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Clinical forensic imaging and fundamental rights in Austria

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Forensic Sciences Research 2017年第2期2卷 65-74页

作者： sophie Kerbacher Michael Pfeifer Bridgette Webb Reingard Riener-Hofer Ludwig Boltzmann Institute for Clinical Forensic Imaging Ludwig Boltzmann GesellschaftGrazAustria

Clinical forensic imaging encompasses the diverse application of imaging procedures that serve the same purpose:to enable the analysis and investigation of criminal activities and consequences of a *** kinds of imaging techniques and their corresponding images can be subsumed under“forensigraphy”,a more comprehensive term for forensic imaging created by the Ludwig Boltzmann Institute for Clinical Forensic Imaging in Graz,*** the word forensigraphy suggests,criminal imaging material should be of use in forensic ***,this can lead to new findings that would not have been revealed without the application of imaging techniques and are moreover admissible as evidence in criminal ***,the admissibility of evidence can only be facilitated through the implementation of clinical forensic imaging techniques into the forensic routine case work,which requires a precise pre-analysis of the corresponding legal *** taking and displaying internal images of a person’s body touches upon various aspects of one’s physical and psychological integrity,imaging methods in general and clinical forensic imaging methods especially have a strong impact on and interfere regularly with the fundamental rights of the concerned *** with regard to a possible medical context,certain legal regulations have to be taken into ***,this paper examines forensic imaging in the field of radiological forensigraphy,specifically its in vivo(***)*** is designed to enlighten readers as to the great significance of legal barriers that emerge from fundamental rights,as laid down in the European Convention on Human Rights(ECHR),when dealing with clinical forensic *** a result,the legal framework of clinical forensic imaging procedures are comprehensively described,the relevant fundamental rights,especially the right to respect for private and family life,the right to data protection and certain procedu

关键词： Forensic science clinical forensic medicine clinical forensic imaging forensigraphy fundamental rights physical examination criminal proceedings ECHR

Association of early follow-up visits with reduced hospital readmissions of newborns:a French population-based data-linkage study

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世界儿科杂志（英文版） 2024年第11期20卷 1138-1144页

作者： Camille Ravel Marion Nimal Steve Nauleau David Lapalus Olivier Bernard Elise Gras sophie Tardieu Farid Boubred APHM Hospital University La ConceptionNeonatal UnitService de Médecine Néonatale147 Boulevard Baille13005 MarseilleFrance Regional Health Agency Provence-Alpes-Côte d'AzurFrance APHM Public Health and Medical Information DepartmentEA 3279CEReSS-Health Service Research and Quality of Life CentreMarseilleFrance APHM Hospital University La ConceptionNeonatal UnitService de Médecine Néonatale147 Boulevard Baille13005 MarseilleFrance Aix-Marseille University INSERMINRAEC2VNMarseilleFrance

Background Newborn care guidelines recommend assessments within a week of discharge from maternity ***,the optimal timing and effectiveness to prevent neonatal hospital readmission are *** study aimed to determine the association between early follow-up visits(EFVs)within three days of postpartum discharge and hospital readmission of newborns up to 15 days of life.Methods This population-based data-linkage study used data from the French National Health Care Database."Healthy"singleton term infants with a gestational age(GA)of ≥ 36 weeks,born between January 1,2017,and November 30,2018,in Southern France,were included.A multivariate regression analysis was performed.Results Among the 67,359 included infants,1519(2.25％)were *** principal causes of hospitalization were infectious diseases(42.4％)and jaundice or growth/nutrition disorders(36.1％).Hospitalized infants were more likely to be born to young and socioeconomically deprived mothers,to be male(54.4％vs.50.6％,P＜0.001),or born early(GA＜38 weeks;28.5％vs.20.5％,P＜0.001).They received 6％less EFVs than non-hospitalized infants(63.7％vs.67.8％,P＜0.001).The multivariable regression logistic analysis revealed that infants who received EFVs had 13％lower odds of being hospitalized than infants without EFVs,with an adjusted odds ratio of 0.87(95％confidence interval=0.78-0.96;P＜0.01).Conclusion EFVs within three days were associated with a 13％reduction in the rate of neonatal hospital ***,EFVs should be implemented to improve infant health and reduce healthcare costs.

关键词： Breastfeeding Bronchiolitis Neonatal jaundice Postpartum discharge Socioeconomic status

Exercise training improves participation in persons with multiple sclerosis:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第3期11卷 393-402页

作者： Thomas Edwards Anne sophie Michelsen Afolasade O.Fakolade Ulrik Dalgas Lara A.Pilutti School of Human Kinetics University of OttawaOttawaON K1N6N5Canada Department of Public Health-Exercise Biology Aarhus UniversityAarhus C 8000Denmark School of Rehabilitation Therapy Queens UniversityKingstonON K7L3N6Canada Interdisciplinary School of Health Sciences Brain and Mind Research InstituteUniversity of OttawaOttawaON K1N6N5Canada

Background Although previous studies have examined the effects of exercise training on other International Classification of Functioning,Disability and Health(ICF)component levels in persons with multiple sclerosis(MS),the effects of exercise training on participation remain *** objectives of this review were to:(1)characterize systematically the use of outcome measures that capture participation in exercise training studies;(2)quantify the effect of exercise training on participation in persons with *** A search of 6 electronic databases(CINAHL,SPORTDiscuss,Embase,MEDLINE,Cochrane Central,and Scopus)was conducted to identify controlled and noncontrolled trials involving exercise training and participation in persons with *** strings were built from Medical Subject Headings and CINAHL *** linking rules were used to identify participation chapters and categories ***-analysis was used to quantify the effect of exercise training on participation in randomized controlled trials comparing exercise effects to no intervention/usual *** We included 49 articles involving controlled and noncontrolled exercise trials in the systematic review of outcome *** captured 16 different outcome measures that captured all 9 participation chapters and identified 89 unique participation *** these 16 outcome measures,mobility was the most commonly represented participation chapter,with 108 items.A subsample of 23 randomized controlled trials was included in the *** overall effect of 0.60(standard error=0.12,95%confidence interval:0.36-0.84,z=4.9,p<0.001)was calculated,indicating a moderate,positive effect of exercise training on *** The current review provides information that can be used to guide the selection of outcome measures that capture participation in studies of exercise training in persons with *** training has a positive effect on outcomes that capture participation,p

关键词： Exercise training ICF framework Multiple sclerosis Participation

Outcome of meniscal repairs in paediatric population:A tertiary centre experience

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World Journal of Orthopedics 2024年第6期15卷 547-553页

作者： Ayman Gabr Samson Williams sophie Dodd Nick Barton-Hanson Department of Trauma&Orthopaedics West Suffolk HospitalSuffolk IP332QZUnited Kingdom Department of Trauma and Orthopaedics Alder Hey Children's HospitalLiverpool L145ABUnited Kingdom

BACKGROUND Meniscal sparing surgery is a widely utilised treatment option for unstable meniscal tears with the aim of minimising the risk of progression towards ***,there is limited data in the literature on meniscal repair outcomes in skeletally immature *** To evaluate the re-operation rate and functional outcomes of meniscal repairs in children and *** We performed a retrospective review of all patients who underwent arthroscopic meniscal repair surgery between January 2007 and January *** patients were under the age of 18 at the time of *** were all performed by a single *** was gathered from our hospital Electronic Patient Records *** primary outcome measure was re-operation rate(need for further surgery on the same meniscus).Secondary outcome measures were surgical complications and patient reported outcome measures that were International Knee Documentation Committee(IKDC),Tegner and Lysholm *** We identified 59 patients who underwent 66 All-inside meniscal repairs(32 medial meniscus and 34 Lateral meniscus).Meniscal repairs were performed utilizing FasT-Fix(Smith and Nephew)*** were 37 males and 22 females with an average age of 14 years(range 6-16).The average follow-up time was 53 months(range 26-140).Six patients had concomitant anterior cruciate ligament reconstruction surgery along with the meniscal *** were no requiring further meniscal repairs and 9 patients underwent partial *** mean postoperative IKDC score was 88(44-100),Tegner score was 7(2-10)and Lysholm score was 94(57-100).CONCLUSION Our results showed that arthroscopic repair of meniscal tears in the paediatric population is an effective treatment option that has a low failure rate and good postoperative clinical with the advantage of preserving meniscal tissues.

关键词： Meniscus Meniscal repair Outcome Meniscal preservation

Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34^(cdc2) kinase

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第7期6卷 656-663页

作者：杨骅郑树 MEIJER Laurent 李士敏 LECLERC sophie 郁琳琳程金泉张苏展 Cancer Institute Zhejiang University Hangzhou 310009 China Departments of Pathology and Interdisciplinary Oncology University of South Florida School of Medicine and H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA Cancer Institute Zhejiang University Hangzhou 310009 China Cell Cycle Laborator CNRS Station Biologique BP 74 29682 Roscoff Cedex Bretagne France School of Pharmaceutical Science Zhejiang University Hangzhou 310031 China Departments of Pathology and Interdisciplinary Oncology University of South Florida School of Medicine and H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

Objective: To screen and evaluate the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25phosphatase. Methods: The affinity chromatography purified glutashione-S-transferase/Cdc25A phosphatase fusion protein and Cdc2/cyclin B from the extracts of starfish M phase oocytes are used as the cell cycle-specific targets for screening the antimitotic constituents. We tested 9 extracts isolated from the Chinese medicinal herbs and vegetables including the agents currently used in cancer treatment by measuring the inhibition of Cdc25A phosphatase and Cdc2 kinase activity. The antitumor activity of the extracts was also evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and flow ***: Cdc25A inhibitory activity and antitumor activity are detected in the extracts isolated from three Chinese medicinal herbs Agrimonapilosa; Herba solani lyrati; Galla chinesis. Conclusion: We found three extracts isolated from Chinese medicinal herbs have potential inhibitory activity of Cdc25 phosphatase using a highly specific mechanism-based screen assay for antimitotic drug discovery.

关键词： Chinese medicinal herbs Cdc25 phosphatase inhibition Cell cycle Anti-tumor activity

Fiber transmission demonstrations in vector mode space division multiplexing

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Frontiers of Optoelectronics 2018年第2期11卷 155-162页

作者： Leslie A. RUSCH sophie LAROCHELLE Centre for Optics Photonics and Lasers ECE Department Universite Laval Quebec G1V 0A6 Canada

Much attention has been focused on the use of scalar modes for space division multiplexing （SDM）. Alternative vector mode bases offer another solution set for SDM, expanding the available trade-offs in system performance and complexity. We present two types of ring core fiber conceived and designed to explore SDM with fibers exhibiting low interactions between supported modes. We review demonstrations of fiber data transmis- sion tbr two separate vector mode bases： one for orbital angular momentum （OAM） modes and one for linearly polarized vector （LPV） modes. The OAM mode demon- strations include short transmissions using commercially available transceivers, as well as kilometer length transmission at extended data rates. The LPV demonstra- tions span kilometer length transmissions at high data rate with coherent detection, as well as a radio over fiber experiment with direct detection of narrowband signals.

关键词： space division multiplexing (SDM) few-mode fiber (FMF) orbital angular momentum (OAM) linearly polarized vector (LPV) modes ring core fiber(RCF) polarization maintaining fiber

The importance of non-carbonate mineral weathering as a soil formation mechanism within a karst weathering profile in the SPECTRA Critical Zone Observatory, Guizhou Province,China

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Acta Geochimica 2017年第3期36卷 566-571页

作者： Oliver W.Moore Heather L.Buss sophie M.Green Man Liu Zhaoliang Song School of Earth Sciences University of Bristol Geography College of Life and Environmental SciencesUniversity of Exeter School of Water Resources and Environment China University of Geosciences (Beijing) Institute of the Surface-Earth System Science Research Tianjin University

Soil degradation, including rocky desertification,of the karst regions in China is severe. Karst landscapes are especially sensitive to soil degradation as carbonate rocks are nutrient-poor and easily eroded. Understanding the balance between soil formation and soil erosion is critical for long-term soil sustainability, yet little is known about the initial soil forming processes on karst terrain. Herein we examine the initial weathering processes of several types of carbonate bedrock containing varying amounts of non-carbonate minerals in the SPECTRA Critical Zone Observatory, Guizhou Province, Southwest China. We compared the weathering mechanisms of the bedrock to the mass transfer of mineral nutrients in a soil profile developed on these rocks and found that soil formation and nutrient contents are strongly dependent upon the weathering of interbedded layers of more silicate-rich bedrock(marls). Atmospheric inputs from dust were also detected.

关键词： Critical zone Chemical weathering Karst Desertification Guizhou Province

Targeting head and neck tumoral stem cells： From biologicalaspects to therapeutic perspectives

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World Journal of Stem Cells 2016年第1期8卷 13-21页

作者： Benoîte Méry Jean-Baptiste Guy sophie Espenel Anne-sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné Department of Radiotherapy Lucien Neuwirth Cancer Institute42271 Saint-Priest en JarezFrance Laboratoire de Radiobiologie Cellulaire et Moléculaire de Lyon Sud Facultéde Médecine Lyon Sud69921 Oullins CedexFrance

Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities.

关键词： Biology Head and neck neoplasms Oralcancer Neoplastic stem cells Molecular targetedtherapy Radiation therapy Chemotherapy

Turning to myelin turnover

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Neural Regeneration Research 2019年第12期14卷 2063-2066页

作者： Tobias J.Buscham Maria A.Eichel sophie B.Siems Hauke B.Werner Department of Neurogenetics Max Planck Institute of Experimental Medicine

Neural plasticity in the adult central nervous system involves the adaptation of myelination, including the formation of novel myelin sheaths by adult-born oligodendrocytes. Yet, mature oligodendrocytes slowly but constantly turn over their pre-existing myelin sheaths, thereby establishing an equilibrium of replenishment and degradation that may also be subject to adaptation with consequences for nerve conduction velocity. In this short review we highlight selected approaches to the normal turnover of adult myelin in vivo, from injecting radioactive precursors of myelin constituents in the 1960s to current strategies involving isotope labeling and tamoxifen-induced gene targeting.

关键词： oligodendrocyte myelin plasticity and turnover degradation tamoxifen metabolic labeling isotope labeling neural plasticity myelinoid bodies central nervous system