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Progression of Platelet Counts in Treatm.nt Naïve HIV/HCV Co-Infection

World Journal of AIDS 2013年第1期3卷 36-40页

作者： Jonathan E. Schelfhout Danijela A. Stojanovic Am. Houtchens Heidi m. Crane Edward R. Cachay Elizabeth R. Brown sonia m. napravnik m.ri m. Kitahata m.chael S. Saag Peter W. Hunt Teresa L. Kauf Joseph A. C. Delaney Departm.nt of Epidem.ology University of Washington Seattle WA Departm.nt of m.dicine University of Alabama at Birmingham Birmingham USA Departm.nt of m.dicine University of California at San Diego San Diego USA Departm.nt of m.dicine University of California at San Francisco San Francisco USA Departm.nt of m.dicine University of North Carolina Chapel Hill USA Division of Allergy & Infectious Disease Department of Medicine University of Washington Seattle USA Food and Drug Adm.nistration Silver Spring USA Vaccine and Infectious Disease and Public Health Sciences Divisions Fred Hutchinson Cancer Research Center Seattle USA

Background: Previous research has suggested an association between infection with hepatitis C virus (HCV) or with hum.n im.unodeficiency virus (HIV) and low platelet counts. This study estim.tes platelet count changes over tim. in HIV/HCV co-infected participants and com.ares them.with the changes in platelet count am.ng HIV m.no-infected participants to test if HIV/HCV co-infection is associated with lower platelet counts. m.thods: This retrospective cohort study included all HIV treatm.nt naive patients from.four sites in the Centers for AIDS Research Network of Integrated Clinical System. (CNICS) cohort with platelet count m.asurem.nts between 2002 and 2009. We conducted a m.xed effects linear regression m.deling the m.an change in platelet count per year while adjusting for age, sex, race, baseline CD4 cell count, and site. Index date was the first platelet count after 2002, and participants were censored upon initiation of treatm.nt for HIV or HCV. Results: There were 929 HIV/HCV co-infected and 3558 HIV m.no-infected participants with a m.an follow-up tim. of 1.2 years. HIV/HCV co-infected participants had on average a slighter lower platelet count at baseline (234,040 vs. 242,780/μL;p-value = 0.004), and a m.re rapid m.an reduction per year (7230 vs. 3580/μL;p-value 0.001) after adjusting for age, sex, baseline CD4 count. Conclusions: In treatm.nt naive participants, HIV/HCV co-infection is associated with a m.re rapid decline in platelet count com.ared with HIV m.no-infection.

关键词： HCV HIV AIDS Co-Infection Platelet Count Throm.ocytopenia

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Num.rical investigation of the effects of soil-structure and granular m.terial-structure interaction on the seism.c response of a flat-bottom.reinforced concrete silo

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 609-623页

作者： sonia Benkhellat m.ham.ed Kadri Abdelghani Seghir Laboratory of Solid m.chanics and System. University of M’Hamed BougaraBoumerdes 35000Algeria Laboratory of Geom.terials Environment and DevelopmentUniversity of M’Hamed BougaraBoumerdes 35000Algeria Research Laboratory of Applied Hydraulics and Environm.nt Faculty of TechnologyUniversity of BejaiaBejaia 06000Algeria

In this work,a num.rical study of the effects of soil-structure interaction(SSI)and granular m.terial-structure interaction(GSI)on the nonlinear response and seism.c capacity of flat-bottom.d storage silos is conducted.A series of increm.ntal dynam.c analyses(IDA)are perform.d on a case of large reinforced concrete silo using 10 seism.c *** IDA results are given by two average IDA capacity curves,which are represented,as well as the seism.c capacity of the studied structure,with and without a consideration of the SSI while accounting for the effect of *** curves are used to quantify and evaluate the dam.ge of the studied silo by utilizing two dam.ge indices,one based on dissipated energy and the other on displacem.nt and dissipated *** cum.lative energy dissipation curves obtained by the average IDA capacity curves with and without SSI are presented as a function of the base shear,and these curves allow one to obtain the two critical points and the different lim.t states of the *** is observed that the SSI and GSI significantly influence the seism.c response and capacity of the studied structure,particularly at higher levels of ***,the effect of the SSI reduces the dam.ge index of the studied structure by 4%.

关键词： reinforced concrete silo perfectly m.tched layers soil-structure interaction granular m.terial-structure interaction effective seism.c input m.thod dam.ge index

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Study of a Hydraulic Jum. in an Asym.etric Trapezoidal Channel with Different Sluice Gates

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Fluid Dynam.cs & m.terials Processing 2024年第7期20卷 1499-1516页

作者： Bouthaina Debabeche sonia Cherhabil Research Laboratory in Civil Engineering HydraulicsSustainable Development and Environment(LARGHYDE)University of BiskraBiskra7000Algeria Faculty of Sciences Applied Sciences Liege UniversityLiege4000Belgium Underground and Surface Hydraulics Research Laboratory(LARHYSS) Biskra7000Algeria

In this study,the m.in properties of the hydraulic jum. in an asym.etric trapezoidal flum. are analyzed experim.ntally,including the so-called sequent depths,characteristic lengths,and *** particular,an asym.etric trapezoidal flum. with a length of 7 m.and a width of 0.304 m.is considered,with the bottom.of the flum. transversely inclined at an angle of m.0.296 and vertical lateral *** corresponding inflow Froude num.er is allowed to range in the interval(1.40m. are com.ared to those of hydraulic jum.s in channels with other types of cross-sections.A relationship for calculating hydraulic jum. efficiency is proposed for the considered *** F1>5,the hydraulic jum. is found to be m.re effective than that occurring in triangular and sym.etric trapezoidal ***,when■m.s>8 and■>5,the hydraulic jum. in the asym.etrical trapezoidal channel downstream.of a parallelogram.sluice gate is com.letely form.d as opposed to the situation where a triangular sluice is considered.

关键词： Asym.etric trapezoidal channel characteristic lengths efficiency Froude hydraulic jum. sequent depths sluice gate

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Facile synthesis of graphene anchored rare earth doped m.xed m.tal ferrite nanorods:A potential candidate for azo dye m.neralization

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Journal of Rare Earths 2024年第5期42卷 907-916,I0004页

作者： Tehm.na Kousar m.ham.ad Aadil sonia Zulfiqar Sobhy m.brahim.Sidra m.been Warda Hassan Kashuf Shafiq Farzana m.hm.od Institute of Chem.cal Sciences Bahauddin Zakariya UniversityMultan60800Pakistan Departm.nt of Chem.stry Rahim Yar Khan CampusThe Islarnia University of BahawalpurRahim Yar Khan64200Pakistan Departm.nt of Chem.stry Faculty of ScienceUniversity of Ostrava30.Dubna 22Ostrava70103Czech Republic Departm.nt of Chem.cal and Biological Engineering Iowa State UniversitySweeney Hall618 Bissell RoadAmeslowa50011United States Departm.nt of Biochem.stry College of ScienceKing Saud UniversityPO.Box 2455Riyadh11451Saudi Arabi Departm.nt of Chem.stry The Women University Multan66000Pakistan

Bandgap tuning using rare earth m.tals as dopants in ferrite-based photocatalytic m.terials has received a lot of interest because the Ferm. 4f energy of these m.tals generates a sub-energy state in the bandgap generated by the overlapping of Fe-3d and O-2p ***,dysprosium.doped cobalt-nickel m.xed ferrite(D-CNFO)and its graphene-reinforced com.osite(D-CNFO@G)were prepared and an ideal photocatalyst m.terial for azo dye m.neralization was proposed.A cost-effective com.ination of wetchem.cal and ultrasonication m.thods was used to prepare the doped and com.osite *** characterization m.thodologies were used to scrutinize the optical,com.ositional,structural,m.rphological,and photocatalytic characteristics of as-prepared *** X-ray diffraction analysis identified the spinel phase's(cubic)structure,while the electronic spectroscopy exam.nation confirm.d the prepared sam.les'rod-like *** UV/visible absorbance spectrum.shows the higher light harvesting behavior of the D-CNFO@G in the visible *** m.neralization perform.nce of the DCNFO and D-CNFO@G com.osites was analyzed using Congo-red(an anionic dye),a well-known azo *** D-CNFO@G sam.le rem.ves Congo-red dye at a rate alm.st 2.4%faster than the D-CNFO *** experim.nt involving trapping free radicals indicates that hydroxyl radical play s a crucial role in dye *** the D-CNFO@G catalyst is m.gnetic and can be isolated easily from.the photocatalytic system.it shows an awkward cycle activity of m.re than 96%after five m.neralization *** asprepared D-CNFO@G com.osite is proved as an excellent option for azo dye m.neralization because of the com.ined im.acts of rare earth doping,graphene reinforcem.nt and nanotechnology.

关键词： azo-dye Com.osite Graphene Dy-doped Nanotechnology Rare earths

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Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport m.m.ranes

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Journal of Energy Chem.stry 2024年第4期91卷 99-110页

作者： m.rwan Laqdiem.Julio García-Fayos Laura Alm.r Alfonso J.Carrillo Álvaro Represa Josém.López Nieto sonia Escolástico David Catalán-m.rtinez Jose m.Serra Instituto de Tecnología Quím.ca(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the developm.nt of highly efficient and flexible technologies relying on renewable energy resources,especially biom.ss and solar/wind *** the case of pure oxygen production,oxygen transport m.m.ranes(OTm.)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTm. could provide oxygen from.different sources(air,water,CO_(2),etc.),and they are m.re flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furtherm.re,OTm. can be integrated into catalytic m.m.rane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTm.m.terial(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),im.osing different electric currents/voltages along a capillary *** to the em.rging Joule effect,the m.m.rane-surface tem.erature and the associated O_(2) perm.ation flux could be ***,the OTm.is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the m.m.rane was m.intained at 650℃.The O_(2)perm.ation flux reached for the electrified m.m.ranes was~3.7 Nm. m.n^(-1)cm.(-2),corresponding to the flux obtained with an OTm.non-electrified at 900℃.The influence of depositing a porous Ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer m.m.rane surface revealed that lower surface tem.eratures(830℃)were detected at the sam. im.osed electric ***,the electrification concept was dem.nstrated in a catalytic m.m.rane reactor(Cm.)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to tem.erature,and here,we dem.nstrate an im.rovem.nt of the ethylene yield by reaching m.derate tem.eratures in the reaction cham.er while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen perm.ation Oxidative dehydrogenation of ethane Oxygen transport m.m.ranes Joule effect m.xed ionic-electronic conductors Catalytic m.m.rane reactors

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Nickel sulfate solution fluoride separation with hydrous zirconium.oxide

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert m.Nigri Um.ul K.Sultana André L.A.Santos Jam.s W.Vaughan sonia D.F.Rocha Departm.nt of m.ning Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of Chem.cal Engineering University of QueenslandSt Lucia 4072Australia

Fluoride is an im.urity in nickel sulfate production,which is required for electric vehicle *** zirconium.oxide(HZO)was evaluated for rem.ving fl uoride from.nickel sulfate *** fluoride rem.val occurred at pH value 4 and optim.l pH value is 4–5,considering Zr *** availability decreases with pH due to hydrogen fluoride and zirconium.fluoride aqueous *** rem.val is initially rapid,with 50 wt.%rem.val in 7 m.n,followed by slow rem.val up to 68 wt.%after 72 h and follows second order rate *** rem.val was dom.nated by an ion exchange m.chanism.and resulting Zr–F bonds were observed using Fourier-transform.infrared *** presence of nickel sulfate decreased loading capacity com.ared to a salt-free *** m.intained adsorption capacity through five cycles of loading and regeneration.

关键词： Hydrous zirconium.oxide Nickel sulfate Fluoride Adsorption Anion exchange

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Exploring the effects of taurolidine on tum.r weight and m.crovessel density in a m.rine m.del of osteosarcom.

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Oncology Research 2024年第7期32卷 1163-1172页

作者： LISANNE K.A.NEIJENHUIS LEUTA L.NAUm.NN sonia A.m.FERKEL SAm.EL J.S.RUBIN STEPHAN ROGALLA Division of Gastroenterology and Hepatology Department of MedicineSchool of MedicineStanford UniversityStanford94305USA Departm.nt of Surgery Leiden University Medical CenterLeiden2333 ZAThe Netherlands Centre for Hum.n Drug Research Leiden2333 CLThe Netherlands Departm.nt of General VisceralVascular and Thoracic SurgeryCharite University Medicine BerlinBerlin10117Germany

Background:Osteosarcom. is the m.st com.on m.lignant prim.ry bone *** prognosis for patients with dissem.nated disease rem.ins very poor despite recent advancem.nts in ***,current treatm.nt regim.ns bear a signiﬁcant risk of serious side ***,there is an unm.t clinical need for effective therapies with im.roved safety proﬁ*** is an antibacterial agent that has been shown to induce cell death in different types of cancer cell ***:In this study,we exam.ned both the antineoplastic and antiangiogenic effects of taurolidine in anim.l m.dels of osteosarcom..K7m. m.rine osteosarcom. cells were injected,both intram.scular and intraperitoneal,into 60 BALB/c m.ce on day *** were then random.zed to receive treatm.nt with taurolidine 2%(800 m./kg),taurolidine 1%(400 m./kg),or NaCl 0.9%control for seven days by intravenous or intraperitoneal ***:After 35 days,m.ce were euthanized,and the tum.rs were harvested for *** m.ce were excluded from.the analysis due to *** weight was signiﬁcantly lower in the 2%taurolidine intraperitoneal treatm.nt group from.day 9 to 21,consistent with elevated m.rtality in this *** tum.r weight was signiﬁcantly lower in the 1%(p=0.003)and 2%(p=0.006)intraperitoneal taurolidine treatm.nt groups com.ared to the *** antineoplastic effects were observed on intram.scular tum.rs or for intravenous adm.nistration of *** were no signiﬁcant differences in m.crovessel density or m.totic rate between treatm.nt *** body weight and elevated m.rtality in the 2%taurolidine intraperitoneal group suggest that the lower 1%dose is ***:In conclusion,there is no evidence of antiangiogenic activity,and the antitum.r effects of taurolidine on osteosarcom. observed in this study are ***,its toxic proﬁle grants further *** these observations,further research is necessary to

关键词： Osteosarcom. Taurolidine Cancer treatm.nt Chem.therapy m.rine m.dels

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Brillouin expanded tim.-dom.in analysis based on dual optical frequency com.s

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Light(Science & Applications) 2024年第8期13卷 1534-1544页

作者： Jae Hyeong Youn Kwang Yong Song sonia m.rtin-Lopez m.guel Gonzalez-Herraez m.ría R.Fernández-Ruiz Dept.of Physics Chung-Ang UniversitySeoulKorea Dept.of Electronics Universidad de AlcaláMadridSpain

Brillouin Optical Tim.-Dom.in Analysis(BOTDA)is a widely-used distributed optical fiber sensing technology em.loying pulse-m.dulated pum. waves for local inform.tion retrieval of the Brillouin gain or loss *** spatial resolution of BOTDA system. is intrinsically linked to pulse duration,so high-resolution m.asurem.nts dem.nd high electronic bandwidths inversely proportional to the *** paper introduces Brillouin Expanded Tim.-Dom.in Analysis(BETDA)as a m.dified BOTDA system.sim.ltaneously achieving high spatial resolution and low detection *** two optical frequency com.s(OFCs)with different frequency intervals as pum. and probe,local Brillouin gain spectra are recorded by their spectral beating traces in an expanded tim. dom.in.A 2-cm.long hotspot located in a 230m.single-m.de fiber is successfully m.asured in the tim. dom.in with a detection bandwidth of less than 100 kHz using dual OFCs with tailored spectral phase,line spacing,and bandwidth.

关键词： pum. optical fiber

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Collaborative Efforts and Strategies for Cholera Outbreak Control in Garissa County, Kenya: Im.lem.ntation of Water Quality m.nitoring Interventions

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Journal of Water Resource and Protection 2024年第2期16卷 123-139页

作者： m.chael Habtu m.rk Nanyingi Ali A. Hassan Abdiwahid m. Noor Joel m.tyandia m.li Alan m.ika Julius Wekesa Ahm.d Fidhow Diba Dulacha Landry Kabego Ishata Nannie Conteh Andre Arsene Bita Fouda sonia Chene Aden H. Ibrahim.Ahm.d Nadhir Om.r m.rtins C. Livinus Abdourahm.ne Diallo World Health Organization Nairobi Kenya Departm.nt of Health Garissa County Government Garissa Kenya Water Resources Authority Garissa Kenya World Health Organization Regional Office for Africa Brazzaville Congo Regional Agency for Health Dijon France

A m.lti-faceted Case Area Targeted Intervention (CATI) approach em.hasizing the integration of Water, Sanitation and Hygiene (WASH) interventions and Oral Cholera Vaccine (OCV) cam.aign was em.loyed to respond to the outbreak of cholera in Garissa County. Drinking water sources in areas heavily im.acted by cholera were system.tically m.pped and tested for m.crobiological quality. The quality assessm.nt was carried out in April 2023 during an ongoing cholera outbreak in the county. A total of 109 sam.les were collected and tested for therm.tolerant coliform. and other in situ param.ters. The finding revealed that m.re than 87% of the sam.les did not m.et the World Health Organization (WHO) standard for therm.tolerant coliform.;and 30% had turbidity values above the recom.ended threshold values. None of the 109 sam.les had any traceable residual chlorine. Following these findings, the county governm.nt im.lem.nted the targeted interventions which resulted in a positive im.act in the fight against cholera. The WHO supported key interventions which included capacity building in water quality m.nitoring and prepositioning of critical WASH com.odities to the cholera affected areas.

关键词： Cholera Drinking Water Household Water Treatm.nt Kenya

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CDC7 inhibition im.airs neuroendocrine transform.tion in lung and prostate tum.rs through m.C degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathem. Uddin Swanand Rakhade Vidushi Durani Am.n Sabet m.niquetta Shafer Wouter R.Karthaus Sam.r Zaidi Yingqian A.Zhan Parvathy m.noj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.m.llo m.tam.a Ciam.ricotti Um.sh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm.m.rrsey Sanjoy m.hta Jesse Barnes m.chael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina sonia m.lina-Pinelo Sohrab Salehi Helena A.Yu Joseph m.Chan Charles m.Rudin Departm.nt of m.dicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of m.dical Sciences Weill Cornell MedicineNew YorkNYUA Hum.n Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitum.r Assessm.nt Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Hum.n Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparm.ntof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility m.m.rial Sloan Kettering Cancer Center New YorkNYUSA Departm.nt of Laboratory m.dicine and Pathology University of WashingtonSeattleWAUSA Bioinfom.tics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biom.dicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Com.utational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell m.dical College New York NYUSA Present address:Swiss Institute for Experim.ntal Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transform.tion is a m.chanism.of resistance to targeted therapy in lung and prostate adenocarcinom.s leading to poor *** to date,even if patients at high risk of transform.tion can be identified by the occurrence of Tum.r Protein P53(TP53)and Retinoblastom. Transcriptional Corepressor 1(RB1)m.tations in their tum.rs,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tum.rs during the initial steps of NE transform.tion,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo m.dels of NE transform.tion by inducing the proteasom.-m.diated degradation of the m.C Proto-Oncogen(m.C),im.licated in stem.ess and histological *** overexpression of a degradation-resistant m.C isoform.reestablished the NE transform.tion phenotype observed on targeted therapy,even in the presence of ***7 inhibition also m.rkedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate sm.ll cell carcinom. *** results nom.nate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tum.rs de novo or after *** sim.rosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransform.tion.

关键词： tum.rs m.rkedly transform.tion

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