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Clinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis

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World Journal of Gastroenterology 2016年第20期22卷 4901-4907页

作者： Ji sook park Jae Sung Ko Jeong Kee Seo Jin Soo Moon Sung Sup park Department of Pediatrics Seoul National University College of Medicine Department of Pediatrics Gyeongsang National University School of Medicine Department of Laboratory Medicine Seoul National University College of Medicine

AIM: To investigate clinical profiles and mutations of ABCB11 in Koreans with progressive familial intrahepatic cholestasis 2 and review the differences between Koreans and ***: Of 47 patients with neonatal cholestasis, five infants had chronic intrahepatic cholestasis with normal γ-glutamyl transpeptidase. Direct sequencing analyses of ABCB11, including exons and introns, were performed from peripheral ***: Living donor-liver transplantation was performed in four patients because of rapidly progressive hepatic failure and hepatocellular carcinoma. Three missense mutations were found in two patients: compound heterozygous 677C>T(S226L)/3007G>A(G1003R) and heterozygous 2296G>A(G766R). The mutations were located near and in the transmembranous space. CONCLUSION: Alterations in the transmembrane of the bile salt export pump in the Korean infants were different from those previously reported in Chinese, Japanease, Taiwan Residents, and European patients.

关键词： Hepatocellular carcinoma Progressive familial intrahepatic cholestasis ABCB11 Bile salt export pump

Cornual patency and integrity following laparoscopic cornuotomy for interstitial pregnancy

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Open Journal of Obstetrics and Gynecology 2012年第2期2卷 127-130页

作者： Young-Sam Choi Dae-sook Eun Yun-Sang Oh Ji-No park Department of Obstetrics and Gynecology of Eun Hospital Kwang-Ju Metropolitan City South Korea

Objective: To evaluate cornual patency and integrity following laparoscopic cornuotomy. Study Design: This is a prospective cohort study on seven women who underwent laparoscopic cornuotomy for interstitial pregnancy. The cornual patency and integrity were evaluated using hysterosalpingography (HSG) and magnetic resonance imaging (MRI). On MRI, the entire cornual wall thickness were measured bilaterally at 5-mm intervals. The thickness of the affected and unaffected cornua matched at the corresponding contralateral point in each of the women. Statistically, all possible pairwise 28 comparisons were compared using paired t-tests. Results: Among six eligible women, four women had excellent cornual patency on the affected side. Among seven women (i.e., 28 pairs), no significant difference was observed in cornual thickness compared to the unaffected cornu and no remarkable defects were seen in the endometrial and cornual contour. But there is no statistical significance. Conclusion: Laparoscopic cornuotomy seems to have advantage to preserve the cornu in interstitial pregnancy.

关键词： Interstitial Pregnancy Cornual Pregnancy Cornuotomy Outcome Cornual Integrity

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae Kim Sung Wook Lee Jin sook Jeong Byeong Ho park Kyung Jin Nam Jin Han Cho Young Hoon Kim Young Hoon Roh Hyung Sik Lee Young Min Choi Sang Young Han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词：肝动脉肝癌化疗晚期疗效灌注治疗方式肝细胞癌

Domain-engineered BiFeO3 thin-film photoanodes for highly enhanced ferroelectric solar water splitting

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Nano Research 2018年第2期11卷 642-655页

作者： Song, Jaesun Kim, Taemin Ludvic Lee, Jongmin Cho, Sam Yeon Cha, Jaeseong Jeong, Sang Yun An, Hyunji Kim, Wan Sik Jung, Yen-sook park, Jiyoon Jung, Gun Young Kim, Dong-Yu Jo, Ji Young Bu, Sang Don Jang, Ho Won Lee, Sanghan School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Department of Materials Science and Engineering Research Institute of Advanced Materials Seoul National University Seoul Republic of Korea Department of Physics Chonbuk National University Jeonju Republic of Korea

In photoelectrochemical （PEC） water splitting, charge separation and collection by the electric field in the photoactive material are the most important factors for improved conversion efficiency. Hence, ferroelectric oxides, in which electrons are the majority carriers, are considered promising photoanode materials because their high built-in potential, provided by their spontaneous polarization, can signifi＇canfly enhance the separation and drift of photogenerated carriers. In this regard, the PEC properties of BiFeO3 thin-film photoanodes with different crystallographic orientations and consequent ferroelectric domain structures are investigated. As the crystallographic orientation changes from （001）pc via （ll0）pc to （lll）p~, the ferroelastic domains in epitaxial BiFeO3 thin films become mono-variant and the spontaneous polarization levels increase to 110 btC/cm2. Consequent136 the photocurrent density at 0 V vs. Ag/AgC1 increases approximately 5.3-fold and the onset potential decreases by 0.180 V in the downward polarization state. It is further demonstrated that ferroelectric switching in the （lll）pc BiFeO3 thin-film photoanode leads to an approximate change of 8,000% in the photocurrent density and a 0.330 V shift in the onset potential. This study strongly suggests that domain-engineered ferroelectric materials can be used as effective charge separation and collection layers for efficient solar water-splitting photoanodes.

关键词： BiFeO3 ferroelectric photoelectrochemical domain orientation pulsed laser deposition

Monsoonal precipitation variation in the East Asia since A.D. 1840 ——Tree-ring evidences from China and Korea

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Science China Earth Sciences 2003年第10期46卷 1031-1039页

作者：刘禹 Won-Kyu park 蔡秋芳 Jung-Wook Seo Hyun-sook Jung The State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'n 710075 China School of Forest Resources Chungbuk National University Cheongju 361-763 Korea Meteorological Research Institute Korea Meteorological Administration Seoul 156-720 Korea

Three tree-ring rainfall reconstructions from China and Korea are used in this paper to investigate the East Asian summer monsoon-related precipitation variation over the past 160 years. Statistically, there is no linear correlation on a year-by-year basis between Chinese and Korean monsoon rainfall, but region-wide synchronous variation on a decadal-scale was observed. More rainfall intervals were 1860-1890, 1910-1925, and 1940-1960, and dry or even drought peri-ods were 1890-1910, 1925-1940, and 1960-present. Reconstructions also display that the East Asian summer monsoon precipitation suddenly changed from more into less around mid-1920. These tree-ring precipitation records were also confirmed by Chinese historical dry-ness/wetness index and Korean historical rain gauge data.

关键词： China, Korea, tree-ring precipitation reconstruction, East Asian summer monsoon precipitation.

Spermatogenic effect of Yacon tubers extracts and its constituents

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Spermatogenic effect of Yacon tubers extracts and its consti...

TROPICAL CYCLOGENESIS DETECTION IN NWP AT KMA

中国药理学会临床药理学专业委员会会议暨第十次全国临床药...

作者： park Jeong-sook YANG Jae-sik HWANG Bang-yeon College of Pharmacy CBITRC Chungbuk National UniversityCheongjuHeungdukgu Gaeshindong San 12Chungbuk 361-763S.Korea

AIM:Smallanthus sonchifolius(Yacon)has been used as a food and folk medicine in the Andes *** was screened the pharmacological effects of a 50% ethanol ex- tract of Yacon on spermatogenesis in *** study is carded out to evaluate the possibility of using Yacon tubers extracts as a fertility agent to treat infertility caused by spermatogenic disorders. METHODS:The dried,pulverized Yacon tubers were extracted with 50% ethanol at 50℃ for 5 h under sonica- *** Yacon extracts were analyzed by using HPLC system on a Kromasil ClS column(250mm×4.6 mm). The Yacon tubers extracts,chlorogenic acid and ferulic acid were administrated to rats once daily by oral gavage. The number of sperm heads in the testis was assessed by counting the number of sperm heads using slight modifica- tion of the procedure reported by Toth et al(1989). RESULTS:After administration of chlorogenic acid and Yacon tuber extracts to rat for 5 weeks,the number of sperm in epididymis were increased by 20.33% and 34.48%,*** femlic acid which was report- ed as a metabolite of chlorogenic acid and constituent of Yacon to estimate the spermatogenic activity was also ad- *** administration of ferulic acid and Yacon tubers extracts,the sperm number were increased by 37.87% and 43.33%,*** ef- fects of chlorogenic acid and ferulic acid were 0.59 times and 0.87 times of Yacon tubers extracts,respectively. CONCLUSION:The spermatogenic effect of Yacon tu- bers extracts may result from the combined effect of chloro- genic acid or its analogues and their metabolites.

关键词： Smallanthus sonchifolius spermatogenesis chlomgenic acid ferulic acid fertility

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Tropical Cyclone Research and Review 2014年第4期3卷 256-269页

作者： Woojeong Lee KiRyong Kang Jiyoung Kim Kun-Young Byun Jong sook park Seonghee Won Yunho park WonTae Yun National Typhoon Center Korea Meteorological AdministrationJejuKorea Weather Radar Center Korea Meteorological AdministrationSeoulKorea Global Environment System Research Division National Institute Meteorological ResearchKorea Meteorological AdministrationJejuKorea Foreast Research Division National Institute Meteorological ResearchKorea Meteorological AdministrationJejuKorea Numerical Model Development Division Korea Meteorological AdministrationSeoulKorea

In this study,a tropical cyclogenesis detection system,Tropical Cyclone Analysis&Forecast(TCAF),was evaluated with an operational numerical model of the Korea Meteorological Administration(KMA).The tracking performance was compared with the result with the ECMWF model input field(TCAF-ECMWF).In order to improve the performance,different tracking time at an interval of 6 hours were *** lowest false alarm rate and the highest hit rate(correct detection)were achieved at 06 hour after the initial tracking *** tracking performance was also tested on two typhoons in 2013,LEEPI(1304)and DANAS(1324).The results showed that the TCAF-ECMWF detected tropical depressions 72 hours before the formation of the typhoon DANAS,which is a 12-hour earlier detection compared with the current performance with the use of KMA’s numerical weather prediction(NWP)model ***,it is expected that TC genesis detection could be improved by determining an optimal tracking time and by using more accurate NWP model data.

关键词： tropical cyclone genesis detection numerical weather prediction

Transient bilateral total blindness after Falcotentorial meningioma operation by occipital bi-transtentorial approach

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Transient bilateral total blindness after Falcotentorial men...

公元1840年以来东亚夏季风降水变化——以中国和韩国的树轮记录为例

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Jeong-Taik Kwon Byoung Hun Lee Yong sook park Department of Neurosurgery Chung-Ang University Hospital

Introduction Meningiomas arising at the falcotentorial junction are *** infratentorial supracerebellar approach and the occipital transtentorial approach are the main approaches used to reach lesions located in the pineal ***,these approach were limitation of fully exposure to bilaterally located *** presentation The 56 year-old female was admitted with headache and visual *** Magnetic resonance image（MRI） study,3.5 well definded midline mass in pineal *** signal intensity was checked owing to calcification and strong *** margin of the mass was internal cerebral vein and vein of Galen which the inferior margin of tumor was compressed by pineal gland mass on Digital Subtraction *** there was no *** the time of admission,there was no visual field deficit and Visual Evoked Potential was *** and CSF markers contribute to the diagnosis of pineal parenchymal tumors,βHCG and AFP were *** was operated by occipital bi-transtentorial approach that consisted of a bilateral（Right side dominant） occipital craniotomy exposing the torcula,superior sagittal sinus,and transverse *** of the tumor was firm and fibrotic mass with calcification,it was not pulled in one side after internal *** tumor was removed and we confirmed the structure of *** The patient well come out of anesthesia and there was no neurological deficits except in total *** does not percept to light and light reflex was *** used immediately steroid and checked *** MRI,the mass was well removed and there was a little blood in subdural space of bilateral occipital *** patient made remarkable improvement after 3 days from operation,Conclusion In the occipital bi-transtentorial approach is well exposed operation field and anatomical structure to *** major advantage of this approach is the better exposition relationship of the opposite mass margin

关键词： Pineal gland tumor Occipital transtentorial approach Falcotentorial meningioma

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中国科学（D辑） 2003年第6期33卷 543-549页

作者：刘禹 Won-Kyu park 蔡秋芳 Jung-Wook Seo Hyun-sook Jung 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710075 韩国忠北大学林学院韩国国家气象局气象研究院

根据中国和韩国3条树木年轮降水记录,本文分析了过去160a以来东亚夏季风降水的变迁历史。统计分析表明,年际间中国和韩国季风降水不存在线性相关,而在10a尺度上则表现出同步变化的趋势。1860～1890,1910～1925,1940～1960年是3个降水量... 详细信息

根据中国和韩国3条树木年轮降水记录,本文分析了过去160a以来东亚夏季风降水的变迁历史。统计分析表明,年际间中国和韩国季风降水不存在线性相关,而在10a尺度上则表现出同步变化的趋势。1860～1890,1910～1925,1940～1960年是3个降水量较多的时段;1890～1910,1925～1940,1960～1998年,则是3个降水量较少的时段。3条降水重建序列均揭示1920年代中期东亚夏季风降水快速由多转少。同时树木年轮季风降水重建序列也被基于中国历史文献记载所划分的旱涝指数和韩国雨量记录所证实。

关键词：中国韩国树木年轮东亚夏季风降水降水变化降水量气候变化