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Clinical and prostate multiparametric magnetic resonance imaging findings as predictors of general and clinically significant prostate cancer risk:A retrospective single-center study

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Current Urology 2023年第3期17卷 147-152页

作者： Matteo Massanova Rebecca Vere sophie robertson Felice Crocetto Biagio Barone Lorenzo Dutto Imran Ahmad Mark Underwood Jonathan Salmond Amit Patel Giuseppe Celentano Jaimin R.Bhatt Department of Urology Queen Elizabeth University HospitalGlasgowUK Department of Neuroscience Reproductive and Odontostomatological SciencesSchool of MedicineUniversity of Naples"FedericoⅡ"NaplesItaly Department of Pathology Queen Elizabeth University HospitalGlasgowUK Department of Radiology Queen Elizabeth University HospitalGlasgowUK

Background:To evaluate the predictive values of Prostate Imaging Reporting and Data System version 2(PI-RADS v2),prostate-specific antigen(PSA)level,PSA density(PSAD),digital rectal examination findings,and prostate volume,individually and in combination,for the detection of prostate cancer(Pca)in biopsy-naïve ***:We retrospectively analyzed 630 patients who underwent transrectal systematic prostate biopsy following prostate multiparametric magnetic resonance imaging.A standard 12-core biopsy procedure was *** and multivariate analyses were performed to determine the significant predictors of clinically significant cancer but not ***:The median age,PSA level,and PSAD were 70 years,8.6 ng/mL,and 0.18 ng/mL/mL,respectively.A total of 374(59.4%)of 630 patients were biopsy-positive for Pca,and 241(64.4%)of 374 were diagnosed with clinically significant Pca(csPCa).The PI-RADS v2 score and PSAD were independent predictors of Pca and *** PI-RADS v2 score of 5 regardless of the PSAD value,or PI-RADS v2 score of 4 plus a PSAD of<0.3 ng/mL/mL,was associated with the highest csPCa detection rate(36.1%-82.1%).Instead,the PI-RADS v2 score of<3 and PSAD of<0.3 ng/mL/mL yielded the lowest risk of ***:The combination of the PI-RADS v2 score and PSAD could prove to be a helpful and reliable diagnostic tool before performing prostate *** with a PI-RADS v2 score of<3 and PSAD of<0.3 ng/mL/mL could potentially avoid a prostate biopsy.

关键词： Prostate cancer Prostate Imaging Reporting and Data System score Multiparametric magnetic resonance imaging Transrectal ultrasound Prostate biopsy Prostate-specific antigen density

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