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Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal

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Journal of Molecular Cell Biology 2018年第6期10卷 494-502页

作者： Benjamin Ravaux sophie Favier Eric Perez and Christine Gourier Laboratoire de Physique Statistique Ecole Normale Superieure/PSL Research UniversityUPMC Univ Paris 06Universite Paris DiderotCNRS75005 ParisFrance

Mammalian fertilization involves membrane events-adhesion,fusion,sperm engulfment,membrane block to polyspermy-whose causes remain largely ***,specific oscillations of the sperm in contact with the egg were shown to be necessary for *** a microfluidic chip to impose the venue for the encounter of two gametes allowed real-time observation of the membrane remodelling occurring at the sperm/egg *** spatiotemporal mapping of egg CD9 revealed that this protein concentrates at the egg/sperm interface as a result of sperm oscillations,until a CDg-rich platform is nucleated on which fusion immediately takes *** 2-5 min after fusion,most of the CD9 leaves the egg for the external aqueous *** an egg membrane wave engulfs the sperm head in^25 *** results show that sperm oscillations initiate the CD9 recruitment that causes gamete fusion after which CD9 and associated proteins leave the membrane in a process likely to contribute to block *** highlight that the gamete fusion story in mammals is an unexpected interplay between mechanical constraints and proteins.

关键词： mammalian fertilization membrane dynamics real-time imaging CDg sperm oscillations gamete fusion

Earwig mothers consume the feces of their juveniles during family life

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Insect Science 2022年第2期29卷 595-602页

作者： sophie Van Meyel Séverine Devers Joël Meunier Institut de Recherche sur la Biologie de l'Insecte UMR 7261CNRSUniversity of ToursToursFrance

Many animals consume the feces of their *** allo-coprophagy can have benefits,such as access to nutrients and symbionts,but also risks for consumers,mainly due to direct contact with pathogens that develop on *** the European earwig Forficula auricularia,mothers and juveniles live in nests lined with their *** surprising habit allows juveniles to consume the feces of their siblings during family life and provides them with nutritional benefits when mothers provide low ***,it was unclear whether earwig mothers also practice allo-coprophagy,and whether this behavior is motivated by their nutritional ***,we set up four types of experimental families in which we manipulated the nutritional needs of mothers and/or juveniles and measured the effects on the production of feces by the juveniles,and the consumption of these feces by the *** results first show that fed juveniles produced more feces pellet in presence of fed compared to food-deprived *** also found that,overall,about 50%of the mothers consumed juveniles *** consumption was both more likely and larger when the feces were produced by fed compared to food-deprived juveniles,while the proportion of feces pellets eaten was larger in food-deprived compared to fed ***,our results reveal that allo-coprophagy involves every family member and suggest that it can have both nutritional and non-nutritional benefits for earwig ***-coprophagy could thus favor the maintenance of mothers in the nest and,more generally,promote the early evolution of family life.

关键词： cooperation coprophagy dermaptera family life parental care

Dedicated population genomics for the silent world： the specific questions of marine population genetics

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Current Zoology 2016年第6期62卷 545-550页

作者： Nicolas BIERNE Francois BONHOMME sophie ARNAUD-HAOND Universite de Montpellier Montpellier France UMR 5554 UM - CNRS - IRD - EPHE Station Marine OREME Sete France CNRS - Institut des Sciences de I'Evolution Montpellier UMR 5554 UM - CNRS - IRD - EPHE Station Marine OREME Sete France Ifremer - MARine Biodiversity Exploitation and Conservation UMR 9190 IRD - IFREMER - UM - CNRS Sete France

Introduction The life cycle of most marine species is characterized by high fecundity, dispersal during a planktonic larval phase and a sessile or sedentary adult phase with large census population size （Figure 1 ）.... 详细信息

关键词：种群遗传学基因组学海洋人群世界

Nerves and hydrogen peroxide： how old enemies become new friends

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Neural Regeneration Research 2017年第4期12卷 568-569页

作者： francesca meda alain joliot sophie vriz centre interdisciplinaire de recherche en biologie(cirb) collège de franceParisFrance université paris diderot sorbonne paris cité biology departmentParisFrance psl research university France

ROS and nerves play together during the regeneration process： For many years, the role of reactive oxygen species （ROS） in neurobiology has mainly focused on its pathological implications in neurodegenerative diseases. Contrasting with this view, ROS were recently put forward as key positive signals for axon growth and repair, highlighting beneficial functions of ROS signalling in the vertebrate adult brain （Borquez et al., 2016）.

关键词： Figure Nerves and hydrogen peroxide how old enemies become new friends

Neoadjuvant or adjuvant therapy for gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第8期7卷 102-110页

作者： Laurent Quéro sophie Guillerm Christophe Hennequin Department of Radiation Oncology Saint Louis Hospital

Currently, there is no international consensus on the best treatment regimen for patients with advanced resectable gastric carcinoma. In the United States, where a limited lymph-node dissection is frequently performed, adjuvant chemoradiotherapy after surgeryis the standard treatment. In Europe, intensified perioperative chemotherapy is commonly administered. In Japan and South Korea, postoperative S-1-based adjuvant chemotherapy after surgery with D2 lymph-node dissection is the standard treatment. Several ongoing trials are currently evaluating the optimal sequence of chemotherapy, radiotherapy, and surgery, as well as the place of targeted therapeutic agents in the treatment of advanced gastric carcinoma.

关键词： Radiotherapy Chemotherapy Review Gastric cancer

Influence of Xyloglucan Molar Mass on Rheological Properties of Cellulose Nanocrystal/Xyloglucan Hydrogels

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Journal of Renewable Materials 2019年第12期7卷 1381-1390页

作者： Malika Talantikite Antoine Gourlay sophie Le Gall Bernard Cathala UR1268 Biopolymères Interactions Assemblages INRA44316NantesFrance

Plant components are an inexhaustible source for the construction of bio-based *** we report,for the first time,the elaboration of biobased cellulose nanocrystals(CNC)/xyloglucan(XG)*** is a hemicellulose displaying a great affinity for cellulose surface and can be thus irreversibly adsorbed on *** of the hydrogels were investigated by varying the molar mass of XG either by enzymatic treatment with Endo-glucanase(EG2)or physical fractionation by ultrasound(US).Fractions were characterised by high-performance size exclusion chromatography(HPSEC)and their monosacchari decompositions were *** fractions with high,average and small molar mass,(800,300 and 100103 g/mol respectively),were selected in order to tune the properties of the ***-gel transition conditions were determined for each fraction by achieving phase diagram using the inverted tube *** properties,assessed by rheology,are improved by increasing XG molar mass since elastic modulus is higher for hydrogels formed with higher molar mass fractions as well as the strain at *** formation is likely due to the adsorption of XG fractions on CNC which increases the effective hydrodynamic volume of CNC leading to steric stabilization and interactions between loops and tails of XG adsorbed.

关键词： Cellulose nanocrystals xyloglucan fractions rheology hydrogels

Androgenic regulation of novel genes in the epididymis

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Asian Journal of Andrology 2007年第4期9卷 545-553页

作者： Bernard Robaire Shayesta Seenundun Mahsa Hamzeh sophie-Anne Lamour Department of Pharmacology and Therapeutics McGill University Montrgal QC H3G1Y6 Canada Department of Obstetrics and Gynecology McGill University Montrgal QC H3G1Y6 Canada

The epididymis is critically dependent on the presence of the testis. Although several hormones, such as retinoids and progestins, and factors secreted directly into the epididymal lumen, such as androgen binding protein and fibroblast growth factor, might play regulatory roles in epididymal function, testosterone （T） and its metabolites, dihydrotestosterone （DHT） and estradiol （E2）, are accepted as the primary regulators of epididymal structure and functions, with the former playing the greater role. To ascertain the molecular action of androgens on the epididymis, three complementary approaches were pursued to monitor changes in gene expression in response to different hormonal milieux. The first was to establish changes in gene expression along the epididymis as androgenic support is withdrawn. The second was to determine the sequence of responses that occur in an androgen deprived tissue upon re-administration of the two metabolites of T, DHT and E2. The third was to study the effects of androgen withdrawal and re-administration on gene expression in immortalized murine caput epididymidal principal cells. Specific responses were observed under each of these conditions, with an expected major difference in the panoply of genes expressed upon hormone withdrawal and re-administration; however, some key common features were the common roles of genes in insulin like growth factor/epidermal growth factor and the relatively minor and specific effects of E2 as compared to DHT. Together, these results provide novel insights into the mechanisms of androgen regulation in epididymal principal cells. （Asian J Androl 2007 July; 9： 545-553）

关键词： epididymis cell culture androgen withdrawal dihydrotestosterone estradiol apoptosis survivin insulin like growth factor

Emergency evacuation in a supermarket during a terrorist attack: towards a possible modelling of the influence of affordances on the evacuation behavior of agents in a complex virtual environment

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Journal of Safety Science and Resilience 2023年第2期4卷 139-150页

作者： Satya Lancel Vincent Chapurlat Gérard Dray sophie Martin EA 4556 EPSYLON Univ Paul Valery Montpelier 3EPSYLON EA 4556F34000MontpelierFrance Laboratoire des Sciences des Risques(LSR) IMT Mines AlesAlesFrance EuroMov Digital Health in Motion Univ MontpellierIMT Mines AlesAlesFrance

During a terrorist attack on a supermarket,the use of emergency exits is essential for effective evacuation and saving ***,people tend to ignore emergency *** behavior can lengthen evacuation times,endanger individuals,and even prove *** this context,we conducted a series of experiments to explore the links between cognition and the dynamics of human capabilities in a complex and changing *** a series of behavioral experiments and computer simulations,we found that active guidance by green flashing lights at emergency exits impacts the behavior of individuals in an emergency evacuation situation in a supermarket;this tested our hypothesis that changing the environment in turn changes the evacuation behavior of *** also show that environmental modification can help in decision-making in an emergency ***,the results of computer simulations support a possible modeling of the influence of affordances on the evacuation behavior of agents in a complexvirtual environment.

关键词： Human behavior in emergency situations environmental affordances multi-agent systems signage emergency exits supermarkets

Colloidally deposited nanoparticle wires for biophysical detection

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Chinese Physics B 2015年第12期24卷 87-90页

作者： sophie C.Shen 刘文韬刁佳杰 University of North Carolina at Chapel Hill College of Environmental Science and Forestry State University of New York Center for Mitochondrial Biology and Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and Technology and Frontier Institute of Life Science Frontier Institute of Science and Technology (FIST)Xi’an Jiaotong University

Among the techniques developed to prepare nanoparticle wires for multiple applications, the colloidal deposition method at interface has been regarded as cost-efficient and eco-friendly, and hence has attracted an increasing amount of research attention. In this report, the recent developments in preparing nanoparticle wires and integrated nanoparticle wire arrays using this technique have been reviewed. Furthermore, we have also discussed the application of these nanoparticle structures in detecting chemical and biological molecules.

关键词： nanoparticle biomolecule electronic detection