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Journal of Molecular Cell Biology 2024年第1期16卷 15-28页

作者： Te Li Min Liu Fan Yu Song Yang Weiwen Bu Kai Liu Jia Yang Hua Ni Mulin Yang Hanxiao Yin Renjie Hong Dengwen Li Huĳie Zhao Jun Zhou Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Protein ScienceCollege of Life SciencesNankai UniversityTianjin 300071China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell EcosystemTianjin 300462China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongShandong Provincial Key Laboratory of Animal Resistance BiologyCollege of Life SciencesShandong Normal UniversityJinan 250014China

Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan ***,the mechanistic link of cilia to CMD complications is still poorly ***,we describe significant cilium disassembly upon treatment of cells with pathologically relevant aldoses rather than the corresponding sugar ***,environmental aldehydes are able to trigger cilium disassembly by the steric hindrance effect of their formyl *** studies reveal that aldehydes stimulate extracellular calcium influx across the plasma membrane,which subsequently activates the calmodulin-Aurora A-histone deacetylase 6 pathway to deacetylate axonemal microtubules and triggers cilium *** vivo experiments further show that Hdac6 knockout mice are resistant to aldehyde-induced disassembly of tracheal cilia and sperm *** findings reveal a previously unrecognized role for formyl group-mediated cilium disassembly in the complications of CMDs.

关键词： carbohydrate metabolism disorder aldose aldehyde cilium disassembly formyl group calcium influx HDAC6

Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel Soares Conceição Rodrigo Menezes Jales Patrick Nunes Pereira Luis Otávio Sarian Glauco Baiocchi sop.ie derchain Agnaldo Lopes da Silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

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上海程十发美术馆建筑隔震设计策略详析

建筑技术开发 2024年第4期51卷 19-21页

作者：吴靖杰同济大学建筑设计研究院(集团)有限公司上海200092

上海程十发美术馆通过采用隔震技术,提升了空间效果及建筑品质。美术馆为实现隔震建筑设计的水平位移要求,针对隔震缝位置选择,整体隔震防水,墙体楼梯隔震处理,电梯设备隔震设计,隔震沟构造等内容,形成了完整的建筑隔震设计体系与策略,... 详细信息

上海程十发美术馆通过采用隔震技术,提升了空间效果及建筑品质。美术馆为实现隔震建筑设计的水平位移要求,针对隔震缝位置选择,整体隔震防水,墙体楼梯隔震处理,电梯设备隔震设计,隔震沟构造等内容,形成了完整的建筑隔震设计体系与策略,实现了高品质的功能及建筑空间与效果。

关键词：程十发美术馆水平位移隔震构造

Effect of Multiple Martensitic Transformations on Structure of Fe-Ni Alloys

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Journal of Materials Science & Technology 2013年第3期29卷 279-282页

作者： V.Danilchenko ie.Dzevin V.Sagaradze G.V.Kurdyumov Institute of Metal Physics NAS of UkraineKievUkraine Institute of Metal Physics Ural Division of RASEkaterinburgRussia

Effect of multiple direct and reverse martensitic transformations on fragmentation of austenitic grains in Fe-Ni alloys have been studied by X-ray diffraction and scanning electron microscopy. An ultra-fine structure was formed by fragmentation inside austenitic grains due to progressing misorientation of austenitic sub-grains during multiple γ-α-γ-martensitic phase transitions. An increase in the number of γ-α-γ-transformations increases misorientation angle between austenitic sub-grains and leads to transformation of an austenitic single crystal into a textured polycrystal. It has been shown that multiple γ-α-γ-martensitic phase transitions change the mechanism of internal stress relaxation from dislocation-based to deformation twinning.

关键词： Austenite Crystal lattice Ultra-fine structure Martensitic transformation

基于分层调制的物理层网络编码系统概率成形设计

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移动通信 2024年第5期48卷 21-26,36页

作者：林宇晨谢肇鹏陈平平福州大学物理与信息工程学院福建福州350116 福州大学先进制造学院福建泉州362251 数字智能化技术国家地方工程研究中心福建福州350116

分层调制是一种根据发送信号的相对重要性对数据流进行不等保护的关键技术。针对双向中继信道下基于分层调制技术的PNC系统进行研究。当系统采用均匀的输入分布时会产生成形损耗,由于传统的分布匹配器的非线性成形编译码过程不适用于PN... 详细信息

分层调制是一种根据发送信号的相对重要性对数据流进行不等保护的关键技术。针对双向中继信道下基于分层调制技术的PNC系统进行研究。当系统采用均匀的输入分布时会产生成形损耗,由于传统的分布匹配器的非线性成形编译码过程不适用于PNC系统,因此提出一种线性概率成形码本方案,以确保其成形编译码过程是线性的,进一步推导了成形系统可达速率表达式。仿真结果表明,所提出的线性成形方案在中低SNR具有0.3 dB的成形增益。

关键词：分层调制概率成形物理层网络编码

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Glucose metabolic phenotype of pancreatic cancer

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World Journal of Gastroenterology 2016年第12期22卷 3471-3485页

作者： Anthony KC Chan Jason ie Bruce Ajith K Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal Infirmary Faculty of Life Sciences University of Manchester

AIM: To construct a global "metabolic phenotype" of pancreatic ductal adenocarcinoma(PDAC) reflecting tumour-related metabolic enzyme ***: A systematic review of the literature was performed using Ovid SP and Pub Med databases using keywords "pancreatic cancer" and individual glycolytic and mitochondrial oxidative phosphorylation(MOP) enzymes. Both human and animal studies investigating the oncological effect of enzyme expression changes and inhibitors in both an in vitro and in vivo setting were included in the review. Data reporting changes in enzyme expression and the effects on PDAC cells, such as survival and metastatic potential, were extracted to construct a metabolic phenotype. RESULTS: Seven hundred and ten papers were initially retrieved, and were screened to meet the review inclusion criteria. 107 unique articles were identified as reporting data involving glycolytic enzymes, and 28 articles involving MOP enzymes in PDAC. Data extraction followed a pre-defined protocol. There is consistent over-expression of glycolytic enzymes and lactate dehydrogenase in keeping with the Warburg effect to facilitate rapid adenosine-triphosphate production from glycolysis. Certain isoforms of these enzymes were over-expressed specifically in PDAC. Altering expression levels of HK, PGI, FBA, enolase, PK-M2 and LDA-A with metabolic inhibitors have shown a favourable effect on PDAC, thus identifying these as potential therapeutic targets. However, the Warburg effect on MOP enzymes is less clear, with different expression levels at different points in the Krebs cycle resulting in a fundamental change of metabolite levels, suggesting that other essential anabolic pathways are being stimulated. CONCLUSION: Further characterisation of the PDAC metabolic phenotype is necessary as currently there are few clinical studies and no successful clinical trials targeting metabolic enzymes.

关键词： Metabolism Pancreatic cancer Warburg effect Metabolic inhibitor Glycolysis Krebs cycle

全身麻醉下胸横肌平面-胸神经阻滞在乳腺癌手术患者中的价值

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南京医科大学学报（自然科学版） 2024年第5期44卷 666-671页

作者：吴春培孙正霞刘辉马丽丽谢辉兰卞清明江苏省肿瘤医院(南京医科大学附属肿瘤医院)麻醉科江苏省肿瘤防治研究所江苏南京210009 徐州医科大学麻醉学院江苏徐州221004

目的:评价胸横肌平面-胸神经(transversus thoracic muscle plane-pectoral nerves,TTP-PECS)阻滞用于减阿片类药物全麻下乳腺癌改良根治术中的安全性与可行性。方法:选择择期行乳腺癌改良根治术的患者60例,随机分为TTP-PECS阻滞联合减... 详细信息

目的:评价胸横肌平面-胸神经(transversus thoracic muscle plane-pectoral nerves,TTP-PECS)阻滞用于减阿片类药物全麻下乳腺癌改良根治术中的安全性与可行性。方法:选择择期行乳腺癌改良根治术的患者60例,随机分为TTP-PECS阻滞联合减阿片药物全麻组(TO组)和常规全身麻醉组(GA组),每组30例。观察并记录两组患者各时点收缩压、舒张压、心率;麻醉诱导前(T0)、插管前即刻(T1)、切皮时(T2)、切除乳腺标本时(T3)、手术结束时(T4)各时点安静及运动状态下的疼痛视觉模拟评分量表(visual analogue scale,VAS);术后24 h 40项恢复质量评分量表(quality of recovery-40,QoR-40)评分;围术期不良反应的发生率。结果:与T0比较,两组患者T1~T4时点收缩压、舒张压、心率均显著降低(P 0.05);TO组术后2 h、6 h、12 h安静及运动状态下VAS评分均显著低于GA组(P <0.05);TO组术后24 h QoR-40量表总评分及情绪状态、身体舒适度、心理支持、疼痛各项评分均显著高于GA组(P <0.05);TO组患者诱导期咳嗽反射及术后恶心呕吐的发生率显著低于GA组(P <0.05)。结论:TTP-PECS阻滞联合羟考酮-丙泊酚减阿片药物全身麻醉可安全用于乳腺癌改良根治术中,术后镇痛效果确切,降低术后恶心呕吐发生率,并能提高患者早期恢复质量。

关键词：胸横肌平面胸神经阻滞羟考酮丙泊酚全身麻醉乳腺癌

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 141-144页

作者： Gyuse AN Bassey ie Udonwa NE Okokon IB Philip-Ephraim EE Department of Family Medicine University of Calabar Teaching Hospital Department of Pathology University of Calabar Teaching Hospital Department of Internal Medicine University of Calabar Teaching Hospital

Objective:To determine the causes of death among human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS) patients as a step to planning strategies to improve mortality from this ***:This study retrospectively analyzed the mortality pattern of adult HIV/AIDS patients in the University of Calabar Teaching Hospital from January 2005 to December *** data were obtained from sexually transmitted infection/acquired immunodeficiency syndrome(STI/AIDS) clinic register,admissions and discharge/death registers as well as the patients’ case records and the hospitals monthly mortality *** obtained included age,sex,diagnosis and cause(s) of *** causes of death considered were the direct causes of death,since the originating antecedent cause of death is the same in all the patients,in this case,HIV/*** was analysed using Epi Info ***:The total number of mortalities during the study period was 350,100 were HIV positive representing 28.6%of all *** advanced HIV/AIDS disease was the leading cause of death in our study representing 27.0%,tuberculosis was the single leading cause of deaths in HIV/AIDS patients constituting about 24.0%of *** was followed by sepsis and septicaemia(13.0%), meningitis and encephalitis,and anaemia accounting for 11.0%,while respiratory diseases constituted 5.0%of the mortality *** highest number of deaths occurred in those aged between 21-50 years(82.0%).Conclusions:The study has shown that HIV/AIDS is a major cause of morbidity and mortality in our *** causes of death reflect the varied spectrum of infection and other forms of organ involvement that affect HIV/AIDS *** present dismal situation of adult patients living with HIV/AIDS calls for enhanced strategies to decrease the mortality trend observed in Nigeria and sub-Saharan Africa.

关键词： Mortality Pattern HIV/AIDS Adult Patients Tertiary health institution

基于PageRank,HITS和SALSA算法的学术论文评价

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情报杂志 2015年第6期34卷 48-54页

作者：苏成 Hee-sop KIM 中国科学技术信息研究所情报方法研究中心北京100038 韩国庆北大学图书馆与信息科学系

科技论文评价对于科研工作者的评价以及相关科研管理工作至关重要。利用PageRank、HITS和SALSA算法进行了"图书馆与信息科学"领域的论文排序实验,比较了不同算法排序列表前100共同论文数和Spearman相关系数,讨论了不同算法特性对排序结... 详细信息

科技论文评价对于科研工作者的评价以及相关科研管理工作至关重要。利用PageRank、HITS和SALSA算法进行了"图书馆与信息科学"领域的论文排序实验,比较了不同算法排序列表前100共同论文数和Spearman相关系数,讨论了不同算法特性对排序结果的影响,最后讨论了不同算法的优缺点、适用范围。

关键词： PageRank HITS SALSA学术论文评价

经阴道超声联合经腹部超声对凶险性前置胎盘的诊断价值分析

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四川生理科学杂志 2024年第5期46卷 1086-1088页

作者：张慧珍刘风杰贾欣欣郑州大桥医院超声科河南郑州450000

目的:探讨经阴道超声联合经腹部超声对凶险性前置胎盘(Permicious Placenta Previa,PPP)的诊断价值。方法:选取2021年1月至2023年1月期间本院产科收治的疑似PPP患者98例作为研究对象,均行经腹部超声、经阴道超声检查,分娩后均进行病理... 详细信息

目的:探讨经阴道超声联合经腹部超声对凶险性前置胎盘(Permicious Placenta Previa,PPP)的诊断价值。方法:选取2021年1月至2023年1月期间本院产科收治的疑似PPP患者98例作为研究对象,均行经腹部超声、经阴道超声检查,分娩后均进行病理检查。以病理结果为“金标准”,对比经腹部、经阴道超声检查结果与病理结果,对比联合检查结果与病理结果,对比经腹部、经阴道及联合检查诊断效能。结果:98例PPP疑似患者分娩后,经病理诊断PPP71例,非PPP27例,经阴道超声诊断真阳性55例,假阳性10例,假阴性16例,真阴性17例,诊断灵敏度为77.46%、特异度为62.96%、准确率为73.47%;经腹部超声诊断真阳性54例,假阳性9例,假阴性17例,真阴性18例,诊断灵敏度为76.06%、特异度为66.67%、准确率为73.47%;经腹部、经阴道超声联合诊断真阳性66例,假阳性4例,假阴性5例,真阴性23例,诊断灵敏度为92.96%、特异度为85.19%、准确率为90.82%,且联合诊断准确度、灵敏度、阴性预测值高于两项检查单独诊断,漏诊率低于单独诊断(P<0.05)。结论:经腹部、经阴道超声联合检查对PPP具有较高诊断价值,优于两项检查单独诊断,可作为临床诊断PPP的有效检查方式。

关键词：经阴道超声经腹部超声凶险性前置胎盘诊断价值