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Cooper.tive hunting in a discr.te pr.dator.pr.y system

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Inter.ational jour.al of Biomathematics 2020年第7期13卷 133-158页

作者： Yunshyong Chow sophia r.j.jang Hua-Ming Wang Institute of Mathematics Academia Sinica Taipei 10617Taiwan Depar.ment of Mathematics and Statistics Texas Tech Univer.ity LubbockTX 79409USA Depar.ment of Statistics Anhui Normal University Wuhu 241003AnhuiP.R.China

We pr.pose and investigate a discr.te-time pr.dator.pr.y system with cooper.tive hunting in the pr.dator.*** model is constr.cted fr.m the classical Nicholson-Bailey host-par.sitoid system with density dependent gr.wth r.te.A sufficient condition based on the model par.meter. for.which both populations can coexist is der.ved,namely that the pr.dator.s maximal r.pr.ductive number.exceeds *** study existence of inter.or.steady states and their.stability in cer.ain par.meter.*** is shown that the system behaves asymptotically similar.to the model with no cooper.tive hunting if the degr.e of cooper.tion is *** cooper.tive hunting,however.may pr.mote per.istence of the pr.dator.for.which the pr.dator.would other.ise go extinct if ther. wer. no cooper.tion.

关键词： Cooper.tive hunting discr.te pr.dator.pr.y system pr.dator.per.istence Neimar.-Sacker.bifur.ation

Asymptotic dynamics of a modified discr.te Leslie-Gower.competition system

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Inter.ational jour.al of Biomathematics 2017年第6期10卷 1-23页

作者： Yunshyong Chow sophia r.-j. jang Institute of Mathematics Academia Sinica Taipei 10617 Taiwan Depar.ment of Mathematics and StatisticsTexas Tech Univer.ity Lubbock TX 79409-1042 USA

We pr.pose a modified discr.te-time Leslie-Gower.competition system of two popula- tions to study competition outcomes. Depending on the magnitude of a par.icular.model par.meter.that measur.s intr.specific competition between individuals within the same population, either.one or.both populations may be subject to Allee effects. The r.sulting system can have up to four.coexisting steady states. Using the theor. of planar.compet- itive maps, it is shown that the model has only equilibr.um dynamics. The competition outcomes then depend not only on the par.meter.r.gimes but may also depend on the initial population distr.butions.

关键词： Competition saddle points Allee effects.

Acoustofluidic separ.tion of pr.late and spher.cal micr.-objects

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Micr.systems & Nanoengineer.ng 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song Ha Lee Keun Young jang Seong jae Lee jinsoo Par. Depar.ment of Mechanical Engineer.ng Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Depar.ment of Polymer.Engineer.ng The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most micr.fluidic separ.tion techniques r.ly lar.ely on object size as a separ.tion *** ability to separ.te micr.-objects based on their.shape is cr.cial in var.ous biomedical and chemical ***,we develop an ondemand,label-fr.e acoustofluidic method to separ.te pr.late ellipsoids fr.m spher.cal micr.par.icles based on tr.veling sur.ace acoustic wave-induced acoustic r.diation for.e and *** fr.ely r.tating non-spher.cal micr.objects wer. aligned under.the pr.gr.ssive acoustic field by the counter.otating r.diation tor.ue,and the major.axis of the pr.late ellipsoids was par.llel to the pr.gr.ssive wave *** specific alignment of the ellipsoidal par.icles r.sulted in a r.duction in the cr.ss-sectional ar.a per.endicular.to the wave *** a consequence,the acoustic backscatter.ng decr.ased,r.sulting in a decr.ased magnitude of the r.diation *** the var.ation in r.diation for.e,which depended on the micr.-object mor.hology enabled the acoustofluidic shape-based *** conducted numer.cal simulations for.the wave scatter.ng of spher.cal and pr.late objects to elucidate the wor.ing mechanism under.ying the pr.posed method.A ser.es of exper.ments with polystyr.ne micr.spher.s,pr.late ellipsoids,and peanut-shaped micr.par.icles wer. per.or.ed for.*** quantitative analysis of the separ.tion efficiency,we confir.ed the high pur.ty and high r.cover. r.te of the pr.posed acoustofluidic shapebased separ.tion of *** a biopar.icle,we utilize Thalassiosir. eccentr.ca to per.or. shape-based separ.tion,as the species has a var.ety of potential applications in dr.g deliver.,biosensing,nanofabr.cation,bioencapsulation and immunoisolation.

关键词： separ.tion spher.cal r.tating

Lipid nanopar.icles deliver.mr.A to the blood-br.in bar.ier

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Nano r.sear.h 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avr.ham Shakked r.ndi Calkins Sebastian r.dden Camille jones jessie Doan Bor. jang Elisa Schr.der.Echever.i r.an Zenhauser. Liming Lian David Loughr.y Hannah E.Peck r.chelle Wiese Dor.thy Koveal Philip j.Santangelo james E.Dahlman Geor.e C.Woodr.ff School of Mechanical Engineer.ng Georgia Institute of TechnologyAtlantaGA 30332USA Par.er.H.Petit Institute for.Bioengineer.ng and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter.Depar.ment of Biomedical Engineer.ng Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanopar.icles(LNPs)have deliver.d r.A to hepatocytes in patients after.intr.venous *** clinical data suppor. effor.s to design LNPs that tr.nsfect cells in the centr.l ner.ous system(CNS).However.deliver. to the CNS has been difficult,in lar.e par. because quantifying on-tar.et deliver. alongside common off-tar.et cell types in adult mice r.mains *** we r.por. methods to isolate differ.nt cell types fr.m the CNS,and subsequently pr.sent mr.A deliver. r.adouts using a liver.detar.eted *** data suggest that LNPs without tar.eting ligands can tr.nsfect cer.br.l endothelial cells in mice after.intr.venous *** the difficulty of cr.ssing the blood-br.in bar.ier.they also under.cor. the value of quantifying deliver. in the CNS with cell-type r.solution instead of whole-tissue r.solution.

关键词： lipid nanopar.icle mr.A nanomedicine centr.l ner.ous system blood-br.in bar.ier

Highly Elastic,Bior.sor.able Polymer.c Mater.als for.Str.tchable,Tr.nsient Electr.nic Systems

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Nano-Micr. Letter. 2024年第6期16卷 1-13页

作者： jeong‑Woong Shin Dong‑je Kim Tae‑Min jang Won Bae Han joong Hoon Lee Gwan‑jin Ko Seung Min Yang Kaveti r.jar.m Sungkeun Han Heeseok Kang jun Hyeon Lim Chan‑Hwi Eom Amay j.Bandodkar.Hanul Min Suk‑Won Hwang KU‑KIST Gr.duate School of Conver.ing Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Depar.ment of Electr.cal and Computer.Engineer.ng North Carolina State UniversityRaleighNC 27606USA Center.for.Advanced Self‑Power.d Systems of Integr.ted Sensor. and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Depar.ment of Integr.tive Ener.y Engineer.ng Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomater.als r.sear.h Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor.r.D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center.for.Advanced Biomolecular.r.cognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substr.tes or.encapsulants in soft and str.tchable for.ats ar. key components for.tr.nsient,bior.sor.able electr.nic systems;however.elastomer.c polymer. with desir.d mechanical and biochemical pr.per.ies ar. ver. limited compar.d to nontr.nsient ***,we intr.duce a bior.sor.able elastomer.poly(glycolide-co-ε-capr.lactone)(PGCL),that contains excellent mater.al pr.per.ies including high elongation-at-br.ak(r.silience and toughness,and tunable dissolution *** of PGCLs as polymer.matr.ces,in combination with conducing polymer.,yields str.tchable,conductive composites for.degr.dable inter.onnects,sensor.,and actuator.,which can r.liably function under.exter.al *** of device components with wir.less modules demonstr.tes elastic,tr.nsient electr.nic sutur. system with on-demand dr.g deliver. for.r.pid r.cover. of postsur.ical wounds in soft,time-dynamic tissues.

关键词： Biodegr.dable elastomer Conductive polymer.composites Biomedical device Tr.nsient electr.nics

夏季长三角地区臭氧非线性响应曲面模型的建立及应用

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环境科学学报 2016年第4期36卷 1383-1392页

作者：严茹莎李莉安静宇卢清黄成王书肖朱云 Car.y j.jang joshua S.Fu 国家环境保护城市大气复合污染成因与防治重点实验室上海200233 上海市环境科学研究院上海200233 清华大学环境学院北京100084 华南理工大学环境与能源学院广州510006 Air.Quality Modeling Gr.up Office of Air Quality Planning and StandardsU. S. Environmental Protection Agency Civil and Envir.nmental Engineer.ng University of Tennessee

2013年8月上旬,长三角地区发生了一次大范围高浓度臭氧污染事件.本研究基于Wr.-CMAQ空气质量模型系统,结合长三角地区大气污染物排放清单,构建了臭氧与其前体物之间的非线性响应曲面模型(r.sponse sur.ace modeling,r.M).基于r.M探讨了... 详细信息

2013年8月上旬,长三角地区发生了一次大范围高浓度臭氧污染事件.本研究基于Wr.-CMAQ空气质量模型系统,结合长三角地区大气污染物排放清单,构建了臭氧与其前体物之间的非线性响应曲面模型(r.sponse sur.ace modeling,r.M).基于r.M探讨了长三角地区O_3化学的敏感性特征,分析了上海市O_3的来源并预测不同情景下O_3的变化,提出O_3污染的最优控制方案.研究结果表明,长三角地区夏季O3主控因素区域差别较大,上海环科院、杭州卧龙桥、南京玄武湖等城区点位属于VOC控制型;徐州铜山、合肥肥西、丽水青田等郊区属于NOx控制型.O_3的敏感性特征在不同浓度水平下也呈现较大差异,随着O_3浓度水平的升高,各地区NOx敏感性均有所增加.从区域来源来看,远距离传输对平日上海O_3贡献较大,占50%以上;而在O_3污染日,本地及区域贡献为72.1%,而远距离传输贡献下降至27.9%.快速预测了110组减排情景,表明在本地及区域前体物均减排70%的情况下,2013年8月上海O_3浓度能完全达标.

关键词：臭氧非线性响应曲面 CMAQ 长三角

Exper.mental and finite element analysis for.fr.ctur. of coating layer.of galvannealed steel sheet

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Tr.nsactions of Nonfer.ous Metals Society of China 2011年第A1期21卷 111-116页

作者： S.I.KIM j.U.HEr.Y.C.jang Y.LEE Sheet Pr.ducts and Pr.cess r.sear.h Gr.up POSCO Techology Research Laboratory Depar.ment of Mechanical Engineer.ng Chung-Ang University

Mechanical pr.per.ies of galvannealed (GA) steel sheet used for.automotive exposed panel and pr.dicted failur. phenomenon of its coating layer.wer. evaluated using finite element method. V-bending test was per.or.ed to under.tand better.the fr.ctur. of coating layer.of GA steel sheet dur.ng plastic defor.ation. Yield str.ngth of the coating layer.was calculated by using a r.lative differ.nce between har.ness of coating layer.measur.d fr.m the nano-indentation test and that of substr.te. To measur. shear.ng str.ngth at the inter.ace between substr.te and coating layer. shear.ng test with two specimens attached by an adhesive was car.ied out. Using the mechanical pr.per.ies measur.d, a ser.es of finite element analyses coupled with a failur. model was per.or.ed. r.sults r.veal that the fr.ctur. of coating layer.occur. in an ir.egular.manner.at the r.gion wher. compr.ssive defor.ation is dominant. Meanwhile, a ser.es of ver.ical cr.cks per.endicular.to mater.al sur.ace ar. obser.ed at the tensile str.ssed-r.gion. It is found that 0.26-0.28 of local equivalent plastic str.in exists at the coating and substr.te at the beginning of failur.. The fr.ctur. of coating layer.depends on ductility of the coating layer.consider.bly as well.

关键词： galvannealed steel sheet fr.ctur. simulation coating layer finite element analysis, failur. model

Pr.diction of clinically actionable genetic alter.tions fr.m color.ctal cancer.histopathology images using deep lear.ing

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Wor.d jour.al of Gastr.enter.logy 2020年第40期26卷 6207-6223页

作者： Hyun-jong jang Ahwon Lee j Kang In Hye Song Sung Hak Lee Depar.ment of Physiology Department of Biomedicine and Health SciencesCatholic Neuroscience InstituteThe Catholic University of KoreaSeoul 06591South Korea Depar.ment of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGr.UND Identifying genetic mutations in cancer.patients have been incr.asingly impor.ant because distinctive mutational patter.s can be ver. infor.ative to deter.ine the optimal ther.peutic str.tegy. r.cent studies have shown that deep lear.ing-based molecular.cancer.subtyping can be per.or.ed dir.ctly fr.m the standar. hematoxylin and eosin(H&E) sections in diver.e tumor. including color.ctal cancer.(Cr.s). Since H&E-stained tissue slides ar. ubiquitously available, mutation pr.diction with the pathology images fr.m cancer. can be a time-and cost-effective complementar. method for.per.onalized *** To pr.dict the fr.quently occur.ing actionable mutations fr.m the H&E-stained Cr. whole-slide images(WSIs) with deep lear.ing-based *** A total of 629 Cr. patients fr.m The Cancer.Genome Atlas(TCGA-COAD and TCGA-r.AD) and 142 Cr. patients fr.m Seoul St. Mar. Hospital(SMH) wer. included. Based on the mutation fr.quency in TCGA and SMH datasets, we chose APC, Kr.S, PIK3CA, SMAD4, and TP53 genes for.the study. The classifier. wer. tr.ined with 360 × 360 pixel patches of tissue images. The r.ceiver.oper.ting char.cter.stic(r.C) cur.es and ar.a under.the cur.es(AUCs) for.all the classifier. wer. *** The AUCs for.r.C cur.es r.nged fr.m 0.693 to 0.809 for.the TCGA fr.zen WSIs and fr.m 0.645 to 0.783 for.the TCGA for.alin-fixed par.ffin-embedded *** pr.diction per.or.ance can be enhanced with the expansion of datasets. When the classifier. wer. tr.ined with both TCGA and SMH data, the pr.diction per.or.ance was *** APC, Kr.S, PIK3CA, SMAD4, and TP53 mutations can be pr.dicted fr.m H&E pathology images using deep lear.ing-based classifier., demonstr.ting the potential for.deep lear.ing-based mutation pr.diction in the Cr. tissue slides.

关键词： Color.ctal cancer Mutation Deep lear.ing Computational pathology Computer.aided diagnosis Digital pathology

长江三角洲地区大气O3和PM10的区域污染特征模拟

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环境科学 2008年第1期29卷 237-245页

作者：李莉陈长虹黄成黄海英李作攀 joshua S. Fu Car.y j. jang David G. Str.ets 上海市环境科学研究院上海200233 Civil and Envir.nmental Engineer.ng University of TennesseeKnoxvilleTN 37996USA Air.Quality Modeling Gr.up Office of Air Quality Planning and StandardsU.S.Environmental Protection AgencyNC 27711USA Decision and Infor.ation Sciences Division Argonne National LaboratoryArgonneIllinois 60439USA

以Tr.CE-P污染源资料及上海市地方排放清单为基础,采用Models-3/CMAQ环境空气质量模型和中尺度气象模式MM5,模拟研究了2001-01和2001-07长三角近地面二次污染物O3及PM10的浓度分布及输送状况,并以上海市国控点2001年冬、夏季各10 d的小... 详细信息

以Tr.CE-P污染源资料及上海市地方排放清单为基础,采用Models-3/CMAQ环境空气质量模型和中尺度气象模式MM5,模拟研究了2001-01和2001-07长三角近地面二次污染物O3及PM10的浓度分布及输送状况,并以上海市国控点2001年冬、夏季各10 d的小时监测数据对模型进行了验证.验证结果显示,Models-3/CMAQ对O3和PM10的模拟结果与监测值的相关系数分别为0.77和0.52;一致性指数分别达到0.81和0.99.模型对O3小时最高浓度的估算偏低27%,标准偏差为-3.1%;对PM10小时平均浓度的估算偏低10%,标准偏差为46%.模型已具备再现和模拟长三角大气污染输送过程的能力,且误差落在可接受的范围之内.模拟结果显示,2001-07长三角区域16个主要城市中,有14个城市O3小时最大浓度超过国家二级标准,高浓度O3可覆盖苏南和浙北广大区域.2001-01泰州、扬州、南京、镇江、常州等城市受本地排放源和北部大气污染输送的影响显著,大气PM10日均浓度超过PM10国家二级标准.长三角地区环境空气质量与污染类型受大气污染传输与化学转化的影响十分明显.夏季太阳辐射较强时,南部城市排放的污染物常以二次污染物的形式影响下风向城市;太阳辐射较弱的情况下,则以一次污染物输送为主的形式影响周边地区.冬季长三角区域颗粒物污染总体水平较高,这与我国北方地区排放的颗粒物在西北风作用下向长三角输送造成的影响密切相关.长三角地区的大气污染已逐渐从局地转为区域问题.

关键词：区域污染污染输送长江三角洲空气质量模拟 Models-3/CMAQ