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Comparison of fungal vs bacterial infections in t.e medical intensive liver unit:Cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： Sarah Khan Hanna hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar t Sims Christine e Koval Aanchal Kapoor Christina C Lindenmeyer Depart.ent of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Depart.ent of Pharmacy Cleveland ClinicClevelandOH 44195United States Depart.ent of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Depart.ent of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Depart.ent of Infectious Disease Cleveland ClinicClevelandOH 44195United States Depart.ent of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes pat.ents to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** to investigate t.e impact of fungal infections among critically ill pat.ents with advanced liver disease,and compare outcomes to those of pat.ents with bacterial *** From our prospective registry of MILU pat.ents from 2018-2022,we included 27 pat.ents with culture-positive fungal infections and 183 with bacterial *** compared outcomes bet.een pat.ents admit.ed to t.e MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among pat.ents with fungal infections was significantly worse relative to t.e bacterial cohort(93%vs 52%,Pt.e majority of t.e fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Pat.ents in t.e fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,Pe to acute kidney injury(78%vs 52%,P=0.014).On MILU admission,t.e fungal cohort had significantly higher Acute Physiology and Chronic Health evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for end-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).t.ere was no significant difference in t.e rate of central line use preceding culture(52%vs 40%,P=0.2).Pat.ents with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among pat.ents with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

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t.e proximity bet.een hydroxyl and single atom determines t.e catalytic reactivity of Rh1/CeO_(2) single-atom catalysts

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Nano Research 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou Congcong Du Juan Li Jianyu Huang hong-xia Shen Abhaya K.Dat.e Shan Jiang Jeffrey t.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photocatalysis on energy and environment College of ChemistryFuzhou UniversityFuzhou 350002China Clean Nano energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China College of Biology and Chemical engineering Jiaxing UniversityJiaxing 314000China Depart.ent of Chemical&Biological engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson School of Chemical engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for Sciences and technologies of energy Materials of Fujian Province(IKKeM) Xiamen 361102China Fujian Key Laboratory of Rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

t.e local structure of t.e metal single-atom site is closely related to t.e catalytic activity of metal single-atom catalysts(SACs).However,constructing SACs with homogeneous metal active sites is a challenge due to t.e surface heterogeneity of t.e conventional ***,we prepared two Rh1/CeO_(2)SACs(0.5Rh1/r-CeO_(2)and 0.5Rh1/c-CeO_(2),respectively)using two shaped CeO_(2)(rod and cube)exposing different facets,i.e.,CeO_(2)(111)and CeO_(2)(100).In CO oxidation reaction,t.e t100 of 0.5Rh1/r-CeO_(2)SACs is 120°C,while t.e t100 of 0.5Rh1/c-CeO_(2)SACs is as high as 200°*** in-situ CO diffuse reflectance infrared Fourier transform spectroscopy(CO-DRIFtS),we found that t.e proximity bet.een OH group and Rh single atom on t.e plane surface plays an important role in t.e catalytic activity of Rh1/CeO_(2)SAC system in CO *** Rh single atom trapped at t.e CeO_(2)(111)crystal surface forms t.e Rh1(OH)adjacent species,which is not found on t.e CeO_(2)(100)crystal surface at room ***,during CO oxidation,t.e OH group far from Rh single atom on t.e 0.5Rh1/c-CeO_(2)disappears and forms Rh1(OH)adjacent species when t.e temperature is above 150°*** formation of Rh1(OH)adjacentCO intermediate in t.e reaction is pivotal for t.e excellent catalytic activity,which explains t.e difference in t.e catalytic activity of Rh single atoms on two different CeO_(2)*** formed Rh1(OH)adjacent-O-Ce structure exhibits good stability in t.e reducing atmosphere,maintaining t.e Rh atomic dispersion after CO oxidation even when pre-reduced at high temperature of 500°*** functional t.eory(DFt)calculations validate t.e unique activity and reaction path of t.e intermediate Rh1(OH)adjacentCO species *** work demonstrates that t.e proximity bet.een metal single atom and hydroxyl can determine t.e formation of active intermediates to affect t.e catalytic performances in catalysis.

关键词： crystal plane Rh1/CeO_(2)single-atom catalyst proximity of Rh and hydroxyl coordination structure CO oxidation

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t.e Origin of Mesozoic A-type Granitoids,Fujian Province,Sout.east China:Insights from Geochronology,Mineralogy and Geochemistry

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Acta Geologica Sinica(english edition) 2024年第3期98卷 630-640页

作者： XIe Qifeng DONG Yunpeng CAI Yuanfeng ZHAI Mingguo XIAO Aifang ZHANG hong Zijin School of Geology and Mining Fuzhou UniversityFuzhou 350108China State Key Laboratory of Continental Dynamics Northwest UniversityXi’an 710069China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China State Key Laboratory of Lithospheric evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

t.e magma sources,origins and precise forming ages of t.e miarolite from Qishan and Kuiqi intrusions are still *** results reveal that,miarolites from t.e Qishan and Kuiqi intrusions yield crystallization ages of~101 and~98 Ma,and t.ey have a high formation temperature(~910℃)and low oxygen fugacity value,indicating crystallization condition at low pressure in t.e upper crust with temperature of 678℃.t.e Qishan and Kuiqi miarolites are characterized by enrichment in SiO_(2) and high-K alkali,depletion in Ca and Mg,and belong to t.e high-K weak peraluminous rock *** samples are enriched in HFSes(i.e.,ta,Zr and Hf)and LILes(i.e.,Ba,P and Sr),depleted in Ba and Sr with t.e negative anomaly of *** t.e primitive mant.e normalized trace element spider diagram,t.e samples show a right-inclined‘seagull-type’pat.ern,combined t.e ratios of(La/Yb)_(N),10000×Al/Ga,Rb/Nb and Nb/ta etc.,t.ey were proved to be alkaline A-type *** t.e characterize of t.e trace elements,t.ey were derived from clay-rich source accompanied pelite melting,and subjected to K-feldspar crystallization *** values of ε_(Hf)(t)and tDM2 are distributed in t.e range of-2.8 to 3.3 with~1.2 Ga,and-6.0 to 4.0 with~1.2 Ga,revealing that t.ey were generated from t.e Mesoproterozoic Cathaysia basement *** comprehensive research reveals t.e Kuiqi and Qishan intrusions derived from crust-mant.e mixing and partial melting of t.e crust,respectively,resulting from lithospheric extension generated by t.e Paleo-Pacific Plate subducted into t.e european-Asian Plate.

关键词： A-type granitoid geochronology extension subduction Mesozoic Sout.east China

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Causal role of immune cells in obstructive sleep apnea hypopnea syndrome:Mendelian randomization study

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World Journal of Clinical Cases 2024年第7期12卷 1227-1234页

作者： Huang-hong Zhao Zhen Ma Dong-Sheng Guan Depart.ent of encephalopathy Henan Provincial Hospital of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Depart.ent of Personnel The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Depart.ent of Neurology Henan Provincial Hospital of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Despite being one of t.e most prevalent sleep disorders,obstructive sleep apnea hypoventilation syndrome(OSAHS)has limited information on its immunologic *** immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to t.e extensive use of genome-wide association studies(GWAS)and genotyping techniques using highdensity genetic markers(e.g.,SNP or CNVs).But this tactic hasn't yet been applied to *** a Mendelian randomization analysis,we analyzed t.e causal link bet.een immune cells and t.e illness in order to comprehend t.e immunological bases of *** to investigate t.e immune cells'association with OSAHS via genetic methods,guiding future clinical *** A comprehensive two-sample mendelian randomization study was conducted to investigate t.e causal relationship bet.een immune cell characteristics and *** statistics for each immune cell feature were obtained from t.e GWAS *** on 731 immune cell propert.es,such as morphologic parameters,median fluorescence intensity,absolute cellular,and relative cellular,was compiled using publicly available genetic *** results'robust.ess,heterogeneity,and horizontal pleiotropy were confirmed using extensive sensitivity *** Following false discovery rate(FDR)correction,no statistically significant.effect of OSAHS on immunophenotypes was ***,two lymphocyte subsets were found to have a significant association with t.e risk of OSAHS:Basophil%CD33dim HLA DR-CD66b-(OR=1.03,95%CI=1.01-1.03,Pell(OR=1.04,95%CI=1.02-1.04,P=0.019).CONCLUSION this study shows a strong link bet.een immune cells and OSAHS through a gene approach,thus offering direction for potential future medical research.

关键词： Obstructive sleep apnea hypopnea syndrome Immunity Causal inference MR analysis Sensitivity

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Low-loss and polarization insensitive 32×4 optical switch for ROADM applications

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Light(Science & Applications) 2024年第5期13卷 875-884页

作者： Xiaotian Zhu Xiang Wang Yanlu Huang Liyan Wu Chunfei Zhao Mingzhu Xiao Luyi Wang Roy Davidson Yanni Ou Brent.e.Litt.e Sai t.Chu Depart.ent of Physics City University of Hong KongTat Chee AvenueHong KongChina. QXP technologies Inc. NO.15th Shanglinyuan 1st RoadXi’anShaanxi 710119China. State Key Laboratory of Information of Photonics and Optical Communications School of Electronic EngineeringBeijing University of Posts and TelecommunicationsBeijing 100876China

Integrated switches play a crucial role in t.e development of reconfigurable optical add-drop multiplexers(ROADMs)that have greater flexibility and compact.ess,ultimately leading to robust single-chip *** decades of research on switches with various structures and platforms,achieving a balance bet.een dense integration,low insertion loss(IL),and polarization-dependent loss(PDL)remains a significant *** this paper,we propose and demonstrate a 32×4 optical switch using high-index doped silica glass(HDSG)for ROADM *** switch is designed to route any of t.e 32 inputs to t.e express ports or drop any channels from 32 inputs to t.e target 4 drop ports or add any of t.e 4 ports to any of t.e 32 express *** switch comprises 188 MachZehnder Interferometer(MZI)type switch elements,88 optical vias for t.e 44 optical bridges,and 618 waveguidewaveguide crossings with three-dimensional(3D)*** 1550 nm,t.e fiber-to-fiber loss for each express channel is below 2 dB,and across t.e C and L bands,below 3 *** each input channel to all 4 drop/add channels at 1550 nm,t.e loss is less than 3.5 dB and less than 5 dB across t.e C and L *** PDLs for all express and input channels to t.e 4 drop/add channels are below 0.3 dB over t.e C band,and t.e crosstalk is under−50 dB for both t.e C and L bands.

关键词： polarization ROADM optical

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Plume-lithosphere interaction in t.e Comei Large Igneous Province: evidence from two types of mafic dykes in Gyangze, south tibet, China

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China Geology 2024年第1期7卷 80-90页

作者： Ya-ying Wang Ling-sen Zeng Li-e Gao Li-long Yan Ling-hao Zhao Jia-hao Gao Ying-long Di Guang-xu Li Yi-hong tian Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China China Nonferrous Metals(Guilin)Geology and Mining Co. LtdGuilin 541004China

two suites of mafic dykes,t1193-A and t1194-A,outcrop in Gyangze area,sout.east *** are in t.e area of Comei LIP and have indistinguishable field occurrences with two ot.er dykes in Gyangze,t0902 dyke with 137.7±1.3 Ma zircon age and t0907 dyke with 142±1.4 Ma zircon age reported by Wang YY et al.(2016),indicating coeval formation *** all t.e four diabase dykes into consideration,two different types,OIB-type and weak enriched-type,can be ***“OIB-type”samples,including t1193-A and t0907 dykes,show OIB-like geochemical features and have initial Sr-Nd isotopic values similar with most mafic products in Comei Large Igneous Provinces(LIP),suggesting that t.ey represent melts directly generated from t.e Kerguelen mant.e ***“weak enriched-type”samples,including t1194-A and t0902 dykes,have Rees and trace element pat.erns showing withinplate affinity but have obvious Nb-ta-ti negative *** show uniform lowerεNd(t)values(−6‒−2)and higher 87Sr/86Sr(t)values(0.706‒0.709)independent of t.eir MgO variation,indicating one enriched mant.e *** t.eir closely spatial and temporal relationship with t.e widespread Comei LIP magmatic products in tethyan Himalaya,t.ese“weak enriched-type”samples are consistent with mixing of melts from mant.e plume and t.e above ancient tethyan Himalaya subcontinental lithospheric mant.e(SCLM)in different *** weak enriched mafic rocks in Comei LIP form one special rock group and most likely suggest large scale hot mant.e plume-continental lithosphere *** process may lead to strong modification of t.e tethyan Himalaya lithosphere in t.e early Cretaceous.

关键词： OIB type diabase Comei Large Igneous Province Weakly enriched diabase Plume-lithosphere interaction Nb-ta-ti negative anomaly Kerguelen plume Geological survey engineering tibet Plateau

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Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunot.erapy of osteosarcoma

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Oncology Research 2024年第4期32卷 691-702页

作者： JIJIe XIAO hong XIAO YUJUN CAI JIANWeI LIAO JUe LIU LIN YAO SHAOLIN LI Depart.ent of Radiology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai510900China Depart.ent of Ultrasound The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou528405China PCFM Lab of Ministry of education School of Materials Science and EngineeringGuangzhou510275China

Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor pat.ent *** has shown great potential in t.e t.eat.ent of ***,t.e immunosuppressive microenvironment severely limits t.e efficacy of osteosarcoma *** dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into t.e acidic tumor ***,we prepared a dual pH-sensitive nanocarrier,loaded with t.e photosensitizer Chlorin e6(Ce6)and CD47 monoclonal antibodies(aCD47),to deliver synergistic photodynamic and immunot.erapy of *** laser irradiation,Ce6 can generate reactive oxygen species(ROS)to kill cancer cells directly and induces immunogenic tumor cell death(ICD),which furt.er facilitates t.e dendritic cell maturation induced by blockade of CD47 by ***,both calreticulin released during ICD and CD47 blockade can accelerate phagocytosis of tumor cells by macrophages,promote antigen presentation,and eventually induce t lymphocyte-mediated antitumor ***,t.e dual pH-sensitive nanodrug loaded with Ce6 and aCD47 showed excellent immune-activating and anti-tumor effects in osteosarcoma,which may lay t.e t.eoretical foundation for a novel combination model of osteosarcoma t.eat.ent.

关键词： Immunot.erapy Osteosarcoma Nanodrug Photodynamic t.erapy CD47

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Double-confined nanoheterostructure Sb/Sb_(2)S_(3)@ti_(3)C_(2)t_(x)@C toward ultra-stable Li-/Na-ion bat.eries

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Rare Metals 2024年第5期43卷 2067-2079页

作者： Dan Wang Qun Ma Huan He Zhi-Yuan Wang Run-Guo Zheng hong-Yu Sun Yan-Guo Liu Chun-Li Liu School of Materials Science and engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Dielectric and electrolyte Functional Material Hebei Province Qinhuangdao 066004China Depart.ent of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin 17035Korea

Antimony-based materials with high capacit.es and moderate potentials are promising anodes for lithium-/-sodium-ion ***,t.eir t.emendous volume expansion and inferior conductivity lead to poor structural stability and sluggish reaction ***,a doubleconfined nanoheterostructure Sb/Sb_(2)S_(3)@ti_(3)C_(2)t_(x)@C has been fabricated through a solvot.ermal method followed by low-temperature heat *** dual protection of“MXene”and“carbon”can bet.er accommodate t.e volume expansion of Sb/Sb_(2)S_(3).t.e strong covalent bond(ti-S,ti-O-Sb,C-O-Sb)can firmly integrate Sb-based material with ti_(3)C_(2)t_(x)and carbon,which significantly improves t.e structure *** addition,t.e carbon layer can restrain t.e oxidation of MXenes,and t.e nano-Sb/Sb_(2)S_(3)can facilitate electron/ion transport and suppress t.e restacking of *** heterogeneous interface bet.een Sb and Sb_(2)S_(3)can furt.er promote interfacial charge *** MXene-Sb/Sb_(2)S_(3)@C-1 with t.e optimal Sb content shows high specific capacit.es,comparable rate propert.es and ultra-stable cycling performances(250 m Ah·g^(-1)after 2500 cycles at 1 A·g^(-1)for sodium-ion bat.eries).ex situ X-ray diffractometer(XRD)test reveals t.e storage mechanism including t.e conversion and alloying process of MXene-Sb/Sb_(2)S_(3)@*** voltammetry(CV)test results demonstrate that t.e pseudocapacitance behavior is dominant in MXene-Sb/Sb_(2)S_(3)@C-1,especially at large *** design paves t.e way for exploring high-performance alloy-based/conversion-type anode for energy storage devices.

关键词： Sb/Sb_(2)S_(3) MXene Carbon Anode Lithium-ion bat.eries Sodium-ion bat.eries

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Intrinsic hard magnetism and t.ermal stability of a thMn_(12)-type permanent magnet

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npj Computational Materials 2022年第1期8卷 1829-1838页

作者： tument.ereg Ochirkhuyag soon Cheol hong Dorj Odkhuu Depart.ent of Physics Incheon National UniversityIncheon22012South Korea Depart.ent of Physics University of UlsanUlsan44610South Korea

Herein,we t.eoretically demonstrate that simple metal(Ga and Al)substitutional atoms,rat.er than t.e conventional transition metal substitutional elements,not only stabilize t.e thMn_(12)-type SmFe_(12) and Sm(Fe,Co)_(12)phases t.ermodynamically but also furt.er improve t.eir intrinsic magnetic propert.es such that t.ey are superior to those of t.e widely investigated SmFe_(11)ti and Sm(Fe,Co)_(11)ti magnets,and even to t.e state-of-t.e-art permanent magnet Nd_(2)Fe_(14)*** specifically,t.e quaternary Sm(Fe,Co,Al)_(12)phase has t.e highest uniaxial magnetocrystalline anisotropy(MCA)of about 8 MJ m^(−3),anisotropy field of 18.2 t,and hardness parameter of 2.8 at room temperature and a Curie temperature of 764 ***,t.e Al and Ga substitutional atoms improve t.e single-domain size of t.e Sm(Fe,Co)_(12)grains by nearly a factor of *** results of MCA and MCA-driven hard magnetic propert.es can be described by t.e strong spin-orbit coupling and orbital angular momentum of t.e Sm 4f-electron orbitals.

关键词： permanent anisotropy stability

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ρ-meson longitudinal leading-twist distribution amplitude revisited and t.e D→ρsemileptonic decay

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Chinese Physics C 2024年第6期48卷 82-91页

作者：钟涛代亚红付海冰 Depart.ent of Physics Guizhou Minzu UniversityGuiyang 550025China

Motivated by our previous study[***.D 104(1),016021(2021)]on t.e pionic leading-twist distribution amplitude(DA),we revisit t.eρ-me son leading-twist longitudinal DAφ_(2;ρ)^(‖)(x,μ)in this study.A model proposed by Chang based on t.e DYyson-Schwinger equations is adopted to describe t.e behavior ofφ_(2;ρ)^(‖)(x,μ).However,t.eξ-moments ofφ_(2;ρ)^(‖)(x,μ)are calculated with t.e QCD sum rules in t.e framework of t.e background field *** sum rule formulas for t.ese moments are *** accurate values for t.e first five nonzeroξ-moments at t.e typical scaleμ=(1.0,1.4,2.0,3.0)GeV are given,e.g.,atμ=1 GeV,(ξ^(2))>_(2;ρ)^(‖)=0.220(6),(ξ^(4))>_(2;ρ)^(‖)=0.103(4),(ξ^(6))>_(2;ρ)^(‖)=0.066(5),(ξ^(8))>_(2;ρ)^(‖)=0.046(4),and(ξ^(10))>_(2;ρ)^(‖)=0.035(3).By fitting t.ese values with t.e least squares method,t.e DSe model forφ_(2;ρ)(x,μ)is *** taking t.e left-handed current light-cone sum rule approach,we obtain t.e transition form factor in t.e large recoil region,i.e.,A_(1)(0)=0.498_(-0.012)^(+0.014),A_(2)(0)=0.460_(-0.047)^(+0.055),and V(0)=0.800_(-0.014)^(+0.015),and t.e ratio r_(2)=0.923_(-0.119)^(+0.133),rV=1.607_(-0.071)^(+0.071).After extrapolating with a rapidly converging series based on z(t)-expansion,we present t.e|V_(cd)|-independent decay width for t.e semileptonic decays D→ρ^(l+)v_(l).Finally,t.e branching fractions are B(D^(0)→ρ^(-)e+v_(e))=1.825_(-0.162)^(+0.170)±0.004,B(D^(+)→ρ^(0)e+v_(e))=2.299_(-0.204)^(+0.214)±0.011,B(D^(0)→ρ^(-)μ^(+)v_(μ))=1.816_(-0.160)^(+0.168)±0.004,and B(D^(+)→ρ^(0)μ+v_(μ))=2.288_(-0.201)^(+0.212)±0.011.

关键词： QCD sum rule charmed meson semileptonic decay Rho meson light-cone distribution amplitude

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