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Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?

Asian Journal of Andrology 2023年第1期25卷 43-49页

作者： Jeffrey J Leow soon hock koh Marcus WL Chow Wayren Loke Rolando Salada Seok Kwan Hong Yuyi Yeow Chau Hung Lee Cher Heng Tan Teck Wei Tan Department of Urology Tan Tock Seng HospitalSingapore 308433Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of Diagnostic Radiology Tan Tock Seng HospitalSingapore 308433Singapore

Magnetic resonance imaging(MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s)on *** role of concurrent systematic in addition to targeted biopsies is currently *** our prospectively maintained database,we identified men with at least one Prostate Imaging-Reporting and Data System(PI-RADS)≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May *** significant prostate cancer(csPCa)was defined as any Gleason grade group≥2 *** 545 patients who underwent MRI fusion-targeted biopsy,222(40.7%)were biopsy naïve,247(45.3%)had previous prostate biopsy(s),and 76(13.9%)had known prostate cancer undergoing active *** cancer was more commonly found in biopsy-naïve men(63.5%)and those on active surveillance(68.4%)compared to those who had previous biopsies(35.2%;both P<0.001).Systematic biopsies provided an incremental 10.4%detection of csPCa among biopsy-naïve patients,versus an incremental 2.4%among those who had prior negative *** regression found age(odds ratio[OR]=1.03,P=0.03),prostate-specific antigen(PSA)density≥0.15 ng ml^(−2)(OR=3.24,P<0.001),prostate health index(PHI)≥35(OR=2.43,P=0.006),higher PI-RADS score(vs PI-RADS 3;OR=4.59 for PI-RADS 4,and OR=9.91 for PI-RADS 5;both P<0.001)and target lesion volume-to-prostate volume ratio≥0.10(OR=5.26,P=0.013)were significantly associated with csPCa detection on targeted *** conclusion,for men undergoing MRI fusion-targeted prostate biopsies,systematic biopsies should not be omitted given its incremental value to targeted biopsies *** factors such as PSA density≥0.15 ng ml^(−2),PHI≥35,higher PI-RADS score,and target lesion volume-to-prostate volume ratio≥0.10 can help identify men at higher risk of csPCa.

关键词： prostate biopsy prostate cancer prostate health index prostate-specific antigen software fusion Uronav

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Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-Hee Park Su-hwan Yun Tae-soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

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An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe Wang MengXi Shi Willie soon ShiCan Qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

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Shape correspondence for cel animation based on a shape association graph and spectral matching

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Computational Visual Media 2023年第3期9卷 633-656页

作者： Shaolong Liu Xingce Wang Xiangyuan Liu Zhongke Wu hock soon Seah Beijing Normal University Beijing 100875China Nanyang Technological University Singapore 639798Singapore

We present an effective spectral matching method based on a shape association graph for finding region correspondences between two cel animation *** formulate the correspondence problem as an adapted quadratic assignment problem,which comprehensively considers both the intrinsic geometric and topology of regions to find the globally optimal *** simultaneously represent the geometric and topological similarities between regions,we propose a shape association graph(SAG),whose node attributes indicate the geometric distance between regions,and whose edge attributes indicate the topological distance between combined region *** convert topological distance to geometric distance between geometric objects with topological features of the pairs,and introduce Kendall shape space to calculate the intrinsic geometric *** utilizing the spectral properties of the affinity matrix induced by the SAG,our approach can efficiently extract globally optimal region correspondences,even if shapes have inconsistent topology and severe *** is also robust to shapes undergoing similarity transformations,and compatible with parallel computing techniques.

关键词： cel animation shape correspondence shape association graph(SAG) spectral matching quadratic assignment Kendall shape space

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Subregion graph: A path planning acceleration structure for characters with various motion types in very large environments

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Computational Visual Media 2015年第2期1卷 105-118页

作者： Nicholas Mario Wardhana Henry Johan hock soon Seah Multi-plAtform Game Innovation Centre(MAGIC) Nanyang Technological University School of Computer Engineering Nanyang Technological University Fraunhofer IDM NTU Nanyang Technological University

Modern computer graphics applications commonly feature very large virtual environments and diverse characters which perform different kinds of motions. To accelerate path planning in such a scenario, we propose the subregion graph data structure. It consists of subregions, which are clusters of locally connected waypoints inside a region, as well as subregion connectivities. We also present a fast algorithm to automatically generate a subregion graph from an enhanced waypoint graph map representation,which also supports various motion types and can be created from large virtual environments. Nevertheless,a subregion graph can be generated from any graphbased map representation. Our experiments show that a subregion graph is very compact relative to the input waypoint graph. By firstly planning a subregion path, and then limiting waypoint-level planning to this subregion path, over 8 times average speedup can be achieved, while average length ratios remain as low as102.5%.

关键词： path planning acceleration very large environments motion types abstraction

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Stroke-Based Surface Reconstruction

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Numerical Mathematics(Theory,Methods and Applications) 2013年第1期6卷 297-324页

作者： Jooyoung Hahn Jie Qiu Eiji Sugisaki Lei Jia Xue-Cheng Tai hock soon Seah Institute of Mathematics and Scientific Computing University of GrazAustria School of Computer Engineering Nanyang Technological UniversitySingapore N-Design Inc. Japan Mathematics Institute University of BergenNorway

In this paper,we present a surface reconstruction via 2D strokes and a vector field on the strokes based on a two-step *** the first step,from sparse strokes drawn by artists and a given vector field on the strokes,we propose a nonlinear vector interpolation combining total variation(TV)and H1 regularization with a curl-free constraint for obtaining a dense vector *** the second step,a height map is obtained by integrating the dense vector field in the first *** discontinuities in surface and discontinuities of surface gradients can be well reconstructed without any surface *** also provide a fast and efficient algorithm for solving the proposed *** vectors on the strokes are interpreted as a projection of surface gradients onto the plane,different types of strokes are easily devised to generate geometrically crucial structures such as ridge,valley,jump,bump,and dip on the *** stroke types help users to create a surface which they intuitively imagine from 2D *** compare our results with conventional methods via many examples.

关键词： Surface reconstruction from a sparse vector field augmented Lagrangian method twostep method curl-free constraint total variation regularization preservation of discontinuities in surface normal vectors

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Fresnel incoherent correlation holography with single camera shot

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Opto-Electronic Advances 2020年第8期3卷 12-22页

作者： Anand Vijayakumar Tomas Katkus Stefan Lundgaard Denver P.Linklater Elena P.Ivanova soon hock Ng Saulius Juodkazis Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceSwinburne University of TechnologyHawthorn 3122Australia Department of Physics Royal Melbourne Institute of TechnologyGPO Box 2476Melbourne 3001Australia Melbourne Centre for Nanofabrication Australian National Fabrication Facility151 Wellington RoadClaytonVIC 3168Australia Tokyo Tech World Research Hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

Fresnel incoherent correlation holography(FINCH)is a self-interference based super-resolution three-dimensional imaging *** in inline configuration requires an active phase modulator to record at least three phase-shifted camera shots to reconstruct objects without twin image and bias *** this study,FINCH is realized using a randomly multiplexed bifocal binary diffractive Fresnel zone lenses fabricated using electron beam *** object space is calibrated by axially scanning a point object along the optical axis and recording the corresponding point spread holograms(PSHs).An object is mounted within the calibrated object space,and the object hologram was recorded under identical experimental conditions used for recording the *** image of the object at different depths was reconstructed by a cross-correlation between the object hologram and the *** potential including bio-medical optics is discussed.

关键词： imaging holography correlation three-dimensional imaging diffractive optics

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Review of Fresnel incoherent correlation holography with linear and non-linear correlations

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Chinese Optics Letters 2021年第2期19卷 1-6页

作者： Vijayakumar Anand Tomas Katkus soon hock Ng Saulius Juodkazis Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceSwinburne University of TechnologyHawthornVIC 3122Australia Melbourne Centre for Nanofabrication ANFFClaytonVIC 3168Australia Tokyo Tech World Research Hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

Fresnel incoherent correlation holography(FINCH)is a well-established incoherent imaging *** FINCH,three selfinterference holograms are recorded with calculated phase differences between the two interfering,differently modulated object waves and projected into a complex *** object is reconstructed without the twin image and bias terms by a numerical Fresnel back propagation of the complex hologram.A modified approach to implement FINCH by a single camera shot by pre-calibrating the system involving recording of the point spread function library and reconstruction by a nonlinear cross correlation has been introduced *** expression of the imaging characteristics from the modulation functions in original FINCH and the modified approach by pre-calibration in spatial and polarization multiplexing schemes are *** study reveals that a reconstructing function completely independent of the function of the phase mask is required for the faithful expression of the characteristics of the modulating function in image *** the polarization multiplexing method by non-linear cross correlation,a partial expression was observed,while in the spatial multiplexing method by non-linear cross correlation,the imaging characteristics converged towards a uniform behavior.

关键词： digital holographic imaging Fresnel incoherent correlation holography holographic techniques imaging systems incoherent holography and speckle noise

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Concurrent amoebic and histoplasma colitis:A rare cause of massive lower gastrointestinal bleeding

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World Journal of Gastroenterology 2010年第10期16卷 1296-1298页

作者： Peng soon koh April Camilla Roslani Kumar Vasudeavan Vimal Mohd Shariman Ramasamy Umasangar Rajkumar Lewellyn Department of Surgery Faculty of MedicineUniversity Malaya Department of Surgery Taiping Hospital Department of Pathology Raja Permaisuri Bainun Hospital

Infective colitis can be a cause of massive lower gastrointestinal bleeding requiring acute surgical intervention. Causative organisms include entamoeba and histoplasma species. However, concurrent colonic infection with both these organisms is very rare, and the in vivo consequences are not known. A 58-year-old male presented initially to the physicians with pyrexia of unknown origin and bloody diarrhea. Amoebic colitis was diagnosed based on biopsies, and he was treated with metronidazole. Five days later, the patient developed massive lower gastrointestinal bleeding with hemorrhagic shock. Emergency total colectomy with end-ileostomy was performed. However, he deteriorated and died on the second postoperative day. Histopathological examination revealed multiple deep ulcers at the hepatic flexure where fungal bodies of mycelial and yeast forms were noted. Isolated lymph nodes showed abscess formation with fungal bodies. Infective fungal colitis with Histoplasma capsilatum was diagnosed. In vitro, amoebic parasites can increase virulence and pathogenicity of histoplasma which may account for the fulminant presentation in this patient. Although rare, this unusual dual infection should be considered in the differential diagnosis of infective colitis, as appropriate antimicrobial treatment may prevent progression to massive lower gastrointestinal bleeding, obviating the need for urgent surgical intervention.

关键词： Gastrointestinal hemorrhage Histoplasma Amoebic colitis Colectomy Infective colitis

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Exploring new frontiers in molecular imaging:Emergence of ^(68)Ga PET/CT

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World Journal of Radiology 2010年第2期2卷 55-67页

作者： Eik hock Tan soon Whatt Goh Department of Nuclear Medicine and PET Singapore General Hospital

Since US Food and Drug Administration approval of 18-fluorodeoxyglucose as a positron tracer,and the development of hybrid positron emission tomography/ computed tomography machines,there has been a great increase in clinical application and progress in the field of nuclear molecular ***,not under- estimating the value of 18F,there are known limitations in the use of this cyclotron-produced positron *** hence turn our focus to an emerging positron tracer, 68 Ga,and examine the advantages,current clinical uses and potential future applications of this radioisotope.

关键词： Gallium 68 Positron emission tomography computed tomography Neuroendocrinology

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