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Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： soo Young Cho Dong Hae Ho Sae Byeok Jo jeong Ho Cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

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World Journal of Emergency Medicine 2024年第4期15卷 256-262页

作者： Jie Er Janice soo Yuan Helen Zhang Gek Hsiang lim Fatimah Lateef Department of Emergency Medicine Singapore General HospitalSingapore 168753Singapore Health Services Research Unit Singapore General HospitalSingapore168753Singapore

BACKGROUND:This study aimed to review bicycle-related injuries during the COVID-19 pandemic to assist with reinforcement or implementation of new policies for injury ***:This is a retrospective descriptive analysis of injuries sustained during cycling for patients 18 years old and above who presented to Singapore General Hospital from January to June *** records were reviewed and *** analyses were used to summarize patient characteristics,and differences in characteristics subgrouped by triage acuity and discharge status were ***:The study included 272 patients with a mean age of 43 years and a male predominance(71.7%).Most presented without referrals(88.2%)and were not conveyed by ambulances(70.6%).Based on acuity category,there were 24(8.8%)Priority 1(P1)patients with 7 trauma activations,174(64.0%)and 74(27.2%)P2 and P3 patients *** most common injuries were fractures(34.2%),followed by superficial abrasion/contusion(29.4%)and laceration/wound(19.1%).Thirteen(4.8%)patients experienced head injury and 85 patients(31.3%)were documented to be wearing a *** majority occurred on the roads as traffic accidents(32.7%).Forty-two patients(15.4%)were admitted with a mean length of stay of 4.1 d and 17(6.3%)undergone surgical *** of 214(78.7%)discharged patients,no re-attendances or mortality were *** the subgroup analysis,higher acuity patients were generally older,with higher proportions of head injuries leading to ***:Our study highlights significant morbidities in bicycle-related *** is also a high proportion of fractures in the young healthy male *** prevention is paramount and we propose emphasizing helmet use and road user safety.

关键词： Cycling Injuries Emergency department

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Flexible thermocouple using a thermoelectric graphene fiber with a seamless junction

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Journal of Materials Science & Technology 2024年第5期172卷 15-22页

作者： Seungwon Kim soomook lim Myeong Hee jeong Wonjoon Kim Seunghyun Baik Ji Won Suk School of Mechanical Engineering Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea Department of Smart Fab.Technology Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea

Temperature is an important physical variable that indicates the condition of the human body and artificial *** wearable applications require the development of temperature sensors with different form *** this study,a fiber-shaped thermoelectric temperature sensor is fabricated using a continuous graphene fiber whose two halves possess different reduction states.A seamless junction is formed by partially reducing a wet-spun graphene oxide fiber with hydroiodic acid(HI)solutions of different ***-half of the fiber is mildly reduced with 0.97 wt%HI,while the other half is highly reduced with 30.6 wt%*** different reduction states of the graphene composite fiber result in different Seebeck coefficients,allowing for the fabrication of a fiber-shaped graphene thermocou-ple without any laborious *** flexible graphene thermocouple exhibits high sensitivity with a thermopower of 12.5μV K^(-1)in the temperature range of room temperature to∼70℃.Furthermore,it exhibits high linearity with a correlation coefficient exceeding 0.995 and fast response with a time constant of 0.24 *** to its mechanical robustness and flexibility,the stand-alone graphene ther-mocouple can be knitted into a cotton fabric glove,which presents a fast response to environmental changes without any external power *** work offers a unique fabrication method for producing a high-performance,flexible thermocouple that features a seamless and clear junction without the use of additional *** alternative method eliminates the complicated assembly processes typically required for conventional thermocouples.

关键词： Graphene fiber Thermocouple Reduced graphene oxide Flexible temperature sensor Seebeck coefficient

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Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway

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Oncology Research 2024年第2期32卷 273-282页

作者： MINJI PARK CHULHWAN BANG WON-soo YUN YUN-MI jeong T&R Biofab Co. Ltd.Seongnam-si13487Korea Department of Dermatology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul02706Korea Department of Mechanical Engineering Tech University of KoreaSi-heung City15073Korea

Fucoidan,a sulfate polysaccharide obtained from brown seaweed,has various bioactive properties,including anti-inflammatory,anti-cancer,anti-viral,anti-oxidant,anti-coagulant,anti-thrombotic,anti-angiogenic,and anti-Helicobacter pylori ***,the effects of low-molecular-weight fucoidan(LMW-F)on melanoma cell lines and three dimensional(3D)cell culture models are not well *** study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced *** wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller *** and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells and patientderived melanoma explants in a 3D-printed collagen *** PTEN/AKT pathway was found to be involved in the anti-melanoma effects of *** blot analysis revealed that LMW-F reduced the phosphorylation of Bcl-2 at Thr 56,which was associated with the prevention of anti-apoptotic activity of cancer *** findings suggested that LMW-F could enhance anti-melanoma chemotherapy and improve the outcomes of patients with melanoma resistance.

关键词： Low-molecular-weight fucoidan Melanoma Patient-derived melanoma explants in a 3D-printed collagen scaffold Anti-melanoma effect PTEN-AKT-Bcl-2 network

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Porocarcinoma in a palm reconstructed with a full thickness skin graft: A case report

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World Journal of Clinical Cases 2024年第3期12卷 665-670页

作者： Seok Beom lim Kun Young Kwon Hoon Kim soo Yeon lim In Chang Koh Department of Plastic and Reconstructive Surgery Konyang University Medical CenterKonyang University of College of MedicineDaejeon 35365South Korea Department of Pathology Konyang University Medical CenterKonyang University of College of MedicineDaejeon 35365South Korea

BACKGROUND Porocarcinoma is a rare type of skin cancer that originates from sweat gland *** is an aggressive malignant skin cancer that is difficult to diagnose clinically owing to its rarity and similarity to squamous cell carcinoma(SCC).CASE SUMMARY This case involved a 92-year-old woman,a farmer by profession,presented with an exophytic and verrucous mass on her left palm that had formed 2 years prior and caused chronic pain and frequent ***,the patient was diagnosed with SCC using a punch biopsy;however,a repeat biopsy with addi-tional immunohistochemical tests was performed for ***,the patient was diagnosed with porocarcinoma and reconstruction was planned using a full-thickness skin *** treatment,the range of motion of the palm was preserved,and the aesthetic outcome was *** 6 mo of follow-up,the patient was satisfied with the *** Porocarcinoma is commonly misdiagnosed as SCC;therefore,clinicians should consider porocarcinomas when evaluating mass-like lesions on the hands.

关键词： Eccrine porocarcinoma Hand defects Reconstructive surgery Sweat gland tumor Skin graft Case report

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Transparent high-performance piezoceramics through pressureless sintering

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Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-lim Yu Woo-Seok Kang Ju-Hyeon Lee Temesgen Tadeyos Zate Young-Jin Lee Bo-Kun Koo Dong-Jin Shin Min-soo Kim soon-Jong jeong Young Ghyu Ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer *** has been a consistent demand for transparent piezoelectric materials for optoelectrical ***,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric ***,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial ***,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline *** this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)*** utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/*** material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

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Immediate secondary rhinoplasty using a folded dermofat graft for resolving complications related to silicone implants: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2426-2430页

作者： Hoon Kim Jong Hyup Kim In Chang Koh soo Yeon lim Department of Plastic and Reconstructive Surgery Konyang University HospitalUniversity of Konyang College of MedicineMyunggok Medical Research InstituteDaejeon 35365South Korea

BACKGROUND Various surgical techniques have been developed to enhance the nose shapes of Asian *** implant augmentation rhinoplasty is widely used because it is relatively easy to perform and often yields satisfactory ***,this technique may lead to complications,including ischemia,necrosis,and *** most appropriate management of these complications,including infection,is immediate implant removal and revision surgery once the accompanying inflammation has ***,the patient may experience distress from nasal deformities during the intervention *** SUMMARY Herein,we describe the case of a patient who underwent a secondary dorsal augmentation,with a folded dermofat graft harvested from the inguinal area and simultaneous implant removal,successfully preventing dimpling of the nasal *** This surgical method can effectively manage implant-related complications following augmentation rhinoplasty using a silicone implant and provide satis-factory patient outcomes.

关键词： Complications Nose deformities Acquired Rhinoplasty Dermofat Surgery Plastic Case report

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Enhancement of liposomal stability and cellular drug uptake by incorporating tributyrin into celecoxib-loaded liposomes

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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 128-133页

作者： Sung Nam Kang soon-Seok Hong soo-Yeon Kim Heungchan Oh Mi-Kyung Lee soo-jeong lim Department of Bioscience and Biotechnology Sejong University98 Kunja-dongKwangjin-guSeoul 143-747Republic of Korea Hanil High School GongjuChungchungnam-Do 314-714Republic of Korea College of Pharmacy Woosuk UniversityWanju-gunJeollabuk-Do 565-701Republic of Korea

Tributyrin,a triglyceride analog of short chain fatty acid butyrate,can act as a prodrug of an anticancer agent *** view of other reports that demonstrated the improved characteristics of conventional liposomes by incorporating small amount of nonphospholipids such as Tween 80,herein we sought to investigate whether the incorporation of tributyrin into the liposomal layers may provide additional advantages for liposomes as an anticancer drug *** were prepared with dimyristoylphosphatidylcholine as a main phospholipid with or without addition of *** was loaded in liposomes as a model anticancer *** 80-incorporated liposomes were also prepared for ***-incorporated liposomes were ineffective in enhancing the skin permeation of celecoxib compared to Tween 80-incorporated ***,tributyrin-incorporated liposomes enhanced the entrapped celecoxib concentration to an extent comparable to Tween 80-incorporated ***,tributyrin-incorporated liposomes exhibited much higher stability compared to Tween 80-incorporated ***,the cellular uptake of celecoxib loaded in tributyrin-incorporated liposomes into mouse melanoma cells were more than 10-fold higher compared to that loaded in conventional-and Tween 80-incorporated *** together,the incorporation of tributyrin into conventional liposomes loaded with anticancer drugs may provide an advanced anticancer drug carrier delivering both drug and tributyrin.

关键词： Tributyrin Liposomes Celecoxib Cancer Formulation

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong Lee Su Bin lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal Byungkwon Yoo Jun Young Jo Nilufer Cakmakci Shabbir Madad Naqvi Hyerim Kim Sungmin Jung Noushad Hussain Ujala Zafar soo Yeong Cho Seunghwan jeong Jaewoo Kim Jung Min Oh Sangwoon Park Youngjin jeong Chong Min Koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center INNOMXENE Co. Ltd.Daejeon 34365Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)C_(2)T_(x) MXene and mechanically-robust carbon nanotube(CNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resistance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissivity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance when exposed to 250 W IR *** multifunctional MXene/CNT Janus film offers a feasible solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

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