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Old stellar population synthesis:new age and mass estimates for Mayall II = G1

Research in Astronomy and Astrophysics 2009年第6期9卷 641-652页

作者： Jun Ma Richard de Grijs Zhou Fan soo-chang rey Zhen-Yu Wu Xu Zhou Jiang-Hua Wu Zhao-Ji Jiang Jian-Sheng Chen Kyungsook Lee Sangmo Tony Sohn National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Physics ＆ Astronomy The University of Sheffield Hicks Building Hounsfield Road Sheffield S3 7RH UK Graduate University Chinese Academy of Sciences Beijing 100049 China Department of Astronomy and Space Science Chungnam National University Daejeon 305-764 Korea Center for Space Astrophysics Yonsei University Seoul 120-749 Korea California Institute of Technology MC 405-47 1200 E. California Boulevard Pasadena CA 91125

Mayall Ⅱ = G1 is one of the most luminous globular clusters （GCs） in M31. Here, we determine its age and mass by comparing multicolor photometry with theoretical stellar population synthesis models. Based on far- and near-ultraviolet GALEX photometry, broad-band UBVRI, and infrared JHKs 2MASS data, we construct the most extensive spectral energy distribution of G 1 to date, spanning the wavelength range from 1538 to 20 000A. A quantitative comparison with a variety of simple stellar population （SSP） models yields a mean age which is consistent with G1 being among the oldest building blocks of M31 and having formed within ～1.7 Gyr after the Big Bang. Irrespective of the SSP model or stellar initial mass function adopted, the resulting mass estimates （of order 10^7M⊙） indicate that GI is one of the most massive GCs in the Local Group. However, we speculate that the cluster＇s exceptionally high mass suggests that it may not be a genuine GC. Our results also suggest that G1 may contain, on average, （1.65±0.63） × 10^2L⊙ far-ultraviolet-bright, hot, extreme horizontal-branch stars, depending on the adopted SSP model. In addition, we demonstrate that extensive multi-passband photometry coupled with SSP analysis enables one to obtain age estimates for old SSPs that have similar accuracies as those from integrated spectroscopy or resolved stellar photometry, provided that some of the free parameters can be constrained independently.

关键词： galaxies individual (M31) -- galaxies star clusters -- galaxies stellar content

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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-González Elena González-rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la Cruz-Ojeda Ester Parras-Martínez Raquel rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors Laboratory Centre de Recherche des CordeliersParis 75006France Department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MALAT,THAP9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir-374b-3p/SMAD7 and MALAT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib

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Role of bioengineering structures made of willow cuttings in marly sediment trapping: assessment of three real-size experiments in the Southern French Alps

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Journal of Mountain Science 2018年第2期15卷 225-236页

作者： Freddy rey Univ.Grenoble Alpes Irstea Grenoble

Improving knowledge on the ability of bioengineering structures made of willow cuttings to enhance efficient and sustainable sediment trapping in marly gullies in the Southern French Alps under a mountainous Mediterranean climate, to decreasesediment trapped per experiment, the mean annual values reached 0.25, 0.14 and 0.08 m3 yr-1 in experiments C, A and B, respectively. Maximum values for one structure reached 1.94 m3 per year in experiment C. The significance of the volumes ofsediment yield at their outlets, is a key issue today for the international scientific community working in geosciences and ecology. This study therefore aims to assess three real-size experiments(A, B and C) carried out between 2003 and 2013 in this environment. A total of 157 bioengineering structures using purple and white willow(Salix purpurea and Salix incana)cuttings – which have been shown to resprout and survive more than 2 years after their installation,corresponding to brush layers with brush mats on wooden sills(BLM), 1.2 m wide and 2 m long,installed on the floors of 33 experimental marly gullies, were monitored. The results showed that sediment trapping occurred upstream of the vegetation barriers from the 1 st year *** the depth of sediment trapped per experiment, the mean annual values reached 11.2 cm yr-1 after 3 years in experiment A, 7.7 cm yr-1 after 2–4 years in experiment C and 5.1 cm yr-1 after 5 years in experiment B. Occasionally, BLMs showed that they could trap up to 16 and 15 cm yr-1 in experiments A and C, respectively. Considering the volumes oftrapped sediment and the sustainability of sediment trapping are discussed, and rules for bioengineering strategies are proposed.

关键词： Erosion Marly gully Vegetation barriers Ecological engineering Salix

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Synthetic gauge fields for ultracold atoms

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National Science Review 2016年第2期3卷 166-167页

作者： Ana Maria rey JILA NIST and Department of PhysicsUniversity of Colorado

Ultracold gases are remarkably versatile and controllable systems with untapped potential to emulate a variety of quantum phenomena[1].Atoms are,however,electrically neutral and therefore it is highly desirable to make them behave as charged *** capability has recently been demonstrated in a series of recent experiments[2-4].Although many challenges remain ahead,

关键词： Synthetic gauge fields for ultracold atoms

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Clustering of voltage-gated ion channels as an evolutionary trigger of myelin formation

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Neural Regeneration Research 2024年第8期19卷 1631-1632页

作者： Henrike Ohm Simone rey Christian Klambt Institut fur Neuro-und Verhaltensbiologie MunsterGermany

Neurons carry apical dendrites that perceive information and a basal axon that transmits the computed information towards its to *** axon originates at the axon hillock which is followed by the axon initial ***,action potentials are initiated that are based on millisecond long openings of specific voltagegated sodium and potassium channels that are conserved in all parahoxozoa(Placozoa,Cnidaria,Bilateria)(Li et al.,2015).

关键词： initiated carry potassium

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The Prevalence and Surgical Repair of Canine Medial Patellar Luxation in Southern Taiwan

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畜牧与兽医 2012年第S2期44卷 59-60页

作者： Chi-Hsien Chien rey-Shyong Chen Pei-Chun Chiu Chih-chang Peng College of Veterinary Medicine Small Animal Surgery and AcupunctureAnimal Hospital National Pingtung University of Science and Technology

Medial patella luxation(MPL)is most common orthopedic disease in toy and miniature *** breed predisposition in the United States has been reported for the Boston Terrier,Chihuahua,Pomeranian,Miniature Poodle,and Yorkshire Terrier[1].In Japan,beside Pomeranian and toy poodle,the Japanese Chin and Shiba are mostly affected breeds[2].Multiple surgical techniques have been applied successfully to correct such disorders including

关键词： medial Japanese miniature breed correct mostly Taiwan Boston bilateral groove

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New strategies for ischemic stroke: internal photobiomodulation therapy

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Neural Regeneration Research 2020年第9期15卷 1658-1659页

作者： Ramón Iglesias-rey José Castillo Clinical Neurosciences Research Laboratory (LINC) Health Research Institute of Santiago de Compostela (IDIS) Clinical University Hospital Universidade de Santiago de Compostela

Epidemiology and physiopathology of ischemic stroke:Every year, around 15 million of people suffer a stroke event all around the world. Among those, around 6.7 million will die, and most of the survivors will suffer s... 详细信息

关键词： pathology Epidemiology ischemic

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Downed logs improve soil properties in old-growth temperate forests of northern Iran

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Pedosphere 2020年第3期30卷 378-389页

作者： Negar MOGHIMIAN Seyed Gholamali JALALI Yahya KOOCH Ana rey Faculty of Natural Resources&Marine Sciences Tarbiat Modares UniversityNoor 46417-76489Iran Department of Biogeography and Global change National Museum of Natural History(MNCN)Spanish Scientific Council(CSIC)C/Serrano 115bisMadrid 28006(Spain

Dead trees, particularly downed logs, play an important role in the dynamics of forest ecosystem. Contribution of decaying wood to C and nutrient pools of forest soils depends on the tree species and degree of wood decay. However, the extent to which the downed logs affect the soil properties of temperate forests has rarely been evaluated. In this study, a mixed beech forest was selected in Liresar region of Mazandaran Province, northern Iran, to investigate if and how the presence of downed logs affected soil quality and function by comparing soils underneath degraded logs and nearby soils of the two dominant tree species(beech and hornbeam). We then explored how these effects occurred as downed logs decomposed by comparing the woods of both tree species at four degrees of decomposition. Degree of decay of downed logs was classified into four classes(DC1–DC4). Eight dead trees of each tree species were selected at the center of each sample plot. Three composite soil samples underneath each decaying log and 100 cm away from a decaying log were collected at two soil depths(0–15 and 15–30 cm) to analyze soil main physicochemical properties and microbial activity. The results revealed that downed logs affected soil physical(5% wetter than control soils), chemical(2% lower pH, 100% increase in organic C and total N in the case of hornbeam, and 2% increase in P), and biological characteristics(soil microbial respiration enhanced by 10%, and microbial biomass C 620 and 351.5 mg kg-1 and microbial biomass N 66.47 and 32.18 mg kg-1, respectively, in the cases of beech and hornbeam), thus resulting in significantly different soil microsites from those without downed logs. Presence of downed logs increased soil microbial activity and soil fertility as wood decayed. Thus, the presence of downed logs is an important factor influencing forest soils and should be taken into consideration in forest management practices.

关键词： beech course woody debris dead tree decay degree hornbeam soil microbial activity soil physicochemical properties

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Insights on ZEB1-AS1:emerging role from cancer to neurodegeneration

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Neural Regeneration Research 2024年第6期19卷 1187-1188页

作者： Stephana Carelli Federica rey Erika Maghraby Cristina Cereda Pediatric Research Center“Romeo ed Enrica Invernizzi” Department of Biomedical and Clinical SciencesUniversity of MilanMilanItaly Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children’s HospitalMilanItaly Department of Biology and Biotechnology“L.Spallanzani” University of PaviaPaviaItaly

Implications for lncRNAs in the central nervous system:Transcriptional dysregulation is a key contributor to the pathogenesis of a wide range of diseases and long non-coding RNAs(lncRNAs)are highly expressed in the nervous ***,amongst the over 50,000 lncRNAs expressed in the human genome,more than 40%are specifically expressed in the brain where their roles in brain development,neuron functions,maintenance.

关键词： ZEB1 diseases pathogenesis

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