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Zircon U-Pb ages and O-Hf isotopes of Quaternary trachytes from the East Sea:Implications for the genesis of low-δ^(18)O magmas

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Geoscience Frontiers 2024年第2期15卷 41-54页

作者： Hyun-Ok choi Jihye Oh Chang Hwan Kim soon young choi Won Hyuck Kim Chan Hong Park Dokdo Research Center East Sea Research InstituteKorea Institute of Ocean Science and TechnologyUljin 36315Republic of Korea Deep-Sea and Seabed Mineral Resources Research Center Korea Institute of Ocean Science and TechnologyBusan 49111Republic of Korea Division of Science Education Kangwon National University1 Gangwondaehak-gilChuncheon-siGangwon-do 24341Republic of Korea

Quaternary intraplate magmatism formed several volcanic islands and seamounts,including Dokdo(DD),Ulleungdo(UD),Simheungtack(ST),Anyongbok,and Isabu in the southwest of the East Sea back-arc *** this study,we present whole-rock geochemical,zircon U–Pb age,and in situ O–Hf isotope data for the submerged volcanic rocks from DD,UD,and ST to provide new insights into the eruption timing of these volcanoes and constrain the magma evolution *** samples used in this study were trachytes and exhibited ferroan,alkalic,and metaluminous to weakly peraluminous *** showed light rare earth element(REE)-enriched patterns with(La/Yb)N ratios of 25.3–31.7 and mostly negative Eu anomalies in a chondrite-normalized REE *** addition,they were enriched in large-ion lithophile elements and high field strength elements;they exhibited positive Pb anomalies and strongly negative Ba,Sr,P,and Ti *** zircons yielded a weighted-mean 206Pb/238U age of 2.61,0.348–0.704,and 2.76–2.94 Ma for the DD,UD,and ST trachytes,*** zircons exhibited lowerδ^(18)O values than normal depleted mantle values,regardless of the crystallization age and spatial distribution of ***δ^(18)O values showed no correlation with U contents or Th/U ratios,indicating that the lowδ^(18)O signatures were of primary magmatic *** Hf isotopic compositions of the zircons were relatively heterogeneous but predominately characterized by positive eHf *** O–Hf mixing modeling revealed that low-δ^(18)O rocks with positive eHf values from the UD and ST volcanoes were derived from a hybrid source of recycled juvenile crustal materials with low-δ^(18)O and positive eHf signatures and an enriched mantle source with normalδ^(18)O and negative eHf *** juvenile oceanic crust in the source was likely metasomatized by seawater at high temperatures prior to *** contrast,the felsic magma that formed the DD volcanoes may have assimilated with regional

关键词： Quaternary intraplate volcanism East Sea Zircon O-Hf isotopes Low-δ^(18)O magma Recycled juvenile oceanic crust

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A Study on Locations of Death and Factors Associated with Death among Cancer Patients in South Korea

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Journal of Biosciences and Medicines 2019年第2期7卷 26-41页

作者： Yong Joo Rhee Yoon-Hee Tae Yong Joo Lee Soomok Jang Joachim Cohen young-soon choi Department of Health Sciences Dongduk Women’s University Seoul South Korea Department of Psychiatry and Behavioral Sciences Feinberg School of Medicine Northwestern University Chicago Illinois USA National Health Insurance Service Wonju Kangwon-do South Korea Department of Palliative Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea Banpo-daero Seocho-gu Seoul South Korea Vrije Universiteit Brussel (VUB) & Ghent University End-of-Life Care Research Group Brussels Belgium

Background: Location of death has been used to examine an indicator for good death. This study aims to examine location of death among patients with three major cancers (gastric, liver, and lung) and other factors associated with location of death in South Korea. Methods: We selected the medical and pharmacy claims data for health services and location of death among the 42,596 decedents with cancer (lung 16,632, liver 15,872, gastric 10,092) from 2009 to 2013. We used logistic regressions to identify factors associated with home death. Outcome measures are locations of death (hospital, outpatient clinics or emergency room and home). Results: Only 8.9% died at home whereas 46.5% died in hospital as inpatients. Patients with more than one comorbid cancer or receivers for any supportive care were significantly more likely to die in hospital. Female and younger than 55 years old liver cancer patients were associated with home death. Patients living in metropolitan area, or paying more insurance premium, or being public aid beneficiaries, were associated with home death. Conclusions: The supportive care service use prior to death was significantly associated with increasing odds to hospital death. Being older than 75, or having multiple cancers was significant factors associated with hospital death, whereas living in metropolitan area, lower income or emergency visit were significant factors with home death. These findings are opposite to what is found, as the palliative care and hospice is predominantly hospital-centered. The findings emphasize a need to available end-of-life care in community for dying patients.

关键词： Supportive Care Location of Death National Health Insurance Program (NHI) Cancer End-of-Life Care

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Wave prediction in a port using a fully nonlinear Boussinesq wave model

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Acta Oceanologica Sinica 2019年第7期38卷 36-47页

作者： young-Kwang choi Seung-Nam Seo Jin-Yong choi Fengyan Shi Kwang-soon Park Civil and Architectural Engineering Department KEPCO Engineering and ConstructionGimcheon-si 39660Republic of Korea Task Force for Construction of RV ISABU Support Facility Korea Institute of Ocean Science and TechnologyBusan Metropolitan City 49111Republic of Korea Operational Oceanography Research Center Korea Institute of Ocean Science and TechnologyBusan Metropolitan City 49111Republic of Korea Center for Applied Coastal Research University of DelawareNewark DE 19716USA

A wave forecasting system using FUNWAVE-TVD which is based on the fully nonlinear Boussinesq equations by Chen(2006)was developed to provide an accurate wave prediction in the Port of Busan,South *** system is linked to the Korea Operational Oceanographic System(KOOS)developed by Park et al.(2015).The computational domain covers a region of 9.6 km×7.0 km with a grid size of 2 m in both directions,which is sufficient to resolve short waves and dominant sea *** total number of grid points exceeds 16 millions,making the model computational *** provide real-time forecasting,an interpolation method,which is based on pre-calculated results of FUNWAVE-TVD and SWAN forecasting results at the FUNWAVE-TVD offshore boundary,was used.A total of 45 cases were pre-calculated,which took 71 days on 924 computational cores of a Linux cluster *** wave generation and propagation from the deep water were computed using the SWAN in *** results provided a boundary condition for the FUNWAVE-TVD forecasting *** verify the model,wave observations were conducted at three locations inside the port in a time period of more than 7 months.A model/model comparison between FUNWAVE-TVD and SWAN was also carried *** is found that,FUNWAVE-TVD improves the forecasting results significantly compared to SWAN which underestimates wave heights in sheltered areas due to incorrect physical mechanism of wave diffraction,as well as large wave heights caused by wave reflections inside the port.

关键词： real-time wave forecasting FUNWAVE-TVD SWAN KOOS wave observations wave diffraction

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Probabilistic seismic performance assessment of lap-spliced RC columns retrofitted by steel wrapping jackets

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Earthquake Engineering and Engineering Vibration 2016年第2期15卷 223-238页

作者： Eunsoo choi Heejung Youn Baik-soon Cho Department of Civil Engineering Hongik University Department of Civil Engineering CTRCInje University

In this study, the seismic fragility curves of two reinforced concrete（RC） columns that were lap-spliced at the bottom and retrofitted with steel wrapping jackets were generated. Their seismic performance was probabilistically assessed in comparison to that of lap-spliced or continuous reinforcement RC columns. This study used two types of steel wrapping jackets, a full jacket and a split jacket. Analytical models of the four types of columns were developed based on the experimental results of the columns using Open SEES, which is effective in conducting nonlinear time history analyses. A suite of ten artificial ground motions, modified from recorded ground motions, was used to perform nonlinear time history analyses of the analytical models with scaling of the peak ground acceleration from 0.1 g to 1.0 g in increments of 0.1 g. The steel wrapping jackets did not increase the medians for yield（slight damage state） of the lap-spiced column and did not exceed the corresponding median of the continuous reinforcement column. However, the two steel jackets increased the medians for failure by 1.872 and 2.017 times, respectively, and exceeded the corresponding median of the continuous reinforcement column by 11.8% and 20.5%, respectively.

关键词： columns reinforcement reinforced exceed acceleration scaling median assessed split probabilistic

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Dietary sophorolipid accelerates growth by modulation of gut microbiota population and intestinal environments in broiler chickens

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Journal of Animal Science and Biotechnology 2022年第1期13卷 256-264页

作者： Min-Jin Kwak Min-young Park Yong-soon choi Junghwan Cho Duleepa Pathiraja Jonggun Kim Hanbae Lee In-Geol choi Kwang-Youn Whang Department of Biotechnology Korea University145 Anam-roSeoul 02841Republic of Korea Pathway Intermediates Seoul 02841Republic of Korea

Background:Gut is a crucial organ for the host’s defense system due to its filtering action of the intestinal membrane from hazardous foreign *** strategy to strengthen the gut epithelial barrier function is to upregulate beneficial microflora populations and their ***(SPL),which is a glycolipid biosurfactant,could increase beneficial microflora and decrease pathogenic bacteria in the gastrointestinal ***,herein,we conducted an experiment with broiler chickens to investigate the fortifying effects of SPL on the host’s gut defense system by modulating the microbiota ***:A total of 5401-day-old chicks(Ross 308)were used,and they were immediately allotted into three treatment groups(6 replications with 30 chicks/pen)according to their initial body *** dietary treatments consisted of CON(basal diet),BAM(10 mg/kg bambermycin),and SPL(10 mg/kg SPL).During the experiment,birds freely accessed feed and water,and body weight and feed intake were measured at the end of each *** d 35,birds(one bird/pen)were sacrificed to collect jejunum and cecum ***:Dietary SPL and BAM supplementation significantly accelerated birds’growth and also significantly improved feed efficiency compared to *** microbial community was significantly separated by dietary SPL supplementation from that of CON,and dietary SPL supplementation significantly increased Lactobacillus *** Akkermansia ***,birds fed with dietary SPL also showed the highest concentration of cecal butyrate among all treatment *** morphological analysis showed that dietary SPL significantly increased villus height,ratio of villus height to crypt depth,goblet cell numbers,and the gene expression levels of claudin-1 and mucin ***,dietary SPL significantly decreased the mRNA expression level of pro-inflammatory cytokine,interleukin-6,and increased that of anti-inflammatory cytokine,interleukin-10,compared

关键词： Broilers Gut microbiota Gut morphology Local inflammation Mucus barrier Sophorolipids

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Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature

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World Journal of Gastroenterology 2016年第41期22卷 9229-9234页

作者： Gyu Ho choi Sun young Ann soon Il Lee Suk BaeKim Il Han Song Dankook University College of Medicine Cheonan 31116South Korea

Primary hepatic neuroendocrine carcinoma(NEC) with concurrent occurrence of hepatocellular carcinoma(HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional patterns; only 2 cases have been reported. Herein, we report a case of collision type concurrent occurrence of HCC and NEC, in which primary hepatic NEC was in only a small portion of the nodule, which is different from the 2 previously reported cases. A 72-year-old male with chronic hepatitis C was admitted to our hospital for a hepatic mass detected by liver computed tomography(CT) at another clinic. Because the nodule was in hepatic segment 3 and had proper radiologic findings for diagnosis of HCC, including enhancement in the arterial phase and wash-out in the portal and delay phases, the patient was treated with laparoscopic left lateral sectionectomy. The pathology demonstrated that the nodule was 2.5 cm and was moderately differentiated HCC. However, a 3 mm-sized focal neuroendocrine carcinoma was also detected on the capsule of the nodule. The tumor was concluded to be a collision type with HCC and primary hepatic NEC. After the surgery, for follow-up, the patient underwent a liver CT every 3 mo. Five multiple nodules were found in the right hepatic lobe on the follow-up liver CT 6 mo post-operatively. As the features of the nodules in the liver CT and MRI were different from that of HCC, a liver biopsy was performed. Intrahepatic recurrent NEC was proven after the liver biopsy, which showed the same pathologic features with the specimen obtained 6 mo ago. Palliative chemotherapy with a combination of etoposide and cisplatin has been administered for 4 months, showing partial response.

关键词： Collision tumor Hepatocellular carcinoma Neuroendocrine carcinoma Chronic hepatitis C

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Niche interactions in epidermal stem cells

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World Journal of Stem Cells 2015年第2期7卷 495-501页

作者： Hye-Ryung choi Sang-young Byun soon-Hyo Kwon Kyoung-Chan Park Department of Dermatology Seoul National University Bundang Hospital

Within the epidermis and dermis of the skin, cells secrete and are surrounded by the extracellular matrix(ECM), which provides structural and biochemical support. The ECM of the epidermis is the basement membrane, and collagen and other dermal components constitute the ECM of the dermis. There is significant variation in the composition of the ECM of the epidermis and dermis, which can affect "cell to cell" and "cell to ECM" interactions. These interactions, in turn, can influence biological responses, aging, and wound healing; abnormal ECM signaling likely contributes toskin diseases. Thus, strategies for manipulating cellECM interactions are critical for treating wounds and a variety of skin diseases. Many of these strategies focus on epidermal stem cells, which reside in a unique niche in which the ECM is the most important component; interactions between the ECM and epidermal stem cells play a major role in regulating stem cell fate. As they constitute a major portion of the ECM, it is likely that integrins and type Ⅳ collagens are important in stem cell regulation and maintenance. In this review, we highlight recent research-including our previous work-exploring the role that the ECM and its associated components play in shaping the epidermal stem cell niche.

关键词： Stem cell niche Epidermal stem cells Integrins Type Ⅳ collagen MiR135b

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Assessment of the clear-sky bias issue using continuous PM10 data from two AERONET sites in Korea

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Journal of Environmental Sciences 2017年第3期29卷 151-160页

作者： Yongjoo choi young Sung Ghim Department of Environmental Science Hankuk University of Foreign StudiesYongin 449-791Korea

A bias in clear-sky conditions that will be involved in estimating particulate matter （PM） concentration from aerosol optical depth （AOD） was examined using PM10 from two Aerosol Robotic Network sites in Korea. The study periods were between 2004 and 2007 at Anmyon and between 2003 and 2011 at Gosan, when both PM10 and AOD were available. Mean PM10 when AOD was available （PMAOD） was higher than that from all PM10 data （PMall） by 5.1 and 9.9 μg/m3 at Anmyon and Gosan, which accounted for 11% and 26% of PMall, respectively. Because of a difference between mean PM10 under daytime clear-sky conditions （PMclear） and PMAoD, the variations in APM10, the difference of PMan from PMdear rather than from PMAoD, were investigated. Although monthly variations in APMlo at the two sites were different, they were positively correlated to those in AT, similarly defined as APM10 except for temperature, at both sites. APM10 at Anmyon decreased to a negative value in January due to an influence of the Siberian continental high-pressure system while APM10 at Gosan was high in winter due to an effect of photochemical production at higher temperatures than at Anmyon.

关键词： AERONETData recovery rateCloud amountWind speedPhotochemical productionSiberian high

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