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全球页岩油形成分布潜力及中国陆相页岩油理论技术进展

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地学前缘 2023年第1期30卷 128-142页

作者：邹才能马锋潘松圻张新顺吴松涛傅国友王红军杨智中国石油勘探开发研究院北京100083 中国石油天然气股份有限公司科技管理部北京100007

全球非常规页岩层系油气资源丰富,富有机质页岩主要沉积在劳亚构造域和特提斯构造域的上侏罗统、渐新统—中新统、白垩系和上泥盆统4套页岩层系内。交汇分析北美典型页岩油区块产量与R_(o)数据关系,提出R_(o)为0.7%作为低熟页岩油和中... 详细信息

全球非常规页岩层系油气资源丰富,富有机质页岩主要沉积在劳亚构造域和特提斯构造域的上侏罗统、渐新统—中新统、白垩系和上泥盆统4套页岩层系内。交汇分析北美典型页岩油区块产量与R_(o)数据关系,提出R_(o)为0.7%作为低熟页岩油和中高熟页岩油的界限,系统评价了全球116个盆地157套页岩层系中高熟页岩油、低熟页岩油技术可采资源量约2512亿t,主要分布在北美洲、南美洲、北非和俄罗斯,以前陆盆地中新界、克拉通盆地古生界、裂谷盆地和被动大陆边缘盆地的中生界为主。海相页岩油受显生宙以来的海侵影响,富集在稳定克拉通和前陆等类型盆地中,具大面积稳定分布、成熟度适中等特征;陆相页岩油受暖室期气候影响,主要在坳陷、断陷等类型盆地中发育,以微纳米级无机孔隙和微页理裂缝为主要储渗空间通道,具有沉积相横向变化大、“甜点区段”局部富集等特征。中国石油工业正经历从“陆相页岩生油”向“陆相页岩产油”转变,初步形成源岩油气“进源找油”地质理论、陆相页岩油高效勘探及低成本开发技术体系,推动中国陆相页岩油取得重要突破。着力加强应用基础理论研究与关键技术攻关,构建地质-工程一体化模式,强化全生命周期管理理念,加快中高熟页岩油“压裂人工油藏”工业化发展,加强低熟页岩油“加热原位转化”技术攻关与工业化试验,推动实现中国“陆相页岩油革命”,夯实“稳油增气”资源基础。

关键词：全球页岩油中高熟页岩油低熟页岩油资源评价非常规油气

DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

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Cancer Biology & Medicine 2024年第3期21卷 252-266页

作者： Junya Yan Shibo Wang Jing Zhang Qiangqiang Yuan Xianchun Gao Nannan Zhang Yan pan Haohao Zhang Kun Liu Jun Yu Linbin Lu Hui Liu Xiaoliang Gao Sheng Zhao Wenyao Zhang Abudurousuli Reyila Yu Qi Qiujin Zhang Shundong Cang Yuanyuan Lu Yanglin pan Yan Kong Yongzhan Nie State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Air Force Military Medical UniversityXi'an 710032China Department of Oncology Henan Provincial People's HospitalZhengzhou University People's HospitalZhengzhou 450o03China Faculty of Life Science Northwest UniversityXi'an 710069China Unit 73211 of the People's Liberation Army Nanjing 211800China Key Laboratory of Resource Biology and Biotechnology in Western China(Ministry of Education) School of MedicineNorthwest UniversityXi'an 710069China Shaanxi University of Chinese Medicine Second Clinical Medicine FacultyXi'an 712046China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Renal Cancer and MelanomaPeking University Cancer Hospital and InstituteBeijing 100142China

Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) ***: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published ***: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and ***: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions.

关键词： DNA damage response-related immune activation immune checkpoint inhibitors biomarker gastrointestinal cancer pan-cancer

A Novel Fall Detection Framework Using Skip-DSCGAN Based on Inertial Sensor Data

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Computers, Materials & Continua 2024年第1期78卷 493-514页

作者： Kun Fang Julong pan Lingyi Li Ruihan Xiang College of Information Engineering China Jiliang UniversityHangzhou310018China

With the widespread use of Internet of Things(IoT)technology in daily life and the considerable safety risks of falls for elderly individuals,research on IoT-based fall detection systems has gainedmuch *** paper proposes an IoT-based spatiotemporal data processing framework based on a depthwise separable convolution generative adversarial network using skip-connection(Skip-DSCGAN)for fall *** method uses spatiotemporal data from accelerometers and gyroscopes in inertial sensors as input data.A semisupervised learning approach is adopted to train the model using only activities of daily living(ADL)data,which can avoid data imbalance ***,a quantile-based approach is employed to determine the fall threshold,which makes the fall detection frameworkmore *** proposed fall detection framework is evaluated against four other generative adversarial network(GAN)models with superior anomaly detection performance using two fall public datasets(SisFall&MobiAct).The test results show that the proposed method achieves better results,reaching 96.93% and 92.75% accuracy on the above two test datasets,*** the same time,the proposed method also achieves satisfactory results in terms ofmodel size and inference delay time,making it suitable for deployment on wearable devices with limited *** addition,this paper also compares GAN-based semisupervised learning methods with supervised learning methods commonly used in fall *** clarifies the advantages of GAN-based semisupervised learning methods in fall detection.

关键词： Fall detection skip-connection depthwise separable convolution generative adversarial networks inertial sensor

Electron beam lithography on nonplanar and irregular surfaces

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Microsystems & Nanoengineering 2024年第2期10卷 1-23页

作者： Chenxu Zhu Huseyin Ekinci Aixi pan Bo Cui Xiaoli Zhu Department of Electrical and Computer Engineering and Waterloo Institute for Nanotechnology(WIN) University of WaterlooWaterlooONCanada

E-beam lithography is a powerful tool for generating nanostructures and fabricating nanodevices with fine features approaching a few nanometers in ***,alternative approaches to conventional spin coating and development processes are required to optimize the lithography procedure on irregular *** this review,we summarize the state of the art in nanofabrication on irregular substrates using e-beam *** overcome these challenges,unconventional methods have been *** instance,polymeric and nonpolymeric materials can be sprayed or evaporated to form uniform layers of electron-sensitive materials on irregular ***,chemical bonds can be applied to help form polymer brushes or self-assembled monolayers on these *** addition,thermal oxides can serve as resists,as the etching rate in solution changes after e-beam ***,e-beam lithography tools can be combined with cryostages,evaporation systems,and metal deposition chambers for sample development and lift-off while maintaining low *** nanopyramids can be fabricated on an AFM tip by utilizing ice as a positive ***,Ti/Au caps can be patterned around a carbon ***,3D nanostructures can be formed on irregular surfaces by exposing layers of anisole on organic ice surfaces with a focused *** advances in e-beam lithography on irregular substrates,including uniform film coating,instrumentation improvement,and new pattern transferring method development,substantially extend its capabilities in the fabrication and application of nanoscale structures.

关键词： lithography beam coating

Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis:Current Knowledge and Future Perspectives

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Current Medical Science 2024年第1期44卷 1-27页

作者： Qi pan Cheng CHEN Yue-jin YANG State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China

Atherosclerosis(AS)is characterized by impairment and apoptosis of endothelial cells,continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells,which is documented as the traditional cellular ***,the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis,transdifferentiation and novel cell death forms such as ferroptosis,pyroptosis,and extracellular trap were *** of novel pathological cellular landscapes provides a large number of therapeutic *** the other side,the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS *** cell-or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse *** the complexity of pathological changes of AS,attempts to develop an almighty medicine based on single mechanisms could be theoretically *** this review,the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical *** future challenges and improvements were also discussed.

关键词： atherosclerosis transdifferentiation extracellular traps efferocytosis stem cell nanoparticles

Efficacy of scraping therapy on blood pressure and sleep quality in stage Ⅰ and Ⅱ essential hypertension: A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第1期22卷 12-21页

作者： Zheng-gang Zhu Jian-ru Wang Xiao-yan pan School of Nursing Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina School of Health Sciences Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia Department of Cardiovascular Medicine the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina

Background Scraping therapy is widely used in treating stage I and II essential hypertension in ***,there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential *** strategy Seven electronic databases(PubMed,Scopus,Cochrane Library,Web of Science,EBSCO,China National Knowledge Infrastructure and Wanfang Data electronic databases)were searched from inception to December *** on the principle of combining subject words with text words,the search strategy was constructed around search terms for“scraping therapy,”“scraping,”“Guasha,”“Gua sha,”“hypertension,”and“high blood pressure”during the database *** criteria Randomized controlled trials(RCTs)were included if they recruited patients with stage I and II essential hypertension and included a scraping therapy *** intervention group received antihypertensive drugs and scraping therapy,while the control group only took antihypertensive *** extraction and analysis Review Manager 5.4.0 and STATA 15.1 were used to enter all the relevant outcome variables to conduct the *** quality of the selected RCTs was assessed using the PEDro *** sensitivity analysis was carried out by iteratively excluding individual studies and repeating the analysis to determine the stability of the findings and identify any studies with greater influence on the *** analysis was performed to find the source of *** plots were used to evaluate the publication bias of included *** Nine RCTs including 765 participants were ***-analysis showed that scraping therapy combined with medication had an advantage over the use of medication alone in lowering systolic blood pressure(mean difference[MD]=?5.09,95%confidence interval[CI]=?6.50 to?3.67,P<0.001)and diastolic blood pressure(MD=?2.66,95%CI=?3.17 to?2.14,P<0.001).Subgroup analysis showed tha

关键词： Scraping therapy Essential hypertension Efficacy Blood pressure Sleep quality Systematic review Meta-analysis

Molecular Generation and Optimization of Molecular Properties Using a Transformer Model

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Big Data Mining and Analytics 2024年第1期7卷 142-155页

作者： Zhongyin Xu Xiujuan Lei Mei Ma Yi pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the properties of a specific molecule to satisfy the specific properties of the generated *** Matched Molecular Pairs(MMPs),which contain the source and target molecules,are used herein,and logD and solubility are selected as the optimization *** main innovative work lies in the calculation related to a specific transformer from the perspective of a matrix *** intervals and state changes are then used to encode logD and solubility for subsequent *** the experiments,we screen the data based on the proportion of heavy atoms to all atoms in the groups and select 12365,1503,and 1570 MMPs as the training,validation,and test sets,*** models are compared with the baseline models with respect to their abilities to generate molecules with specific *** show that the transformer model can accurately optimize the source molecules to satisfy specific properties.

关键词： molecular optimization transformer Matched Molecular Pairs(MMPs) logD solubility

Shear band evolution and acoustic emission characteristics of sandstone containing non-persistent flaws

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 497-513页

作者： Shuting Miao Peng-Zhi pan Chuanqing Zhang Lei Huo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China CASIC Research Institute of Intelligent Decision Engineering Wuhan430040China

Direct shear tests were conducted on sandstone specimens under different constant normal stresses to study the coalescence of cracks between non-persistent flaws and the shear sliding characteristics of the shear-formed *** image correlation and acoustic emission(AE)techniques were used to monitor the evolution of shear bands at the rock bridge area and microcracking *** experimental results revealed that the shear stresses corresponding to the peak and sub-peak in the stressdisplacement curve are significantly affected by the normal *** localization bands emerged at both the tip of joints and the rock bridge,and their extension and interaction near the peak stress caused a surge in the AE hit rate and a significant decrease in the AE b *** and curvilinear strain bands were detected at low normal stress,while high normal stress generally led to more microcracking events and longer coplanar cracks at the rock bridge ***,an increase in normal stress resulted in a higher AE count rate and more energetic AE events during friction sliding along the shearformed *** was observed that the elastic energy released during the crack coalescence at the prepeak stage was much greater than that released during friction sliding at the post-peak *** than 75%of AE events were located in the low-frequency band(0e100 kHz),and this proportion continued to rise with increasing normal ***,more AE events of low AF value and high RA value were observed in specimens subjected to high normal stress,indicating that greater normal stress led to more microcracks of shear nature.

关键词： Shear band evolution Acoustic emission(AE) Crack coalescence Normal stress Shear sliding

Effect of Wave Nonlinearity on the Instantaneous Seabed Liquefaction

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China Ocean Engineering 2024年第1期38卷 93-103页

作者： WANG Zhao-jun SUI Ti-ti ZHANG Chi pan Jun-ning Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of TransportNanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Coastal Disaster and Protection(Hohai University) Ministry of EducationNanjing 210098China The National Key Laboratory of Water Disaster Prevention Nanjing 210098China

The nonlinear variation of wave is commonly seen in nearshore area,and the resulting seabed response and liquefaction are of high concern to coastal *** this study,an analytical formula considering the nonlinear wave skewness and asymmetry is adopted to provide wave pressure on the seabed *** liquefaction depth attenuation coefficient and width growth coefficient are defined to quantitatively characterize the nonlinear effect of wave on seabed *** on the 2D full dynamic model of wave-induced seabed response,a detailed parametric study is carried out in order to evaluate the influence of the nonlinear variation of wave loadings on seabed ***,new empirical prediction formulas are proposed to fast predict the maximum liquefaction under nonlinear *** indicate that(1)Due to the influence of wave nonlinearity,the vertical transmission of negative pore water pressure in the seabed is hindered,and therefore,the amplitude decreases significantly.(2)In general,with the increase of wave nonlinearity,the liquefaction depth of seabed decreases *** under asymmetric and skewed wave loading,the attenuation of maximum seabed liquefaction depth is the most significant among all the nonlinear wave ***,highly skewed wave can cause the liquefaction depth of seabed greater than that under linear wave.(3)The asymmetry of wave pressure leads to the increase of liquefaction width,whereas the influence of skewedness is not significant.(4)Compared with the nonlinear waveform,seabed liquefaction is more sensitive to the variation of nonlinear degree of wave loading.

关键词： nonlinear wave seabed response seabed liquefaction numerical simulation liquefaction prediction