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Study on macro and micro shear strength of continuously graded and gap-graded sand

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Particuology 2024年第3期86卷 101-116页

作者： Peiran Zhao songyu Liu Kai wu School of Transportation Southeast UniversityNanjing210096China

The particle gradation of sand has a significant influence on its shear strength,yet the similarities and differences between the effects of continuous and gap grading have yet to be fully *** this study,the discrete element method(DEM)was used to simulate biaxial tests on granular samples that were both continuously graded and *** macroscopic analysis revealed that the shear strength of continuously graded sands increases initially and then decreases as the uniformity of particle size distribution *** the other hand,the lack of medium particles in gap-graded sands amplifies the difference in particle size between coarse and fine particles,leading to a decrease in shear ***,both continuous and gap gradings affect the internal packing structure of the particle assembly,which consequently affects particle stress distributions,contact forces,coordination numbers,stress-induced anisotropies,and contact force networks,thus having an impact on the macroscopic shear *** global uniformity of particle size distribution was unidirectionally affected by continuous grading,while gap grading had a locally bidirectional *** findings provide a better understanding of the effects of particle grading on the macroscopic shear strength of sands.

关键词： Biaxial test Shear strength Particle gradation Discrete element method Micromechanics

Mechanism of action of cordycepin in the treatment of hepatocellular carcinoma via regulation of the Hippo signaling pathway

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Food Science and Human Wellness 2024年第2期13卷 1040-1054页

作者： Xiaomin Li Qing Liu songyu Xie Xiaoping wu Junsheng Fu College of Life Sciences Mycological Research CenterFujian Agriculture and Forestry UniversityFuzhou 350002China

Hepatocellular carcinoma(HCC)is one of the common most malignant *** study aimed to determine the in vitro and in vivo anticancer activity of cordycepin and elucidate its mechanism of *** results of in vitro and in vivo studies revealed that cordycepin inhibited proliferation and migration in HepG-2 cells and inhibited the growth of HepG-2 xenograft-bearing nude mice by inducing *** sequencing analysis revealed a total of 403 differential genes,which revealed that cordycepin may play an anti-HCC role by regulating Hippo signaling *** regulatory effects of cordycepin on the Hippo signaling pathway was further investigated using a YAP1 *** results demonstrated that cordycepin upregulated the expression of MST1 and LAST1,and subsequently inhibited YAP1,which activated the Hippo signaling *** in turn downregulated the expression of GBP3 and ETV5,and subsequently inhibited cell proliferation and ***,YAP1 regulated the expression of Bax and Bcl-2,regulated the mitochondrial apoptotic pathway,and induced apoptosis by upregulating the expression of the caspase-3 *** summary,this study reveals that cordycepin exerts its anti-hepatocarcinoma effect through regulating Hippo signaling pathway,and GBP3 and ETV5 may be potential therapeutic targets for hepatocarcinoma.

关键词： Cordycepin Hepatocellular carcinoma Hippo signaling pathway GBP3 ETV5

A DNA-based nanocarrier for efficient cancer therapy

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Journal of Pharmaceutical Analysis 2021年第3期11卷 330-339页

作者： Muhammad Abbas Mirza Muhammad Faran Ashraf Baig Yaliang Zhang Yu-Shun Yang songyu wu Yiqiao Hu Zhong-Chang Wang Hai-Liang Zhu State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023PR China State Key Laboratory of Analytical Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023PR China Institute of Drug Research and Development Medical School of Nanjing UniversityNanjing210093PR China

The study aimed to achieve enhanced targeted cytotoxicity and cell-internalization of cisplatin-loaded deoxyribonucleic acid-nanothread(CPT-DNA-NT),mediated by scavenger receptors into HeLa ***-NT was developed with stiff-topology utilizing circular-scaffold to encapsulate *** force microscopy(AFM)characterization of the DNA-NT showed uniformity in the structure with a diameter of 50-150 nm and length of 300-600 *** successful fabrication of the DNA-NT was confirmed through native-polyacrylamide gel electrophoresis analysis,as large the molecular-weight(polymeric)DNA-NT did not split into constituting strands under applied current and *** results of cell viability confirmed that blank DNA-NT had the least cytotoxicity at the highest concentration(512 nM)with a viability of 92%as evidence of its biocompatibility for drug *** assay showed superior cytotoxicity of CPT-DNA-NT than that of the free CPT due to the depot release of CPT after DNA-NT *** DNA-NT exhibited targeted cell internalizations with the controlled intracellular release of CPT(from DNA-NT),as illustrated in confocal ***,in vitro cytotoxicity assessment through flow cytometry showed enhanced apoptosis(72.7%)with CPT-DNA-NT(compared to free CPT;64.4%).CPT-DNA-NT,being poly-anionic,showed enhanced endocytosis via scavenger receptors.

关键词： DNA-nanothread Cisplatin Drug delivery Scavenger receptors Caveolae HeLa cell line

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“海洋入宪”模式比较研究

环球法律评论 2010年第4期32卷 127-133页

作者：吴淞豫祝捷中国政法大学大连海事大学武汉大学武汉大学比较宪法研究中心

各国宪法对海洋入宪问题采用了"海域"和"海权"各自分立、结合并存等迥异的立法方式。海域立宪模式又进而分为概括宣告式、地名罗列式、条约依据式等六类,"海权立宪模式"则又分为分层式、授权式、专列海洋资源式三类。海洋入宪时机集中... 详细信息

各国宪法对海洋入宪问题采用了"海域"和"海权"各自分立、结合并存等迥异的立法方式。海域立宪模式又进而分为概括宣告式、地名罗列式、条约依据式等六类,"海权立宪模式"则又分为分层式、授权式、专列海洋资源式三类。海洋入宪时机集中选择在海洋权益纠纷高峰期。中国与邻国海权纠纷凸起,维护海权急需宪法依据,海洋入宪的时机已经成熟。宜采用"海域"与"海权"并存的方式,并以授权式规范为主实现海洋入宪。

关键词：海洋法宪法海域海权

A photovoltaic hydrogen generation system using fuzzy logic control-based maximum power point tracking

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A photovoltaic hydrogen generation system using fuzzy logic ...

Hybrid MPC-based control of maximum power point tracking in PV power systems

第35届中国过程控制会议

作者： songyu Luo AiMin An Yan wu XianGui Li JiangTao Li College of Electrical and Information Engineering Lanzhou University of Technology Key Laboratory of Gansu Advanced Control for Industrial Processes

In this paper, the modeling of the PV hydrogen production system and the optimization control method are studied, and a compound maximum power point tracking control technique is proposed to improve the quality of PV power generation as well as the efficiency of hydrogen production. Firstly, the overall structure of the PV hydrogen production system is constructed, and mathematical models of PV arrays, PEM electrolyzer, hydrogen storage tanks, storage batteries, etc. are established;secondly,the basic concepts, basic principles, and flow charts of the fuzzy logic control(FLC) and the adaptive Gray Wolf algorithm(GWO) are introduced;finally, the GWO algorithm is combined with the PV hydrogen production system, and maximum power point tracking control control based on this algorithm is modeled and simulation analysis, and the effectiveness and feasibility of the proposed technique are verified by simulation comparison. The simulation results show that the maximum power point tracking control control system based on the adaptive GWO algorithm has a smaller power oscillation range and power loss near the maximum power point, and the dynamic response time of the maximum power point tracking control control system proposed in this paper is shortened by an average of 0.04 s. The power oscillation of the system has been effectively reduced by17.2%, and the energy conversion efficiency has been improved, which highlights the advantages of the scheme. By comparing and analyzing with the traditional maximum power point tracking control optimization control method, it is verified that the proposed method improves the operation index of the PV hydrogen production system to a certain extent, and at the same time reduces the fluctuation amplitude of the input power of the PEM electrolyzer, and strengthens the dynamic balance capability of the PV hydrogen production system.

关键词： Photovoltaic power generation Hydrogen production from electrolyzed water Optimize control

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Hybrid MPC-based control of maximum power point tracking in ...

第35届中国过程控制会议

作者： Yan wu Aimin An songyu Luo Hailong Zuo Jinhu Niu College of Electrical and Information Engineering Lanzhou University of Technology Key Laboratory of Gansu Advanced Control for Industrial Processes Gansu Guokai New Energy Equipment Co. LTD

Aiming at the P-V curves of PV arrays presenting multi-peak characteristics under the partial shading condition(PSC),the traditional conductivity increment(INC) method and particle swarm algorithm(PSO) are prone to fall into the local optimal solution, as well as the existence of the tracking power with poor stability and accuracy in tracking the PV array's global maximum power point. This paper proposes a hybrid PV MPPT control strategy based on APSO-INC and MPC. Firstly,the proposed hybrid APSO-INC algorithm initially locates the maximum power, secondly tracks the maximum power through Model Predictive Control(MPC), and finally controls the boost converter in order to achieve the point of tracking the maximum power of the photovoltaic system in a changing environment. The proposed system is simulated and evaluated under various dynamic conditions using Matlab/Simulink. The simulation results show that the algorithm overcomes the shortcomings of easily falling into local optimal solutions at the PSC, the total maximum power point tracking time is reduced, and the power oscillations are smaller compared to the traditional methods. It has the advantages of good tracking accuracy and high stability.

关键词： Maximum power point tracking Partial Shade Conditions(PSC) APSO-INC Model Predictive Control(MPC) Photovoltaic(PV)

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论行政诉讼受案范围之立法技术

国家检察官学院学报 2007年第1期15卷 131-137页

作者：吴淞豫武汉大学法学院湖北武汉430072

对我国行政诉讼受案范围之立法技术,应当从两个方面予以完善:在宏观上由宪法明确授予法院行政审判权,并在此基础上将行政受案范围在基本法层面具体化,实现立法技术在宪法和基本法之间的协调,再以确认和保障相对人诉权为逻辑前提,在不同... 详细信息

对我国行政诉讼受案范围之立法技术,应当从两个方面予以完善:在宏观上由宪法明确授予法院行政审判权,并在此基础上将行政受案范围在基本法层面具体化,实现立法技术在宪法和基本法之间的协调,再以确认和保障相对人诉权为逻辑前提,在不同效力层级之法律规范性文件中分别对行政诉讼受案范围作出规定。微观上以行政争议为基本范畴,在宪法、行政诉讼法以及其他法律规范中甄别使用肯定式和否定式。

关键词：行政诉讼受案范围立法技术

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行政诉讼受案范围之立法技术探析

社科纵横 2007年第1期22卷 24-26,35页

作者：吴淞豫武汉大学法学院湖北武汉430072

本文以行政诉讼法修改中更好体现理论成果,完善现有立法技术为初衷,以行政诉讼受案范围立法技术为研究对象,认为应当从两方面把握其内涵:宏观上在法律体系中何种效力等级的规范性法律文件中规定受案范围,不同效力等级的法律的规定区别... 详细信息

本文以行政诉讼法修改中更好体现理论成果,完善现有立法技术为初衷,以行政诉讼受案范围立法技术为研究对象,认为应当从两方面把握其内涵:宏观上在法律体系中何种效力等级的规范性法律文件中规定受案范围,不同效力等级的法律的规定区别、衔接以及逻辑起点的选择;微观上法律条文本身逻辑体系(以何为受案范围确立的基本范畴)、表述方式(肯定式还是否定式)的甄别使用。在比较和分析了域外行政诉讼受案范围立法技术的前提下,认为我国行政诉讼的受案范围立法技术应当从两个方面完善:宏观上首先在宪法中明确司法机关对行政行为的审查权,明确司法是行政争议最终解决途径(最终裁决权),以确认和保障相对人诉权为逻辑前提,在不同效力层级之法律规范性文件中分别确立;微观上应以行政争议为基本范畴,在宪法、行政诉讼法以及其他法律中甄别使用肯定式和否定式。

关键词：行政诉讼受案范围立法技术

具有网络时延的直线开关磁阻电机位置跟踪控制

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深圳大学学报（理工版） 2017年第4期34卷 434-440页

作者：胡松钰吴伟钱松潘剑飞邱丽深圳大学机电与控制工程学院广东深圳518060

针对直线开关磁阻电机网络化运行诱导时延及位置跟踪控制等问题,结合系统在线辨识获得电机模型,将网络化直线开关磁阻电机运动控制系统建模为马尔可夫时延系统.提出具有反馈通道时延的网络化直线开关磁阻电机位置跟踪控制方法,利用Lyapu... 详细信息

针对直线开关磁阻电机网络化运行诱导时延及位置跟踪控制等问题,结合系统在线辨识获得电机模型,将网络化直线开关磁阻电机运动控制系统建模为马尔可夫时延系统.提出具有反馈通道时延的网络化直线开关磁阻电机位置跟踪控制方法,利用Lyapunov稳定性定理和线性矩阵不等式技术得到系统稳定的充分条件,给出状态反馈控制器设计.选取4组不同频率和幅值的正弦参考信号进行实验验证,证实该方法是有效可行的.

关键词：系统辨识网络化控制系统网络诱导时延直线开关磁阻电机李雅普诺夫方法位置跟踪控制器