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Building quality primary health care development in the new era towards universal health coverage:a Beijing initiative

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Global Health Research and Policy 2023年第1期8卷 2-7页

作者： Minghui Ren Tuohong Zhang Jin Xu Jie Qiao Jianrong Qiao Siyan Zhan Jiangmei Qin Daping Song Yanru Fang Yifang Lin Xiaopeng Jiang Yan Guo Qingyue Meng Xu Qian Yunguo Liu sophia siu chee chan Feng Zhao Winnie Yip Hong Wang Minmin Wang Hui Yin Zuokun Liu Na Li Xinyi Song Fangfang Liu Yinzi Jin Fangjing Liu Yangmu Huang Department of Global Health School of Public HealthPeking UniversityBeijingChina Institute for Global Health Peking UniversityBeijingChina China Centre for Health Development Studies Peking UniversityBeijingChina Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingChina World Health Organization Representative Office in China BeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina China National Health Development Research Center BeijingChina College of Agronomy and Biotechnology China Agricultural UniversityBeijingChina Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina School of Public Health Fudan UniversityShanghaiChina Global Health Research Center Duke Kunshan UniversityKunshanJiangsuChina School of Nursing LKS Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Health Nutrition and Population South Asia RegionWorld BankBangkokThailand Department of Global Health and Population Harvard T H Chan School of Public HealthBostonMAUSA Bill&Melinda Gates Foundation BeijingChina

Primary health care(PHC)is the most effective way to improve people’s health and well-being,and primary care services should act as the cornerstone of a resilient health system and the foundation of universal health *** promote high quality development of PHC,an International Symposium on Quality Primary Health Care Development was held on December 4-5,2023 in Beijing,China,and the participants have proposed and advocated the Beijing Initiative on Quality Primary Health Care *** Beijing Initiative calls on all countries to carry out and strengthen 11 actions:fulfill political commitment and accountability;achieve“health in all policies”through multisectoral coordination;establish sustainable financing;empower communities and individuals;provide community-based integrated care;promote the connection and integration of health services and social services through good governance;enhance training,allocation and motivation of health workforce,and medical education;expand application of traditional and alternative medicine for disease prevention and illness healing;empower PHC with digital technology;ensure access to medicinal products and appropriate technologies;and last,strengthen global partnership and international health *** Initiative will enrich the content of quality development of PHC,build consensus,and put forward policies for quality development of PHC in China in the new era,which are expected to make contributions in accelerating global actions.

关键词： Primary health care Universal health coverage Sustainable development agenda

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促进初级卫生保健高质量发展,迈向全民健康新时代的北京倡议

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中国全科医学 2024年第10期27卷 1149-1152页

作者：任明辉张拓红徐进乔杰乔建荣詹思延秦江梅宋大平房验茹林奕芳姜晓朋郭岩孟庆跃钱序刘运国 sophia siu chee chan 赵峰 Winnie Yip 汪宏王敏敏尹惠刘佐坤李娜宋心怡刘方方金音子周书铎刘芳静黄旸木北京大学公共卫生学院北京市100191 北京大学全球卫生研究院北京市100191 北京大学中国卫生发展研究中心北京市100191 北京大学第三医院北京市100191 世界卫生组织驻华代表处北京市100600 国家卫生健康委卫生发展研究中心北京市100044 中国农业大学农学和生物科技学院北京市100193 复旦大学附属华山医院上海市200040 复旦大学公共卫生学院上海市200032 昆山杜克大学全球健康研究中心江苏省昆山市215316 香港大学李嘉诚医学院护理学院中国香港特别行政区999077 世界银行南亚区域健康营养与人口部门泰国曼谷10330 哈佛大学陈曾熙公共卫生学院全球健康与人口学系美国波士顿02115 比尔及梅琳达·盖茨基金会北京市100049

初级卫生保健是改善人们健康和福祉的最有效途径,初级卫生保健服务应成为有韧性的卫生系统的基石和全民健康覆盖的基础。为推动初级卫生保健高质量发展,2023年12月4—5日,初级卫生保健高质量发展国际研讨会在中国北京召开,与会代表提出... 详细信息

初级卫生保健是改善人们健康和福祉的最有效途径,初级卫生保健服务应成为有韧性的卫生系统的基石和全民健康覆盖的基础。为推动初级卫生保健高质量发展,2023年12月4—5日,初级卫生保健高质量发展国际研讨会在中国北京召开,与会代表提出并通过了《初级卫生保健高质量发展北京倡议》。该倡议呼吁开展和加强11项行动:落实政府承诺和责任;通过多部门协同将健康融入所有政策;建立可持续的筹资;赋能社区和个人;提供以社区为基础的整合型服务;以良好的治理促进健康服务和社会服务衔接融合;加强人力资源的培训、配置和激励及医学教育;推广传统医学和替代医学在疾病预防和疾患疗愈中的应用;数字赋能初级卫生保健;确保医药产品和适宜技术的可及;增进全球伙伴关系与国际卫生合作。倡议将丰富初级卫生保健高质量发展内涵,凝聚共识,为促进中国初级卫生保健新时代高质量发展政策,加快全球实现全民健康覆盖进程做出贡献。

关键词：初级卫生保健全民健康覆盖可持续发展议程倡议北京

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An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline(alkaloids) from Stephania tetrandra roots

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Journal of Integrative Medicine 2021年第4期19卷 311-316页

作者： Eric Wei Chiang chan siu Kuin Wong Hung Tuck chan Faculty of Applied Sciences UCSI UniversityKuala Lumpur 56000Malaysia School of Foundation Studies Xiamen University MalaysiaSelangor 43900Malaysia Secretariat of the International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Tetrandrine(TET) and fangchinoline(FAN) are dominant bisbenzylisoquinoline(BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linked by oxygen bridges. The molecular structures of TET and FAN are exactly the same, except that TET has a methoxy(-OCH3) group, while FAN has a hydroxyl(-OH) group at C7. In this overview,the current knowledge on the chemistry, pharmacology and anticancer properties of TET and FAN have been updated. The focus is on colon and breast cancer cells, because they are most susceptible to TET and FAN, respectively. Against colon cancer cells, TET inhibits cell proliferation and tumor growth by inducing apoptosis and G1 cell cycle arrest, and suppresses adhesion, migration and invasion of *** breast cancer cells, FAN inhibits cell proliferation by inducing apoptosis, G1-phase cell cycle arrest and inhibits cell migration. The processes involve various molecular mechanisms and signaling pathways. Some insights on the ability of TET and FAN to reverse multi-drug resistance in cancer cells and suggestions for future research are provided.

关键词： Tetrandrine Fangchinoline Alkaloids Pharmacology Anticancer Multi-drug resistance

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Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties

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Journal of Integrative Medicine 2018年第3期16卷 147-152页

作者： Eric Wei Chiang chan siu Kuin Wong Hung Tuck chan Faculty of Applied Sciences UCSI University School of Science Monash University Secretariat of International Society for Mangrove Ecosystems Faculty of Agriculture University of the Ryukyus

This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond,two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus： fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of ***. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex *** compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed.

关键词： Vitexicarpin Polymethylflavone Apoptosis Molecular mechanisms

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TRANSFECTION AND CELL FUSION BY FEMTOSECOND LASERS

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 113-125页

作者： HAO HE siu KAI KONG KAM TAI chan Department of Electronic Engineering The Chinese University of Hong Kong ShatinN.T.Hong Kong Department of Biochemistry The Chinese University of Hong Kong ShatinN.T.Hong Kong

Biophotonics is an exciting and fast-expanding frontier which involves the fusion of advanced photonics and *** has not only created many novel methodologies for biomedical research,but also achieved many significant results as an *** to femtosecond(fs)laser technologies,important progresses have been made regarding the manipulation,imaging,and engineering of biological samples ranging from single molecules to tissues in the last 20 *** ultrashort pulses at near-infrared band provide many advantages:high nonlinear efficiency,low absorption by biological samples,high spatial and temporal resolution and confinement,and low *** are noninvasive and easy to *** the mechanism of how fs laser pulses interact with cells remains unclear,experimental results have shown that they could open up the cell membrane and hence made optical transfection and optical cell fusion *** this review,some of the seminal works on transfection and cell fusion by fs lasers are *** ideas behind and the experimental details will be described together with a highlight on their ***,the thermal effect is analyzed based on multiphoton excitation and plasma formation in an aqueous environment to explain the nontoxic characteristic of fs laser ***,some applications of fs laser induced transfection and cellcell fusion with potential major impact in biomedical sciences are proposed.

关键词： Biophotonics transfection cell fusion femtosecond laser

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Sarcopenia in pancreatic cancer–effects on surgical outcomes and chemotherapy

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World Journal of Gastrointestinal Oncology 2019年第7期11卷 527-537页

作者： Miu Yee chan Kenneth siu Ho Chok Department of Surgery Queen Mary Hospital 102 Pokfulam Road Hong Kong China Department of Surgery and State Key Laboratory for Liver Research The University of Hong Kong Hong Kong China

Sarcopenia is found in up to 65% of pancreatic cancer patients. The definition and diagnostic methods for sarcopenia have changed over the years, and the measurement of skeletal muscle mass with cross-sectional imaging has become the most popular way of assessment, although the parameters measured vary among different studies. It is still debatable that there is an association between sarcopenia and postoperative pancreatic fistula, but most studies showed a higher risk in patients with sarcopenic obesity. Long-term survival is worse in sarcopenic patients, as shown by meta-analysis. Sarcopenia is also associated with decreased survival and higher toxicity in patients receiving chemotherapy, and chemotherapy also tends to potentiate sarcopenia. Treatment for sarcopenia still remains an area for research, although oral supplements, nutritional modifications and exercise training have been shown to improve sarcopenia.

关键词： Sarcopenia Pancreatic cancer Clinical outcomes Surgical outcomes Chemotherapy Radiotherapy

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Phenolic constituents and anticancer properties of Morus alba(white mulberry) leaves

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Journal of Integrative Medicine 2020年第3期18卷 189-195页

作者： Eric Wei Chiang chan siu Kuin Wong Joseph Tangah Tomomi Inoue Hung Tuck chan Faculty of Applied Sciences UCSI University56000 CherasKuala LumpurMalaysia School of Foundation Studies Xiamen University Malaysia43900 SepangSelangorMalaysia Forest Research Centre Sabah Forestry Department90009 SandakanSabahMalaysia Centre for Environmental Biology and Ecosystem Studies National Institute for Environmental Studies(NIES)OnogawaTsukuba 305-0053Japan Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves(MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins(benzofurans), caffeoylquinic acids(phenolic acids) and morachalcones(chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were Pub Med,Pub Med Central, Science Direct, Google, Google Scholar, J-Stage, Pub Chem and China National Knowledge Infrastructure.

关键词： Flavonoids Benzofurans Cytotoxic Moracins Morachalcones Chalcomoracin

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Graphs Whose Critical Groups Have Larger Rank

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Acta Mathematica Sinica,English Series 2011年第9期27卷 1663-1670页

作者： Yao Ping HOU Wai chee SHIU Wai Hong chan Departement of Mathematics Hu'nan Normal University Changsha 410081 P. R. China Department of Mathematics Hong Kong Baptist University Kowloon Tong Hong Kong P. R. China

The critical group C（G） of a graph G is a refinement of the number of spanning trees of the graph and is closely connected with the Laplacian matrix. Let r（G） be the minimum number of generators （i.e., the rank） of the group C（G） and β（G） be the number of independent cycles of G. In this paper, some forbidden induced subgraphs axe given for r（G） = n - 3 and all graphs with r（G） = j3（G） = n - 3 are characterized

关键词： Critical group of a graph Laplacian matrix Smith normal form

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An overview of Pu-erh tea and its health-promoting effects of lipid-lowering and anti-obesity

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Journal of Chinese Pharmaceutical Sciences 2021年第8期30卷 623-633页

作者： Eric Wei Chiang chan siu Kuin Wong Hung Tuck chan Faculty of Applied Sciences UCSI University56000 Cher asKuala LumpurMalaysia School of Foundation Studies Xiamen University MalaysiaBandar Sunsuria43900 SepangSelangorMalaysia Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

As a dark tea,Pu-erh tea(PET)is produced from sun-dried leaves of Camellia sinensis *** mainly in Yunnan Province of *** microorganisms are involved in the fermentation of *** them,Aspergillus niger is most *** is believed that the longer the preservation period,the better is the quality and taste of PET,which is commercially available as loose,compressed or instant tea *** components of PET include flavones,flavanols,flavonols,phenolic acids,alkaloids and *** this overview,the lipid-lowering and anti-obesity effects of PET were discussed based on animal models and human trials,and our study provided some insights into possible mechanisms of bioactive compounds,such as theabrownin,catechins,lovastatin and gallic *** bioactivities of PET and some information on Fuzhuan brick tea were also *** of information cited were from Google Scholar,Pub Med,Pub Med Central,Science Direct,J-Stage,Pub Chem,Directory of Open Access Journals(DOAJ),and China National Knowledge Infrastructure(CNKI).

关键词： Pu-erh tea Fuzhuan brick tea Fermentation Lipid-lowering Anti-obesity

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Alpinia zerumbet, a ginger plant with a multitude of medicinal properties： An update on its research findings

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Journal of Chinese Pharmaceutical Sciences 2017年第11期26卷 775-788页

作者： Eric Wei Chiang chan siu Kuin Wong Hung Tuck chan Faculty of Applied Sciences UCSI University Cheras 56000 Kuala Lumpur Malaysia School of Science Monash University Sunway Petaling Jaya 46150 Selangor Malaysia Secretariat International Society for Mangrove Ecosystems c/o Faculty of Agriculture University of the Ryukyus 903-0129 Okinawa Japan

In this review, the botany and uses of Alpinia zerumbet(yan shan jiang) are described, and the current knowledge of its phytochemistry, pharmacological properties, and clinical trials is summarized. An important ginger crop in East Asia, A. zerumbet has many uses, both medicinal and non-medicinal. Leaves are used to produce essential oils and herbal teas. Rhizomes are consumed as spices, and stem fibers are made into paper, fabrics, and handicrafts. In Brazil, tea from A. zerumbet leaves is believed to have hypotensive, diuretic, and anti-ulcerogenic properties. This species possesses many medicinal properties due to its chemical constituents, including flavonoids, phenolic acids, phenylpropanoids, kava pyrones, sterols, and terpenoids. Extracts of A. zerumbet display antioxidant, antimicrobial, insecticidal, anthelmintic, tyrosinase and melanogenesis inhibitory, anti-atherogenic, anti-aging, anti-glycation, integrase and neuraminidase inhibitory, lifespan prolongation, hair growth promotion, anticancer, antidepressant, anxiolytic, anti-obesity, analgesic, anti-inflammatory, hypolipidemic, anti-ulcerogenic, anti-platelet, osteoblastic, osteogenic, thrombolytic, and cardiac arrhythmogenic activities. Essential oils of A. zerumbet leaves have antimicrobial, larvicidal, antinociceptive, hypotensive, vasorelaxant, myorelaxant, antispasmodic, antidepressant, anxiolytic, anti-neuraminidase, anti-atherogenic, anti-aging, anti-melanogenic, anti-tyrosinase, cytoprotective, cardiodepressive, antipsychotic, analgesic, anti-inflammatory, and tissue healing activities. Clinical trials conducted in Brazil showed that extracts of A. zerumbet have hypotensive and diuretic effects whereas topical application of the essential oil has positive therapeutic effects on patients with fibromyalgia. Spanning two continents of Asia and South America, A. zerumbet is truly a multi-purpose ginger plant with promising medicinal properties.

关键词： Alpinia zerumbet Shell ginger Phytochemistry Pharmacology Clinical trials

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