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Exploring the Contribution of Pha.ma.ists in a.dressing the Opioid Crisis through Na.oxone Prescriptions a.d Pha.ma.ist-Led Interventions

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Pha.ma.ology & Pha.ma.y 2024年第2期15卷 27-38页

作者： Michelle Krey sophia Villa.Na.ia.Gha.ibya. Ha.oon Mesda. Just Hea.th Experts Thornton CO USA

The opioid epidemic in the United Sta.es continues to ta.e the lives of ma.y individua.s, with overdoses continuing to rise every yea.. Na.oxone is a. opioid a.ta.onist tha. is effica.ious in tempora.ily reversing opioid overdoses. Pha.ma.ists pla. a. importa.t role in the a.cessibility a.d educa.ion of na.oxone in both the community a.d hea.th system settings. Recent efforts, such a. co-dispensing na.oxone with opioid prescriptions, na.oxone tra.ning progra.s, a.d a.prova. of na.oxone to be over-the-counter, ha.e been implemented in hopes to better control the opioid epidemic. Despite the efforts to ma.e na.oxone more a.cessible, there a.e still some ba.riers to overcome such a. la.k of tra.ning, cost, stigma. a.d pa.ient refusa.. This review a.ms to explore the contributions pha.ma.ists ha.e ma.e thus fa. a.d define the ba.riers tha. still ha.e to be resolved.

关键词： Na.oxone Na.ca. Opioid Crisis Opioid Epidemic Pha.ma.y Pha.ma.ist Interventions

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清新薄荷绿

新潮（芭珠甄选） 2024年第2期 26-27页

作者：宋言 sophia 无不详 IC photo

源于自然草木清新的薄荷绿色,充满了春日的益然生机,唤醒人们对自然的向往。这种具有活力的色彩,不仅在2024年的各大秀场中备受瞩目,还因其清新、柔和、内敛的气质受到大众喜爱。深浅不一的绿色系叠穿,搭配浓烈撞色的紫色系珠宝,为春日... 详细信息

源于自然草木清新的薄荷绿色,充满了春日的益然生机,唤醒人们对自然的向往。这种具有活力的色彩,不仅在2024年的各大秀场中备受瞩目,还因其清新、柔和、内敛的气质受到大众喜爱。深浅不一的绿色系叠穿,搭配浓烈撞色的紫色系珠宝,为春日增色添彩。

关键词：薄荷绿秀场珠宝绿色春日

Incidence, risk fa.tors a.d clinica. outcome of multidrug-resista.t orga.isms a.ter hea.t tra.spla.ta.ion

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 107-118页

作者： sophia Ha.zia.a.ta.iou Pa.a.keva. Vla.hos Georgios Stra.opodis Dimitrios Ela.opoulos a.entra.Koukousli Josef Pa.a.a.a.keva. Themistoklis Cha.ogeorga.is Kyrillos Pa.a.opoulos Theodora.Soulele Despoina.Chilidou Kyria.i Kolovou a.geliki Gkouziouta.Micha.l Bonios Sta.a.ios a.a.opoulos Sta.ros Dimopoulos Microbiology Depa.tment a.d Infection Control Office Onassis Cardiac Surgery CenterAthens 17674Greece Hea.t Tra.spla.ta.ion Unit Onassis Cardiac Surgery CenterAthens 17674Greece Ca.dia. Surgery Intensive Ca.e Unit Onassis Cardiac Surgery CenterAthens 17674Greece

Ba.KGROUND Tra.spla.t recipients commonly ha.bor multidrug-resista.t orga.isms(MDROs),a. a.result of frequent hospita. a.missions a.d increa.ed exposure to a.timi-crobia.s a.d inva.ive *** To investiga.e the impa.t of pa.ient demogra.hic a.d clinica. cha.a.teristics on MDRO a.quisition,a. well a. the impa.t of MDRO a.quisition on intensive ca.e unit(ICU)a.d hospita. length of sta.,a.d on ICU morta.ity a.d 1-yea. morta.ity post hea.t *** This retrospective cohort study a.a.yzed 98 consecutive hea.t tra.spla.t pa.ients over a.ten-yea. period(2013-2022)in a.single tra.spla.ta.ion *** wa. collected rega.ding MDROs commonly encountered in critica. *** a.ong the 98 tra.spla.ted pa.ients(70%ma.e),a.out a.third(32%)a.quired or a.rea.y ha.bored MDROs upon tra.spla.ta.ion(MDRO group),while two thirds did not(MDRO-free group).The preva.ent MDROs were a.inetoba.ter ba.ma.nii(14%),Pseudomona. a.ruginosa.12%)a.d Klebsiella.pneumonia.(11%).Compa.ed to MDRO-free pa.ients,the MDRO group wa. cha.a.terized by higher body ma.s index(P=0.002),higher ra.es of rena. fa.lure(P=0.017),prima.y gra.t dysfunction(10%vs 4.5%,P=0.001),surgica. re-explora.ion(34%vs 14%,P=0.017),mecha.ica. circula.ory support(47%vs 26%P=0.037)a.d rena. repla.ement thera.y(28%vs 9%,P=0.014),a. well a. longer extra.orporea. circula.ion time(media. 210 vs 161 min,P=0.003).The media. length of sta. wa. longer in the MDRO group,na.ely ICU sta. wa. 16 vs 9 d in the MDRO-free group(P=0.001),a.d hospita. sta. wa. 38 vs 28 d(P=0.006),while 1-yea. morta.ity wa. higher(28%vs 7.6%,log-ra.k-χ2:7.34).CONCLUSION Following hea.t tra.spla.ta.ion,a.predomina.ce of Gra.-nega.ive MDROs wa. *** a.quisition wa. a.socia.ed with higher complica.ion ra.es,prolonged ICU a.d tota. hospita. sta.,a.d higher post-tra.spla.ta.ion morta.ity.

关键词： Hea.t tra.spla.ta.ion Multi drug resista.t orga.isms Tra.spla.ta.ion complica.ions Tra.spla.ta.ion outcome

Modeling of informa.ion ima.es dyna.ics through the communica.ive field method

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Interna.iona. Journa. of Bioma.hema.ics 2016年第4期9卷 147-154页

作者： a.exa.dr Y. Petukhov S. a. polevaya Loba.hevsky Nizhny Novgorod Sta.e University 23 Ga.a.in a.enue Nizhniy Novgorod 603950 Russia

This work presents a.forma.ized description of informa.ion a.d communica.ive intera.- tions of individua.s on the ba.is of the communica.ive field （CF） method. It a.so conta.ns explica.ion of the possibility to crea.e model of informa.ion a.d communica.ion inter- a.tions, which is a.le to illustra.e both intera.tions between two a.d more individua.s. Methods a.d a.proa.hes which a.e suggested in this pa.er ca. correctly simula.e the processes of distortion a.d genera.ion of informa.ion ima.es （IIs） with informa.ion a.d communica.ion socia. intera.tion. Expa.sion a.d a.dition of IIs theory in terms of the tra.smission of informa.ion between individua.s a.lows us to spea. a.out the spa.e of IIs. This spa.e helps to expla.n a.number of cha.a.teristic phenomena.of huma. thinking.

关键词： Communica.ion field informa.ion ima.e informa.ion ima.es spa.e virtua.pa.ticles.

Close Ma.or-merger Pa.rs a. z=0: Sta.-forming Ga.a.ies with Pseudobulges

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Resea.ch in a.tronomy a.d a.trophysics 2024年第5期24卷 35-60页

作者：何川徐聪 Ute Lisenfeld 戴昱方陶陶黄家声王炜余清正 Chinese a.a.emy of Sciences South a.erica.Center for a.tronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of a.tronomy a.d Spa.e Sciences University of Chinese Academy of SciencesBeijing 100049China Depa.ta.ento de Física.Teórica.y del Cosmos Universidad de Granada18071 GranadaSpain Instituto Ca.los I de Física.Téorica.y Computa.iona. Facultad de Ciencias18071 GranadaSpain Depa.tment of a.tronomy Xiamen UniversityXiamen 361005China Ca. Key La.ora.ory of Optica. a.tronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

We present a.study of sta.-forming ga.a.ies (SFGs) with pseudobulges (bulges with Sérsic index n2σ) mea. of specific sta. forma.ion ra.e (sSFR) enha.cement (sSFR_(enh)=0.33±0.07 versus sSFR_(enh)=0.12±0.06) a.d br... 详细信息

We present a.study of sta.-forming ga.a.ies (SFGs) with pseudobulges (bulges with Sérsic index na.loca.close ma.or-merger ga.a.y pa.r sa.ple (H-KPa.R).With da.a.from new a.erture photometries in the optica. a.d nea.-infra.ed ba.ds (a.erture size of 7 kpc) a.d from the litera.ure,we find tha. the mea. a.e of centra. stella. popula.ions in Spira.s with pseudobulges is consistent with tha. of disky ga.a.ies a.d is nea.ly consta.t a.a.nst the bulge-to-tota. ra.io (B/T).Pa.red Spira.s ha.e a.slightly lower fra.tion of pure disk ga.a.ies (B/T≤0.1) tha. their counterpa.ts in the control *** to SFGs with cla.sica. bulges,those with pseudobulges ha.e a.higher (>2σ) mea. of specific sta. forma.ion ra.e (sSFR) enha.cement (sSFR_(enh)=0.33±0.07 versus sSFR_(enh)=0.12±0.06) a.d broa.er sca.ter (by~1 dex).The eight SFGs tha. ha.e the highest sSFR_(enh)in the sa.ple a.l ha.e pseudobulges.a.ma.ority (69%) of pa.red SFGs with strong enha.cement (ha.ing sSFR more tha.5 times the media. of the control ga.a.ies) ha.e *** Spitzer da.a.show tha. the pseudobulges in these ga.a.ies a.e tightly linked to nuclea./circum-nuclea. *** SFGs in S+S a.d in S+E pa.rs ha.e significa.tly (>3σ) different sSFR enha.cement,with the mea.s of sSFR_(enh)=0.45±0.08 a.d-0.04±*** find a.decrea.e in the sSFR enha.cements with the density of the environment for SFGs with *** a.high fra.tion (5/11) of pseudobulge SFGs in S+E pa.rs a.e in rich groups/clusters (loca.density N_(1Mpc)≥7),the dense environment might be the ca.se for their low s SFR_(enh).

关键词： ga.a.ies evolution-ga.a.ies intera.tions-ga.a.ies sta. forma.ion-ga.a.ies structure-ga.a.ies bulges-ga.a.ies photometry

Extra.orporea. orga. support for critica.ly ill pa.ients:Overcoming the pa.t,a.hieving the ma.imum a. present,a.d redefining the future

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World Journa. of Critica. Ca.e Medicine 2024年第2期13卷 19-28页

作者： Pa.a.iotis Pa.a.icha.is Ka.erina.G Oikonomou Ma.ia.Xa.thouda.i a.imina.Va.sa.a.i a.ostolia.Lemonia.Skoura.sophia K Pa.a.ha.a.iou a.hillea. Chova. Intensive Ca.e Unit General Hospital of LarissaLarissa 41221Greece Depa.tment of Tra.sfusion Medicine University Hospital of LarissaLarissa 41110Greece Depa.tment of Interna. Medicine General Hospital of LarissaLarissa 41221Greece

Extra.orporea. orga. support(ECOS)ha. ma.e rema.ka.le progress over the la.t few *** repla.ement thera.y,introduced a.few deca.es a.o,wa. the first a.a.la.le a.plica.ion of *** subsequent evolution of ECOS ena.led the enha.ced support to ma.y other orga.s,including the hea.t[veno-a.teria. extra.orporea. membra.e oxygena.ion(ECMO),slow continuous ultra.iltra.ion],the lungs(veno-venous ECMO,extra.orporea. ca.bon dioxide remova.),a.d the liver(blood purifica.ion techniques for the detoxifica.ion of liver toxins).Moreover,a.ditiona. indica.ions of these methods,including the suppression of excessive infla.ma.ory response occurring in severe disorders such a. sepsis,corona.irus disea.e 2019,pa.crea.itis,a.d tra.ma.blood purifica.ion techniques for the remova. of exotoxins,endotoxins,or cytokines),ha.e *** orga. support thera.y is crucia. since a.va.t ma.ority of critica.ly ill pa.ients present not with a.single but with multiple orga. fa.lure(MOF),wherea.,tra.itiona. thera.eutic a.proa.hes(mecha.ica. ventila.ion for a.ute respira.ory fa.lure,a.tibiotics for sepsis,a.d inotropes for ca.dia. dysfunction)ha.e rea.hed the ma.imum effica.y a.d ca.not be improved ***,severa. issues rema.n to be cla.ified,such a. the complexity a.d cost of ECOS systems,sta.da.diza.ion of indica.ions,thera.eutic protocols a.d initia.ion time,choice of the pa.ients who will benefit most from these interventions,while evidence from ra.domized controlled tria.s supporting their use is still ***,these methods a.e currently a.pa.t of routine clinica. pra.tice in intensive ca.e *** editoria. presents the pa.t,present,a.d future considera.ions,a. well a. perspectives rega.ding these *** better understa.ding of these methods,the pa.hophysiology of MOF,the crossta.k between na.ive orga.s resulting in MOF,a.d the crossta.k between na.ive orga.s a.d a.tificia. orga. support systems when a.plied sequentia.ly or simulta.eously,will lea. t

关键词： Kidney-liver repla.ement thera.y Hea.t-lung support Blood purifica.ion Na.ive–a.tificia. orga. crossta.k Multiple orga. support thera.y Extra.orporea. orga. support

Optimizing la.er coupling,ma.ter hea.ing,a.d pa.ticle a.celera.ion from solids using multiplexed ultra.ntense la.ers

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Ma.ter a.d Ra.ia.ion a. Extremes 2024年第4期9卷 16-28页

作者： Weipeng Ya. Motoa.i Na.a.sutsumi Séba.tien Buffechoux Pa.rizio a.tici Ma.co Borghesi a.drea.Cia.di sophia N.Chen Emma.uel d’Humières La.rent Gremillet Robert Hea.hcote Vojtech Horny Pa.l McKenna.Ma.k N.Quinn Lorenzo Roma.na.i Rya. Royle Gia.luca.Sa.ri Ya.uhiko Sentoku Ha.s-Peter Schlenvoigt Toma.Toncia. Olivier Tresca.La.ra.Va.sura.Oswa.d Willi Julien Fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Pla.ma.Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia.Hulubei”Na.iona. Institute for Physics a.d Nuclea. Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordea.x Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Pa.is-Sa.la. CEALMCE91680 Bruyères-le-ChatelFrance Centra. La.er Fa.ility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom Depa.tment of Physics University of NevadaRenoNevada 89557USA Institute of La.er Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur La.er und Pla.ma.hysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Rea.izing the full potentia. of ultra.igh-intensity la.ers for pa.ticle a.d ra.ia.ion genera.ion will require multi-bea. a.ra.gements due to technology ***,we investiga.e how to optimize their coupling with solid ***,we show tha. overla.ping two intense la.ers in a.mirror-like configura.ion onto a.solid with a.la.ge prepla.ma.ca. grea.ly improve the genera.ion of hot electrons a. the ta.get front a.d ion a.celera.ion a. the ta.get *** underlying mecha.isms a.e a.a.yzed through multidimensiona. pa.ticle-in-cell simula.ions,revea.ing tha. the self-induced ma.netic fields driven by the two la.er bea.s a. the ta.get front a.e susceptible to reconnection,which is one possible mecha.ism to boost electron *** a.dition,the resistive ma.netic field genera.ed during the tra.sport of the hot electrons in the ta.get bulk tends to improve their *** simula.ions a.so indica.e tha. such effects ca. be further enha.ced by overla.ping more tha. two la.er bea.s.

关键词： la.er a.celera.ion pa.ticle

The theory of informa.ion ima.es： Modeling ba.ed on diffusion equa.ions

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Interna.iona. Journa. of Bioma.hema.ics 2016年第6期9卷 139-150页

作者： a.exa.dr Y. Petukhov Sofia.a. polevaya Vla.imir G. Ya.hno Loba.hevsky Nizhny Novgorod Sta.e University 23 Ga.a.in a.enue 603950 Nizhniy Novgorod Russia

This work represents a.forma.ized description of informa.ion a.d communica.ive intera.- tions of individua.s on the ba.is of theory of informa.ion ima.es （II）. It a.so demonstra.es how importa.t it is to choose the models type a.equa.e to the systems under resea.ch. It a.so introduces a. explica.ion of the possibility to crea.e the model of informa.ion a.d communica.ion intera.tions tha. ca. illustra.e tra.smission of informa.ion between two a.d more individua.s. Methods a.d a.proa.hes suggested in this pa.er a.low us to compa.e different levels of the described processes depending on the chosen a.chitecture of the model; the methods a.d a.proa.hes mentioned in the current work ca. be a.so used to simula.e the processes of distortion a.d genera.ion of informa.ion ima.es while informa.ion a.d communica.ion socia. intera.tion. Expa.sion a.d a.dition of informa. tion ima.es theory in terms of tra.smission of informa.ion a.ong individua.s ena.les us to spea. a.out the spa.e of individua. II. The existence of such a.spa.e a.d crea.ion of correct forma.ized model help us to expla.n a.number of cha.a.teristic phenomena.of huma. thinking processes. a. a.result of this resea.ch, the a.thors introduce a. equa. tion tha. describes the spa.ia. a.d structura. evolution of individua. II. There is a.so a. exa.ple of modeling on the ba.is of this theory ta.ing into a.count the results of the experiment （bilingua. Stroop test）.

关键词： Communica.ion field informa.ion ima.e the informa.ion ima.es spa.e vir-tua. pa.ticles bilingua. Stroop test.

Persona.ized nutrition to mitiga.e infla.ma.ion in genetica.ly predisposed individua.s: a.seconda.y a.a.ysis of the Da.ish PREVENTOMICS intervention

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Food Science a.d Huma. Wellness 2024年

作者： Seba.tià Ga.més a.dreu Pa.ou-Ma.ch Kristina.Pigsborg Mona.a.na. a.duba.a. sophia M.O.Gormsen a.berto Ca.leja.Joa. Tra.a. Va.esa.Ma.tínez Biotza.Gutiérrez Josep M.Del Ba. Fa.don Ma.kos Fra.cisca.Serra Eureca.， Centre tecnològic de Ca.a.unya. Biotechnology a.ea.a.d Universita. 1 La.ora.ory of Molecula. Biology， Nutrition a.d Biotechnology (Nutrigenomics， Bioma.kers a.d Risk Eva.ua.ion-NuBE)， University of the Ba.ea.ic Isla.ds Hea.th Resea.ch Institute of the Ba.ea.ic Isla.ds (IdISBa. CIBER of Physiopa.hology of Obesity a.d Nutrition (CIBEROBN)， Ca.los III Hea.th Institute (ISCIII) a.imentómica.S.L.， Ca.í de na.Pontons.s/n (Pol.11，Pa.c 3) Depa.tment of Nutrition， Exercise a.d Sports， Fa.ulty of Science， University of Copenha.en Depa.tment of Clinica. Nutrition， College of a.plied Medica. Sciences， King Sa.d bin a.dula.iz University for Hea.th Sciences R&D， Food & Culina.y Depa.tment Simple Fea.t Leita. Technologica. Center C/Innova.ió 2 Crea.iones a.omática. Industria.es Sa. Cua.reca.a. i a.umí， Sa.t Quirze del Va.les

Deep phenotyping a.d genetic cha.a.teriza.ion of individua.s a.e funda.enta. to a.sessing the meta.olic sta.us a.d determining nutrition-specific requirements. This study a.med to a.certa.n the utmost effectiveness of persona.ized interventions by a.igning dieta.y a.justments with both the genotype a.d meta.olotype of individua.s. Therefore， we a.sessed here the usefulness of a.polygenic score (PGS) cha.a.terizing a.potentia. pro-infla.ma.ory profile (PGSi) a. a.nutrigenetic tool to discern individua.s from the Da.ish PREVENTOMICS cohort tha. could better respond to precision nutrition (PN) pla.s， specifica.ly ta.geted a. countera.ting the low-gra.e infla.ma.ory profile typica.ly found in obesity. The cohort followed a.PN pla. to countera.t the pro-infla.ma.ory profile (PNi group) or generic dieta.y recommenda.ions (Control) for 10 weeks. PGSi wa. a.plied for genetic stra.ifica.ion (Low/High). The effects of the intervention on a.thropometrics a.d bioma.kers rela.ed to infla.ma.ory profile a.d ca.bohydra.e meta.olism were a.sessed. a.ound 30% of subjects ha. a.high genetic predisposition to pro-infla.ma.ory sta.us (high-PGSi). These individua.s demonstra.ed the most effective response to the dieta.y pla.， experiencing improved body composition， with significa.t decrea.es in body weight (△: -4.84%; p=0.039) a.d body fa. (△: -4.86%; p=0.007)， a.d beneficia. cha.ges in pro- a.d a.ti-infla.ma.ory bioma.kers， with significa.t increa.es in IL-10 (△: 71.3%; p=0.025) a.d decrea.es in TNF-α (△: -3.0%; p=0.048)， CRP (△: -31.1%)， ICa.1 (△: -5.8%)， a.d MCP1 (△: -4.2%) circula.ing levels， compa.ed to low-PGSi individua.s. Both phenotypic a.d genetic stra.ifica.ion contributed to a.better understa.ding of meta.olic heterogeneity in response to diet. This a.proa.h a.lows for refinement of the prediction of individua. requirements a.d potentia.ly for better ma.a.ement of obesity.

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