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Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis

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World Journal of Gastroenterology 2017年第13期23卷 2396-2403页

作者： soon kyu lee Myeong Jun Song Seok Hyun Kim Byung Seok lee Tae Hee lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae soon Young Ko Jae Dong lee Division of Hepatology Department of Internal MedicineDaejeon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea Department of Internal Medicine Chungnam University Hospital Department of Internal Medicine Konyang University Hospital Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung Buk University Hospital Department of Internal Medicine Konkuk University Chungju Hospital

AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients.

关键词： Tenofovir Decompensated liver cirrhosis Compensated liver cirrhosis Virological response Renal safety

Risk factors of biliary intervention by imaging after livingdonor liver transplantation

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World Journal of Gastroenterology 2016年第7期22卷 2342-2348页

作者： soon kyu lee Jong Young Choi Dong Myung Yeo Young Joon lee Seung Kew Yoon Si Hyun Bae Jeong Won Jang Hee Yeon Kim Dong Goo Kim Young Kyoung You Division of Hepatology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Surgery College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

AIM:To determine the risk factors of biliary intervention using magnetic resonance cholangiopancreatography(MRCP) after living donor liver transplantation(LDLT).METHODS: We retrospectively enrolled 196 patients who underwent right lobe LDLT between 2006 and 2010 at a single liver transplantation center. Direct duct-to-duct biliary anastomosis was performed in all 196 patients. MRCP images routinely taken 1 mo after LDLT were analyzed to identify risk factors for biliary intervention during follow-up, such as retrograde cholangiopancreatography or percutaneous transhepatic biliary drainage. Two experienced radiologists evaluated the MRCP findings, including the anastomosis site angle on three-dimensional images, the length of the filling defect on maximum intensity projection, bile duct dilatation, biliary stricture, and ***: Eighty-nine patients underwent biliary intervention during follow-up. The anastomosis site angle [hazard ratio(HR) = 0.48; 95% confidence interval(CI), 0.30-0.75, P < 0.001], a filling defect in the anastomosis site(HR = 2.18, 95%CI: 1.41-3.38,P = 0.001), and biliary leakage(HR = 2.52, 95%CI: 1.02-6.20, P = 0.048) on MRCP were identified in the multivariate analysis as significant risk factors for biliary intervention during follow-up. Moreover, a narrower anastomosis site angle(i.e., below the median angle of 113.3°) was associated with earlier biliary intervention(38.5 ± 4.2 mo vs 62. 1 ± 4.1 mo, P < 0.001). Kaplan-Meier analysis comparing biliary intervention-free survival according to the anastomosis site angle revealed that lower survival was associated with a narrower anastomosis site angle(36.3% vs 62.0%, P < 0.001).CONCLUSION: The biliary anastomosis site angle in MRCP after LDLT may be associated with the need for biliary intervention.

关键词： Magnetic resonance cholangiopancreatography Liver transplantation Living donor Biliary intervention Endoscopic retrograde cholangiopancreatography Percutaneous transhepatic biliarydrainage

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol lee Won-Hee Park Su-hwan Yun Tae-soon Kwon Duckhee lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

FEA technique of hot plate forming process using cell-typed die with cooling device

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中国有色金属学会会刊：英文版 2012年第S3期22卷 831-837页

作者： Jung-Min lee In-kyu lee kyung-Hun lee Dae-soon KIM Byung-Min KIM Dongnam Regional Division Korea Institute of Industrial Technology School of Mechanical Engineering Pusan National University Industrial Technology Division Hyundai Heavy Industries

Hot plate forming using a cell-typed die is a process for forming a large thick plate with a spherical shape for the manufacture of a large spherical LNG ***-typed upper and lower dies made of a framework of steel plates fitted to make a grid pattern are used in this process,and an air-cooling device is separately installed inside the lower die.A finite element analysis (FEA) technique was developed,which included hot forming,air flow,cooling and thermal deformation analysis for the hot plate forming process using the cell-typed ***,the convective and interface heat transfer coefficients were used to reproduce analytically the effects of the cooling device in the hot plate forming analysis.A small-scale model test of the process was conducted to verify the FEA *** analysis results show that the curvature of the final plate agrees well with that of the designed experiment within a maximum relative error of 0.03% at the corner of the plate.

关键词： cell-typed die hot plate forming spherical LNG tank heat transfer coefficient

Pretransplant absolute monocyte count in peripheral blood predicts posttransplant tumor prognosis in patients undergoing liver transplantation for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 250-258页

作者： Young-kyu Kim Seong Hoon Kim Seung-Duk lee soon-ae lee Sang-Jae Park Center for Liver Cancer National Cancer Center323 Ilsan-ro Ilsandong-gu Goyang-si Gyeonggi-do Republic of Korea Department of Surgery College of Medicine Kangwon National University 1 Kangwondaehak-gilChuncheon-si Gangwon-do 200-701 Republic of Korea

BACKGROUND: Preoperative absolute monocyte count in peripheral blood(AMCPB) is closely associated with prognoses in not only various malignancies but also hepatocellular carcinoma(HCC). The purpose of this study was to evaluate whether pretransplant AMCPB predicts posttransplant outcomes in patients with HCC undergoing liver transplantation(LT).METHOD: We retrospectively analyzed relationships between clinicopathologic factors involving pretransplant AMCPB and tumor recurrence or survival in 256 patients who had undergone LT for HCC between January 2005 and April ***: ROC curve analysis showed that AMCPB >200/mm3was a risk factor for tumor recurrence; 43 patients showed higher AMCPB(>200/mm3), whereas 213 showed lower AMCPB(≤200/mm3) at the time of LT. On multivariate analysis,pretransplant high AMCPB, positive findings in pretransplant18F-FDG PET/CT, pathological maximal tumor size >5 cm,intrahepatic metastasis, moderately or poorly differentiated tumor and microvascular invasion were independent factors affecting recurrence-free survival. When we performed subgroup analysis based on the Milan criteria, high AMCPB was an independent factor for predicting HCC recurrence in patients with tumor beyond the Milan criteria(P=0.004), and not for patients within the ***: This study demonstrated that pretransplant AMCPB could predict tumor recurrence after LT for HCC,especially in patients with tumor beyond the Milan criteria.

关键词： liver transplantation hepatocellular carcinoma recurrence survival monocyte count

Graft-to-recipient weight ratio lower to 0.7% is safe without portal pressure modulation in right-lobe living donor liver transplantation with favorable conditions

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 18-24页

作者： Seung Duk lee Seong Hoon Kim Young-kyu Kim soon-Ae lee Sang-Jae Park Center for Liver Cancer National Cancer Center

BACKGROUND: The low graft-to-recipient weight ratio(GRWR) in adult-to-adult living donor liver transplantation(LDLT) is one of the major risk factors affecting graft survival. The goal of this study was to evaluate whether the lower limit of the GRWR can be safely reduced without portal pressure modulation in right-lobe LDLT. METHODS: From 2005 to 2011, 317 consecutive patients from a single institute underwent LDLT with right-lobe grafts without portal pressure modulation. Of these, 23 had a GRWR of less than 0.7%(group A), 27 had a GRWR of ≥0.7%, <0.8%(group B), and 267 had a GRWR of more than and equal to 0.8%(group C). Medical records, including recipient, donor, operation factors, laboratory findings and complications were reviewed retrospectively. RESULTS: The baseline demographics showed low model for end-stage liver disease score(mean 16.3±8.9) and high percentage of hepatocellular carcinoma(231 patients, 72.9%). Three groups by GRWR demonstrated similar characteristics except recipient body mass index and donor gender. For smallforsize syndrome, there were 3(13.0%) in group A, 1(3.7%) in group B, and 2 patients(0.7%) in group C(P<0.001). Hepatic artery thrombosis was more frequently observed in group A than in groups B and C(8.7% vs 3.7% vs 1.9%, P=0.047). However, among the three groups, graft survival rates at 1 year(100% vs 96.3% vs 93.6%) and 3 years(91.7% vs 73.2% vs 88.1%) were not different(P=0.539). In laboratory measurements,there was no group difference in total bilirubin and albumin. However, prothrombin time was longer in group A within postoperative 1 week and platelet count was lower in groups A and B within postoperative 1 month. CONCLUSION: A GRWR lower to 0.7% is safe and does not need to modulate portal pressure in adult-to-adult LDLT using the right-lobe in favorable conditions including low model for end-stage liver disease score.

关键词： graft-to-recipient weight ratio living donor liver transplantation small-for-size graft small-for-size syndrome

Nitrogen-and Oxygen-Containing Porous Ultrafine Carbon Nanofiber:A Highly Flexible Electrode Material for Supercapacitor

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Journal of Materials Science & Technology 2017年第5期33卷 424-431页

作者： Kai Wei kyu-Oh Kim kyung-Hun Song Chang-Yong Kang Jung soon lee Mayakrishnan Gopiraman Ick-Soo Kim College of Textile and Clothing Engineering Soochow UniversitySuzhou215021China Nano Fusion Technology Research Group Division of Frontier FibersInstitute for Fiber Engineering(IFES)Interdisciplinary Cluster for Cutting Edge Research(ICCER)Shinshu UniversityTokida 3-15-1UedaNagano Prefecture386-8567Japan Department of Fiber System Engineering Dankook UniversityYoungin 448-701Republic of Korea Department of Clothing&Textiles PaiChai UniversityDaejeon 302-735Republic of Korea Department of Metallurgical Engineering Pukyong National UniversityBusan 608-739Republic of Korea Department of Clothing and Textiles Chungnam National UniversityDaejeon 305-764Republic of Korea

Herein, we report a simple and effective preparation of ultrafine CNFs （u-CNFs） with high surface area via electrospinning of two immiscible polymers [polyacrylonitrile （PAN） and poly（methyl methacry- late）（PMMA）] followed by calcination at high temperature in an inert atmosphere. Various electrospinning conditions were optimized in detail. Four different kinds of PAN/PMMA ratios （10/0, 7：3, 5：5 and 3：7） were chosen and found that the PAN/PMMA ratio of 3：7 （PAN/PMMA-3：7） is the optimum one. BET anal- ysis showed the specific surface area of the u-CNFs-3：7 was 46Z57 m2/g with an excellent pore volume （1.15 cms g-l） and an average pore size （9.48 nm）： it is about 25 times higher than the conventional CNFs （c-CNFs）. TEM and FE-SEM images confirmed the ultrafine structure of the CNFs with a thinner fiber di- ameter of-50 nm. The graphitic nature and atomic arrangement of the u-CNFs were investigated by Raman and XPS analyses. For the supercapacitor application, unlike the common electrode preparation methods, the u-CNFs-3：7 was used without any activation, chemical or mechanical modifications. The u-CNFs- 3：7 showed a better specific capacitance of 86 Fig in 1 mol/L 1-12S04 when compared to pure CNFs. The excellent physicochemical properties make the u-CNFs-3：7 an alternative choice to the existing CNFs for the supercapacitors.

关键词： Carbon fiber Porosity Electron microscopy Surface analysis Supercapacitor

Extracolonic findings of computed tomographic colonography in Koreans

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World Journal of Gastroenterology 2009年第12期15卷 1487-1492页

作者： Sung Keun Park Dong Il Park Sun-Young lee Sang Kil lee Young-Ho Kim soon Jin lee Jeong-Sik Byeon kyu Chan Huh Ki-Nam Shim Department of Medicine Sungkyunkwan University School of MedicineKangbuk Samsung Hospital 108Pyung-dongJongro-guSeoul 110-746South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 110-746South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 110-746South Korea Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul110-746South Korea Departments of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul110-746South Korea Department of Internal Medicine Ulsan University College of MedicineAsan Medical CenterSeoul110-746South Korea Department of Internal Medicine Konyang University School of MedicineDaejon 302-718South Korea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 110-746South Korea

AIM:To determine the frequency and characteristics of extracolonic lesions detected using computed tomographic(CT)***:The significance of extracolonic lesions was classified as high,intermediate,or *** records were reviewed to establish whether further investigations were carried out pertaining to the extracolonic lesions that were detected by CT ***:A total of 920 cases from 7 university hospitals were included,and 692 extracolonic findings were found in 532(57.8%)*** 692 extracolonic findings,60 lesions(8.7%)were highly significant,250(36.1%)were of intermediate significance,and 382(55.2%)were of low *** colonography revealed fewer extracolonic findings in subjects who were without symptoms(P<0.001),younger(P<0.001),or who underwent CT colonography with no contrast enhancement(P=0.005).CT colonography with contrast enhancement showed higher cost-effectiveness in detecting highly significant extracolonic lesions in older subjects and in subjects with ***:Most of the extracolonic findings detected using CT colonography were of less significant *** role of CT colonography would be optimized if this procedure was performed with contrast enhancement in symptomatic older subjects.

关键词： Computed tomographic colonography Extracolonic lesion Cost Contrast enhancement Clinical availability

Comparison of the rheological properties of four root canal sealers

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International Journal of Oral Science 2015年第1期7卷 56-61页

作者： Seok Woo Chang Young-kyu lee Qiang Zhu Won Jun Shon Woo Cheol lee Kee Yeon Kum Seung Ho Baek In Bog lee Bum-soon Lim Kwang Shik Bae Department of Conservative Dentistry School of Dentistry Kyung Hee University National Instrumentation Center for Environmental Management Seoul National University Department of Endodontology School of Dental Medicine University of Connecticut Health Center Department of Conservative Dentistry Dental Research Institute School of Dentistry Seoul National University Dental Hospital Seoul National University Dental Research Institute and Department of Dental Biomaterials School of Dentistry Seoul National University

The flowability of a root canal sealer is clinically important because it improves the penetration of the sealer into the complex root canal system. The purpose of this study was to compare the flowabilities of four root canal sealers, measured using the simple press method （ISO 6876）, and their viscosities, measured using a strain-controlled rheometer. A newly developed, calcium phosphate-based root canal sealer （Capseal） and three commercial root canal sealers （AH Plus, Sealapex and Pulp Canal Sealer EWT） were used in this study. The flowabilities of the four root canal sealers were measured using the simple press method （n= 5） and their viscosities were measured using a strain-controlled rheometer （n=5）. The correlation between these two values was statistically analysed using Spearman＇s correlation test. The flow diameters and the viscosities of the root canal sealers were strongly negatively correlated （p= -0.8618）. The viscosity of Pulp Canal Sealer EWT was the lowest and increased in the following order： AH Plus〈Sealapex〈Capseal （P〈0.05）. All of the tested root canal sealers showed characteristic time- and temperature-dependent changes in their rheological properties. The viscosities measured using the strain-controlled rheometer were more precise than the flowabilities measured using the simple press method, suggesting that the rheometer can accurately measure the rheological properties of root canal sealers.

关键词： Capseal rheological property root canal sealer strain-controlled rheometer