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Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease:pathologic roles and therapeutic implications

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Translational Neurodegeneration 2021年第4期10卷 643-665页

作者： Hyeon soo Kim Sujin Kim soo jung shin Yong Ho Park Yunkwon Nam Chae won Kim Kang won Lee Sung-Min Kim In Duk jung Hyun Duk Yang Yeong-Min Park Minho Moon Department of Biochemistry College of MedicineKonyang UniversityDaejeon 35365Republic of Korea Research Institute for Dementia Science Konyang UniversityDaejeon 35365Republic of Korea Dandi Bioscience Inc 6th Floor of Real Company Building66Achasan-roSungdong-guSeoulRepublic of Korea Harvard Neurology Clinic 294 Gwanggyojungang-roSuji-guYongin 16943Republic of Korea Department of Immunology School of MedicineKonkuk University268ChungwondaeroChungju-siChungcheongbuk-doRepublic of Korea

Alzheimer's disease(AD)is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive *** in the development of therapeutics targeting amyloid-β(Aβ)and tau;principal proteins inducing pathology in AD,suggest a paradigm shift towards the development of new therapeutic *** gram-negative bacteria and lipopolysaccharides(LPS)are attractive new targets for AD ***,an altered distribution of gram-negative bacteria and their LPS has been reported in AD ***,gram-negative bacteria and their LPS have been shown to affect a variety of AD-related pathologies,such as Aβ homeostasis,tau pathology,neuroinflammation,and ***,therapeutic approaches targeting gram-negative bacteria or gram-negative bacterial molecules have significantly alleviated AD-related pathology and cognitive *** multiple evidence showing that the gram-negative bacteria and their LPS play a crucial role in AD pathogenesis,the pathogenic mechanisms of gram-negative bacteria and their LPS have not been ***,we summarize the roles and pathomechanisms of gram-negative bacteria and LPS in ***,we discuss the possibility of using gram-negative bacteria and gram-negative bacterial molecules as novel therapeutic targets and new pathological characteristics for AD.

关键词： Alzheimer's disease Gram-negative bacteria Lipopolysaccharide Exotoxin Amyloid beta Tau

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Parameter estimation for building energy models using GRcGAN

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Building Simulation 2023年第4期16卷 629-639页

作者： Hansol shin Cheol-soo Park Department of Architecture and Architectural Engineering College of EngineeringSeoul National UniversitySeoul08826R.O.Korea Institute of Construction and Environmental Engineering Institute of Engineering ResearchCollege of EngineeringSeoul National UniversitySeoul08826R.O.Korea

Parameter estimation methods can be classified into(1)manual(trial-and-error),(2)numerical optimization(optimization,sampling),(3)Bayesian inference(Bayes filter,Bayesian calibration),and(4)machine learning(generative model).Bayesian calibration has been widely used because it can capture stochastic nature of uncertain ***,the results of Bayesian calibration could be biased by(1)the prior distribution assumed by the expert’s subjective judgment;(2)the likelihood function that cannot always describe the true likelihood;and(3)the posterior distribution approximation method,such as the Markov Chain Monte Carlo,which requires significant computation *** overcome this,a new approach using a generator-regularized continuous conditional generative adversarial network(GRcGAN)is presented in this *** target parameters of the DOE reference building model were *** was trained to estimate uncertain parameters using simulated monthly electricity and gas *** can successfully estimate five uncertain parameters based on 1,000 training data *** proposed approach presents a potential for stochastic parameter estimation.

关键词： generative adversarial networks generative model parameter estimation inverse problem model calibration parameter uncertainty

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Microstructure evolution and mechanical properties of Ti-B-N coatings deposited by plasma-enhanced chemical vapor deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 722-728页

作者： jung Ho shin Kwang soo CHOI Tie-gang WANG Kwang Ho KIM Roman NOWAK National Core Research Center for Hybrid Materials Solution Pusan National University School of Materials Science and Engineering Pusan National University State Key Laboratory of Corrosion and Protection Institute of Metal ResearchChinese Academy of Sciences School of Chemical Technology Aalto University

Ternary Ti-B-N coatings were synthesized on AISI 304 and Si wafer by plasma-enhanced chemical vapor deposition (PECVD) technique using a gaseous mixture of TiCl4,BCl3,H2,N2,and *** virtue of X-ray diffraction analysis,X-ray photoelectron spectroscopy,scanning electron microscope,and high-resolution transmission electron microscope,the influences of B content on the microstructure and properties of Ti B N coatings were investigated *** results indicated that the microstructure and mechanical properties of Ti-B-N coatings largely depend on the transformation from FCC-TiN phase to HCP-TiB2 *** increasing B content and decreasing N content in the coatings,the coating microstructure evolves gradually from FCC-TiN/a-BN to HCP-TiB2 /a-BN via FCC-TiN+HCP-TiB2/*** highest microhardness of about 34 GPa is achieved,which corresponds to the nanocomposite Ti-63%B-N (mole fraction) coating consisting of the HCP-TiB2 nano-crystallites and amorphous BN *** lowest friction-coefficient was observed for the nanocomposite Ti-41%B-N (mole fraction) coating consisting of the FCC-TiN nanocrystallites and amorphous BN

关键词： Ti-B-N coating plasma-enhanced chemical vapor deposition (PECVD) nanocomposite coating hardness friction coefficient

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ASL Recognition by the Layered Learning Model Using Clustered Groups

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Computer Systems Science & Engineering 2023年第4期45卷 51-68页

作者： jungsoo shin Jaehee jung Department of Information and Communication Engineering Myongji UniversityYonginKorea

American Sign Language(ASL)images can be used as a communication tool by determining numbers and letters using the shape of the ***,ASL can have an key role in communication for hearing-impaired persons and conveying information to other persons,because sign language is their only channel of *** ASL recognition methods primarily adopt images,sensors,and pose-based recognition techniques,and employ various gestures together with *** study briefly reviews these attempts at ASL recognition and provides an improved ASL classification model that attempts to develop a deep learning method with *** the proposed model,the collected ASL images were clustered based on similarities in shape,and clustered group classification was first performed,followed by reclassification within the *** experiments were conducted with various groups using different learning layers to improve the accuracy of individual image *** selecting the optimized group,we proposed a meta-layered learning model with the highest recognition rate using a deep learning method of image *** proposed model exhibited an improved performance compared with the general classification model.

关键词： American sign language deep learning recognition CNN ResNet clustered group

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Factors influencing stereoacuity levels after surgery to correct unilateral developmental cataracts in children

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 331-336页

作者： soo jung Lee Wan-soo Kim Department of Ophthalmology Haeundae Paik Hospital

·AIM: To evaluate factors influencing stereoacuity after surgery to correct unilateral developmental pediatric cataracts. ·METHODS: We retrospectively surveyed 110 patients who had undergone removal of unilateral acquired developmental cataracts and primary posterior chamber intraocular lens implantation between February 1992 and December 2009. In all patients, stereoacuity was assessed using the Titmus test at the last follow -up period of minimum 2 years after surgery. Patients were divided into two groups according to the extent of stereoacuity : group 1 ( = 42 ) had stereoacuity values ≤ 100sec/arc and group 2 ( =68) values >100sec/arc. The values of ten parameters associated with stereoacuity were measured in each group: Cataract types, preoperative best corrected visual acuity (BCVA) of the affected eyes, preoperative inter -ocular difference of BCVA, age at cataract surgery, operative method, secondary cataract, postoperative strabismus, postoperative BCVA of the affected eyes, postoperative inter-ocular difference of BCVA, and anisometropia. ·RESULTS: The extent of stereoacuity was significantly associated with both operative method and secondary cataract ( =0.000 and =0.016, respectively). All patients in whom the posterior capsule was preserved, had poor stereoacuity >100sec/arc. Significant correlations with the extent of stereoacuity were found with postoperative strabismus ( =0.048),postoperative BCVA of the affected eyes ( =0.002), anisometropia ( =0.034). ·CONCLUSION: Postoperative stereoacuity was better in patients who underwent either optic capture or anterior vitrectomy after posterior continuous curvilinear capsulorhexis, and who didn’t develop secondary cataracts or strabismus postoperatively. Furthermore, postoperative BCVA of the affected eyes, and anisometropia influenced the stereoacuity of the patients surgically treated for unilateral developmental pediatric cataracts. ·

关键词： anisometropia developmental cataract secondary cataract stereoacuity stereopsis strabismus unilateral pediatric cataract visual acuity

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Factors associated with strabismus after cataract extraction and primary intraocular lens implantation in congenital cataracts

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 522-527页

作者： soo jung Lee Wan-soo Kim Department of Ophthalmology Haeundae Paik Hospital

AIM:To evaluate factors associated with the development of strabismus after cataract extraction and primary intraocular lens ***:The medical records of 122 patients,aged1.5mo to 9y,who had undergone cataract extraction with primary intraocular lens implantation between January1993 and August 2011 were *** patients(17 eyes)with strabismus before cataract surgery were *** were divided into those with congenital bilateral cataracts(64 patients,128 eyes)and those with unilateral cataracts(44 patients,44 eyes).The associations between the development of strabismus and age at cataract surgery,pre-and post-cataract extraction corrected distance visual acuity(CDVA),interocular CDVA difference,nystagmus,surgical method,and secondary cataract were ***:Factors significantly associated with the development of strabismus included age at cataract surgery(≤1y),preoperative mean CDVA≤20/100,presence of nystagmus in the bilateral cataract group and postoperative interocular CDVA difference>20/70 in the unilateral *** CDVA≤20/100 and preservation of posterior capsule,and presence of secondary cataract were significant factors in both ***:Children with congenital cataracts should be monitored carefully after cataract surgery for the development of strabismus,especially when they underwent surgery at age≤1y,and they have nystagmus,large postoperative interocular CDVA difference,poor preoperative and postoperative CDVA,preservation of the posterior capsule,or secondary cataract.

关键词： strabismus congenital cataract nystagmus

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Journal of Central South University 2013年第9期20卷 2440-2446页

作者： LEE Sang-hyuk shin Seung-soo Department of Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University Department of Information Security Tongmyong University

Similarity measure design on non-overlapped data was carried out and compared with the case of overlapped *** feature of similarity on overlapped data to non-overlapped data was provided by *** the artificial data illustration,it was proved that the conventional similarity measure was not proper to calculate the similarity measure of the non-overlapped *** overcome the unbalance problem,similarity measure on non-overlapped data was obtained by considering neighbor ***,different approaches to design similarity measure were proposed and proved by consideration of neighbor *** the example of artificial data,similarity measure calculation was carried *** measure extension to intuitionistic fuzzy sets(IFSs)containing uncertainty named hesitance was also followed.

关键词： similarity measure overlapped data non-overlapped data intuitionistic data

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Formation Mechanism of Chunky Graphite and Its Preventive Measures

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Journal of Materials Science & Technology 2008年第3期24卷 289-295页

作者： Hideo Nakae Sanghoon jung Ho-Chul shin Department of Materials Science and Engineering Waseda University National Institute of AIST Corporate Res.and Dev.Div. Hyundai.Kia Motors

The formation mechanism of chunky graphite has been reviewed and studied. The study consisted of a unidirectional solidification method, a small droplet method and a furnace cooling method. Four kinds of iron samples were prepared, namely, the pure Fe-C, Fe-C-S, Fe-C-Ce and Fe-C-Si-Ce alloys, and three kinds of nickel samples, namely the Ni-C, Ni-C-S and Ni-C-Mg alloys. The results of the unidirectional solidification of the Ni-C alloys showed that spheroidal graphite is not observed in the continuous solidified region, in which only flake-like graphite is observed, while spheroidal graphite is usually observed in the quenched liquid region. The existence of spheroidal graphite in the solidified phase is recognized only in the discontinuous growth mode of the Ni-C-Mg alloy solidified at 150 mm/h. This means that the spheroidal graphite is directly crystallized from the melt and entrapped by the flake-like chunky graphite that is formed by the continuous growth mode. In the small droplet method, a small piece of the Fe-C or Fe-C-Ce sample was melted on a pure graphite plate then cooled at a different cooling rate in a He-3%H2 atmosphere. The graphite in the Fe-C-Ce alloy is usually spherical. Nevertheless, the graphite morphology of the final solidified area changed from spherical to chunky and chunky to ledeburite with an increase in the cooling rate. This means that the chunky graphite is formed in the residual liquid region by the solidification into Fe-graphite system. The sample was cooled in a furnace, and the graphite morphology changes from spherical to chunky and chunky to ledeburite with the decrease in the Si content. These phenomena can be confirmed by the cooling curves of these samples.

关键词： Chunky graphite Spheroidal graphite Solidification Cooling curve

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Noncommutative Versions of the Singer-Wermer Conjecture with Linear Left θ-derivations

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Acta Mathematica Sinica,English Series 2008年第11期24卷 1891-1900页

作者： Yong soo jung Kyoo Hong PARK Department of Mathematics Sun Moon University Asan Chungnam 336-708 Korea Department of Mathematics Education Seowon University Cheongju Chungbuk 361-742 Korea

The noncommutative Singer-Wermer conjecture states that every linear （possibly unbounded） derivation on a （possibly noncommutative） Banach algebra maps into its Jacobson radical. This conjecture is still an open q... 详细信息

关键词： linear left θ-derivation linear θ-derivation Jacobson radical nil radical

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User Interface-Based Repeated Sequence Detection Method for Authentication

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Intelligent Automation & Soft Computing 2023年第3期35卷 2573-2588页

作者： shin Jin Kang soo Kyun Kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

In this paper,we propose an authentication method that use mouse and keystroke dynamics to enhance online privacy and *** proposed method identiﬁes personalized repeated user interface(UI)sequences by analyzing mouse and keyboard *** this end,an Apriori algorithm based on the keystroke-level model(KLM)of the human–computer interface domain was *** proposed system can detect repeated UI sequences based on KLM for authentication in the *** effectiveness of the proposed method is veriﬁed through access test-ing using commercial applications that require intensive UI *** results show using our cognitive mouse-and-keystroke dynamics system can com-plement authentication at the application level.

关键词： Authentication keystroke-level model(KLM) keystroke mouse dynamics

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