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Diagnostic accuracy of administrative database for bile duct cancer by ICD-10 code in a tertiary institute in Korea

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 575-580页

作者： young-Jae Hwang Seon Mee park soomin Ahn Jongchan Lee young soo park Nayoung Kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnamKorea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongjuKorea Department of Pathology Seoul National University Bundang HospitalSeoungnamKorea Department of Internal Medicine and Institute of Liver Research Seoul National University College of MedicineSeoulKorea Tumor Microenvironment Global Core Research Center Seoul National UniversitySeoulKorea

Background:Administrative database provides valuable information for large cohort studies,especially when tissue diagnosis is rather difficult such as the diagnosis for bile duct cancer(BDC).The aim of this study was to evaluate the diagnostic accuracy of administrative database for BDC by International Classification of Diseases(ICD)-10 codes in a tertiary ***:BDC and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of BDC were identified in the National Health Insurance Service(NHIS)database by ICD 10-code supported by V *** control group was selected from cases without ICD-10 codes for BDC.A definite or possible diagnosis was defined according to pathologic *** records,images,and pathology reports were analyzed to evaluate ICD-10 codes for ***,specificity,positive predictive value,and negative predictive value for BDC were analyzed according to diagnostic criteria and cancer ***:A total of 1707 patients with BDC and 1707 controls were *** those with BDC,1320(77.3%)were diagnosed by definite ***(99.4%)of them had *** of definite diagnosis was the highest for ampulla of Vater(88.9%),followed by that for extrahepatic(84.9%)and intrahepatic(68.3%)*** positive cases commonly had hepatocellular *** overall diagnosis of BDC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.94%,98.33%,98.30%,and 99.94%,*** accuracies were similar regardless of diagnostic criteria or tumor ***:Administrative database for BDC collected according to ICD-10 code with V code shows good accuracy.

关键词： National Health Insurance Service Bile duct cancer ICD-10

Complete remission of advanced hepatocellular carcinoma by radiofrequency ablation after sorafenib therapy

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World Journal of Gastroenterology 2015年第8期21卷 2568-2572页

作者： Jung Gil park soo young park Hye Won Lee Division of Gastroenterology and Hepatology Department of Internal Medicine CHA University Gumi CHA Medical Center Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Kyungpook National University Department of Pathology School of Medicine Kyungpook National University

Sorafenib,a potent multikinase inhibitor,lead to a significant improvement in progression free survival and overall survival in patients with advanced hepatocellular carcinoma(HCC).Though sorafenib has proven its efficacy in advanced stage HCC,there are limitedreports on the role of sorafenib allowing for curative treatment by *** herein report a case of advanced HCC with vascular invasion,which showed treatment response by sorafenib therapy as to allow for radiofrequency ablation as curative *** patient was followed-up for 6 mo without recurrence with continued sorafenib therapy.

关键词： Hepatocellular carcinoma Radiofrequency ablation S

Indolocarbazole-Based Small Molecule Cathode-Active Material Exhibiting Double Redox for High-Voltage Li-Organic Batteries

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Energy & Environmental Materials 2024年第5期7卷 86-94页

作者： Hyunji park Hyojin Kye Jong-Sung Lee young-Chang Joo Dong Joo Min Bong-Gi Kim soo young park Ji Eon Kwon Laboratory for Supramolecular Optoelectronic Materials(LSOM) Department of Materials Science and EngineeringResearch Institute of Advanced Materials(RIAM)Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite MaterialsKorea Institute of Science and Technology(KIST)92 Chudong-roBongdong-eupWanju-gunJeonbuk 55324Korea Department of Organic and Nano System Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University567 Baekje-daeroDeokjin-guJeonjuJeonbuk 54896Korea

Most organic electrode materials(OEMs)for rechargeable batteries employ n-type redox centers,whose redox potentials are intrinsically limited<3.0 V versus Li^(+)/***,p-type materials possessing high redox potentials experience low specific capacities because they are capable of only a single redox reaction within the stable electrochemical window of typical ***,we report 5,11-diethyl-5,11-dihydroindolo[3,2-b]carbazole(DEICZ)as a novel p-type OEM,exhibiting stable plateaus at high discharge potentials of 3.44 and 4.09 V versus Li^(+)/***,the second redox potential of DEICZ is within the stable electrochemical *** mechanism of the double redox reaction is investigated using both theoretical calculations and experimental measurements,including density functional theory calculations,ex situ electron spin resonance,and X-ray photoelectron ***,hybridization with single-walled carbon nanotubes(SWCNT)improves the cycle stability and rate performance of DEICZ owing to theπ-πinteractions between the SWCNT and co-planar molecular structure of DEICZ,preventing the dissolution of active materials into the *** DEICZ/SWCNT composite electrode maintains 70.4%of its initial specific capacity at 1-C rate and also exhibits high-rate capability,even performing well at 100-C ***,we demonstrate its potential for flexible batteries after applying 1000 bending stresses to the composite electrode.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

Accuracy of an administrative database for pancreatic cancer by international classification of disease 10th codes: A retrospective large-cohort study

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World Journal of Gastroenterology 2019年第37期25卷 5619-5629页

作者： young-Jae Hwang Seon Mee park soomin Ahn Jong-Chan Lee young soo park Nayoung Kim Departments of Internal Medicine Seoul National University Bundang HospitalSeoungnam 13620South Korea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongju 28644South Korea Departments of Pathology Seoul National University Bundang HospitalSeoungnam 13620South Korea Department of Internal Medicine and Institute of Liver Research and Tumor Microenvironment Global Core Research Center Seoul National University College of MedicineSeoul 08826South Korea

BACKGROUND Korean National Health Insurance(NHI)claims database provides ***,studies regarding accuracy of administrative database for pancreatic cancer(PC)have not been *** aimed to identify accuracy of NHI database regarding PC classified by international classification of disease(ICD)-10 *** To identify the accuracy and usefulness of administrative database in PC and the accurate ICD codes for PC with *** Study and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of PC were identified in NHI database by international classification of diseases,10th revision edition(ICD-10 codes)supported with V codes.V code is issued by medical doctors for covering 95%of medical cost by Korean *** to pathologic reports,definite or possible diagnoses were defined using medical records,images,and *** A total of 1846 cases with PC and controls were *** PC,only 410(22.2%)cases were identified as specific cancer sites including head in 234(12.7%)cases,tail in 104(5.6%)cases and body in 72(3.9%)*** PC,910(49.3%)cases were diagnosed by definite *** of these were adenocarcinoma(98.0%).The rates of definite diagnosis of PC were highest in head(70.1%)followed by body(47.2%)and tail(43.3%).False-positive cases were pancreatic cystic neoplasm and metastasis to the *** terms of the overall diagnosis of PC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.95%,98.72%,98.70%,and 99.95%,*** accuracy was similar both in terms of diagnostic criteria and tumor *** Korean NHI claims database collected according to ICD-10 code with V code for PC showed good accuracy.

关键词： Korean national health insurance Accuracy Pancreatic cancer International classification of disease Sensitivity Specificity

Successful treatment of multiple hepatocellular adenomas with percutaneous radiofrequency ablation

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World Journal of Gastroenterology 2013年第42期19卷 7480-7486页

作者： Sun young Ahn soo young park young Oh Kweon Won young Tak Han Ik Bae Seung Hyun Cho Department of Internal Medicine Kyungpook National University HospitalDaegu 700-721South Korea Department of Pathology Kyungpook National University HospitalDaegu 700-721South Korea Department of Radiology Kyungpook National University HospitalDaegu 700-721South Korea

Hepatocellular adenoma (HCA) is one of the important complications of glycogen storage disease type?Ia (GSD-Ia) because it can be transformed into hepatocellular carcinoma. Although surgical resection is a standard treatment of choice for solitary HCA, multiple HCAs in GSD-Ia patients present as therapeutic challenges for curative treatment. Therefore, treatment strategy according to malignant potential is important in management of HCAs in GSD-Ia. The authors present a case of histologically proven multiple HCAs without β-catenin mutations occurred in a GSD-Ia patient treated successfully with percutaneous radiofrequency ablation as a minimally invasive therapy.

关键词： Glycogen storage disease Hepatocellular adenoma Radiofrequency ablation β-catenin activation Glycogen storage disease

Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第43期18卷 6284-6289页

作者： Se young Jang Hyun Gu park Min Kyu Jung Chang Min Cho soo young park Seong Woo Jeon Won young Tak young Oh Kweon Sung Kook Kim young Hoon Jeon Department of Internal Medicine Kyungpook National University School of Medicine Daegu 700-721 South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University School of Dentistry Daegu 700-721 South Korea

AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and 30 November 2010. This was a randomized cross-over study, in which each patient underwent ERCP twice, once with BIS monitoring and once with control monitoring. Whether BIS monitoring was done during the first or second ERCP procedure was random. Patients were intermittently administered a mixed regimen including midazolam, pethidine, and propofol by trained nurses. The nurse used a routine practice to monitor sedation using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale or the BIS monitoring. The total amount of midazolam and propofol used and serious side effects were compared between the BIS and control groups. RESULTS:The mean total propofol dose administered was 53.1 ± 32.2 mg in the BIS group and 54.9 ± 30.8 mg in the control group (P = 0.673). The individual propofol dose received per minute during the ERCP procedure was 2.90 ± 1.83 mg/min in the BIS group and 3.44 ± 2.04 mg in the control group (P = 0.103). The median value of the MOAA/S score during the maintenance phase of sedation was comparable for the two groups. The mean BIS values throughout the procedure (from insertion to removal of the endoscope) were 76.5 ± 8.7 for all 59 patients in using the BIS monitor. No significant differences in the frequency of < 80% oxygen saturation, hypotension (< 80 mmHg), or bradycardia (< 50 beats/min) were observed between the two study groups. Four cases of poor cooperation occurred, in which the procedure should be stopped to add the propofol dose. After adding the propofol, the procedure could be conducted successfully (one case in the BIS group, three cases in the control group). The endoscopist rated patient sedation as exc

关键词： Conscious sedation Bispectral index monitors Pancreatic neoplasm Endoscopic retrograde cholangiopancreatography

Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors——8 cases: A case report

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World Journal of Gastroenterology 2019年第16期25卷 2010-2018页

作者： Jwa Hoon Kim Min-Hee Ryu young soo park Hyun Jin Kim Hyojung park Yoon-Koo Kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Pathology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

BACKGROUND Intra-abdominal desmoid tumors(DTs) can mimic recurrence or progression of gastrointestinal stromal tumors(GISTs). Differential diagnosis is important to avoid unnecessary or inappropriate *** SUMMARY All 8 patients experienced surgical resection of GIST, and median time to diagnosis of DT was 1.8 years after surgical resection. All sites of DT were in the peritoneum around the surgical sites of GIST. The following clinical suspicion coupled with radiological findings contributed to the suspicion of intraabdominal DTs:(1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST;(2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib;(3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and(4) a lesion showing mild or no hypermetabolic activity on 18 fluorodeoxyglucose-positron emission tomography,contrary to initially hyperactive lesion of GIST. All DTs were surgically removed except for one unresectable DT and only one DT recurred at another site of peritoneum, which was also surgically *** Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST.

关键词： Desmoid tumor Gastrointestinal stromal tumor Radiology Surgicalresection Imatinib mesylate Case report

Clinical significance of MET gene amplification in metastatic or locally advanced gastric cancer treated with first-line fluoropyrimidine and platinum combination chemotherapy

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Chinese Journal of Cancer Research 2019年第4期31卷 620-631页

作者： Seyoung Seo Min-Hee Ryu Baek-Yeol Ryoo Yangsoon park young soo park young-soon Na Chae-Won Lee Ju-Kyung Lee Yoon-Koo Kang Departments of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Asan Institute for Life Science Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

Objective: To investigate the clinical significance of MET gene amplification in patients with gastric cancer in the palliative ***: MET amplification was assessed using fluorescence in situ hybridization(FISH) in 50 patients and quantitative polymerase chain reaction(qPCR) in 326 patients;259 patients treated with first-line fluoropyrimidine and platinum were included for survival ***: The results of FISH and qPCR indicated that the c-MET/CEP7 ratio was correlated with gene copy number. The optimal cutoff value for the copy number using qPCR to detect MET gene amplification with FISH was 5(κ=0.778, P5 detected by qPCR. MET-amplified gastric cancer was associated with an Eastern Cooperative Oncology Group(ECOG) performance status(PS) score of ≥2(33.3% vs. 10.5% P=0.007), peritoneal metastasis(76.2% vs. 46.2%, P=0.008), and elevated bilirubin levels(28.6% vs. 7.3%, P=0.006). The median overall survival(OS) and progression-free survival(PFS) were 11.9 and 5.6 months, respectively. MET-amplified gastric cancer was not associated with survival outcomes [hazard ratio(HR)=0.68, 95% confidence interval(95% CI): 0.35-1.32,P=0.254 for PFS;HR=0.68, 95% CI: 0.35-1.32, P=0.251 for OS].Conclusions: qPCR can be used to detect MET gene amplification. MET amplification was not a predictor of poor prognosis in patients with metastatic or unresectable gastric cancer.

关键词： MET amplification advanced gastric cancer prognosis quantitative real-time polymerase chain reaction

Potentiostatic corrosion protection technology under cavitation condition for 5083-H116 Al alloy

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Transactions of Nonferrous Metals Society of China 2013年第11期23卷 3206-3214页

作者： Seung-Jun LEE young-soo park Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Division of Maritime Transportation Science College of Maritime Sciences Korea Maritime and Ocean University

This study aims to characterize the cavitation damage behavior of aluminum alloys in seawater and thus to enhance its cavitation resistance. Potentiostatic experiments were performed under various potential conditions to determine the optimum protection potentials, at which cavitation damage was suppressed. A potential range was selected for the experiment from -2.2 to -1.4 V, which corresponded to the concentration and activation polarization regions on the cathodic polarization curve of the 5083-H116 alloy. After the experiments, the current density-time behavior was investigated, and the degree of surface damage was observed using three-dimensional microscopy and scanning electron microscopy （SEM）, The optimum protection potential was determined to be in the range of-l.9 to -1.5 V under which the cavitation damage was reduced significantly.

关键词： Al alloy cavitation potentiostatic experiment seawater