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高粱型日粮中提高猪和家禽生产性能的方法(续完)

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国外畜牧学（猪与禽） 2016年第9期36卷 36-40页

作者：米雁朱琳娜罗静如 sonia Y.Liu Peter H.Sellet Aaron J.Cowieson 上海欧耐施生物技术有限公司

上期回顾:上期对高粱抗营养作用的机制、高粱颗粒的破碎方法及制粒条件对营养物质利用率和生产性能的影响等方面进行了阐述。

关键词：家禽生产抗营养作用物质利用率消化率淀粉糊化生产性能糊化度饲料加工代谢能饲料添加剂

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Association between mucosal surface pattern under near focus technology and Helicobacter pylori infection

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World Journal of Gastrointestinal Endoscopy 2021年第10期13卷 518-528页

作者： Felipe Fiuza Fauze Maluf-Filho Edson Ide Carlos Kiyoshi Furuya Jr sonia Nadia Fylyk Jennifer Nakamura Ruas Luciana Stabach Gabriela Albuquerque Araujo Sergio Eiji Matuguma Ricardo Sato Uemura Christiano Makoto Sakai Kendi Yamazaki Sergio Shiguetoshi Ueda Paulo Sakai Bruno Costa Martins Department of Endoscopy Hospital Alemão Oswaldo CruzSão Paulo 01323-020Brazil

BACKGROUND Many studies evaluated magnification endoscopy(ME)to correlate changes on the gastric mucosal surface with Helicobacter pylori(***)***,few studies validated these concepts with high-definition endoscopy without *** To access the association between mucosal surface pattern under near focus technology and *** infection status in a western *** Cross-sectional study including all patients referred to routine upper *** exams were performed using standard high definition(S-HD)followed by near focus(NF-HD)*** of erythema,erosion,atrophy,and nodularity were recorded during S-HD,and surface mucosal pattern was classified using NF-HD in the gastric *** were taken for rapid urease test and *** One hundred and eighty-seven patients were analyzed from August to November *** those,47(25.1%)were ***+,and 42(22.5%)had a previous *** *** the examination with S-HD,erythema had the best sensitivity for *** detection(80.9%).Exudate(99.3%),nodularity(97.1%),and atrophy(95.7%)demonstrated better specificity values,but with low sensitivity(6.4%-19.1%).On the other hand,the absence of erythema was strongly associated with ***-(negative predictive value=92%).With NF-HD,56.2%of patients presented type 1 pattern(regular arrangement of collecting venules,RAC),and only 5.7%of RAC+patients were ***+.The loss of RAC presented 87.2%sensitivity for *** detection,70.7%specificity,50%positive predictive value,and 94.3%negative predictive value,indicating that loss of RAC was suboptimal to confirm *** infection,but when RAC was seen,*** infection was *** The presence of RAC at the NF-HD exam and the absence of erythema at S-HD were highly predictive of *** negative *** the other hand,the loss of RAC had a suboptimal correlation with the presence of ***.

关键词： Diagnosis Endoscopy Gastric infection Gastritis Helicobacter pylori Sensitivity and specificity

Leprosy presented as cutaneous erythema

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Chinese Medical Journal 2013年第19期126卷 3797-3797页

作者： Wang Fang Hwang, sonia Kay Huang Hai-yan Du Juan Ding Xiao-lan Myint, Soe Lwin Zhang Jian-zhong Peking Univ Peoples Hosp Dept Dermatol Beijing 100044 Peoples R China

To the editor：Leprosy is rarely seen in dermatology clinics,thus it is easily misdiagnosed when presented as *** first patient presented with sole red plaques on the left ear with numbness,and the second patient pres... 详细信息

关键词： Leprosy presented erythema

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宝贝也安家

安家 2002年第1期 39-39页

作者： sonia

对了,自本期起,我们新开辟《安家小宠》栏目,为这些可爱的小精灵们开辟一块属于它们自己的园地。如果您的家中饲养着这些小宝贝,不妨将它们生活中的趣闻告诉我们,让我们与读者一起共享。

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天花未死？

环球科学 2013年第4期 46-51页

作者：索妮亚· 沙阿(sonia Shah) 苏静静(翻译) 不详北京大学医学史中心

一万年前，当天花第一次出现时，人类除了祈祷，向神灵请求援助之外，完全没有抵抗能力。天花病毒首先侵入鼻腔或胸腔的表皮，然后蔓延至全身各处，直到皮肤表面出现很多充满病毒的水泡。历史上，从有记录开始，感染天花病毒的患者有1／... 详细信息

一万年前，当天花第一次出现时，人类除了祈祷，向神灵请求援助之外，完全没有抵抗能力。天花病毒首先侵入鼻腔或胸腔的表皮，然后蔓延至全身各处，直到皮肤表面出现很多充满病毒的水泡。历史上，从有记录开始，感染天花病毒的患者有1／3最终以死亡告终，仅仅在20世纪，就有超过3亿人因此毙命。

关键词：天花病毒抵抗能力 20世纪

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又一个似水流年

安家 2002年第1期 128-128页

作者： sonia

Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model

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World Journal of Hepatology 2016年第21期8卷 902-914页

作者： Sylvie Lagaye sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol Institut Pasteur INSERM Institut Cochin INSERM U1016CNRS UMR8104Universite Paris Descartes(UMR S1016) Genoscience Pharma KU Leuven Rega Institute Laboratoire Alphabio APHP Groupe Hospitalier La Pitie Salpe-triereService de Chirurgie digestive et Hepato bilio pancreatique APHP Groupe Hospitalier CochinService de Chirurgie digestiveHepato-biliaire et Endocrinienne Universite Paris Descartes APHP Groupe Hospitalier CochinUnite d’Hepatologie Institut Pasteur Departement de Recherche TranslationnelleINSERM

AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.

关键词： Host antiviral therapy Hepatitis C virus Tissue culture Autophagy Quinoline derivative

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医药中的纳米科技

环球科学 2021年第23期 86-91页

作者：索尼桠·孔特拉孙亚飞(翻译) 不详

随着分子生物学的兴起,科学家已经在很大程度上从微观层面认识了生物的运作机制。如今,纳米机器人的问世为这个领域注入了新的活力。自20世纪50年代以来,抗生素的流行挽救了无数人的生命,但是,抗生素的滥用也逐渐成为我们无法忽略的问题。

关键词：纳米机器人纳米科技人的生命分子生物学运作机制新的活力抗生素微观层面

Adverse effects induced by chromium Ⅵ, cadmium and arsenic exposure on hypothalamus-pituitary physiology

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BIOCELL 2016年第1期40卷 15-18页

作者： JIMENA P.CABILLA sonia A.RONCHETTI BEATRIZ H.DUVILANSKI Instituto de Investigaciones Biomédicas(INBIOMED)UBA-CONICET Facultad de MedicinaUniversidad de Buenos AiresParaguay 215510°pisoCiudad Autónoma de Buenos AiresC1121ABGArgentina

Environmental contamination with some metalloids and heavy metals(M/HM)raises concern due to well known adverse effects on *** these pollutants,chromium VI(Cr VI),cadmium(Cd)and arse-nic(As)are frequently present as a result of natural sources or due to industrial *** are able to easily enter the organism and negatively affect many organs and *** vivo(exposure to Cr VI,Cd or As through drinking water)and in vitro experiments(primary pituitary cell cultures)were performed in male Wistar rats to address their actions on hypothalamus-pituitary *** the M/HM accumulated in hypothalamus and pi-tuitary gland and decreased pituitary cell viability and prolactin release mostly by generation of reactive oxygen species,since it was partially prevented by antioxidant *** the pituitary,they increased lipid peroxy-dation and the expression of several oxidative stress *** death was mainly due to caspase-dependent ***(prolactin-secreting cells)were the most affected pituitary ***-driven cell death was also partially calcium-and ***,Cd stimulated the production of low levels of nitric oxide which exerted cytoprotective *** results showed that these M/HM display deleterious actions in hypothalamic-pituitary physiology by altering hormone release and promoting cell death.

关键词： metalloid heavy metals cell death oxidative stress hormone release