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Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

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Journal of Sport and Health Science 2024年第4期13卷 484-498,F0003页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop jin-soo kim Robert U.Newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this *** has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased *** avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simpliﬁes the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and ***,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical *** date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer ***,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an inﬂuential candidate driving cancer inhibitory effects regardless of training *** for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关键词： Cancer cells High intensity interval training Moderate intensity continuous training Resistance training Myokines

Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer

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World Journal of Gastrointestinal Surgery 2023年第9期15卷 2032-2041页

作者： Ji Hyeong Song Tae Jeong Oh Sungwhan An Kyung Ha Lee Ji Yeon kim jin soo kim Department of Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Genomictree Inc.Daejeon 34027South Korea Department of Surgery College of MedicineChungnam National UniversityDaejeon 35015South Korea

BACKGROUND Early detection of colorectal cancer(CRC)is essential to reduce cancer-related morbidity and *** DNA(sDNA)testing is an emerging method for early CRC ***-2(SDC2)methylation is a potential biomarker for the sDNA *** DNA methylation is an early epigenetic event during tumorigenesis and can occur in the normal colonic mucosa during aging,which can compromise the sDNA test *** In this prospective study,we enrolled 151 patients with CRC who underwent curative surgical resection between September 2016 and May *** stool samples were collected from 123 patients and postoperative samples were collected from 122 patients.A total of 104 samples were collected from both preoperative and postoperative *** promoter methylation of SDC2 in sDNA was assessed using linear target enrichment quantitative methylation-specific real-time polymerase chain *** parameters were analyzed using the results of SDC2 *** Detection rates of SDC2 methylation in the preoperative and postoperative stool samples were 88.6%and 19.7%,*** tumor size(3 cm,P=0.019)and advanced T stage(T3–T4,P=0.033)were positively associated with the detection rate of SDC2 methylation before *** sex was associated with false positives after surgery(P=0.030).Cycle threshold(CT)values were significantly decreased postoperatively compared with preoperative values(P<0.001).The postoperative negative conversion rate for preoperatively methylated SDC2 was 79.3%(73/92).CONCLUSION Our results suggested that the SDC2 methylation test for sDNA has acceptable sensitivity and ***,small size and early T stage tumors are associated with a low detection rate of SDC2 *** the cycle threshold values significantly decreased after surgery,SDC2 methylation test for sDNA might have a diagnostic value for CRC.

关键词： Biomarkers DNA methylation Syndecan-2 Colorectal cancer

Comparison of two Nd:YAG laser posterior capsulotomy: cruciate pattern vs circular pattern with vitreous strand cutting

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 235-239页

作者： jin-soo kim Jung Yeol Choi Ji-Won Kwon Won Ryang Wee Young Keun Han Department of Ophthalmology Seoul National University College of Medicine Department of Ophthalmology Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Ophthalmology Seonam University College of Medicine Myongji Hospital

AIM： To investigate the effects and safety of neodymium： yttrium-aluminium-garnet（Nd：YAG） laser posterior capsulotomy with vitreous strand cuttingMETHODS： A total of 40 eyes of 37 patients with symptomatic posterior capsular opacity（PCO） were included in this prospective randomized study and were randomly subjected to either cruciate pattern or round pattern Nd：YAG posterior capsulotomy with vitreous strand cutting（modified round pattern）. The best corrected visual acuity（BCVA）, intraocular pressure（IOP）, refractive error, endothelial cell count（ECC）, anterior segment parameters, including anterior chamber depth（ACD） and anterior chamber angle（ACA） were measured before and 1 mo after the laser posterior capsulotomy. RESULTS： In both groups, the BCVA improved significantly（P〈0.001 for the modified round pattern group, P=0.001 for the cruciate pattern group）; the IOP and ECC did not significantly change. The ACD significantly decreased（P〈0.001 for both） and the ACA significantly increased（P=0.001 for the modified round pattern group and P=0.034 for the cruciate group）. The extent of changes in these parameters was not significantly different between the ***： Modified round pattern Nd：YAG laser posterior capsulotomy is an effective and safe method for the treatment of PCO. This method significantly changes the ACD and ACA, but the change in refraction is not significant. Modified round pattern Nd：YAG laser posterior capsulotomy can be considered a good alternative procedure in patients with symptomatic PCO.

关键词： posterior capsulotomy modified round pattern vitreous strand cutting anterior segment parameter

A squamous metaplasia in a gastric ulcer scar of the antrum

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World Journal of Gastroenterology 2008年第8期14卷 1296-1298页

作者： Young-Seok Cho jin-soo kim Hyung-Keun kim Jeong-Seon Ji Byung-Wook kim Hiun-Suk Chae Sok-Won Han Kyu-Yong Choi In-Sik Chung Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Kangnam St. Mary’s Hospital Seoul Korea

An 81-year-old man presented with epigastric pain and weight loss for one month. He had a past history of pulmonary tuberculosis, 10 years ago. We performed a gastroscopy, which showed a linear depressed whitish gastric ulcer scar (0.8 cm in length) in the posterior wall of the prepyloric antrum. The result of biopsy was reported as squamous epithelium. Immunohistochemical staining using an antibody to high molecular weight cytokeratin (HMC) revealed positive staining in the squamous epithelium. Two years later, the lesion was followed up. The lesion remained at same site endoscopically, but no squamous epithelium could be seen microscopically.

关键词： Squamous metaplasia Gastric ulcer scar High molecular weight cytokeratin

Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal

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Acta Pharmacologica Sinica 2004年第4期25卷 3-13页

作者： Sun-woo LIM,Bo-kyung SUN,Bum-soon CHOI,Sylvia GLOWACKA,Alison J COX,Darren J KELLY,Yong-soo kim,jin kim,Byung-kee BANG,Chul-woo YANG Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Anatomy the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea MD PhD

AIM: To examine whether the reversibility of chronic cyclosporine A (CsA) nephrotoxicity is associated with apoptotic cell death and its regulatory factors. METHODS: Chronic CsA nephrotoxicity was induced in Sprague- Dawley rats by administering CsA (15 mg/kg, sc) for 5 weeks, and then withdrawing it for 5 or 10 weeks. The effect of CsA withdrawal on apoptotic cell death was evaluated by an in situ TdT-mediated deoxyuridine triphos- phate-biotin nick end-labeling (TUNEL) assay and the expression of pro-apoptotic [(transforming growth factor- beta1 (TGF-β1) and Fas] and anti-apoptotic [epidermal growth factors (EGF) and Bcl-2] factors. RESULTS: Discontinuation of CsA induced significant decreases in TUNEL-positive cells in a time-dependent manner and the reduction in TUNEL-positive cells was correlated with the tubulointerstitial fibrosis score (r=0.919, P<0.01). Upregulation of TGF-β1 and Fas expression in CsA-treated rat kidneys was decreased significantly after with- drawal of CsA. In contrast, downregulated EGF and Bcl-2 expression returned to normal or supernormal levels. CONCLUSION: CsA withdrawal is associated with a decrease in apoptotic cell death and with changes in the expression of pro-apoptotic and anti-apoptotic molecules involved in renal wound repair. This may constitute one of the mechanisms underlying the reversibility of chronic CsA nephrotoxicity.

关键词： cyclosporine apoptosis bcl-2 fas epidermal growth factor transforming growth factor-beta fibrosis

Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial

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Chinese Journal of Cancer 2017年第11期36卷 609-617页

作者： Kyung-Hee Lee Tae Won kim Jung-Hun Kang jin-soo kim jin-Seok Ahn Sun-Young kim Hwan-Jung Yun Young-Jun Eum Sung Ae Koh Min Kyoung kim Yong Sang Hong Jeong Eun kim Gyeong-Won Lee Department of Hematology-Oncology Yeungnam University Medical Center Daegu 42415 South Korea Department of Oncology Asan Medical Center University of Ulsan Seoul 05505 South Korea Department of Hematology-Oncology Gyeongsang National University Hospital Jinju 52727 South Korea Department of Internal Medicine SMG-SNU Boramae Medical Center Seoul 07061 South Korea Division of Hematology-Oncology Department of Medicine Samsung Medical Center Seoul 06351 South Korea Department of Hematology.Oncology National Cancer Center Ilsan 10408 South Korea Department of Hematology-Oncology Chungnam National University Hospital Daejeon 35015 South Korea Medical Affairs Mundipharma Korea Ltd Seoul 04637 South Korea Department of Oncology Asan Medical Center University of Ulsan College of Medicine 388.1 Pungnap-dong Songpa-gu Seoul 138.736 South Korea

Background: Controlled-release oxycodone/naloxone(OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone(OX-CR) for the control of cancer-related pain in Korean ***: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale(NRS) pain score ≥4] from seven Korean oncology/hematology centers. Patients in the intention-to-treat(ITT) population were randomized(1:1) to OXNCR or OX-CR groups. OXN-CR was administered starting at 20 mg/10 mg per day and up-titrated to a maximum of80 mg/40 mg per day for 4 weeks, and OX-CR was administered starting at 20 mg/day and up-titrated to a maximum of 80 mg/day for 4 *** primary efficacy endpoint was the change in NRS pain score from baseline to week4, with non-inferiority margin of-1.5. Secondary endpoints included analgesic rescue medication intake, patientreported change in bowel habits, laxative intake, quality of life(QoL), and safety ***: Of the ITT population comprising 128 patients, 7 with missing primary efficacy data and 4 who violated the eligibility criteria were excluded from the efficacy analysis. At week 4, the mean change in NRS pain scores was not significantly different between the OXN-CR group(n = 58) and the OX-CR group(n = 59)(-1.586 vs.-1.559,P = 0.948). The lower limit of the one-sided 95% confidence interval(-0.776 to 0.830) for the difference exceeded the non-inferiority margin(P < 0.001). The OXN-CR and OX-CR groups did not differ significantly in terms of analgesic rescue medication intake, change in bowel habits, laxative intake, QoL, and safety ***: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatmen

关键词： Constipation Naloxone Oxycodone Quality of life Safety

Post-Translational Regulation of FLOWERING LOCUS T Protein in Arabidopsis

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Molecular Plant 2016年第2期9卷 308-311页

作者： soo-jin kim Sung Myun Hong Seong Jeon Yoo Suhyun Moon Hye Seung Jung Ji Hoon Ahn Creative Research Initiatives Department of Life Sciences Korea University Seoul 136-701 Korea

Dear Editor,Here, we report the developmental regulation of proteolytic cleavage of the FLOWERING LOCUS T （FT） protein. FT, a mem- ber of the phosphatidylethanolamine-binding protein （PEBP） family, functions as a florigen or a component of florigen. PEBP binds phosphoethanolamine, and its ligand-binding domain is evolutionarily conserved from bacteria to plants and animals （Schoentgen and Jolles, 1995; Bradley et al., 1996）. PEBPs regulate important signaling pathways to control growth and differentiation （Chautard et al., 2004）. Some animal PEBP homologs undergo post-translational regulation. For example,

关键词： cleavage functions phosphoethanolamine

Anemia after gastrectomy for early gastric cancer:Long-term follow-up observational study

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World Journal of Gastroenterology 2012年第42期18卷 6114-6119页

作者： Chul-Hyun Lim Sang Woo kim Won Chul kim jin soo kim Yu Kyung Cho Jae Myung Park In Seok Lee Myung-Gyu Choi Kyo-Young Song Hae Myung Jeon Cho-Hyun Park Department of Internal Medicine The Catholic University of Korea College of MedicineSeoul 137-701South Korea Department of Surgery The Catholic University of Korea College of MedicineSeoul 137-701South Korea

AIM:To identify the incidence and etiology of anemia after gastrectomy in patients with long-term follow-up after gastrectomy for early gastric ***:The medical records of those patients with early gastric adenocarcinoma who underwent curative gastrectomy between January 2006 and October 2007 were *** with anemia in the preoperative workup,cancer recurrence,undergoing systemic chemotherapy,with other medical conditions that can cause anemia,or treated during follow up with red cell transfusions or supplements for anemia were *** was defined by World Health Organization criteria(Hb 100 fL) with vitamin B 12 *** profile of anemia over 48 mo of follow-up was ***:One hundred sixty-one patients with gastrectomy for early gastric cancer were *** incidence of anemia was 24.5% at 3 mo after surgery and increased up to 37.1% at 48 mo after *** incidence of iron deficiency anemia increased during the follow up and became the major cause of anemia at 48 mo after *** of chronic disease and megaloblastic anemia were *** incidence of anemia in female patients was significantly higher than in male patients at 12(40.0% vs 22.0%,P = 0.033),24(45.0% vs 25.0%,P = 0.023),36(55.0% vs 28.0%,P = 0.004),and 48 mo(52.0% vs 31.0%,P = 0.022) after *** with total gastrectomy showed significantly higher incidence of anemia than patients with subtotal gastrectomy at 48 mo after surgery(60.7% vs 31.3%,P = 0.008).The incidence of iron deficiency was significantly higher in female patients than in male patients at 6(35.4% vs 13.3%,P = 0.002),12(45.8% vs 16.8%,P

关键词： Gastrectomy Stomach neoplasms Anemia Iron deficiency Vitamin B 12 deficiency

Importance of dietary supplementation of soluble and insoluble fibers to sows subjected to high ambient temperatures during late gestation and effects on lactation performance

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Animal Nutrition 2024年第1期16卷 73-83页

作者： Seung Min Oh Abdolreza Hosseindoust Sang Hun Ha Jun Young Mun Joseph Moturi Habeeb Tajudeen Yo Han Choi Su Hyup Lee jin soo kim Gyeongbuk Livestock Research Institute Yeongju 63052Republic of Korea Department of Animal Industry Convergence Kangwon National UniversityChuncheon 24341Republic of Korea Swine Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Department of Swine Science Korea National University of Agriculture and FisheriesJeonju 54874Republic of Korea

Heat stress adversely affects sows'performance,which can be improved by applying proper nutritional *** study was conducted to investigate the interactive effects of dietary fiber levels and sources on sows'reproductive performance,metabolic response during gestation,and the carry-over influence on litter performance in the lactation period during heat stress(average room temperature of 27.1°C).Fifty-four multiparous sows(Landrace×Yorkshire;initial body weight of 236.3±16 kg;2,3and 4 parities)at d 90 of gestation were assigned to a 2×3 factorial arrangement(9 sows/treatment),involving 2 dietary fiber levels(4.5%and 6%crude fiber)and 3 dietary fiber sources(wheat bran[WB],palm kernel meal[PK],and beet pulp[BP]).Sows fed the BP diet had highest(P<0.01)feed intake and constipation index and lowest(P<0.01)farrowing *** weight(P=0.041)and litter weight(P<0.01)at weaning were higher in sows in the BP treatment compared to PK *** in the BP treatment showed the greatest(P<0.01)digestibility of crude protein and neutral detergent *** fecal concentration of acetate was the lowest(P<0.01)in the PK *** short-chain fatty acid production was increased in the WB and BP treatments compared with the *** in the BP treatment showed the lowest(P=0.036)hair *** blood insulin concentration of sows was higher(P=0.026)in the high fiber(6%)treatment compared with the low fiber(4.5%)treatment at 90 min and120 min after the *** concentration of phthalic acid,succinic acid,phenylethylamine,hydrocinnamic acid,iron,linoleic acid,glycerol,ketone,and formamide were increased(P<0.05)in the BP treatment compared with the *** BP treatment with high soluble fiber content improved the constipation index,farrowing duration,and litter performance,while high insoluble fibers increased sows comfort and reduced stress factors including respiratory rate and rectal ***,both soluble and insoluble sources of fiber are ne

关键词： Soluble fiber Insoluble fiber Beet pulp Wheat bran Palm kernel Metabolites