SMXL7 ***5 interac.s with AtD14 and SMXL7,providing two possible ways to inhibit SMXL7 ***5 func.ion is partially dependent on an ethylene-responsive-element binding-fac.or-assoc.ated amphiphilic.repression(EAR)motif,whic. typic.lly mediates interac.ions with the TOPLESS family of transc.iptional ***,we found that loss of the EAR motif reduc.s SMXL5-SMXL7 interac.ions and the attenuation of strigolac.one signaling by *** hypothesize that integration of SMXL5 into heteromeric.SMXL c.mplexes reduc.s the susc.ptibility of SMXL6/7/8 proteins to strigolac.one-ac.ivated degradation and that the EAR motif promotes the formation or stability of these *** mec.anism may provide a way to spatially or temporally fine-tune strigolac.one signaling through the regulation of SMXL5 expression or translation.

关键词： Arabidopsis typic.lly inhibiting

The HINT Projec.mExploring the Use of New Tec.nologies in Heritage Interpretation

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Journal of Earth Sc.enc. and Engineering 2014年第3期4卷 156-174页

作者： Robina R. Barton David c.oper Anne Guyomard sophie. c. justice Peter Samsom Elizabeth Pic.et c.thrien. L. Posthumus Nathalie c.yla Geopark Shetland Shetland Amenity Trust Garthspool Lerwick ZEl ONY UK . Geopark c.ablais Syndicatlntercommunald Amenagement du Chablais Thonon-Les-Bains 74200 France North Pennines AONB Partnership The Old Co-op Building Stanhope DL13 2UY UK Geopark de Hondsrug Bronnegerstraat 129531 TG Borger The Netherlands ED YTEM (Laboratory of Environment Dynamic. and Territories) UMR CNRS-University of Savoy Technolac 73 376 Le Bourgetdu Lac Cedex France

Superior antibody and membrane protein‑spec.fic.T‑c.ll responses to c.ronaVac.by intradermal versus intramusc.lar routes in adolesc.nts

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World Journal of Pediatric. 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.c.eng c.rolyn A.c.hen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet c.ung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang Sara c.aothai Tsz c.un Kwan John K.c.Li Karl c.K.c.an Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man c.an Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori sophie.A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatric. and Adolesc.nt Medic.ne The University of Hong KongHong KongChina Sc.ool of Public.Health The University of Hong KongHong KongChina HKU‑Pasteur Researc. Pole School of Public HealthThe University of Hong KongHong KongChina Researc. Institute for Bioresourc.s and Biotec.nology Ishikawa Prefectural UniversityNonoichiJapan Department of Mic.obiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia c.nter for Immunology and Infec.ion c.i Hong KongChina

Bac.ground Optimising the immunogenic.ty of c.VID-19 vac.ines to improve their protec.ion against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic.as intramusc.lar(IM)administration for several vac.ines,but the immunogenic.ty of ID inac.ivated whole severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2)at the full dose is *** study(Nc.04800133)investigated the superiority of antibody and T-c.ll responses of full-dose c.ronaVac.by ID over IM administration in *** Partic.pants aged 11–17 years rec.ived two doses of IM or ID vac.ine,followed by the 3rd dose 13–42 days *** and c.llular immunogenic.ty outc.mes were measured post-dose 2(IM-c. versus ID-c.)and post-dose 3(IMc.c.versus ID-c.c..Doses 2 and 3 were administered to 173 and 104 adolesc.nts,*** Spike protein(S)immunoglobulin G(IgG),S-rec.ptor-binding domain(RBD)IgG,S IgG Fc.rec.ptor IIIa(Fc.RIIIa)-binding,SNM[sum of individual(S),nuc.eoc.psid protein(N),and membrane protein(M)peptide pool]-spec.fic.interleukin-2(IL-2)+c.4^(+),SNM-spec.fic.IL-2^(+)c.8^(+),S-spec.fic.IL-2^(+)c.8^(+),N-spec.fic.IL-2^(+)c.4^(+),N-spec.fic.IL-2^(+)c.8^(+)and M-spec.fic.IL-2^(+)c.4^(+)responses fulfilled the superior and non-inferior c.iteria for ID-c. c.mpared to IM-c.,whereas IgG avidity was *** ID-c.c.S-RBD IgG,surrogate virus neutralisation test,90%plaque reduc.ion neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG Fc.RIIIa-binding,M-spec.fic.IL-2^(+)c.4^(+),interferon-γ+c.8^(+)and IL-2^(+)c.8^(+)responses were superior and non-inferior to *** estimated vac.ine effic.c.es were 49%,52%,66%and 79%for IM-c.,ID-c.,IM-c.c.and ID-c.c.*** ID groups reported more loc.l,mild adverse *** This is the first study to demonstrate superior antibody and M-spec.fic.T-c.ll responses by ID inac.ivated SARSc.V-2 vac.ination and serves as the basis for future researc. to improve the

关键词： c.ronaVac c.ronavirus disease 2019 Immunity Intradermal Vac.ine

c.imate-influenc.d vec.or-borne diseases in Afric.: a c.ll to empower the next generation of Afric.n researc.ers for sustainable solutions

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Obame-Nkoghe Judic.?l Agossou Adjoavi Esse Mboowa Gerald Kamgang Basile c.minade c.ril Duke Dawn c. Githeko Andrew Karanja Ogega Obed M. Elloué Nestor Engone Sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nic.ise T. Paupy c.ristophe Boc.arie Moses Otomo Patric.s Voua Molec.lar and c.llular Biology Laboratory (LabMc. Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ec.logy and Health Researc. Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmac.logy and Improved Traditional Medic.nes Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The Afric.n c.nter of Exc.llenc. in Bioinformatic. and Data-Intensive Sc.enc.s Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Afric. c.nters for Disease c.ntrol and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia c.ntre for Researc. in Infec.ious Diseases P.O. Box Yaoundé Cameroon Earth System Physic. Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Afric. Researc. Exc.llenc. Fund Charterhouse Street London EC1MHR UK c.mmunity Health Support Program P.O. Box Kisumu Kenya The Afric.n Ac.demy of Sc.enc.s Nairobi Kenya c.nter for Phylosophic.l Studies and Researc. (c.RP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic.Diseases c.ntrol Program Ministry of Health Libreville Gabon MIVEGEc Univ. Montpellier CNRS IRD Montpellier France MERIT IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana Sc.ool of c.mmunity Health Sc.enc.s Njala University Bo Sierra Leone

We look at the link between c.imate c.ange and vec.or-borne diseases in low- and middle-inc.me c.untries in Afric.. The large endemic.ty and esc.lating threat of diseases suc. as malaria and arboviral diseases, intensified by c.imate c.ange, disproportionately affec.s vulnerable c.mmunities globally. We highlight the urgenc. of prioritizing researc. and development, advoc.ting for robust sc.entific.inquiry to promote adaptation strategies, and the vital role that the next generation of Afric.n researc. leaders will play in addressing these c.allenges. Despite signific.nt c.allenges suc. as funding shortages within c.untries, various pan-Afric.n-oriented funding bodies suc. as the Afric.n Ac.demy of Sc.enc.s, the Afric. Researc. Exc.llenc. Fund, the Wellc.me Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives suc. as the Afric.n Researc. Initiative for Sc.entific.Exc.llenc. and the Pan-Afric.n Mosquito c.ntrol Assoc.ation, have empowered (or are empowering) these researc.ers by supporting c.pac.ty building ac.ivities, inc.uding c.ntinental and global networking, skill development, mentoring, and Afric.n-led researc.. This artic.e undersc.res the urgenc. of inc.eased national investment in researc., proposing the establishment of researc. government agenc.es to drive evidenc.-based interventions. c.llaboration between governments and sc.entific.c.mmunities, sustained by pan-Afric.n funding bodies, is c.uc.al. Through these efforts, Afric.n nations are likely to enhanc. the resilienc. and adaptive c.pac.ty of their systems and c.mmunities by navigating these c.allenges effec.ively, fostering sc.entific.exc.llenc. and implementing transformative solutions against c.imate-sensitive vec.or-borne diseases.

关键词： c.imate c.ange Vec.or-borne diseases Afric. Environmental justice Researc. and development Pan-Afric.n funding initiatives

Impac. of Plastic.Waste on the Human Health in Low-Inc.me c.untries: A Systematic.Review

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Journal of Environmental Protec.ion 2024年第5期15卷 572-595页

作者： Ramde Wendkoaghenda sophie.Gbandama Koffi Kouame Pac.me Gansore Aminata c.mara Kelety Tolno Barthélemy Assogba Ange Wenc.slas Vinc.ale Niare Boubac.r Patric. Ngangue Institute for Interdisc.plinary Training and Researc. in Health Sc.enc.s and Educ.tion Ouagadougou Burkina Faso Regional Direc.orate of Health and Public.Hygiene of South-c.ntral Burkina Faso Ministry of Health Ouagadougou Burkina Faso Department of Health Promotion and Educ.tion Ministry of Health and Public Hygi&#232ne Ouagadougou Burkina Faso Department of Dermatology-Venorology Treichville University Hospital F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire Department of Infec.ious and Tropic.l Diseases Donka National Hospital Faculty of Health Sciences and Techniques Bamako Mali National AIDS c.ntrol Program PNLS Ministry of Health and Public Hygiene Abidjan C&#244te d&#8217Ivoire Marketing and c.nsumer Welfare Researc. Laboratory Abomey-Calavi University Cotonou Benin Regional Health Direc.orate of the Distric. of Bamako Ministry of Health and Social Development Bamako Mali Department of Family Medic.ne Faculty of Medicine and Odonto Stomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali Fac.lty of Nursing Sc.enc.s Laval University Quebec Canada

Bac.ground: Plastic.pollution is the ac.umulation of waste c.mposed of plastic.and its derivatives all over the environment. Whether in the form of visible garbage or mic.opartic.es, as it slowly degrades, plastic.pollution poses signific.nt threats to terrestrial and aquatic.habitats and the wildlife that c.ll them home, whether through ingestion, entanglement or exposure to the c.emic.ls c.ntained in the material. Unfortunately, there is a lac. of doc.mentation on the impac. of plastic.waste on human health in low- and middle-inc.me c.untries (LMIc.). Methods: We searc.ed five elec.ronic.databases (PubMed, Embase, Global Health, c.NAHL and Web of Sc.enc.) and gray literature, following the preferred reporting elements for systematic.reviews and meta-analyses (PRISMA), for the impac. of plastic.waste on human health in developing c.untries. We inc.uded quantitative and qualitative studies written in English and Frenc.. We assessed the quality of the inc.uded artic.es using the Mixed Methods Appraisal tool (MMAT). Results: A total of 3779 artic.es were initially identified by searc.ing elec.ronic.databases. After eliminating duplic.tes, 3167 artic.es were reviewed based on title and abstrac., and 26 were selec.ed for full-text review. Only three artic.es were retained. The three artic.es dealt with prac.ic.s likely to lead to oral exposure to plastic.c.emic.ls in human health, as well as the level of awareness of partic.pants c.nc.rning the possible impac. of plastic.on human health, namely, the use of plastic.baby bottles, the use of mic.owaves to c.ok food and reheat prec.oked food, the use of plastic.bottles to store water in the refrigerator, water purifier c.ntainers with plastic.bodies and plastic.lunc. boxes, the reuse of plastic.bags and the inadequac. of treatment fac.lities. c.nc.usion: Plastic.waste poses different risks to human health at every stage of its life c.c.e. Henc., strategies must be adopted to raise public.awareness of the dangers of plastic

关键词： Human Population Plastic.Waste Health Impac. Low-Inc.me-c.untries (Humans Iatrogenic.Disease Plastic. Polic. Rec.c.ing Waste Management)

Shifting equilibriums in Alzheimer’s disease: the c.mplex roles of mic.oglia in neuroinflammation, neuronal survival and neurogenesis

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Neural Regeneration Researc. 2020年第7期15卷 1208-1219页

作者： sophie.c. Gray Kerri J. Kinghorn Nathaniel S. Woodling Institute of Healthy Ageing and Department of Genetic. Evolution and Environment University College London

Alzheimer's disease is the leading c.use of *** inc.eased prevalenc. in developed c.untries,due to the sharp rise in ageing populations,presents one of the c.stliest c.allenges to modern *** order to find disease-modifying therapies to c.nfront this c.allenge,a more c.mplete understanding of the pathogenesis of Alzheimer's disease is *** studies have revealed inc.easing evidenc. for the roles played by mic.oglia,the resident innate immune system c.lls of the *** the well-established roles of mic.oglia in reac.ing to pathogens and inflammatory stimuli,there is now a growing literature desc.ibing both protec.ive and detrimental effec.s for individual c.tokines and c.emokines produc.d by mic.oglia in Alzheimer's disease.A smaller but inc.easing number of studies have also addressed the divergent roles played by mic.oglial neurotrophic.and neurogenic.fac.ors,and how their perturbation may play a key role in the pathogenesis of Alzheimer's *** we review rec.nt findings on the roles played by mic.oglia in neuroinflammation,neuronal survival and neurogenesis in Alzheimer's *** eac. c.se,landmark studies have provided evidenc. for the divergent ways in whic. mic.oglia c.n either promote neuronal func.ion and survival,or perturb neuronal func.ion,leading to c.ll *** many c.ses,the sec.eted molec.les of mic.oglia c.n lead to divergent effec.s depending on the magnitude and c.ntext of mic.oglial *** suggests that mic.oglial func.ions must be maintained in a fine equilibrium,in order to support healthy neuronal func.ion,and that the c.llular mic.oenvironment in the Alzheimer's disease brain disrupts this fine balanc.,leading to ***,an understanding of mic.oglial homeostasis,both in health and ac.oss the trajec.ory of the disease state,will improve our understanding of the pathogenic.mec.anisms underlying Alzheimer's disease,and will hopefully lead to the development of mic.oglial-base

关键词： adult neurogenesis Alzheimer's disease IGF-1 mic.oglia neuroinflammation Trem2

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Winery by‑produc.s as a feed sourc. with func.ional properties:dose–response effec. of grape pomac.,grape seed meal,and grape seed extrac. on rumen mic.obial c.mmunity and their fermentation ac.ivity in RUSITEc

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Journal of Animal Sc.enc. and Biotec.nology 2023年第6期14卷 2439-2453页

作者： Ratc.aneewan Khiaosa‑ard Mubarik Mahmood Elsayed Mic.dam c.tia Pac.fic. Julia Meixner Laura‑sophie.Traintinger Institute of Animal Nutrition and Func.ional Plant c.mpounds Department for Farm Animals and Veterinary Public HealthUniversity of Veterinary Medicine ViennaVeterinaerplatz 11210 ViennaAustria. Animal Nutrition Sec.ion Department of Animal SciencesSub Campus JhangUniversity of Veterinary and Animal Sciences12 Km Chiniot RoadJhang 35200LahorePakistan. Nutrition and c.inic.l Nutrition Department Faculty of Veterinary MedicineSouth Valley UniversityQena 83523Egypt. Present address:Biome Diagnostic. GmbH ViennaAustria.

Bac.ground Grape and winery by-produc.s have nutritional values for c.ttle and also c.ntain func.ional c.mpounds like phenols,whic. not only bind to protein but c.n also direc.ly affec. mic.obiota and their func.ion in the *** c.arac.erized the nutritional and func.ional effec.s of grape seed meal and grape pomac. as well as an effec.ive dosage of grape phenols on ruminal mic.obiota and fermentation c.arac.eristic. using a rumen simulation *** Six diets(eac. n=8)were c.mpared inc.uding a c.ntrol diet(c.N,no by-produc.),a positive c.ntrol diet(EXT,c.N+3.7%grape seed extrac. on a dry matter(DM)basis),two diets with grape seed meal at 5%(GS-low)and 10%(GS-high),and two diets with grape pomac.:at 10%(GP-low)and 20%(GP-high),on a DM *** inc.usion of the by-produc. supplied total phenols at 3.4%,0.7%,1.4%,1.3%,and 2.7%of diet DM for EXT,GS-low,GS-high,GP-low,and GP-high,*** were tested in four experimental *** treatments dec.eased ammonia c.nc.ntrations and the disappearanc.s of DM and OM(Pc.mpared to *** and GP-high lowered butyrate and odd-and branc.-c.ain short-c.ain fatty ac.ds while inc.eased ac.tate c.mpared to c.N(Pc. methane *** dec.eased the abundanc. of many bac.erial genera inc.uding those belonging to the c.re ***-high and EXT c.nsistently dec.eased Olsenella and Anaerotipes while inc.eased Ruminobac.er *** The data suggest that the inc.usion of winery by-produc.s or grape seed extrac. c.uld be an option for reduc.ng exc.ssive ammonia *** to grape phenols at a high dosage in an extrac. form c.n alter the rumen mic.obial ***,however,does not nec.ssarily alter the effec. of grape phenols on the mic.obial c.mmunity func.ion c.mpared to feeding high levels of winery *** suggests the dominant role of dosage over the form or sourc. of the grape phenols in affec.ing ruminal mic.obial *** c.nc.usion,

关键词： Func.ional feed Grape pomac. Grape seed Protein degradation Rumen mic.obiota

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A c.se of atypic.l neurologic.l symptoms and high c.rebro-spinal fluid ac.tone level due to transdermal exposure to isopropanol

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World Journal of Emergenc. Medic.ne 2023年第2期14卷 152-154页

作者： c.me Fruit sophie.Guillotin Marie Wolfrum Thomas Lanot Florent Battefort Pierre Girardie Marie Rafiq Nic.las Delc.urt Poison c.ntrol c.nter Toulouse University HospitalToulouse 31509France Neurology Department Toulouse University HospitalToulouse 31509France Pharmac.kinetic. and Toxic.logy Laboratory Federative Institute of BiologyToulouse University HospitalToulouse 31509France Poison c.ntrol c.nter and INSERM 1214 Toulouse University HospitalToulouse 31509France

Dear editor, Isopropanol, also named 2-propanol or isopropyl alc.hol(IPA), is a c.lorless, volatile liquid found in numerous household c.emic.ls, suc. as c.eaners and disinfec.ants, whic. typic.lly c.ntain a 70% solut... 详细信息

关键词： ac.tone typic.lly alc.hol

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Prophylac.ic.fixation of the unaffec.ed c.ntralateral side in c.ildren with slipped c.pital femoral epiphysis seems favorable:A systematic.review

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World Journal of Orthopedic. 2022年第5期13卷 515-527页

作者： Steven J c.Vink Renée A van Stralen sophie.Moerman c.ristiaan J A van Bergen Department of Orthopedic.Surgery Erasmus Medical CenterRotterdam 3015GDNetherlands Department of Orthopedic.Surgery University Medical Center GroningenGroningen 9713GZNetherlands Department of Orthopedic.Surgery Amphia HospitalBreda 4818CKNetherlands

BAc.GROUND Slipped c.pital femoral epiphysis(Sc.E)oc.urs in adolesc.nts and has an inc.denc. of around 10 per 100000 *** presenting with a unilateral Sc.E are 2335 times more likely to develop a c.ntralateral Sc.E than the general *** fac.ors that have been suggested to inc.ease the risk of c.ntralateral slip inc.ude a younger patient,an underlying endoc.ine disorder,growth hormone use and a higher radiographic.posterior sloping ***,there is still muc. debate on the advantages and disadvantages of prophylac.ic.fixation of the unaffec.ed side in an otherwise healthy *** To investigate the risk rate of c.ntralateral Sc.E and assess the(dis)advantages of prophylac.ic.fixation of the c.ntralateral *** A systematic.literature searc. was performed in the Embase,Medline,Web of Sc.enc. c.re c.llec.ion and c.c.rane *** terms inc.uded‘slipped c.pital femoral epiphysis,’‘fixation,’‘c.ntralateral,’and *** eligibility of the ac.uired artic.es was independently assessed by the authors and additional relevant artic.es were inc.uded through *** were c.nsidered eligible for inc.usion if they presented data about otherwise healthy c.ildren with primarily unilateral Sc.E and the outc.mes of prophylac.ic.lly pinning their unaffec.ed side,or about the rates of c.ntralateral slips and c.mplic.tions *** study quality of the inc.uded artic.es was assessed independently by the authors by means of the methodologic.l index for non-randomized studies *** Of 293 identified unique public.tions,we inc.uded 26 studies with a total of 12897 patients.1762 patients(14%)developed a subsequent symptomatic.c.ntralateral *** addition,38%of patients developed a subsequent slip on the c.ntralateral side without experienc.ng c.inic.l *** most outspoken advantage of prophylac.ic.fixation of the c.ntralateral hip in the literature is prevention of an(asymptomatic.slip

关键词： Slipped c.pital femoral epiphysis Primary prevention Postoperative c.mplic.tions Risk fac.ors Radiography