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Intimal sarcoma of the pulmonary artery with multiple lung metastases: Long-term survival case

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World Journal of Clinical Oncology 2017年第4期8卷 366-370页

作者： sonia garcía-cabezas Macarena Centeno-Haro Simona Espejo-Pérez Elvira Carmona-Asenjo Alberto L Moreno-Vega Rosa Ortega-Salas Amalia Palacios-Eito Department of Radiation Oncology Reina Sofia University Hospital Department of Pathological Anatomy Reina Sofia University Hospital Department of Radiology Reina Sofia University Hospital Department of Nuclear Medicine Reina Sofia University Hospital Department of Medical Oncology Reina Sofia University Hospital

Pulmonary artery intimal sarcoma(PAIS) is a rare tumor with a very poor prognosis. Clinical and radiological findings usually mimic thromboembolic disease, leading to diagnostic delays. The treatment of choice is surgery, and adjuvant chemotherapy and radiotherapy have limited results. We report the case of a 48-year-old male patient, initially suspected with pulmonary thromboembolism. The angio-CT revealed a filling defect in the pulmonary artery trunk. The patient underwent surgery, resulting in with complete resection of the mass with a diagnosis of PAIS. The tumor progressed rapidly in the lung, requiring surgery of multiple lung metastases. The patient was treated with stereotactic body radiation therapy(SBRT) on two occasions for new pulmonary lesions. In the last follow-up(4 years after initial diagnosis), the patient was disease-free. In conclusion, SBRT proved to be an alternative treatment to metastasectomy, allowing palliative chemotherapy to be delayed or omitted, which may result in improved quality of life.

关键词： Intimal sarcoma of the pulmonary artery Lung metastases Metastasectomy Stereotactic body radiation therapy Treatment

Re-irradiation for high-grade gliomas:Has anything changed?

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World Journal of Clinical Oncology 2021年第9期12卷 767-786页

作者： sonia garcía-cabezas Eleonor Rivin del Campo Juan Solivera-Vela Amalia Palacios-Eito Department of Radiation Oncology Reina Sofia University HospitalCordoba 14004Spain Department of Radiation Oncology Tenon University HospitalParis 75020France Department of Neurosurgery Reina Sofia University HospitalCordoba 14004Spain

Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary *** radiation therapy techniques,new imaging methods,published experience,and a better radiobiological knowledge of brain tissue have positioned re-irradiation(re-RT)as an option for many of these *** must be individualized,taking into account the pattern of relapse,previous treatment,and functional status,as well as the patient’s preferences and expected quality of *** questions remain unanswered with respect to re-RT:Who is the most appropriate candidate,which dose and fractionation are most effective,how to define the target volume,which imaging technique is best for planning,and what is the optimal timing?This review will focus on describing the most relevant studies that include re-RT as salvage therapy,with the aim of simplifying decision-making and designing the best available therapeutic strategy.

关键词： Re-irradiation Recurrent glioma High-grade gliomas Glioblastoma Radiosurgery Stereotactic radiotherapy

Oligometastases in prostate cancer:Ablative treatment

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World Journal of Clinical Oncology 2019年第2期10卷 38-51页

作者： Amalia Palacios-Eito Amelia Béjar-Luque Milagrosa Rodríguez-Li?án sonia garcía-cabezas Department of Radiation Oncology Reina Sofia University Hospital

Technological advances in radiotherapy have led to the introduction of techniques such as stereotactic body radiation therapy(SBRT), allowing the administration of ablative doses. The hypothesis that oligometastatic disease may be cured through local eradication therapies has led to the increasing use of SBRT in patients with this type of disease. At the same time, scientific advances are being made to allow the confirmation of clinically suspected oligometastatic status at molecular level. There is growing interest in identifying patients with oligometastatic prostate cancer(PCa) who may benefit from curative intent metastasis-directed therapy, including SBRT. The aim is to complement, replace or delay the introduction of hormone therapy or other systemic therapies. The present review aims to compile the evidence from the main ongoing studies and results on SBRT in relation to oligometastatic PCa; examine aspects where gaps in knowledge or a lack of consensus persist(e.g., optimum schemes, response assessment, identification and diagnosis of oligometastatic patients); and document the lack of first-level evidence supporting the use of such techniques.

关键词： Oligometastases Metastasis-directed therapy Stereotactic body radiation therapy Stereotactic ablative radiotherapy Prostate cancer

Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion:A case report and review of literature

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World Journal of Clinical Cases 2025年第4期13卷 48-55页

作者： Pierre Curings sonia Ramos-Pascual Kinga Michalewska Nicolas Gibert Lionel Erhard Mo Saffarini AlexisNogier Department of Hand Surgery Clinique TrenelSainte-Colombe 69560France Medical Research ReSurg SANyon 1260VaudSwitzerland Department of Hand Surgery Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Department of Orthopaedics Clinique TrenelSainte-Colombe 69560France

BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous *** treatments include direct tendon suture or tendon transfer,most commonly from the ring *** optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon *** SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a *** patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and *** patient was treated with two stage thumb *** first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon *** second intervention consisted of PL tendon graft and BR tendon ***-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 *** Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.

关键词： Brachioradialis tendon transfer Flexor pollicis longus Palmaris longus tendon graft Replantation Thumb amputation Thumb avulsion Case report

Effect of ground motion duration on inelastic displacement ratio of SDOF systems

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 423-439页

作者： Saman Yaghmaei-Sabegh sonia Daneshgari Department of Civil Engineering University of TabrizTabriz 51666-16471Iran

In this paper,the influence of ground motion duration on the inelastic displacement ratio,C_(1),of highly damped SDOF systems is *** this purpose,two sets of spectrally equivalent long and short duration ground motion records were used in an analysis to isolate the effects of ground motion duration *** effect of duration was evaluated for observed values of C_(1) by considering six ductility levels,and different damping and post-yield stiffness ratios.A new predictive equation of C_(1) also was developed for long and short duration *** of non-linear regression analysis of the current study provide an expression with which to quantify the duration *** on the average values of estimated C_(1) ratios for long duration records divided by C_(1) for a short duration set,it is concluded that the maximum difference between long and short duration records occurs when the damping ratio is 0.3 and the post-yield stiffness ratio is equal to zero.

关键词： inelastic displacement ratio long and short duration earthquakes highly damped SDOF systems ductility

Response of bioaerosol cells to photocatalytic inactivation with ZnO and TiO_(2)impregnated onto Perlite and Poraver carriers

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 137-149页

作者： Mariana Valdez-Castillo sonia Arriaga Environmental Science Department Institute for Scientific and Technological Research of San Luis PotosiIPICYT.Camino Presa San Jose 2055Lomas 4a SeccionCP 78216San Luis PotosiMexico

Bioaerosols are airborne microorganisms that cause infectious sickness,respiratory and chronic health *** have become a latent threat,particularly in indoor *** is a promising process to inactivate completely bioaerosols from ***,in systems treating a continuous air flow,catalysts can be partially lost in the gaseous *** avoid such phenomenon,supporting materials can be used to fix *** the present work,four photocatalytic systems using Perlite or Poraver glass beads impregnated with ZnO or TiO_(2)were *** inactivation mechanism of bioaerosols and the cytotoxic effect of the catalysts to^bioaeros^ls were *** plug flow photocatalytic reactor treated a bioaerosol flow of 460×10^(6)cells/m^(3)_(air)with a residence time of 5.7 *** Cytometry(FC)was used to quantify and characterize bioaerosols in terms of dead,injured and live *** most efficient system was ZnO/Perlite with 72%inactivation of bioaerosols,maintaining such inactivation during 7.5 h due to the higher water retention capacity of Perlite(2.8 mL/gpcriite)in comparison with Poraver(1.5 mL/gperiite).However,a global balance showed that Ti0_(2)/Poraver system triggered the highest level of cytotoxicity to bioaerosols retained on the support after 96 h with 95%of dead *** and FC analyses showed that the mechanism of inactivation with ZnO was based on membrane damage,morphological cell changes and cell lysis;whereas only membrane damage and cell lysis were involved with Ti0_(2).Overall,results highlighted that photocatalytic technologies can completely inactivate bioaerosols in indoor environments.

关键词： Immobilized catalysts Continuous flow Photocatalysis Bioaerosols Cytotoxicity Inactivation mechanism

Use of bone morphogenetic proteins in mesenchymal stemcell stimulation of cartilage and bone repair

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World Journal of Stem Cells 2016年第1期8卷 1-12页

作者： sonia Scarfì Department of Earth Environment and Life SciencesUniversity of Genova16132 GenovaItaly

The extracellular matrix-associated bone morphogenetic proteins(BMPs) govern a plethora of biological processes. The BMPs are members of the transforming growth factor-β protein superfamily, and they actively participate to kidney development, digit and limb formation, angiogenesis, tissue fibrosis and tumor development. Since their discovery, they have attracted attention for their fascinating perspectives in the regenerative medicine and tissue engineering fields. BMPs have been employed in many preclinical and clinical studies exploring their chondrogenic or osteoinductive potential in several animal model defects and in human diseases. During years of research in particular two BMPs, BMP2 and BMP7 have gained the podium for their use in the treatment of various cartilage and bone defects. In particular they have been recently approved for employment in non-union fractures as adjunct therapies. On the other hand, thanks to their potentialities in biomedical applications, there is a growing interest in studying the biology of mesenchymal stem cell(MSC), the rules underneath their differentiation abilities, and to test their true abilities in tissue engineering. In fact, the specific differentiation of MSCs into targeted celltype lineages for transplantation is a primary goal of the regenerative medicine. This review provides an overview on the current knowledge of BMP roles and signaling in MSC biology and differentiation capacities. In particular the article focuses on the potential clinical use of BMPs and MSCs concomitantly, in cartilage and bone tissue repair.

关键词： Mesenchymal stem cells Cartilage Bonerepair Bone morphogenetic protein

Exploring aramid as emerging contender for CO_2 capture

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Chinese Journal of Chemical Engineering 2016年第7期24卷 850-855页

作者： sonia Zulfiqar Muhammad Ilyas Sarwar Department of Chemistry School of Natural Sciences (SNS) National University of Sciences and Technology (NUST) Department of Chemistry Quaid-i-Azam University

To prevent CO_2 accumulation in the atmosphere generated from scorching of fossil fuels, carbon capture and sequestration(CCS) technology is considered as a potential route to mitigate the emissions of CO_2 from reaching the atmosphere. Power generation from sources such as gas, coal and biomass can fulfill the energy demand more readily than many other sources of electricity production. Thus these sources may be retained as important alternative option in the global energy cycle. In order to curtail CO_2, porous aramid network was fabricated by the condensation of 1,3,5-benzenetricarbonyl trichloride and 1,3-phenylenediamine in 1,4-dioxane solvent. Aramid was characterized for various analyses including FTIR, XRD, TGA, BET surface area and pore size analysis, FESEM and CO_2 adsorption measurements. Excellent thermal stability was provided by strong amide linkages in the polymer backbone. Optimum CO_2 uptake of aramid was achieved to be 23.14 mg·g^(-1) at 273 K at 0.1 MPa. The basic amide groups of network structure showed greater affinity for CO_*** thermal stability of aramid makes it a promising sorbent for CO_2 capture in adverse conditions.

关键词： Greenhouse gasCO2 capturePolymers

Numerical investigation of the effects of soil-structure and granular material-structure interaction on the seismic response of a flat-bottom reinforced concrete silo

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 609-623页

作者： sonia Benkhellat Mohammed Kadri Abdelghani Seghir Laboratory of Solid Mechanics and Systems University of M’Hamed BougaraBoumerdes 35000Algeria Laboratory of Geomaterials Environment and DevelopmentUniversity of M’Hamed BougaraBoumerdes 35000Algeria Research Laboratory of Applied Hydraulics and Environment Faculty of TechnologyUniversity of BejaiaBejaia 06000Algeria

In this work,a numerical study of the effects of soil-structure interaction(SSI)and granular material-structure interaction(GSI)on the nonlinear response and seismic capacity of flat-bottomed storage silos is conducted.A series of incremental dynamic analyses(IDA)are performed on a case of large reinforced concrete silo using 10 seismic *** IDA results are given by two average IDA capacity curves,which are represented,as well as the seismic capacity of the studied structure,with and without a consideration of the SSI while accounting for the effect of *** curves are used to quantify and evaluate the damage of the studied silo by utilizing two damage indices,one based on dissipated energy and the other on displacement and dissipated *** cumulative energy dissipation curves obtained by the average IDA capacity curves with and without SSI are presented as a function of the base shear,and these curves allow one to obtain the two critical points and the different limit states of the *** is observed that the SSI and GSI significantly influence the seismic response and capacity of the studied structure,particularly at higher levels of ***,the effect of the SSI reduces the damage index of the studied structure by 4%.

关键词： reinforced concrete silo perfectly matched layers soil-structure interaction granular material-structure interaction effective seismic input method damage index