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Asian Journal of Urology 2023年第3期10卷 364-371页

作者： Qinghui Wu Kesavan Esuvaranathan Teck Kheng Lee soo leong foo Jian Ping Chai Edmund Chiong Department of Urology National University HospitalSingapore Department of Surgery National University of SingaporeSingapore Institute of Technical Education Technology Development CentreSingapore Invivo Medical Pte.Ltd. Singapore

Objective:To design a device to increase the accuracy of the targeting process and reduce the radiation exposure to both the patients and the medical ***:We analyzed the inherent problem and designed the External Assist Targeting Device(EATD)to assist in the alignment of needle targeting on the desired renal calyx under fluoroscopic *** EATD was designed to allow rapid and precise access to calyces at all angles,with a simple two-step puncture protocol developed for puncturing a target renal *** then tested the device in a pilot human trial with four ***:In experiments with phantom models,the time for successful targeting was reduced by 31%using the *** mean fluoroscopic time was reduced by 40%.In initial human trial,the puncture time was shortened by 66%and the radiation dose was decreased by 65%compared to free-hand *** complication was observed during the ***:The EATD was found to be cost effective,portable,simple to set up,and safe to operate for assisting in the percutaneous nephrolithotomy *** preliminary tests showed high degree of accuracy in gaining precise access to a targeted renal calyx with much shorter time and lesser radiation *** EATD also has the potential to be used to access other organs with precision under fluoroscopic guidance.

关键词： Percutaneous nephrolithotomy Kidney puncture Renal calculi Targeting device Fluoroscopy guidance

Adjuvant therapy for gastric cancer:Current and future directions

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World Journal of Gastroenterology 2014年第38期20卷 13718-13727页

作者： Marcus foo Trevor leong Division of Radiation Oncology and Cancer Imaging and Cancer Imaging Peter MacCallum Cancer Centre University of Melbourne

The management of gastric cancer continues to evolve. Whilst surgery alone is effective when tumours present early,a large proportion of patients are diagnosed with loco-regionally advanced disease,resulting in high locoregional and distant relapse rates,with subsequent poor survival. Early attempts at improving outcomes following resection were disappointing;however,randomized trials have now established either post-operative chemoradiotherapy(INT0116) or peri-operative chemotherapy as standard adjuvant therapies in the Western world. There remain,however,significant differences in the approach to management between the West and East. In Asia,where there is the highest incidence of gastric cancer,extended resection followed by adjuvant chemotherapy represents the standard of care. This review discusses current standard adjuvant therapy in gastric adenocarcinoma,as well as recent and ongoing trials investigating novel(neo)adjuvant approaches,which hope to build on the successes of previous studies.

关键词： Adjuvant Gastric Stomach Cancer Chemoradiation Chemoradiotherapy Chemotherapy Peri-operative Neo-adjuvant

Mesomorphic behaviour of new azomethine liquid crystals having terminal bromo substituent

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Chinese Chemical Letters 2012年第2期23卷 177-180页

作者： Sie Tiong Ha Teck leong Lee Siew Ling Lee Guan Yeow Yeap Yip foo Win Siew Teng Ong Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparMalaysia Ibnu Sina Institute for Fundamental Science Studies Universiti Teknologi Malaysia81310 UTM SkudaiMalaysia Liquid Crystal Research Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenMalaysia Department.of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparMalaysia

A homologous series of azomethine esters,4-n-alkanoyloxybenzylidene-4＇-bromoanilines possessing even number of carbon atoms at the terminal alkanoyloxy chain（C_（n-1）H_（2n-1）COO- n = 8,10,12,14,16,18） was synthesized and *** n-octanoyloxy to n-dodecanoyloxy derivatives exhibited enantiotropic smectic A and smectic B phases,n-tetradecanoyloxy to n-octadecanoyloxy derivatives possessed enantiotropic smectic A and monotropic smectic B properties.n-Decanoyloxy derivatives demonstrated the optimum exhibition for both smectic A and smectic B *** was found that the length of terminal alkanoyloxy chain has an influence on mesomorphic properties.

关键词： Liquid crystals Schiff base ester Enantiotropic Smectic A Smectic B

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FBG-based smart bed system for healthcare applications

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Frontiers of Optoelectronics 2010年第1期3卷 78-83页

作者： Jianzhong HAO Maniyeri JAYACHANDRAN Poh leong KNG Siang fook foo Phyo Wai AUNG AUNG Zhaohui CAI 1. Fusionopolis Way #21-01 Connexis Singapore 138632 Singapore

This paper presents a smart fiber Bragg grating(FBG) sensor system with an unobtrusive and easy-to-use FBG sensor bed, which automatically monitors the behavior of bedridden patients and their vital signs based on indicative spatio-temporal signature for adaptive intervention triggering and activity planning. We present the subtle design, fabrication, calibration, implementation and deployment issues of the FBG pressure sensors to be used in hospitals or nursing homes to prevent bedsore generation, patient falling out of the bed, and life-threatening situations such as patient's heart rate weakening, breathing pattern change, etc. Through trials conducted in the laboratory for respiratory rate monitoring with a sample group of 10 subjects, the system showed maximum error of ± 1 breaths per minute as compared to manual counting.

关键词： fiber Bragg grating (FBG) unobtrusive vital signs spatio-temporal pressure sensor

Leveraging on Video Technology for High-Leverage Practices

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Leveraging on Video Technology for High-Leverage Practices

Unusual cause of hemorrhagic pleural effusion:A case report

The Conference on Information Technology in Education(CITE 2012)

作者： leong Yew Hoong Ho foo Him National Institute of Education Nanyang Technological University

In redesigning a methods course for Singapore Secondary Mathematics prospective teachers, we leverage on video technology to help them learn about the instructional practice of going through textbook-type questions. We find that this innovation generates learning all round - both for the student teachers as well as teacher educators.

关键词： Mathematics Teacher Education Video Technology High-Leverage Practices

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World Journal of Clinical Infectious Diseases 2022年第1期12卷 41-46页

作者： Kee Tat Lee Kar Nim leong Ting soo Chow Peng Shyan Wong Department of Medicine Hospital Sultanah BahiyahAlor Setar 05460KedahMalaysia Infectious Disease Unit Department of MedicineHospital Pulau PinangGeorgetown 10990Pulau PinangMalaysia

BACKGROUND Infected aortic aneurysms are uncommon and difficult to *** present a case of infected aortic aneurysm with recurrent nontyphoidal Salmonella *** SUMMARY A 68-year-old gentleman presented with non-specific symptoms and was found to have nontyphoidal Salmonella bacteremia and was treated with intravenous *** his condition did not improve,and he developed a multiloculated right pleural *** was done to drain hemorrhagic pleural *** computed tomography demonstrated descending thoracic aorta saccular aneurysm with periaortic hematoma likely due to recent bleed and extending to the right pleural *** was referred to cardiothoracic surgery team and was planned for medical therapy in view of hemodynamic stability and no evidence of active *** completed intravenous antibiotic for 5 wk and refused surgical ***,he was admitted twice for recurrent nontyphoidal Salmonella ***,he agreed for surgical intervention and underwent endovascular aortic repair 3 mo ***,his condition remained stable with no recurrence of *** Our case highlights the importance of high index of suspicion of infected aortic aneurysm in patients with Salmonella bacteremia with high-risk factors such as atherosclerosis.

关键词： Infected aneurysm Aorta Nontyphoidal Salmonella Pleural effusion Case report

Gastric peritoneal carcinomatosis-a retrospective review

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World Journal of Gastrointestinal Oncology 2017年第3期9卷 121-128页

作者： Hwee leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee soo Melissa Ching Ching Teo Division of Surgical Oncology National Cancer Centre Singapore Dvision of Medical Oncology National Cancer Centre Singapore

AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of *** We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral *** We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their

关键词： Peritoneal carcinomatosis Gastric cancer

Prediction of overall survival following colorectal cancer surgery in elderly patients

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World Journal of Gastrointestinal Surgery 2019年第5期11卷 247-260页

作者： Isaac Seow-En Winson Jianhong Tan Sreemanee Raaj Dorajoo Sharon Hui Ling Soh Yi Chye Law soo Yeun Park Gyu-Seok Choi Wah Siew Tan Choong leong Tang Min Hoe Chew Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Department of General Surgery Sengkang General HospitalSingapore 544886Singapore Department of Pharmacy National University of SingaporeSingapore 117559Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Colorectal Cancer Center Kyungpook National University Chilgok HospitalKyungpook National University School of MedicineDaegu 702-210South Korea

BACKGROUND With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid *** major surgery for these elderly patients can be *** accurate tool demonstrating post-operative survival probability would be useful for surgeons and their *** To integrate clinically significant prognostic factors relevant to elective colorectal surgery in the elderly into a validated pre-operative scoring *** In this retrospective cohort study,patients aged 70 and above who underwent surgery for CRC at Singapore General Hospital between 1 January 2005 and 31 December 2012 were identified from a prospectively maintained *** with evidence of metastatic disease,and those who underwent emergency surgery or had surgery for benign colorectal conditions were excluded from the *** primary outcome was overall 3-year overall survival(OS)following surgery.A multivariate model predicting survival was derived and validated against an equivalent external surgical cohort from Kyungpook National University Chilgok Hospital,South *** analyses were performed using Stata/MP Version *** A total of 1267 patients were identified for *** median post-operative length of stay was 8[interquartile range(IQR)6-12]d and median follow-up duration was 47(IQR 19-75)*** OS was 78(IQR 65-85)*** multivariate analysis,the factors significant for predicting overall mortality were serum albumin<35 g/dL,serum carcinoembryonic antigen≥20μg/L,T stage 3 or 4,moderate tumor cell differentiation or worse,mucinous histology,rectal tumors,and pre-existing chronic obstructive lung *** age alone was not found to be *** Korean cohort consisted of 910 *** Singapore cohort exhibited a poorer OS,likely due to a higher proportion of advanced *** the clinicopathologic di

关键词： Colorectal cancer surgery Elderly Overall survival Pre-operative prognostic score

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai leong Tam Han Chong Toh Roger Sik-Yin foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

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诺梅克斯材料和诺梅克斯蜂窝结构的力学特性

钢结构 2008年第2期23卷 77-77页

作者： Choon Chiang foo Gin Boay Chai leong Keey Seah

介绍了对诺梅克斯纸和诺梅克斯蜂窝的线弹性力学特性的大量测试结果。诺梅克斯纸的基本力学特性被应用于有限元模型和诺梅克斯蜂窝结构分析。有限元计算结果与试验结果以及人们熟知的Gibson和Ashby公式计算结果进行对比,观测了诺梅克斯... 详细信息

介绍了对诺梅克斯纸和诺梅克斯蜂窝的线弹性力学特性的大量测试结果。诺梅克斯纸的基本力学特性被应用于有限元模型和诺梅克斯蜂窝结构分析。有限元计算结果与试验结果以及人们熟知的Gibson和Ashby公式计算结果进行对比,观测了诺梅克斯蜂窝模数的尺寸效应。

关键词：诺梅克斯纸诺梅克斯蜂窝线弹性力学特性有限元模型结构分析尺寸效应

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