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Lessons on mobile apps for COVID-19 from China

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Journal of Safety Science and Resilience 2021年第2期2卷 40-49页

作者： sophia L.Zhou Xianhan Jia Samuel P.Skinner William Yang Isabelle Claude Mass Academy of Math and Science Worcester Polytechnic Institute85 Prescott StreetWorcesterMA 01605United States Department of Computer Science Worcester Polytechnic Institute100 Institute RoadWorcesterMA 01609United States Department of Physics Worcester Polythenic Institute100 Institute RoadWorcesterMA 01609United States Department of Biomedical Engineering Worcester Polytechnic Institute100 Institute RoadWorcesterMA 10609United States

The COVID-19 pandemic has impacted the global society and human life *** countries have launched COVID-19 mobile apps with a wide range in how these apps *** it is hoped that these apps can assist in the fight against COVID-19,many are worried about user *** implemented“health code”systems,which assigned neighborhoods and citizens a specific health code,meant to indicate their risk of having been exposed to *** most widely used health code systems were hosted on the popular apps WeChat and Alipay,each with billions of *** experts argued that China’s use of mobile applications was essential to its successful combat against *** in this study are a summary of mobile technology usage in China,a review of previous studies of mobile technology in healthcare,and a brief survey of some existing mobile applications for COVID-19 that were *** included are outcomes of interviews with healthcare and public safety experts and a public survey to understand how mobile applications were used in China’s response to *** interviews revealed four important themes:personal privacy,community involvement,government involvement,and situational *** was found that a key concern was maintaining a balance between collecting and utilizing personal information,as well as protecting this *** addition,close collaboration between local communities and the national government was *** applications assisted in communication and coordination but did not replace the work of people such as delivery drivers and contact *** results also showed that there was room for improvement,especially accessibility for the elderly or those unfamiliar with *** results were obtained from our *** was interesting to find that the apps were mostly used for“accessing information on COVID-19.”In addition,respondents overwhelmingly identified“information”as the most valuable featur

关键词： Mobile apps COVID-19 response Survey Interview Lessons

Disease spectrum and use of cholecystolithotomy in gallstone ileus

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 553-557页

作者： Nicholas E Williams Justin S Gundara sophia Roser Jaswinder S Samra Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt.LeonardsSydneyNSW 2065Australia

BACKGROUND: Gallstone ileus is a heterogeneous and highly morbid condition that suffers from a lack of consensus regarding the timing and approach to management of the biliary tree and associated fistula. METHODS: We report three cases that demonstrate the spectrum of gallstone ileus with classical examples of both Barnard’s and Bouveret’s syndromes. Clinical presentation diagnostic imaging, surgical technique and outcome are discussed. RESULTS: One patient with Barnard’s syndrome presented with recurrent gallstone ileus. To minimize the risks of complex, definitive biliary surgery and avoid further recurrent episodes, a cholecystolithotomy was performed with effect Two cases of Bouveret’s syndrome were successfully managed with enterolithotomy/cholecystectomy and multivisceral resection respectively, thus highlighting the diverse nature of this disease and management options. CONCLUSIONS: Following enterolithotomy, potentially morbid definitive one-stage surgery in typically compromised, elderly patients needs to be weighed against the risk of recurrence and ongoing biliary pathology. We suggest the use of open cholecystolithotomy for the removal of residual gallstones when the patient is not suitable for definitive biliary surgery.

关键词： cholecystectomy biliary tract disease gallstone ileus biliary tract surgery

Role of scintigraphy in inflammatory bowel disease

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World Journal of Gastroenterology 2009年第22期15卷 2693-2700页

作者： Maria I Stathaki sophia I Koukouraki Nikolaos S Karkavitsas Ioannis E Koutroubakis Department of Nuclear Medicine University Hospital of Heraklion Department of Gastroenterology University Hospital of Heraklion

The diagnosis of inflammatory bowel disease(IBD) depends on direct endoscopic visualization of the colonic and ileal mucosa and the histological study of the obtained *** and scintigraphic methods are mainly used as an adjunct to *** this review,we focus on the diagnostic potential of nuclear medicine *** value of all radiotracers is described with special reference to those with greater experience and more satisfactory ***-99m hexamethylpropylene amine oxime white blood cells remain a widely acceptable scintigraphic method for the diagnosis of IBD,as well as for the evaluation of disease extension and ***,pentavalent Tc-99m dimercaptosuccinic acid has been recommended as an accurate variant and a complementary technique to endoscopy for the follow-up and assessment of disease *** emission tomography alone or with computed tomography using fluorine-18 fluorodeoxyglucose appears to be a promising method of measuring inflammation in IBD patients.

关键词： Crohn's disease Technetium-99m pentavalent dimercaptosuccinic acid Intestinal inflammation Scintigraphy Ulcerative colitis

Secure storage and accessing the data in cloud using optimized homomorphic encryption

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Journal of Control and Decision 2023年第1期10卷 90-98页

作者： S.Gnana sophia K.K.Thanammal S.S.Sujatha Department of Computer Science and Application MS UniversityS.T.Hindu CollegeNagercoilIndia

Different efforts have been undertaken to customizing a security and privacy concern in clouddata access. Therefore, the security measures are reliable and the data access was verified as themajor problem in the cloud environment. To overcome this problem, we proposed an efficientdata access control using optimized homomorphic encryption (HE). Because users outsourcetheir sensitive information to cloud providers, data security and access control is one of themost difficult ongoing cloud computing research projects. Existing solutions that rely on cryptographictechnologies to address these security issues result in significant complexity for bothdata and cloud service providers. The experimental results show that the key generation is 7.6%decreased by HE and 14.14% less than the proposed method. The encryption time is 11.34% lessthan the optimized HE and 23.28% decreased by ECC. The decryption time is 13.18% and 24.07%when compared with HE and ECC respectively.

关键词： Homomorphic encryption(HE) elliptical curve cryptography(ECC) data security cloud computing data access

促进初级卫生保健高质量发展,迈向全民健康新时代的北京倡议

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中国全科医学 2024年第10期27卷 1149-1152页

作者：任明辉张拓红徐进乔杰乔建荣詹思延秦江梅宋大平房验茹林奕芳姜晓朋郭岩孟庆跃钱序刘运国 sophia Siu Chee Chan 赵峰 Winnie Yip 汪宏王敏敏尹惠刘佐坤李娜宋心怡刘方方金音子周书铎刘芳静黄旸木北京大学公共卫生学院北京市100191 北京大学全球卫生研究院北京市100191 北京大学中国卫生发展研究中心北京市100191 北京大学第三医院北京市100191 世界卫生组织驻华代表处北京市100600 国家卫生健康委卫生发展研究中心北京市100044 中国农业大学农学和生物科技学院北京市100193 复旦大学附属华山医院上海市200040 复旦大学公共卫生学院上海市200032 昆山杜克大学全球健康研究中心江苏省昆山市215316 香港大学李嘉诚医学院护理学院中国香港特别行政区999077 世界银行南亚区域健康营养与人口部门泰国曼谷10330 哈佛大学陈曾熙公共卫生学院全球健康与人口学系美国波士顿02115 比尔及梅琳达·盖茨基金会北京市100049

初级卫生保健是改善人们健康和福祉的最有效途径,初级卫生保健服务应成为有韧性的卫生系统的基石和全民健康覆盖的基础。为推动初级卫生保健高质量发展,2023年12月4—5日,初级卫生保健高质量发展国际研讨会在中国北京召开,与会代表提出... 详细信息

初级卫生保健是改善人们健康和福祉的最有效途径,初级卫生保健服务应成为有韧性的卫生系统的基石和全民健康覆盖的基础。为推动初级卫生保健高质量发展,2023年12月4—5日,初级卫生保健高质量发展国际研讨会在中国北京召开,与会代表提出并通过了《初级卫生保健高质量发展北京倡议》。该倡议呼吁开展和加强11项行动:落实政府承诺和责任;通过多部门协同将健康融入所有政策;建立可持续的筹资;赋能社区和个人;提供以社区为基础的整合型服务;以良好的治理促进健康服务和社会服务衔接融合;加强人力资源的培训、配置和激励及医学教育;推广传统医学和替代医学在疾病预防和疾患疗愈中的应用;数字赋能初级卫生保健;确保医药产品和适宜技术的可及;增进全球伙伴关系与国际卫生合作。倡议将丰富初级卫生保健高质量发展内涵,凝聚共识,为促进中国初级卫生保健新时代高质量发展政策,加快全球实现全民健康覆盖进程做出贡献。

关键词：初级卫生保健全民健康覆盖可持续发展议程倡议北京

p53 as a hub in cellular redox regulation and therapeutic target in cancer

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Journal of Molecular Cell Biology 2019年第4期11卷 330-341页

作者： Sofi E.Eriksson sophia Ceder Vladimir J.N.Bykov Klas G.Wiman Karolinska Institutet Department of Oncology-Pathology BioClinicum Stockholm Sweden

The TP53 tumor suppressor gene encodes a DNA-binding transcription factor that regulates multiple cellular processes including cell growth and cell death. The ability of p53 to bind to DNA and activate transcription is tightly regulated by post-translational modifications and is dependent on a reducing cellular environment. Some p53 transcriptional target genes are involved in regulation of the cellular redox homeostasis, e.g. TIGAR and GLS2. A large fraction of human tumors carry TP53 mutations, most commonly missense mutations that lead to single amino acid substitutions in the core domain. Mutant p53 proteins can acquire so called gain-of-function activities and influence the cellular redox balance in various ways, for instance by binding of the Nrf2 transcription factor, a major regulator of cellular redox state. The DNA-binding core domain of p53 has 10 cysteine residues, three of which participate in holding a zinc atom that is critical for p53 structure and function. Several novel compounds that refold and reactivate missense mutant p53 bind to specific p53 cysteine residues. These compounds can also react with other thiols and target components of the cellular redox system, such as glutathione. Dual targeting of mutant p53 and redox homeostasis may allow more efficient treatment of cancer.

关键词： p53 redox regulation mutation oxidative stress Nrf2 thiols cancer therapy

Protective effect of Mollugo nudicaulis *** acute liver injury induced by perchloroethylene in experimental rats

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 862-867页

作者： Sundaraj Rajamanikandan Thangaraj Sindhu Dhanapal Durgapriya Dominic sophia Paramasivam Ragavendran Velliyur Kanniappan Gopalakrishnan Department of Bioinformatics Karpagam UniversityCoimbatore-641 021India Department of Biochemistry Karpagam UniversityCoimbatore-641 021India

Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(***) against perchloroethylene-induced ***:The hepatoprotective activity of the ethanol extract of ***(200 mg/kg body wt) was studied in percholoroethylene (1 000 mg/kg body wt) induced hepatotoxicity in Wistar albino *** serum levels of AST, ALT,ALP,bilirubin and the liver content of SOD,CAT,GPx,GST,CSH,vitamin C were assessed to evaluate the hepatoprotective and antioxidant activities of the *** activity of the extract was compared with silymarin,a standard reference *** addition,serum urea,uric acid and creatinine levels were measured to evaluate the kidney *** histopathological examination of the liver tissues was observed to support the biochemical ***: The results revealed that the extract significantly(P<0.05) restored the serum levels of AST,ALT, ALP,bilinibin and significantly(P<0.05) increased the antioxidant enzymes SOD,CAT,GPx,GST, GSH,vitamin C in perchloroethylene-induced rats to its *** biochemical observations were suppoited by the histopathological studies of the liver ***:The results led to the conclusion that *** possess hepatoprotective and antioxidant activites against perchloroethylene-induced hepatotoxicity in rats.

关键词： Mollugo nudicaulis Perchloroethylene Hepatoprotective activity Antioxidants Histopathological studies

COUP-TFⅡ, a prognostic marker and therapeutic targei for prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 360-361页

作者： Jun Qin sophia Tsai Ming-JerTsai Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77005 USA

The absence of a biomarker to predict the aggressiveness of prostate cancerpatients is the major obstacle in deciding which prostate cancer patient should be treated. In this report, we show that COUP transcription factor Ⅱ （COUP-TFⅡ）, a mem- ber of the nuclear receptor superfamily, antagonizes the transforming growth factor （TGF）-β-induced growth barrier to facilitate tumor metastasis and provide a molecular mechanism for how PTEN indolent tumors acquire metastatic potential. More impor- tantly,

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Protective roles of Vigna subterranea(Bambara nut) in rats with aspirin-induced gastric mucosal injury

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Journal of Integrative Medicine 2018年第5期16卷 342-349页

作者： Morufu Eyitayo Balogun Elizabeth Enohnyaket Besong Jacinta Nkechi Obimma Ogochukwu sophia Mbamalu Fankou Serges Athanase Djobissie Department of Physiology Faculty of MedicineEbonyi State University Clinical Services Department National Obstetrics Fistula Centre

Objective： Vigna subterranea is widely consumed as a traditional staple food in Nigeria and some West African countries. The ethanolic seed extract of V. subterranea （EEVS） was investigated for its gastroprotective effects on aspirin plus pylorus ligation-induced gastric ulcerated rats using an in vivo assay. Methods： Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 using aspirin plus pylorus ligation. Rats in Group I were orally pretreated with 3% Tween 80 only as normal control. Groups 2 to 5 were pretreated with 3% Tween B0 （ulcer group）, 20 mg/kg of omeprazole （positive group）, and 200 and 400 mg/kg of EEVS （experimental groups）, respectively, once daily for 21 days before ulcer induction. Parameters including those for gastric secretions, ulcerated areas and gastric wall histology were assessed. Levels of superoxide dismutase （SOD）, glutathione peroxidase （GPx）, and malondialdehyde （MDA） in the gastric tissue homogenate were also determined. Results： Pretreatment with EEVS significantly （P 〈 0.05） reduced the ulcer index, gastric volume and total acidity in rats with aspirin plus pylorus ligation-induced ulcer. The pH and mucus of gastric content increased significantly （P 〈 0.05） while the levels of SOD and GPx were observed to be elevated with a reduced amount of MDA. Significant severe gastric mucosal injury was exhibited in the ulcer group and EEVS or omeprazole offered significant （P〈0.05） protection against mucosal ulceration. Histologically, the gastric submucosal layer showed remarkable decrease in edema and leucocytes infiltration compared with ulcer group. Conclusion： The study suggests that EEVS offered a protective action against aspirin plus pylorus ligationinduced gastric ulcers in Wistar rats. The protective effect might be mediated via antisecretory, cytopro- tective and antioxidative mechanisms.

关键词： Vigna subterranea Anti-oxidative Aspirin plus pylorus ligation Gastric ulcers Rats