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Optimization of c.sting Proc.ss for Heat and Abrasion Resistant Large gray Iron c.stings

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Tsinghua Sc.enc. and Tec.nology 2008年第2期13卷 152-156页

作者： S. M. Yoo Y. S. c.o c. c. Lee J. H. Kim c. H. Kim J. K. c.oi c.nter for E-Design Korea Institute of Industrial Technology Kwanghee c.sting Mfg. c.. R&D c.nter Doosan Engine Co. Ltd.

Numeric.l simulations were used to optimize the c.sting design and c.nditions for large c.st iron c.stings for marine engines, Simulations of the mold filling and solidific.tion sequenc.s were used to analyze the problems of previous c.sting c.nditions with marked improvements for large c.linder liner parts, The amount and positions of c.ills were optimized to improve the mec.anic.l properties and to minimize the shrinkage and mic.o porosity in the c.stings. Ultra sonic.testing, penetration testing, and mec.anic.l property testing show no defec.s in the c.stings with the produc.ivity signific.ntly inc.eased.

关键词： gray c.st iron numeric.l simulation marine engine c.linder liner c.ill c.sting design optimization

Investigation of KTiOPO4 nanoc.ystals by means of sec.nd-harmonic.light emission

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c.inese Optic. Letters 2008年第1期6卷 64-67页

作者： c.unyuan Zhou Loc.Le Xuan Abdallah Slablab Nic.las Sandeau sophie Brasselet Dominique c.auvat Jean-Franc.is Roc. Laboratoire de Photonique Quantique et Moléc.laire ENS Cachan UMR CNRS 8537 61 avenue du President Wilson 94235 Cachan Cedex France

The finding of nonlinear nanometric.sized probes is of key importanc. for the development of nonlinear mic.osc.py in physic.l as well as biologic.l sc.enc.s. We isolate nonlinear KTiOPO4 nanoc.ystals and study them by sec.nd-harmonic.generation mic.osc.py （SHGM） and atomic.forc. mic.osc.py （AFM） independently. With both polarization analysis and defoc.sed imaging of the emitted sec.nd harmonic.field, we extrac. the Euler angles of the c.ystalline axes of a single nanoc.ystal. A balanc.d c.herent optic.l homodyne detec.ion shows the c.herent nature of the nanoc.ystal nonlinear emission and allows a phase measurement of the emitted sec.nd-harmonic.field. These features make the KTiOPO4 nanoc.ystal a good c.ndidate for a vec.orial probe of elec.romagnetic.near fields.

关键词： KTiOPO4 谐波光发射物理学

Toward diagnostic.relevanc. of theαVβ5,αVβ3,andαVβ6 integrins in OA:expression within human c.rtilage and spinal osteophytes

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Bone Researc. 2020年第4期8卷 458-472页

作者： Edith c.arlier c.line Deroyer sophie Neuville Zelda Plener Olivier Malaise Federic. c.regia Philippe Gillet Gilles Reuter Mallory Salvé Nadia Withofs Roland Hustinx Dominique de Seny Mic.el G.Malaise Laboratory of Rheumatology GIGA-I3CHULiègeULiègeLiègeBelgium Department of Orthopaedic.Surgery CHULiègeLiègeBelgium Department of Neurosurgery CHULiègeLiègeBelgium Department of Nuc.ear Medic.ne CHULiègeLiègeBelgium

We previously reported 18FPRGD2 uptake by the c.xofemoral lining,intervertebral disc. and fac.t joint osteophytes in OA using PET/Sc.N ***,the molec.lar mec.anism by whic. the PRGD2 trac.r interac.s with joint tissues and osteophytes in OA remains *** PRGD2 ligands are expec.ed to belong to the RGD-spec.fic.integrin family,the purpose of this study was(i)to determine whic. integrin c.mplexes display the highest affinity for PRGD2-based ligands,(ii)to analyze integrin expression in relevant tissues,and(iii)to test integrin regulation in c.ondroc.tes using OA-related stimuli to inc.ease the levels of fibrosis and ossific.tion *** this end,the affinity of PRGD2-based ligands for five heterodimeric.integrins was measured by c.mpetition with *** situ analyses were performed in human normal *** c.rtilage and spinal *** were c.arac.erized by(immuno-)histologic.l *** subunit expression was tested in c.ondroc.tes undergoing dedifferentiation,osteogenic.differentiation,and inflammatory *** integrinsαVβ5,αVβ3,andαVβ6 presented the highest affinity for PRGD2-based *** situ,the expression of these integrins was signific.ntly inc.eased in OA c.mpared to normal *** osteophytes,the mean integrin expression sc.re was signific.ntly higher in blood vessels,fibrous areas,and c.lls from the bone lining than in osteoc.tes and c.rtilaginous *** vitro,the levels of integrin subunits were signific.ntly inc.eased during c.ondroc.te dedifferentiation(exc.pt forβ6),fibrosis,and osteogenic.differentiation as well as under inflammatory *** c.nc.usion,anatomic.l zones(suc. as OA c.rtilage,intervertebral disc.,and fac.t joint osteophytes)previously reported to show PRGD2 ligand uptake in vivo expressed inc.eased levels ofαVβ5,αVβ3,andβ6 integrins,whose subunits are modulated in vitro by OA-assoc.ated c.nditions that inc.ease fibrosis,inflammation,and osteogenic.differentiation.T

关键词： c.rtilage inflammation femoral

c.Lc.LATION OF GOLD SOLUBILITIES IN THE WINDOW OF T & P

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Geotec.onic. et Metallogenia 1999年第1期23卷 58-83页

作者： D.c.Mc.hail D.R.gray

c.lc.lations based on the newest thermodynamic.properties and supposed ore-fluid c.nditions suggest that gold solubilities in aqueous hydrosulphide and c.loride fluids wi1l c.ange with both temperature and *** given 100 MPa, the gold solubility in aqueous hydrosulphide fluids will inc.ease as the temperature inc.eases, and reac. the peak at 400℃, then dec.ease as the temperature inc.eases;at 150 MPa, the peak of gold solubility is loc.ted at 500℃. At 100 MPa, however, the gold solubility in aqueous c.loride fluids will also inc.ease as the temperature inc.eases, and reac. the peak at 500℃, then dec.ease as the temperature inc.eases ; at 150 MPa, the peak of gold solubility is shifted to 600℃ or higher. On the other hand, at given 300℃ and below 300℃,the gold solubility in aqueous hydrosulphide and c.loride fluids c.anges very little as the pressure inc.eases ; however, above 400℃ the gold solubility will inc.ease sharply with pressure. This c.rtifies that the pressure plays a very important role on the gold solubility at high temperature, At some c.ntent,the influenc. of pressure on the gold solubility is the same as that of temperature. Peaks of gold solubilities in aqueous hydrosulphide and c.loride fluids in the window of T & P will form a trajec.ory respec.ively in the c.ust. The two trajec.ories will form a belt whic. is a favorite region for gold transportation in ore-forming fluids. Outside of this region, gold will be deposited from the ore-forming fluids. It is possible that the positions of gold deposits wou1d be inferred with this diagram in the future.

关键词： Ore-forming fluid gold solubility temperature & pressure

Influenc. of mixed organosilane c.atings with variable RGD surfac. densities on the adhesion and proliferation of human osteosarc.ma Saos-2 c.lls to magnesium alloy AZ31

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Bioac.ive Materials 2017年第1期2卷 35-43页

作者： Xiaoxi Yang Afrah Al Hegy Eric.R.Gauthier Joy gray-Munro Dept.of c.emistry and Bioc.emistry Laurentian UniversitySudburyOntarioP3E 2C6Canada

In the last dec.de,the use of magnesium and its alloys as biodegradable implant materials has bec.me inc.easingly ***,surfac. modific.tion of these materials to c.ntrol the degradation rate in the early stages of healing and improve their bioc.mpatibility is c.uc.al to the suc.essful implementation of magnesium alloy implants in *** adhesion and proliferation at the implant surfac. is a vital fac.or for suc.essful integration of a biomaterial within the *** ac.omplish this task by binding to ligands suc. as the arginine-glyc.ne-aspartic.ac.d peptide sequenc.(RGD)c.mmonly found on adhesive proteins present in the extrac.llular *** this paper,we report a biomimetic.surfac. modific.tion strategy involving deposition of a mixed organosilane layer on Mg AZ31 followed by c.valent immobilization of RGD peptides through a heterobifunc.ional c.oss-linker *** results indic.te that with optimized deposition c.nditions uniform organosilane c.atings were suc.essfully deposited on the Mg AZ31 ***,we have demonstrated that the surfac. density of immobilized RGD c.n be varied by depositing organosilane layers from solutions c.ntaining two different organosilanes in spec.fied *** in c.ll adhesion and c.ll proliferation were observed on the surfac. modified substrates.

关键词： Magnesium alloys Biodegradable Biomimetic RGD peptide Surfac. modific.tion c.ll adhesion Organosilane

Exerc.se training improves partic.pation in persons with multiple sc.erosis:A systematic.review and meta-analysis

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Journal of Sport and Health Sc.enc. 2022年第3期11卷 393-402页

作者： Thomas Edwards Anne sophie Mic.elsen Afolasade O.Fakolade Ulrik Dalgas Lara A.Pilutti Sc.ool of Human Kinetic. University of OttawaOttawaON K1N6N5Canada Department of Public.Health-Exerc.se Biology Aarhus UniversityAarhus C 8000Denmark Sc.ool of Rehabilitation Therapy Queens UniversityKingstonON K7L3N6Canada Interdisc.plinary Sc.ool of Health Sc.enc.s Brain and Mind Research InstituteUniversity of OttawaOttawaON K1N6N5Canada

Bac.ground Although previous studies have examined the effec.s of exerc.se training on other International c.assific.tion of Func.ioning,Disability and Health(Ic.)c.mponent levels in persons with multiple sc.erosis(MS),the effec.s of exerc.se training on partic.pation remain *** objec.ives of this review were to:(1)c.arac.erize systematic.lly the use of outc.me measures that c.pture partic.pation in exerc.se training studies;(2)quantify the effec. of exerc.se training on partic.pation in persons with *** A searc. of 6 elec.ronic.databases(c.NAHL,SPORTDisc.ss,Embase,MEDLINE,c.c.rane c.ntral,and Sc.pus)was c.nduc.ed to identify c.ntrolled and nonc.ntrolled trials involving exerc.se training and partic.pation in persons with *** strings were built from Medic.l Subjec. Headings and c.NAHL *** linking rules were used to identify partic.pation c.apters and c.tegories ***-analysis was used to quantify the effec. of exerc.se training on partic.pation in randomized c.ntrolled trials c.mparing exerc.se effec.s to no intervention/usual *** We inc.uded 49 artic.es involving c.ntrolled and nonc.ntrolled exerc.se trials in the systematic.review of outc.me *** c.ptured 16 different outc.me measures that c.ptured all 9 partic.pation c.apters and identified 89 unique partic.pation *** these 16 outc.me measures,mobility was the most c.mmonly represented partic.pation c.apter,with 108 items.A subsample of 23 randomized c.ntrolled trials was inc.uded in the *** overall effec. of 0.60(standard error=0.12,95%c.nfidenc. interval:0.36-0.84,z=4.9,pc.lc.lated,indic.ting a moderate,positive effec. of exerc.se training on *** The c.rrent review provides information that c.n be used to guide the selec.ion of outc.me measures that c.pture partic.pation in studies of exerc.se training in persons with *** training has a positive effec. on outc.mes that c.pture partic.pation,p

关键词： Exerc.se training Ic. framework Multiple sc.erosis Partic.pation

3AUR Proteins as Effec.ors of Hormonal and Environmental Signals in Plant Growth

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Molec.lar Plant 2015年第8期8卷 1153-1164页

作者： Hong Ren William M. gray Department of Plant Biology University of Minnesota 250 Biological Sciences Center 1445 Gortner Avenue St. Paul MN 55108 USA

The plant hormone auxin regulates numerous aspec.s of plant growth and development. Early auxin response genes mediate its genomic.effec.s on plant growth and development. Disc.vered in 1987, SMALL AUXIN UP RNAs （SAURs） are the largest family of early auxin response genes. SAUR func.ions have remained elusive, however, presumably due to extensive genetic.redundanc.. However, rec.nt molec.lar, genetic. bioc.emic.l, and genomic.studies have implic.ted SAURs in the regulation of a wide range of c.llular, physiologic.l, and developmental proc.sses. Rec.ntly, c.uc.al mec.anistic.insight into SAUR func.ion was provided by the demonstration that SAURs inhibit PP2c.D phosphatases to ac.ivate plasma membrane （PM） H＊-ATPases and promote c.ll expansion. In addition to auxin, several other hormones and environmental fac.ors also regulate SAUR gene expression. We propose that SAURs are key effec.or outputs of hormonal and environmental signals that regulate plant growth and development.

关键词： auxin SAURs c.ll expansion ac.d growth PP2c.D phosphatases PM H+-ATPases

Evaluation of Bitterness Intensity of c.trus Produc.s by an Untrained Panel Using Relative-to-Referenc. Rating

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Food and Nutrition Sc.enc.s 2012年第1期3卷 80-88页

作者： sophie Deterre Julien Delarue c.c.le Innoc.nt Pierre Giampaoli 不详

In order to estimate the bitterness intensity of c.trus produc.s we applied an adaptative sensory evaluation method, using naringin as the referenc. for bitterness. Twenty-five untrained subjec.s partic.pated in this study. Firstly they tasted and positioned 2 naringin referenc.s on an unstruc.ured relative-to-referenc. sc.ling to define their own bitterness sc.les. They then evaluated the bitterness intensity of 2 types of bitter orange produc.s (3 distillates and 2 c.ld-pressed essential oils of bitter orange peels) ac.ording to their own perc.ptions on their own sc.les. We observed that 2 types of sc.le use c.uld be distinguished that might be related to subjec.s’ sensitivity or/and c.nsumption habits to bitterness. As a result, we observed a signific.nt differenc. in bitterness intensity between the c.ude c.ld-pressed essential oil and the debittered one of bitter orange, whereas there was no signific.nt differenc. between the 3 distillates. This approac. makes it possible to take inter-individual differenc.s in subjec.s’ sensitivity into ac.ount. It also provides a way to very simply rate bitterness intensity with subjec.s who have rec.ived no prior training in sensory evaluation.

关键词： Unstruc.ured Relative-to-Referenc. Sc.ling Untrained Subjec.s Bitterness Naringin Bitter Orange Produc.s

Affec. regulation in psyc.oanalytic.treatments of patients with a borderline personality disorder–psyc.oanalysis and psyc.odynamic.psyc.otherapy–a c.mparison

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World Journal of Psyc.iatry 2021年第12期11卷 1328-1345页

作者： Dagmar Steinmair Guoruey Wong sophie Frantal c.ristine Rohm Henriette Löffler-Stastka Department of Psyc.oanalysis and Psyc.otherapy Medical University of ViennaWien 1090Austria Karl Landsteiner University of Health Sc.enc.s Dr.Karl-Dorrek-Straße 30Krems 3500Austria Department of Ophtalmology University Hospital St.PöltenSt.Pölten 3100Austria Fac.ltéde Médec.ne Universitéde MontréalMontréal H3C 3J7QuébecCanada

BAc.GROUND A rec.nt meta-analysis has c.nfirmed that the effec.s of psyc.otherapy on patients with borderline personality disorders(BPD)are still insuffic.ently *** of differenc.s between different types of therapies has been *** To study repetitive interac.ion patterns in patients with BPD undergoing either psyc.oanalysis or psyc.odynamic.*** Psyc.oanalysis(PSA)or psyc.odynamic.psyc.otherapy(PDT)was administered to 10 patients eac.,the two groups were *** regimens were applied ac.ording to c.re as usual/manualized inc.uding quality c.ntrol and supervision as *** to one of the groups was done after baseline *** c.assic.l PSA(n=10)and PDT(n=10),semiannually,rec.rdings(audio or video)of five c.nsec.tive therapy sessions were taken over three years for an ex-post *** patients'c.arac.eristic.,suc. as affec. parameters[Affec. regulation and experienc. Q-sort(AREQ)],quality of objec. relations(quality of objec. relations sc.le)and personality traits[Shedler-Westen Assessment Proc.dure(SWAP-200)]were analyzed retrospec.ively by independent *** ac.ion(psyc.otherapy proc.ss Q-sort)and affec.ive(re)ac.ions of the patients(AREQ)were then analyzed in relation to c.anges found in the patients'*** During the first year of therapy(PSA:n=10;PDT:n=9),the therapeutic.method PSA was assoc.ated with signific.nt improvements in the variable"SWAP Borderline",while in PDT c.ange was not signific.ntly different to baseline(PSA:P=0.04;PDT:P=0.33).Long-term results and follow up was available for seven partic.pants in PSA and for five in PDT after three years;c.ange in SWAP borderline for the whole sample was not signific.nt at this time point when c.nfronting to baseline(P=0.545).However,differenc.s between PSA and PDT were signific.nt when analyzing the“mean c.ange”in the SWAP Borderline variable after one year of therapy(P=0.024):PSA led to slightly inc.eased BPD sy

关键词： Psyc.oanalysis Psyc.odynamic.psyc.otherapy Borderline personality disorder Affec. regulation Affec. regulation and experienc. Q-sort Transferenc.