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Cooperative hunting in a discrete predator-prey system

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International journal of Biomathematics 2020年第7期13卷 133-158页

作者： Yunshyong Chow sophia r-j.jang Hua-Ming Wang Institute of Mathematics Academia Sinica Taipei 10617Taiwan Department of Mathematics and Statistics Texas Tech University LubbockTX 79409USA Department of Statistics Anhui Normal University Wuhu 241003AnhuiP.R.China

We propose and investigate a discrete-time predator-prey system with cooperative hunting in the predator *** model is constructed from the classical Nicholson-Bailey host-parasitoid system with density dependent growth rate.A sufficient condition based on the model parameters for which both populations can coexist is derived,namely that the predator’s maximal reproductive number exceeds *** study existence of interior steady states and their stability in certain parameter *** is shown that the system behaves asymptotically similar to the model with no cooperative hunting if the degree of cooperation is *** cooperative hunting,however,may promote persistence of the predator for which the predator would otherwise go extinct if there were no cooperation.

关键词： Cooperative hunting discrete predator-prey system predator persistence Neimark-Sacker bifurcation

Acoustofluidic separation of prolate and spherical micro-objects

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Microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song Ha Lee Keun Young jang Seong jae Lee jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

Asymptotic dynamics of a modified discrete Leslie-Gower competition system

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International journal of Biomathematics 2017年第6期10卷 1-23页

作者： Yunshyong Chow sophia r.-j. jang Institute of Mathematics Academia Sinica Taipei 10617 Taiwan Department of Mathematics and StatisticsTexas Tech University Lubbock TX 79409-1042 USA

We propose a modified discrete-time Leslie-Gower competition system of two popula- tions to study competition outcomes. Depending on the magnitude of a particular model parameter that measures intraspecific competition between individuals within the same population, either one or both populations may be subject to Allee effects. The resulting system can have up to four coexisting steady states. Using the theory of planar compet- itive maps, it is shown that the model has only equilibrium dynamics. The competition outcomes then depend not only on the parameter regimes but may also depend on the initial population distributions.

关键词： Competition saddle points Allee effects.

Lipid nanoparticles deliver mrNA to the blood-brain barrier

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Nano research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked randi Calkins Sebastian rudden Camille jones jessie Doan Bora jang Elisa Schrader Echeverri ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck rachelle Wiese Dorothy Koveal Philip j.Santangelo james E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered rNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mrNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mrNA nanomedicine central nervous system blood-brain barrier

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： jeong‑Woong Shin Dong‑je Kim Tae‑Min jang Won Bae Han joong Hoon Lee Gwan‑jin Ko Seung Min Yang Kaveti rajaram Sungkeun Han Heeseok Kang jun Hyeon Lim Chan‑Hwi Eom Amay j.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor r&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

夏季长三角地区臭氧非线性响应曲面模型的建立及应用

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环境科学学报 2016年第4期36卷 1383-1392页

作者：严茹莎李莉安静宇卢清黄成王书肖朱云 Carey j.jang joshua S.Fu 国家环境保护城市大气复合污染成因与防治重点实验室上海200233 上海市环境科学研究院上海200233 清华大学环境学院北京100084 华南理工大学环境与能源学院广州510006 Air Quality Modeling Group Office of Air Quality Planning and StandardsU. S. Environmental Protection Agency Civil and Environmental Engineering University of Tennessee

2013年8月上旬,长三角地区发生了一次大范围高浓度臭氧污染事件.本研究基于WrF-CMAQ空气质量模型系统,结合长三角地区大气污染物排放清单,构建了臭氧与其前体物之间的非线性响应曲面模型(response surface modeling,rSM).基于rSM探讨了... 详细信息

2013年8月上旬,长三角地区发生了一次大范围高浓度臭氧污染事件.本研究基于WrF-CMAQ空气质量模型系统,结合长三角地区大气污染物排放清单,构建了臭氧与其前体物之间的非线性响应曲面模型(response surface modeling,rSM).基于rSM探讨了长三角地区O_3化学的敏感性特征,分析了上海市O_3的来源并预测不同情景下O_3的变化,提出O_3污染的最优控制方案.研究结果表明,长三角地区夏季O3主控因素区域差别较大,上海环科院、杭州卧龙桥、南京玄武湖等城区点位属于VOC控制型;徐州铜山、合肥肥西、丽水青田等郊区属于NOx控制型.O_3的敏感性特征在不同浓度水平下也呈现较大差异,随着O_3浓度水平的升高,各地区NOx敏感性均有所增加.从区域来源来看,远距离传输对平日上海O_3贡献较大,占50%以上;而在O_3污染日,本地及区域贡献为72.1%,而远距离传输贡献下降至27.9%.快速预测了110组减排情景,表明在本地及区域前体物均减排70%的情况下,2013年8月上海O_3浓度能完全达标.

关键词：臭氧非线性响应曲面 CMAQ 长三角

Experimental and finite element analysis for fracture of coating layer of galvannealed steel sheet

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 111-116页

作者： S.I.KIM j.U.HEr Y.C.jang Y.LEE Sheet Products and Process research Group POSCO Techology Research Laboratory Department of Mechanical Engineering Chung-Ang University

Mechanical properties of galvannealed (GA) steel sheet used for automotive exposed panel and predicted failure phenomenon of its coating layer were evaluated using finite element method. V-bending test was performed to understand better the fracture of coating layer of GA steel sheet during plastic deformation. Yield strength of the coating layer was calculated by using a relative difference between hardness of coating layer measured from the nano-indentation test and that of substrate. To measure shearing strength at the interface between substrate and coating layer, shearing test with two specimens attached by an adhesive was carried out. Using the mechanical properties measured, a series of finite element analyses coupled with a failure model was performed. results reveal that the fracture of coating layer occurs in an irregular manner at the region where compressive deformation is dominant. Meanwhile, a series of vertical cracks perpendicular to material surface are observed at the tensile stressed-region. It is found that 0.26-0.28 of local equivalent plastic strain exists at the coating and substrate at the beginning of failure. The fracture of coating layer depends on ductility of the coating layer considerably as well.

关键词： galvannealed steel sheet fracture simulation coating layer finite element analysis, failure model

Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning

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World journal of Gastroenterology 2020年第40期26卷 6207-6223页

作者： Hyun-jong jang Ahwon Lee j Kang In Hye Song Sung Hak Lee Department of Physiology Department of Biomedicine and Health SciencesCatholic Neuroscience InstituteThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGrOUND Identifying genetic mutations in cancer patients have been increasingly important because distinctive mutational patterns can be very informative to determine the optimal therapeutic strategy. recent studies have shown that deep learning-based molecular cancer subtyping can be performed directly from the standard hematoxylin and eosin(H&E) sections in diverse tumors including colorectal cancers(CrCs). Since H&E-stained tissue slides are ubiquitously available, mutation prediction with the pathology images from cancers can be a time-and cost-effective complementary method for personalized *** To predict the frequently occurring actionable mutations from the H&E-stained CrC whole-slide images(WSIs) with deep learning-based *** A total of 629 CrC patients from The Cancer Genome Atlas(TCGA-COAD and TCGA-rEAD) and 142 CrC patients from Seoul St. Mary Hospital(SMH) were included. Based on the mutation frequency in TCGA and SMH datasets, we chose APC, KrAS, PIK3CA, SMAD4, and TP53 genes for the study. The classifiers were trained with 360 × 360 pixel patches of tissue images. The receiver operating characteristic(rOC) curves and area under the curves(AUCs) for all the classifiers were *** The AUCs for rOC curves ranged from 0.693 to 0.809 for the TCGA frozen WSIs and from 0.645 to 0.783 for the TCGA formalin-fixed paraffin-embedded *** prediction performance can be enhanced with the expansion of datasets. When the classifiers were trained with both TCGA and SMH data, the prediction performance was *** APC, KrAS, PIK3CA, SMAD4, and TP53 mutations can be predicted from H&E pathology images using deep learning-based classifiers, demonstrating the potential for deep learning-based mutation prediction in the CrC tissue slides.

关键词： Colorectal cancer Mutation Deep learning Computational pathology Computer-aided diagnosis Digital pathology

长江三角洲地区大气O3和PM10的区域污染特征模拟

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环境科学 2008年第1期29卷 237-245页

作者：李莉陈长虹黄成黄海英李作攀 joshua S. Fu Carey j. jang David G. Streets 上海市环境科学研究院上海200233 Civil and Environmental Engineering University of TennesseeKnoxvilleTN 37996USA Air Quality Modeling Group Office of Air Quality Planning and StandardsU.S.Environmental Protection AgencyNC 27711USA Decision and Information Sciences Division Argonne National LaboratoryArgonneIllinois 60439USA

以TrACE-P污染源资料及上海市地方排放清单为基础,采用Models-3/CMAQ环境空气质量模型和中尺度气象模式MM5,模拟研究了2001-01和2001-07长三角近地面二次污染物O3及PM10的浓度分布及输送状况,并以上海市国控点2001年冬、夏季各10 d的小... 详细信息

以TrACE-P污染源资料及上海市地方排放清单为基础,采用Models-3/CMAQ环境空气质量模型和中尺度气象模式MM5,模拟研究了2001-01和2001-07长三角近地面二次污染物O3及PM10的浓度分布及输送状况,并以上海市国控点2001年冬、夏季各10 d的小时监测数据对模型进行了验证.验证结果显示,Models-3/CMAQ对O3和PM10的模拟结果与监测值的相关系数分别为0.77和0.52;一致性指数分别达到0.81和0.99.模型对O3小时最高浓度的估算偏低27%,标准偏差为-3.1%;对PM10小时平均浓度的估算偏低10%,标准偏差为46%.模型已具备再现和模拟长三角大气污染输送过程的能力,且误差落在可接受的范围之内.模拟结果显示,2001-07长三角区域16个主要城市中,有14个城市O3小时最大浓度超过国家二级标准,高浓度O3可覆盖苏南和浙北广大区域.2001-01泰州、扬州、南京、镇江、常州等城市受本地排放源和北部大气污染输送的影响显著,大气PM10日均浓度超过PM10国家二级标准.长三角地区环境空气质量与污染类型受大气污染传输与化学转化的影响十分明显.夏季太阳辐射较强时,南部城市排放的污染物常以二次污染物的形式影响下风向城市;太阳辐射较弱的情况下,则以一次污染物输送为主的形式影响周边地区.冬季长三角区域颗粒物污染总体水平较高,这与我国北方地区排放的颗粒物在西北风作用下向长三角输送造成的影响密切相关.长三角地区的大气污染已逐渐从局地转为区域问题.

关键词：区域污染污染输送长江三角洲空气质量模拟 Models-3/CMAQ