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Asian Journal of Andrology 2018年第4期20卷 372-378页

作者： Juhyun Park Sung Yong Cho Kwanjin Park Ji Sun Chai Hwancheol Son soo Woong Kim Jae-Seung Paick Min Chul Cho Department of Urology Seoul National University College of Medicine SMG-SNU Boramae Medical Center Seoul 03080 Korea Department of Urology Seoul Nationa University College of Medicine Seoul National University Hospital Seoul 07061 Korea

We evaluated whether lim-kinase 2 inhibitor （limK2i） could improve erectile function by suppressing corporal fibrosis through the normalization of the Rho-associated coiled-coil protein kinase 1 （ROCK1）/limK2/Cofilin pathway in a rat model of cavernous nerve crush injury （CNCl）. Sixty 11-week-old male Sprague-Dawley rats were divided equally into five groups： sham surgery （S）, CNCl （I）, and CNCl treated with low-dose （L）, medium-dose （M）, and high-dose （H） limK2i. The L, M, and H groups were treated with a daily intraperitoneal injection of limK2i （2.5, 5.0, and 10.0 mg kg-1 body weight, respectively） for 1 week after surgery. The erectile response was assessed using electrostimulation at 1 week, postoperatively. Penile tissues were processed for Masson＇s trichrome staining, double immunofluorescence, and Western blot assay. Erectile responses in the H group improved compared with the I group, while the M group showed only partial improvement. A significantly decreased smooth muscle/collagen ratio and an increased content of fibroblasts positive for phospho-/IMK2 were noted in the I group. The M and H groups revealed significant improvements in histological alterations and the dysregulated limK2/Cofilin pathway, except for limK2 phosphorylation in the M group. The inhibition of limK2 did not affect the ROCK1 protein expression. The content of fibroblasts positive for phospho-limK2 in the H group returned to the level found in the S group, whereas it did not in the M group. However, the L group did not exhibit such improvements. Our data suggest that the inhibition of limK2, particularly with administration of 10.0 mg kg^-1 body weight limK2i, can improve corporal fibrosis and erectile function by normalizing the limK2/Cofilin pathway.

关键词： erectile dysfunction fibrosis lim kinase penis prostatectomy

Influence of Site-Specific Fertilizer Application Using Gps and Digital Fertility Map on Rice Yield and Quality

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Influence of Site-Specific Fertilizer Application Using Gps ...

Stevens-Johnson Syndrome and Hypothermia Associated with Anti-tuberculosis Medication in a Patient with Heart Failure

亚洲精细农业与计算机农业应用联合大会

作者： jeong-Hyun Chi Jae-Hong Lee Jung-soo Park Hee-dong Kim Byoung-rourl Choi Kyung-Yeol Park In-Gue Jung Gyeonggi-do Agricultural Research and Extension Services Hwaseong 445-972 Korea National Academy of Agricultural Science Rural Development Administration Suwon 441-857 Korea

Th is study was conducted to investigate the effect of site-specific variable fertilization following digital fert ility map generated fro m soil analysis on rice growth and yield. The site -specific application of fert ilizer was implemented by using rice transplanter equipped with side dressing applicator and global positioning system（GPS）. Coefficient of variation（C.V.） o f soil nitrogen content was reduced after experiment, and spatial variat ion of semivariogram was reduced. Rice g rowth fro m tillering to ripening stage, plant height, tiller and panicle nu mber increased at site -specific variable fertilization treat ment, and coefficient variation（C.V.） of each growth characteristics was lower than those of conventional fertilizat ion treat ment. As a result, rice field uniformity increased by site-specific variable fertilizer application. Head rice y ield of site-specific application plot increased by 9% to 492kg/10a fro m 450kg/10a of the control plot, and its CV was significantly reduced to 3.5 compared to 7.8 o f the control plot. In addition, there was no significant difference at amy lose, protein contents and whiteness of milled rice, but its CV was reduced.

关键词： Site-specific variable fertilization Dig ital fertility map So il nitrogen content Rice gro wth Head rice yield Protein contents

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Chinese Medical Journal 2015年第20期128卷 2837-2838页

作者： Sang-Ok Jung Min-Ji Cho Dong-II Park Sun-Young Kim Ju-Ock Kim Sung-soo Jung Hee-Sun Park jeong-Eun Lee Jae-Young Moon Chae-Uk Chung Department of Internal Medicine Division of Pulmonology and Critical Care Medicine College of Medicine Chungnam National University Hospital Jung-gu Daejeon 301-721 Korea

To the Editor： Although rare, multiple adverse events associated with anti-tuberculosis （TB） medication can occur simultaneously in patients with underlying diseases. Here, we describe a 76-year-old man with several preexisting disorders in whom anti-TB medication caused multiple, simultaneous adverse events, including Stevens-Johnson syndrome （SJS）, hypothermia, and lactic acidosis.

关键词： tuberculosis patient diseases

Characterization of mouse clonal mesenchymal stem cell lines established by subfractionation culturing method

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World Journal of Stem Cells 2011年第8期3卷 70-82页

作者： Myung-Shin Jeon Tac-Ghee Yi Hyun-Ja lim Sun-Hwa Moon Moon-Hee Lee Joon-soon Kang Chul-soo Kim Dae-Hyun Lee Sun U Song Clinical Research Center School of Medicine Inha University 7-2063-GaShinheung-DongChung-GuInchon 400-711South Korea

AIM:To characterize single-cell-derived mouse clonal mesenchymal stem cells (mcMSCs) established with bone marrow samples from three different mouse strains. METHODS:We established mcMSC lines using subfractionation culturing method from bone marrow samples obtained from long *** lines were characterized by measuring cell growth, cell surface epitopes, differentiation potential, lineage-specific gene expression and T-cell suppression capability. Nonclonal MSCs isolated by the conventional gradient centrifugation method were used as controls. RESULTS:All mcMSC lines showed typical nonclonal MSC-like spindle shape morphology. Lines differed inoptimal growth density *** surface epitope prof iles of these mcMSC lines were similar to those of nonclonal MSCs. However, some lines exhibited different expression levels in a few epitopes, such as CD44 and CD105. Differentiation assays showed that 90% of the mcMSC lines were capable of differentiating into adipogenic and/or chondrogenic lineages, but only 20% showed osteogenic lineage differentiation. T-cell suppression analysis showed that 75% of the lines exhibited T-cell suppression capability. CONCLUSION:mcMSC lines have similar cell morphology and cell growth rate but exhibit variations in their cell surface epitopes, differentiation potential, lineage-specifi c gene expression and T-cell suppression capability.

关键词： Clonal stem cells Bone marrow stem cells Multilineage differentiation Clonal stromal cell isolation T-cell suppression

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不同粒径级砂土渗透破坏特性试验研究

人民珠江 2018年第7期39卷 57-62页

作者：穆林钧钟加录 lim jeong Yeul 金光日延边大学工学院土木工程系吉林延吉133020 K-water Institute Infrastructure Research Center

砂土渗透破坏的本质是水土相互作用的结果,由于土体内部单个颗粒的实际受力情况差异较大,影响土体管涌破坏的参数的研究甚少。利用自主改进组装的渗透破坏试验装置,进行了一系列砂土室内渗透破坏试验,采用误差及回归方程方法研究了颗粒... 详细信息

砂土渗透破坏的本质是水土相互作用的结果,由于土体内部单个颗粒的实际受力情况差异较大,影响土体管涌破坏的参数的研究甚少。利用自主改进组装的渗透破坏试验装置,进行了一系列砂土室内渗透破坏试验,采用误差及回归方程方法研究了颗粒级配、约束应力等对砂土渗透破坏特性的影响,得出了试样渗透破坏过程中涌砂量、渗流流速、水头差等的变化规律。试验结果表明:在应力为150 kPa,最大粒径为5 mm时,管涌破坏的流沙量达到最小值;基于试验数据,研究了砂土管涌破坏过程中管涌参数的变化规律以及管涌侵蚀机理,为管涌险情的预警预报进一步提供科学的理论依据。

关键词：砂土渗透破坏参数侵蚀机理管涌

利用GPS信息的并联混合动力公交车的监控算法(英文)

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汽车安全与节能学报 2011年第1期2卷 39-44页

作者： Daeheung LEE Jongyeol jeong Changwoo SHIN Yeongil PARK Wonsik lim Sukwon CHA 国立首尔大学机械与航天工程学院国立首尔技术大学机械设计与汽车工程学院国立首尔技术大学汽车工程系

为使混合动力电动公交车更加有效,开发了一种控制发动机和电动机之间的功率分布的监控策略。该混合动力公交车的监控器利用所采集的诸如海拔高度、车速和来自全球定位系统(GPS)接收器的路线图等信息,优化燃料经济性。在两种动力源之间,... 详细信息

为使混合动力电动公交车更加有效,开发了一种控制发动机和电动机之间的功率分布的监控策略。该混合动力公交车的监控器利用所采集的诸如海拔高度、车速和来自全球定位系统(GPS)接收器的路线图等信息,优化燃料经济性。在两种动力源之间,该控制算法使用了功率分配比(PSR)。通过动力学编程理论所导出的功率分配比(PSR)曲线,可以导出一种最佳控制方案。结果表明:与常规公交车相比,该并联混合公交车节省燃料消耗15%～40%。

关键词：混合动力电动汽车(HEV) 控制算法荷电状态(SOC) 全球定位系统(GPS) 功率分配比(PSR)

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中国、韩国、日本传统医学简介与比较

亚太传统医药 2017年第16期13卷 1-2页

作者： Hye-lim Park Hun-soo Lee Byung-Cheul Shin Jian-Ping Liu Qinghua Shang Hitoshi Yamashita Byungmook lim 国立釜山大学北京中医药大学大阪医科大学

传统医学在中国、韩国、日本均比较受欢迎。通过查阅政府网站、相关研究报告,总结比较三个国家传统医学在政策、教育方面的异同。结果表明,中韩两国的传统医学体系较为相似,而日本传统医学体系与两者差异较大。在教育方面,中韩两国都是... 详细信息

传统医学在中国、韩国、日本均比较受欢迎。通过查阅政府网站、相关研究报告,总结比较三个国家传统医学在政策、教育方面的异同。结果表明,中韩两国的传统医学体系较为相似,而日本传统医学体系与两者差异较大。在教育方面,中韩两国都是双系统教学体系,传统医学与现代医学共同教学。平均每个传统医学专业学生要接受6年的教育才能有资格行医。针刺、艾灸、拔罐等均是纳入医保的医疗手法。然而,在日本,常规西医占主流地位,只有一些主流传统医学治疗方法才被纳入医保。三个国家传统医学的异同都是基于各国多年文化背景与相关政策的影响,了解其异同有利于相互学习、共同进步。

关键词：传统医学中国韩国日本

Forward-viewing endoscopic ultrasound-guided NOTES interventions: A study on peritoneoscopic potential

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World Journal of Gastroenterology 2013年第41期19卷 7160-7167页

作者： Seung Uk jeong Hassanuddin Aizan Tae Jun Song Dong Wan Seo Su-Hui Kim Do Hyun Park Sang soo Lee Sung Koo Lee Myung-Hwan Kim Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 138-736South Korea Department of Internal Medicine Ilsan Paik HospitalInje UniversityKoyang 411-706South Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To evaluate the feasibility of diagnostic and therapeutic transgastric(TG)peritoneoscopic interventions with a forward-viewing endoscopic ultrasound(FV-EUS).METHODS:This prospective endoscopic experimental study used an animal *** TG peritoneoscopic interventions and EUS examination of the intraabdominal organs were performed using an FV-EUS on 10 animal models(1 porcine and 9 canine).The procedures carried out include EUS evaluation and endoscopic biopsy of intraperitoneal organs,EUS-guided fine needle aspiration(EUS-FNA),EUS-guided radiofrequency ablation(EUS-RFA),and argon plasma coagulation(APC)for hemostatic *** animals were kept alive for 7 d,and then necropsy was performed to evaluate results and ***:In all 10 animals,TG peritoneoscopy,followed by endoscopic biopsy for the liver,spleen,abdominal wall,and omentum,was performed *** helped control minor *** of intra-abdominal solid organs with real-time EUS was accomplished with *** EUS-FNA was successfully performed on the liver,spleen,and ***,a successful outcome was achieved with EUSRFA of the hepatic *** adverse events were recorded during the ***:Peritoneoscopic natural orifice transluminal endoscopic surgery(NOTES)interventions through FV-EUS were feasible in providing evaluation and performing endoscopic *** promises potential as a platform for future EUS-based NOTES.

关键词： Forward-viewing endoscopic ultrasound Oblique-viewing endoscopic ultrasound Endoscopic ultrasound guided intervention Peritoneoscopy Natural orifice transluminal endoscopic surgery

Analysis on the Direct-Driven High Power Permanent Magnet Generator for Wind Turbine

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Analysis on the Direct-Driven High Power Permanent Magnet Ge...