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Expert Opinions on the Concept of Blood Stasis in China: An Interview Study

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Chinese Journal of Integrative Medicine 2016年第11期22卷 823-831页

作者： Tae-young Choi Ji Hee Jun Ju Ah Lee Bongki Park sooseong you Jeeyoun Jung Myeong Soo Lee Medical Research Division Korea Institute of Oriental Medicine

Objective: To study various experts’ opinions on the definition and diagnosis of blood stasis in China. Methods: We e-mailed the selected experts to explain the purpose of the study and to invite them to participate and asked them to name a time for the investigator to call them. Eight experts and five organizations were interviewed in the research community investigating blood stasis in China. Results: Six main categories emerged from the interviews:(1) blood stasis concepts;(2) blood stasis-related biomarkers;(3) methods of diagnosing blood stasis;(4) drugs for promoting blood circulation and dissipating stasis;(5) blood stasis-related diseases; and(6) blood stasis-related societies. The consensus among the interviewed experts was that the definition of blood stasis is rather complicated and that there is no gold standard marker for detecting blood stasis. Conclusion: This paper acquired experts’ opinions on the definition and diagnosis of blood stasis in order to establish a modern concept of blood stasis. This paper also developed a diagnostic tool and diagnostic indices for blood stasis and identified biological indices and pathologic mechanisms related to blood stasis, which might be of great reference value in future blood stasis standardization research.

关键词： blood stasis concept interview experts Chinese medicine

Standardization and Future Directions in Pattern Identification Research: International Brainstorming Session

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Chinese Journal of Integrative Medicine 2016年第9期22卷 714-720页

作者： Jeeyoun Jung Bongki Park Ju Ah Lee sooseong you Terje Alraek 卞兆祥 Stephen Birch Tae-Hun Kim 徐浩 Chris Zaslawski Byoung-Kab Kang Myeong Soo Lee Medical Research Division Korea Institute of Oriental Medicine National Research Center in Complementary and Alternative Medicine Department of Community Medicine UiT The Artic University of Norway University College of Health Sciences Campus Kristiania Institute of Acupuncture School of Chinese Medicine Hong Kong Baptist University Xiyuan Hospital China Academy of Chinese Medical Sciences College of Traditional Chinese Medicine University of Technology

An international brainstorming session on standardizing pattern identification（PI） was held at the Korea Institute of Oriental Medicine on October 1, 2013 in Daejeon, South Korea. This brainstorming session was convened to gather insights from international traditional East Asian medicine specialists regarding PI standardization. With eight presentations and discussion sessions, the meeting allowed participants to discuss research methods and diagnostic systems used in traditional medicine for PI. One speaker presented a talk titled ＂The diagnostic criteria for blood stasis syndrome： implications for standardization of PI＂. Four speakers presented on future strategies and objective measurement tools that could be used in PI research. Later, participants shared information and methodology for accurate diagnosis and PI. They also discussed the necessity for standardizing PI and methods for international collaborations in pattern research.

关键词： pattern identification international symposium Chinese medicine

Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules

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Journal of Traditional Chinese Medicine 2019年第1期39卷 15-25页

作者： Eun-Yeong Kim Tae-Wook Chung Hee-Jung Choi Yeon-Seop Jung Syng-Ook Lee Jun-Yong Choi Hyung Sik Kim sooseong you Myeong Soo Lee Ki-Tae Ha School of Korean Medicine and Korean Medical Research Center for Healthy Aging Pusan National UniversityYangsan 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-aging Pusan National UniversityYangsan 50612Republic of Korea Department of Food Science and Technology Keimyung UniversityDaegu 42601Republic of Korea National Clinical Research Center for Korean Medicine Korean Medicine Hospital of Pusan National UniversityYangsan 50612Republic of Korea Laboratory of Molecular Toxicology School of PharmacySungKyunKwan UniversitySuwon 16419Republic of Korea Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea

OBJECTIVE: To find out the combination of the extracts from Paeonia lactiflora Pallas(PL), Rehmannia Glutinosa var. Purpurea Makino(RG), Perilla Frutescens var. Acuta Kudo(PF) to increase endometrial ***: Herbal medicines were extracted with boiling water and polysaccharides were *** examined the effect of PL, RG, and PF(PRP), a most effective herbal formula deduced from constitutive ingredient herbs of Antai Yin which is composed of PRP, on the leukemia inhibitory factor(LIF) expression and endometrial ***: The combination of the extracts from PRP induced the LIF expression in Ishikawa cells and increased the adhesion between Ishikawa and JAr cells. In addition, PRP-induced attachment of JAr cells onto Ishikawa cells and expression of adhesion molecules, ITGAV, ITGB5, CD44 s, and Lselectin, are significantly reduced by knock-down of LIF ***: Induced by the combination of the PRP extracts, the adhesion between trophoblast and endometrial cells are mediated by expression of LIF and adhesion molecules. Thus, we suggest the combination of the PRP extracts may be a novel therapy for enhancing embryo implantation rate.

关键词： Paeonia Rehmannia Perilla Embryo implantation Endometrium Leukemia inhibitory factor Cell adhesion molecules

中草药对治疗癌症恶病质动物模型有效性的系统性回顾（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第1期20卷 9-22页

作者： Bongki PARK sooseong you William C.S.CHO Jun-Yong CHOI Myeong Soo LEE Liver and Immunology Research Center Oriental College Daejeon University Clinical Medicine Division Korea Institute of Oriental Medicine Department of Clinical Oncology Queen Elizabeth Hospital Department of Korean Internal Medicine School of Korean Medicine Pusan National University

本综述总结利用中草药治疗癌症恶病质的临床前研究及其潜在的机制,是首个针对中草药治疗癌症恶病质动物模型成效进行系统性回顾评价的研究。本文通过检索PubMed、EMBASE、Allied and Complementary Medicine Database以及Web of Scienc... 详细信息

本综述总结利用中草药治疗癌症恶病质的临床前研究及其潜在的机制,是首个针对中草药治疗癌症恶病质动物模型成效进行系统性回顾评价的研究。本文通过检索PubMed、EMBASE、Allied and Complementary Medicine Database以及Web of Science四大代表性的资料库(检索时间至2016年12月),就中草药治疗癌症恶病质的随机对照动物试验进行系统性回顾分析,并采用CAMARADE评分清单进行质量评价。分析结果显示:在十四项中草药及其化合物中,除了姜黄素外其他如黄连、黄连素、病得灵、清暑益气汤、黄芩、补中益气汤、六君子汤、橙皮苷、苍术呋喃烃、十全大补汤、小柴胡汤、知母及黄柏等都已被证实可以通过抗炎、调节神经内分泌途径、调节泛素蛋白酶体系统或蛋白质合成来改善癌症恶病质的症状。因此,利用中草药治疗癌症恶病质是一种有效的方法。然而该结论尚需要有更详细的分子机制和活性化合物的实验研究验证。

关键词：癌症恶病质中草药传统东亚医学系统性回顾

Current Research and Future Directions in Pattern Identification： Results of an International Symposium

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Chinese Journal of Integrative Medicine 2016年第12期22卷 947-955页

作者： Myeong Soo Lee Ju Ah Lee Terje Alraek 卞兆祥 Stephen Birch Hirozo Goto Jeeyoun Jung 高尚德 Sang-Kwan Moon Bongki Park Kyung-Mo Park sooseong you Kyung-Jin Yun Chris Zaslawski Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea National Research Center in Complementary and Alternative Medicine UiT The Artic University of Norway Troms 9037 Norway University College of Health Sciences Institute of Acupuncture Oslo 0855 Norway School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR China Department of Kampo Medicine Hokusei Hospital Toyama 930-0814 Japan College of Chinese Medicine China Medical University Taiwan China Department of Cardiovascular and Neurologic Disease Hospital of Korean Medicine Kyung Hee University Seoul 130-872 Republic of Korea Department of Biomedical Engineering Kyung Hee University Yongin Republic of Korea College of Traditional Chinese Medicine University of technologysydney(Post Box 1231) Australia

A symposium on pattern identification（PI）was held at the Korea Institute of Oriental Medicine（KIOM）on October 2,2013,in Daejeon,South *** symposium was convened to provide information on the current research in PI as well as suggest future research *** participants discussed the nature of PI,possible research questions,strategies and future international collaborations in pattern *** eight presentations and an extensive panel discussion,the symposium allowed participants to discuss research methods in traditional medicine for *** speaker presented the topic,＇Clinical pattern differentiation and contemporary research in PI.＇Two speakers presented current trends in research on blood stasis while the remaining five other delegates discussed the research methods and future directions of PI *** participants engaged in in-depth discussions regarding the nature of PI,potential research questions,strategies and future international collaborations in pattern research.

关键词： pattern identification international symposium Chinese medicine traditional Korean medicine