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中国有色冶金 1992年第1期29卷 39-42页

作者： e.J.hayes 那富智

1990年是镍工业的另一个好年景。非中央计划经济国家的镍需求量增长3%,达到680000t,已连续四年创纪录了。

关键词：中央计划经济伦敦金属交易所市场经济国家不锈钢产量库存量不锈钢生产现货价格西部矿业镍铁精炼厂

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全球纺织纤维市场趋势

国际纺织导报 2009年第1期37卷 4-4,6页

作者： C．e.hayes 汪玲玲（译）行兰（校）纺织市场研究中心（美国）不详

全球纺织加工行业(含服装业)2007年制造水平增长8%,达11 500亿美元(图1～图3).

关键词：纺织纤维市场趋势化学纤维制造水平加工行业植物纤维年增长率服装业

Surgically-induced brain injury:where are we now?

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Chinese Neurosurgical Journal 2020年第1期6卷 45-55页

作者： Travis Zachary D. Sherchan Prativa hayes William K. Zhang John H. Department of earth and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92354USA Department of Physiology and Pharmacology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA Department of Anesthesiology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA

Neurosurgical procedures cause inevitable brain damage from the multitude of surgical manipulations ***,retraction,thermal damage from electrocautery,and intraoperative hemorrhage cause immediate and long-term brain injuries that are directly linked to neurosurgical operations,and these types of injuries,collectively,have been termed surgical brain injury(SBI).For the past decade,a model developed to study the underlying brain pathologies resulting from SBI has provided insight on cellular mechanisms and potential therapeutic *** model,as seen in a rat,mouse,and rabbit,mimics a neurosurgical operation and causes commonly encountered post-operative complications such as brain edema,neuroinflammation,and *** this review,we elaborate on SBI and its clinical impact,the SBI animal models and their clinical relevance,the importance of applying therapeutics before neurosurgical procedures(i.e.,preconditioning),and the new direction of applying venom-derived proteins to attenuate SBI.

关键词： Brain injury Cerebral edema Preconditioning Neurotherapeutics Venom therapies

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抗血管生成:一种治疗癌症的新方法

英国医学杂志中文版 2003年第4期6卷 228-231页

作者： A J hayes L Y Li M e Lippman 周云飞 Lombardi Cancer Center Georgetown University Medical Center3970 Reservoir Road Washington DC 20007USA surgical registrar Lombardi Cancer Center Georgetown University Medical Center3970 Reservoir Road Washington DC 20007USA biochemistry Lombardi Cancer Center Georgetown University Medical Center3970 Reservoir Road Washington DC 20007USA professor of medicine and pharmacology

由于人们认识到肿瘤的生长依赖血管生成,因而找到了治疗肿瘤的许多新途径,并开发了对抗血管生成的新药。这些研究在实验动物模型中均已取得显著成功,若能转用于临床治疗,将对病人的生存有重大作用。过去20年间。

关键词：癌症治疗血管肿瘤药物

evaluation of a Rapid Immunochromatographic Middle east Respiratory Syndrome Coronavirus Antigen Detection Assay

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Infectious Microbes & Diseases 2022年第4期4卷 175-177页

作者： Susanna Kar-Pui Lau Kenneth Sze-Ming Li Jade Lee-Lee Teng Sunitha Joseph hayes Kam-Hei Luk Joshua Fung Ulrich Wernery Patrick Chiu-Yat Woo Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Central Veterinary Research Laboratory DubaiUnited Arab Emirates PhD Program in Translational Medicine and Department of Life Sciences National Chung Hsing UniversityTaichungTaiwan The ieGG and Animal Biotechnology Research Center National Chung Hsing UniversityTaichungTaiwan

Middle east respiratory syndrome coronavirus(MeRS-CoV)infection in humans has a high mortality of>30%.Dromedaries are the reservoir of MeRS-CoV and the main source of human ***,MeRS-CoV infections in dromedaries are usually *** diagnosis of MeRS-CoV infection in these animals is important in preventing camel-to-human transmission of the *** possible cross-reactivity of a previously reported rapid nucleocapsid protein-based antigen detection assay for MeRS-CoV was examined with different CoVs,including Tylonycteris bat CoV HKU4,dromedary camel CoV UAe-HKU23,human CoV-229e,human CoV-OC43,severe acute respiratory syndrome CoV-2 and rabbit CoV HKU14,where none of them showed false-positive *** assay was further validated using quantitative real-time reverse transcription-polymerase chain reaction-confirmed MeRS-CoV-positive and MeRS-CoV-negative dromedary nasal samples collected in Dubai,the United Arab emirates,which showed that the rapid antigen detection assay has a specificity of 100%and sensitivity of 91.7%.

关键词： MeRS-CoV rapid antigen detection assay dromedary camels

Attachment of <i>escherichia coli</i>to fine sediment particles within construction sediment basins

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Advances in Bioscience and Biotechnology 2013年第3期4卷 407-414页

作者： elizabeth A. Kunkel Charles V. Privette Calvin B. Sawyer John C. hayes Biosystems engineering Clemson University Clemson USA

The conventional best management practice of sediment basins may create a reservoir for pathogenic bacteria. The fine particles that enter these basins have been shown to provide protection for bacteria;the small pores of clays and silts minimize predators and block sunlight. Therefore, while these basins decrease sediment loadings to water bodies downstream, they may introduce harmful levels of pathogenic bacteria into surface waters. In addition to causing human health risks, high bacteria levels alter natural biological makeup of downstream ecosystems. This paper describes the attachment of escherichia coli to various particle sizes in construction site sediment basins. Five sediment basins, located in Anderson, South Carolina were sampled after rain events to explore trends that exist between various particle sizes and e. coli densities. Results provide evidence to suggest that sediment basins are a reservoir for pathogenic bacteria. Data showed that most e. coli attached to smaller particles with diameters less than 0.004 mm. These particles do not settle out of the water column quickly and are often passed through the basin during intense storms. Consequently, high levels of bacteria are passed to downstream waters. This research provides considerable evidence that the clays and silts within man-made construction basins can cause detrimental effects to South Carolina surface waters. With this knowledge, better stormwater management practices may be developed with the goal of remediating impaired surface waters of South Carolina.

关键词： e. coli Sediment Sediment Basins erosion Stormwater Runoff Construction

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南海北部陆缘东部的双船地震深反射剖面

南海北部陆缘东部的双船地震深反射剖面

1993年中国地球物理学会第九届学术年会

作者：姚伯初曾维军 D．e.hayes S．Spangler 地质矿产部广州海洋地质调查局地质矿产部广州海洋地质调查局 Lamont-Doherty earth Observatory of Columbia University New York1096L Lamont-Doherty earth Observatory of Columbia University New York1096L

＜正＞1985年底,我们和美国哥伦比亚大学拉蒙特-多尔蒂地质观测所在南海中、北部进行了一次科学合作,目的是研究边缘海小洋盆地海底扩张和张裂边缘（被动大陆边缘）的拉张演化模式。在工作中,双方各派一条调查船。每条船都有测深、重力...

＜正＞1985年底,我们和美国哥伦比亚大学拉蒙特-多尔蒂地质观测所在南海中、北部进行了一次科学合作,目的是研究边缘海小洋盆地海底扩张和张裂边缘（被动大陆边缘）的拉张演化模式。在工作中,双方各派一条调查船。每条船都有测深、重力、磁法、多道地震(48Q道地震系统,包

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控制e_h电位的硫化矿无捕收剂浮选分离

国外金属矿选矿 1991年第12期28卷 21-36页

作者： R.A.hayes 李海红

通过e_n电位控制研究了无捕收剂时方铅矿、黄铜矿和闪锌矿单矿物以及它们的混合矿的浮选行为。结果表明所研究的每种硫化矿的无捕收剂可浮性直接与它们的氧化难易程度以及所产生的疏水性表面状态的稳定性有关。疏水性表面物质可能是元素... 详细信息

通过e_n电位控制研究了无捕收剂时方铅矿、黄铜矿和闪锌矿单矿物以及它们的混合矿的浮选行为。结果表明所研究的每种硫化矿的无捕收剂可浮性直接与它们的氧化难易程度以及所产生的疏水性表面状态的稳定性有关。疏水性表面物质可能是元素硫(由质谱检测)或富硫贫金属的表面。矿物无捕收剂浮选可浮性顺序为,黄铜矿>方铅矿>闪锌矿。方铅矿和黄铜矿的混合矿在还原环境中磨矿,通过控制e_h电位可以得到分离.这时,它们的可浮性比单矿物时增强了。在氧化环境中磨矿,由于亲水性氧化物在矿物表面生成,导致选择性和可浮性降低。此外还讨论了有关浮选试验结果。

关键词：硫化矿铅矿无捕收剂浮选 eh电位

Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array

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Horticulture Research 2019年第1期6卷 1623-1637页

作者： Craig M.Hardner Ben J.hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace University of Queensland Queensland Alliance for Agriculture and Food InnovationBrisbaneQLD 4072Australia The New Zealand Institute for Plant and Food Research Limited Hawke’s Bay Research CentreHastings 4130New Zealand Department of Horticulture Washington State UniversityPullmanWA 99164USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA UMR 1332 BFP INRAUniversity of Bordeaux33140 Nouvelle-AquitaineFrance Council for Agricultural Research and economics(CReA) Fruit Unit of ForlìVia la Canapona1 bis47121 Emilia-RomagnaItaly Centre Technique Interprofessionnel des Fruits et Légumes(CTIFL) 751 Chemin de Balandran30127 BellegardeFrance Department of Horticulture Washington State UniversityIrrigated Agriculture Research and Extension Center24106N Bunn RoadProsserWA 99350USA

The timing of fruit maturity is an important trait in sweet cherry production and *** variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across *** such genotype-by-environment interaction(G×e)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry *** this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic *** disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among *** most parsimonious G×e model allowed heterogeneous genetic variance and pairwise covariances among ***-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across *** indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new *** G×e for this trait indicated that phenotypes of individuals will be stable across similar *** analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments.

关键词： maturity environments breeding

白介素1A基因多态性增加了阿尔茨海默病患者颅内小神经胶质细胞活性

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 41-42页

作者： hayes A. Green e.K. Pritchard A. Prof. D.M.A. Mann 郭俊 Neuroscience Research Group University of Manchester Hope Hospital Manchester M6 8HD United Kingdom

Objective: To investigate the impact of possession of the -889 C/T polymorphi sm of the interleukin 1A gene (IL-1A) and the -511 C/T polymorphism of the int erleukin 1B gene (IL-1B) on the extent of neuroinflammation in the brain in Alz heimers disease (AD), as demonstrated by the degree of microglial cell activit y associated with each IL-1A and IL-1B genotype. Method: Microglial cell activ ity within the frontal cortex was determined in 68 patients with necropsy confir med AD by image analysis as the percentage area of tissue occupied by ferritin i mmunostained material (microglial cell load). IL-1A, IL-1B, and apolipoprotein e (APOe) genotyping were performed by polymerase chain reaction on DNA extracte d from frontal cortex or cerebellum. Results: The microglial cell load was 31%g reater in patients with IL-1A T allele, 62%greater with IL1A TT genotype, but 108%greater with IL-1A TT genotype in combination with APOe 4 allele. No effec ts on microglial cell load occurred with polymorphisms in IL-1B, or APOe alone. Conclusions: Polymorphisms within IL-1A influence the degree of brain microgli al cell activation, especially in bearers of APOe 4 allele, reinforcing the impo rtance of neuroinflammatory processes in the pathogenesis of AD, and supporting the rationale for treating the disease with inflammation modulating drugs.

关键词：阿尔茨海默病神经胶质细胞基因多态性内小额叶皮质载脂蛋白颅内神经免疫染色炎症程度聚合酶链反应