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A plausible pathway to prebiotic peptides via amino acid amides on the primordial Earth

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Earth and Planetary Physics 2024年第6期8卷 868-877页

作者： DingWei Gan XiangMin Lei RenWu Zhou songsen fu Jing Sun RuSen Zhou Kostya(Ken)Ostrikov YuFen Zhao JianXi Ying Institute of Drug Discovery Technology Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life SciencesNingbo UniversityNingbo Zhejiang 315211China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China College of Food Science and Engineering Tianjin University of Science and TechnologyTianjin 300457China School of Chemistry and Physics Queensland University of TechnologyBrisbaneQLD 4000Australia Department of Chemical Biology College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

The prebiotic synthesis of peptides prior to ribosome-catalyzed processes remains an *** synthesis of abiotic peptides from amino acids(AAs)is primarily constrained by high activation energies and unfavorable thermodynamics,necessitating the identification of plausible prebiotic alternatives for synthesizing prebiotic *** we present a plausible pathway to the formation of prebiotic peptides,wherein oligopeptides,oligopeptide amides,and cyclic oligopeptides can be directly synthesized from amino acid amides(AA-NH2)under wet–dry cycle conditions without the need for any *** subsequent investigation revealed that AA-NH2 demonstrated more favorable thermodynamic reaction effects than AAs in peptide *** contrast to the polymerization of AAs,the process of peptide formation through the polymerization of AA-NH2 was significantly ***,AA-NH2 was discovered to function as a“bridge”for the formation of peptides from AAs,thereby facilitating their participation in the synthesis of intricate peptide *** the basis of these findings,a plausible mechanism for the prebiotic origin network of peptides under primordial Earth conditions has been ***,this research presents a plausible pathway for the generation of prebiotic peptides and peptide libraries within prebiotic environments.

关键词： prebiotic chemistry origin of life chemical evolution peptide

Nphos:Database and Predictor of Protein N-phosphorylation

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 139-151页

作者： Ming-Xiao Zhao Ruo-Fan Ding Qiang Chen Junhua Meng fulai Li songsen fu Biling Huang Yan Liu Zhi-Liang Ji Yufen Zhao Institute of Drug Discovery Technology Ningbo UniversityNingbo 315211China Department of Chemical Biology Key Laboratory for Chemical Biology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Zhejiang Key Laboratory of Pathophysiology Department of Biochemistry and Molecular BiologyHealth Science CenterNingbo UniversityNingbo 315211China BGI Genomics BGI-ShenzhenShenzhen 518083China Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China

Protein N-phosphorylation is widely present in nature and participates in various biological ***,current knowledge on N-phosphorylation is extremely limited compared to that on *** this study,we collected 11,710 experimentally verified N-phosphosites of 7344 proteins from 39 species and subsequently constructed the database Nphos to share up-to-date information on protein *** these substantial data,we characterized the sequential and structural features of protein ***,after comparing hundreds of learning models,we chose and optimized gradient boosting decision tree(GBDT)models to predict three types of human N-phosphorylation,achieving mean area under the receiver operating characteristic curve(AUC)values of 90.56%,91.24%,and 92.01%for pHis,pLys,and pArg,***,we discovered 488,825 distinct N-phosphosites in the human *** models were also deployed in Nphos for interactive N-phosphosite *** summary,this work provides new insights and points for both flexible and focused investigations of *** will also facilitate a deeper and more systematic understanding of protein N-phosphorylation modification by providing a data and technical *** is freely available at http://***/Nphos/and http://***/Nphos/.

关键词： N-phosphorylation Post-translational modification Machine learning Database Benchmark dataset

“一村一名大学生工程”学员创业情况的调查与反思——以南昌电大为例

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江西广播电视大学学报 2019年第1期21卷 79-82页

作者：武云飞周慧云付松森江西广播电视大学南昌市分校江西南昌330046

通过对南昌电大"一村一名大学生工程"项目(以下简称"一村一")在校学生的创业方面的情况进行调查和分析,并从办学单位自身方面进行剖析与反思找出影响"一村一"学员缺乏创业意愿的原因,提出解决问题的办法,激发更多"一村一"学员的创业热情... 详细信息

通过对南昌电大"一村一名大学生工程"项目(以下简称"一村一")在校学生的创业方面的情况进行调查和分析,并从办学单位自身方面进行剖析与反思找出影响"一村一"学员缺乏创业意愿的原因,提出解决问题的办法,激发更多"一村一"学员的创业热情,从而投身到农村创业的实践中去。

关键词：农民大学生创业意愿调查

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基于N-磷酰化氨基酸探讨激酶磷转移机制

中国科学：化学 2023年第3期53卷 338-348页

作者：傅松森李福来黄碧玲蔡华欢倪锋应见喜刘艳付川高祥李艳梅赵玉芬宁波大学新药技术研究院宁波315211 厦门大学化学化工学院厦门361005 厦门大学药学院厦门361102 清华大学化学系北京100084

N-磷酰化的α-氨基酸可以发生多种磷转移反应,而且只有α-氨基酸可以被磷激活.在生命系统中,磷的转移在生物信息传递中扮演了关键角色.双组分系统(two-component system,TCS)是细菌感应并响应外界复杂环境最为重要的信号传导系统,其分... 详细信息

N-磷酰化的α-氨基酸可以发生多种磷转移反应,而且只有α-氨基酸可以被磷激活.在生命系统中,磷的转移在生物信息传递中扮演了关键角色.双组分系统(two-component system,TCS)是细菌感应并响应外界复杂环境最为重要的信号传导系统,其分子基础为磷酸根从ATP依次传递到组氨酸激酶的组氨酸(P–N键)和下游调控蛋白的天冬氨酸(P–OCO键);在高等生物中,ATP经激酶将磷酸根传递到底物蛋白的羟基(P–O键),催化中心中高度保守的酸性和碱性氨基酸不可或缺.如果N-磷酰化氨基酸是微型的TCS模型,那么高等生物激酶是否利用类似TCS的磷传递机制?本文总结了N-磷酰化α-氨基酸和激酶介导的磷转移过程,探讨N-磷酰化氨基酸模型作为磷转移系统“分子化石”的可能性,希望为激酶催化机制及基于激酶的新药研发提供新思路.

关键词： N-磷酰化氨基酸激酶磷转移双组分系统