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Virus-host Interactions during Hepatitis C Virus Entry-Implications for Pathogenesis and Novel Treatment Approaches

Virologica Sinica 2008年第2期23卷 124-131页

作者： Joachim Lupberger Mirjam B. Zeisel Anita Haberstroh Eva K. Schnober sophie krieger Eric Soulier Christine Thumann Cathy Royer Samira Fafi-Kremer Catherine Schuster Franoise Stoll-Keller Hubert E. Blum Thomas F. Baumert Inserm U748 Hpitaux Universitaires de Strasbourg Université Louis Pasteur 3 Rue Koeberle Department of Medicine II University of Freiburg

Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary target cell. Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between the virus and the target cell that is required for successful entry into the cell and initiation of infection. This step is an important determinant of tissue tropism and pathogenesis; it thus represents a major target for antiviral host cell responses, such as antibody-mediated virus neutralization. Following the development of novel cell culture models for HCV infection our understanding of the HCV entry process and mechanisms of virus neutralization has been markedly advanced. In this review we summarize recent developments in the molecular biology of viral entry and its impact on pathogenesis of HCV infection, development of novel preventive and therapeutic antiviral strategies.

关键词： Hepatitis C virus Viral entry Entry inhibitor Neutralizing antibodies

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Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

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Signal Transduction and Targeted Therapy 2022年第3期7卷 790-801页

作者： Hernando Lopez-Bertoni Amanda Johnson Yuan Rui Bachchu Lai sophie Sail Maureen Malloy Jonathan BCoulter Maria Lugo-Fagundo Sweta Shudir Harmon Khela Christopher Caputo Jordan J.Green John Laterra Hugo W.Moser Research Institute at Kennedy krieger BaltimoreMDUSA Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Biomedical Engineering Institute for NanoBioTechnologyand the Translational Tissue Engineering CenterJohns Hopkins University School of MedicineBaltimoreMDUSA Bloomberg School of Public Health Department of Environmental Health and EngineeringThe Johns Hopkins University School of MedicineBaltimoreMDUSA The Department of Radiation Oncology and Molecular Radiation Sciences The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Ophthalmology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Materials Science&Engineering and Chemical&Biomolecular Engineering Johns Hopkins UniversityBaltimoreMDUSA Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5m... 详细信息

关键词： TET2 5hmC convert

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