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Macrophage activation syndrome in children with Kawasaki disease: diagnostic and therapeutic approaches

World Journal of Pediatrics 2020年第6期16卷 566-574页

作者： Seung Beom Han soo-young lee Department of Pediatrics Daejeon St.Mary's Hospital.College of MedicineThe Catholic University of Korea64 Daeheung-ro.Jung-guDaejeon 34943Republic of Korea Department of Pediatrics.Bucheon St.Mary's Hospital College of MedicineThe Catholic University of Korea327 Sosa-roWonmi-gu.Bucheon 14647Republic of Korea

Background Macrophage activation syndrome(MAS)is a rare,life-threatening complication of Kawasaki disease(KD).Early recognition and treatment of MAS are very important,but sometimes it is difficult to distinguish MAS from a severe form of *** sources A PubMed search was performed in Clinical Queries using the key terms“macrophage activation syndrome or secondary hemophagocytic lymphohistiocytosis(HLH)”and“Kawasaki disease”.Results KD patients with MAS show high intravenous immunoglobulin(IVIG)resistance and coronary *** is also as high as MAS in other *** fever greater than 10 days is highly associated with development of MAS in *** is observed in more than two-thirds of KD patients with *** is often the earliest laboratory finding of *** is highly specific and sensitive for detecting MAS in KD;so,ferritin levels should be checked if there are unexplained clinical exacerbations in KD *** the under-recognition of MAS in KD,it is prudent to consider resistant KD as occult/subclinical *** KD patients with MAS have good outcomes on immune ***,if KD patients fulfill the HLH-2004 diagnostic criteria,they may undergo longer and more intensive treatment than *** The possible existence of MAS should be taken into account when a KD patient shows persistent fever,splenomegaly,thrombocytopenia,hyperferritinemia,or IVIG *** under-diagnosis of MAS in patients with KD is an important issue to be ***,however,there is a possibility of over-treatment of MAS in patients with KD.

关键词： Macrophage activation syndrome Kawasaki disease Children

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Febrile infants:written guidelines to reduce non-essential hospitalizations

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World Journal of Pediatrics 2021年第5期17卷 555-556页

作者： Ji Yoon Oh soo-young lee Department of Pediatrics Bucheon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea327 Sosa-roWonmi-guBucheon 14647.Republic of Korea

Management of febrile infants,especially those younger than 3 months of age,is of clinical importance due to the relatively high risk of serious bacterial infection(SBI),such as bacterial meningitis,bacteremia,or urinary tract infection(UTI)[1].Fortunately,reliable guidelines for assessing the risk of SB I in febrile infants have been developed to help determine whether an infant should be hospitalized,undergo lumbar puncture,or be treated with antibiotics[2].However,many hospitals do not have written institutional guidelines,so clinicians often make decisions based on their own experience and knowledge[3-5].For a consistent approach to febrile infants,our hospital plans to introduce written *** this study,we estimated the expected effects of these guidelines and compared our data with the results of previous domestic studies.

关键词： febrile infection urinary

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Antibiotic use in children with Kawasaki disease

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World Journal of Pediatrics 2018年第6期14卷 621-622页

作者： Seung Beom Han soo-young lee Department of Pediatrics St.Paul’s HospitalCollege of MedicineThe Catholic University ofK orea180 Wangsan-roDongdaemun-guSeoul 02559RepublicofK orea

As the diagnostic criteria for Kawasaki disease (KD) consist of the clinical features that are shared by other childhood febrile illnesses [1, 2], KD is sometimes confused with a bacterial infection, leading to clinical situations in which children with the disease receive antibiotics (3–5)Here, we report the extent of antibiotic use in children with KD and the clinical parameters confusing KD with a bacterial infection.

关键词： Antibiotic children Kawasaki disease

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Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

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Acta Pharmaceutica Sinica B 2020年第3期10卷 462-474页

作者： Han Saem Son Jiae lee Hye In lee Narae Kim You-Jin Jo Gong-Rak lee Seong-Eun Hong Minjeong Kwon Nam young Kim Hyun Jin Kim Jin Ha Park soo young lee Woojin Jeong Department of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(BA)has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we explored the role of BA in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly suppressed interleukin-1β(IL-1β)*** inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β*** reporter assay and the inhibitor study of IL-1βtranscription suggested that BA inhibited nuclear factor-κB and activator protein-1 by regulating IκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of IL-1β*** also promoted osteoblast ***,BA protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

关键词： Benzydamine Osteoclast Bone Interleukin-1β Nuclear factor-κB Activator protein-1

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Early rehabilitation programs after laparoscopic colorectal surgery:Evidence and criticism

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World Journal of Gastroenterology 2013年第46期19卷 8543-8551页

作者： Duck-Woo Kim Sung-Bum Kang soo-young lee Heung-Kwon Oh Myung-Hoon In Department of Surgery Seoul National University Bundang Hospital

During the past several decades,early rehabilitation programs for the care of patients with colorectal surgery have gained *** randomized controlled trials and meta-analyses have confirmed that the implementation of these evidence-based detailed perioperative care protocols is useful for early recovery of patients after colorectal *** cared for based on these protocols had a rapid recovery of bowel movement,shortened length of hospital stay,and fewer complications compared with traditional care ***,most of the previous evidence was obtained from studies of early rehabilitation programs adapted to open colonic ***,limited evidence exists on the effects of early rehabilitation after laparoscopic rectal resection,although this procedure seems to be associated with a higher morbidity than that reported with traditional *** this article,we review previous studies and guidelines on early rehabilitation programs in patients undergoing rectal *** investigated the status of early rehabilitation programs in rectal surgery and analyzed the limitations of these *** also summarized indications and detailed protocol components of current early rehabilitation programs after rectal surgery,focusing on laparoscopic resection.

关键词： Colorectal cancer Enhanced recovery after surgery Early rehabilitation Fast-track Laparoscopy Rectal

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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon lee Jeongin Seo Hana lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim soo young lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Unsupervised Extraction of Video Features for Lipreading

Unsupervised Extraction of Video Features for Lipreading

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亚太地区国际脑研究研讨会

作者： Michelle Jeungeun lee soo-young lee Department of BioSystems Department of BioSystems Brain Science Research Center and Department of EECS Korea Advanced Institute of Science and Technology Korea

＜正＞ It is very important to know the basic components of the patterns we want to recognize or synthesize. For speeches the basic components, also called as features, are Gabor-like signals localized both in time and frequency. For images the features are Gabor like edge patterns. In this paper we report the features of video streams extracted from the video clips of human lip motion. Three unsupervised algorithms are investigated for the

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Intra-His bundle block in 2:1 atrioventricular block

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World Journal of Cardiology 2015年第10期7卷 700-702页

作者： Seung Pyo Hong Yon Woong Park young soo lee Division of Cardiology Department of Internal Medicine Daegu Catholic University Medical Center

Intra-hisian atrioventricular(AV) block is not a common phenomenon, but it is important for the development of advanced or complete AV block. We observed a 77-yearold female patient with the 2:1 AV block due to an intrahisian block. In this case we tried to detect the block site, but an alternating pattern of the AH conduction was noted on the His-electrogram in the electrophysiological study(EPS). The cause of the confusing finding might have been the instability of the catheter to record a His potential. We could detect a splitting of the Hiselectrogram with an intra-hisian block after minimal manipulation of the catheter. The authors' observations suggest that catheter stability is important for a precise recording in the EPS and radiofrequency catheter ablation procedure.

关键词： Cardiac electrophysiologic techniques Bundle of Hi

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Exhaustive Exercise Induces Nrf2-driven Antioxidant Enzyme Expression and Apoptosis in Human Peripheral Blood Mononuclear Cells

Exhaustive Exercise Induces Nrf2-driven Antioxidant Enzyme E...

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第14届国际自由基学术大会

作者： Si-young Kim young-soo lee Hye-Kyung Na young-Joon Surh National Research Laboratory of Molecular Carcinogenesis and Chemoprevention College of Pharmacy Seoul National University 599 Gwanak-ro Gwanak-gu Seoul 151-742 South Korea Physical Education College of Arts & Physical Education Sejong University 98 Gunja-Dong Gwangjin-Gu Seoul 143-747 South Korea

＜正＞There are multiple lines of compelling evidence supporting that moderate exercise potentiates body’s defense capacity against various injuries. However, intense exercise causes free radical generation and oxida...

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Korean Atmospheric Environmental Impact Assessment for Thermal Power Plant

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Journal of Geoscience and Environment Protection 2014年第4期2卷 25-27页

作者： young soo lee Ji Su Bae Yu Jin Kang Yu Jin Kang Korea Environment Institute Seoul South Korea

Korea has adopted Environmental Impact Assessment (hereafter “EIA”) system for more than 3 decades. There are 74 big projects subject to EIA according to (Environmental Impact Assessment Law (No. 10892). For thermal power plant of which output is more than 10 MW, EIA must be done by proponents. To assess impact on atmospheric environment, proponents utilize air dispersion models and to minimize the adverse impact on air quality, state-of-the-art add-on control technology is applied.

关键词： Thermal Power Plant Korean Atmospheric EIA Methodology

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