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Transactions of Nonferrous Metals Society of China 2020年第1期30卷 27-40页

作者： Xiao-feng WANG Tong-ya SHI He-bin WANG song-ze zhou Wen-fei PENG Yong-gang WANG Key Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo 315211China School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

The effects of strain rate on the mechanical properties,microstructure and texture of Al-Mg-Si-Cu alloy were investigated through tensile test,microstructure and texture *** results show that strain rate has some influences on the mechanical properties and microstructure,but a slight influence on the ***,yield strength,ultimate tensile strength and elongation increase first,then remain unchanged,and finally increase with increasing strain *** of strain rate,microstructure in the vicinities of the fracture regions of all the specimens is composed of the slightly elongated ***,some differences in misorientation angle distributions can be *** strain rate increases,the low angle grain boundaries(LAGBs)increase first,and then *** in the vicinities of the fracture regions are almost identical with increasing strain rate.

关键词： Al-Mg-Si-Cu alloy strain rate mechanical properties microstructure texture

Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： Gui-Ming Deng Hai-Bin song Zhong-ze Du Ying-Wei Xue Hong-Jiang song Yuan-zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value of<41 Hounsfield units(HU)for patients with a body mass index(BMI)<25 kg/m^(2)and<33 HU for those with a BMI≥25 kg/m^(2).The log-rank test was used to compare progression-free survival(PFS)and overall survival(OS),and a Cox proportional hazard model was used to identify prognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor Prognostic factor Overall survival Progression-free survival

Decreased Nrf2 protein level and low sperm quality in intractable spermatocystitis

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Asian Journal of Andrology 2024年第2期26卷 189-194页

作者： Shi-ze Wang Jian-Nan Liu Fen-Fang zhou Ye-Jin-Peng Wang Peng Zhang song-Tao Cheng Department of Urology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Management and Clinical Medicine School of Medicine and HealthWuhan PolytechnicUniversityWuhan 430071China

To investigate the molecular etiology of low sperm quality in patients with intractable spermatocystitis,spermatozoa samples from patients with persistent hematospermia undergoing transurethral seminal vesiculoscopy and healthy volunteers were *** samples were collected from the seminal vesicles through transurethral seminal vesiculoscopy or by masturbation *** quality was analyzed by a WLJY-9000 color semen analysis *** of tumor necrosis factor alpha(TNFa)and interleukin-6(IL-6)in the seminal plasma was performed using enzyme-linked immunosorbent assay(ELISA).Measurement of H_(2)O_(2)in the seminal plasma was performed with a hydrogen peroxide *** protein levels of nuclear factor erythroid 2-related factor 2(Nrf2)and phosphorylated-Nrf2(p-Nrf2)were measured by western blot analysis and immunofluorescence *** sperm quality parameters and increased levels of inflammatory cytokines(TNFa,IL-6,and H_(2)O_(2))in the seminal plasma were detected among the semen samples from the patients with persistent ***2 and p-Nrf2 were strongly expressed in the nucleus and periphery of human sperm cells,according to the results of the immunofluorescence *** protein levels of Nrf2 and p-Nrf2 were significantly lower in the spermatozoa samples from patients with persistent hematospermia than in those from healthy volunteers with normal sperm *** results suggested that Nrf2 signaling might play a role in the low sperm quality of patients with intractable spermatocystitis.

关键词： H_(2)O_(2) Nrf2 sperm quality spermatocystitis

Micro defects formation and dynamic response analysis of steel plate of quasi-cracking area subjected to explosive load

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Defence Technology（防务技术） 2024年第1期31卷 580-593页

作者： Zheng-qing zhou ze-chen Du Xiao Wang Hui-ling Jiang Qiang zhou Yu-long Zhang Yu-zhe Liu Pei-ze Zhang Research Institute of Macro-Safety Science University of Science and TechnologyBeijing100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China School of Mechanical Engineering Nantong UniversityNantong226019China China North Industry Advanced Technology Generalization Institute Beijing100089China China Academy of Ordnance Science China

As the protective component,steel plate had attracted extensive attention because of frequently threats of explosive *** this paper,the evolution of microstructure and the mechanism of damage in the quasi-cracking area of steel plate subjected to explosive load were discussed and the relationships between micro defects and dynamic mechanical response were *** the explosion experiment,five observation points were selected equidistant from the quasi-cracking area of the section of the steel plate along the thickness direction,and the characteristics of micro defects at the observation points were analyzed by optical microscope(OM),scanning electron microscope(SEM) and electron backscattered diffraction(EBSD).The observation result shows that many slip bands(SBs) appeared,and the grain orientation changed obviously in the steel plate,the two were the main damage types of micro *** addition,cracks,peeling pits,grooves and other lager micro defects were appeared in the lower area of the *** stress parameters of the observation points were obtained through an effective numerical *** mechanism of damage generation and crack propagation in the quasicracking area were clarified by comparing the specific impulse of each observation point with the corresponding micro *** result shows that the generation and expansion of micro defects are related to the stress area(*** upper compression area,the neutral plane area,and the lower tension area).The micro defects gather and expand at the grain boundary,and will become macroscopic damage under the continuous action of tensile ***,the micro defects at the midpoint of the section of the steel plate in the direction away from the explosion center(*** horizontal direction) were also *** was found that the specific impulse at these positions were much smaller than that in the thickness direction,the micro defects were only SBs and a few micro cracks,and the those decrea

关键词： Explosive load Quasi-cracking area Micro defects Steel plate Dynamic response Numerical simulation

Type I interferon pathway in pediatric systemic lupus erythematosus

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World Journal of Pediatrics 2024年第7期20卷 653-668页

作者： Yu zhou Hong‑Mei song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalBeijingChina

Background The role of type I interferon(IFN-I)signaling in systemic lupus erythematosus(SLE)has been well ***,unanswered questions remain regarding the applicability of these findings to pediatric-onset *** aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset *** sources A literature search was conducted in the PubMed database using the following keywords:“pediatric systemic lupus erythematosus”and“type I interferon”.Results IFN-I signaling is increased in pediatric SLE,largely due to the presence of plasmacytoid dendritic cells and pathways such as cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase 1 and Toll-like receptor(TLR)4/*** extracellular traps and oxidative DNA damage further stimulate IFN-I *** variants in IFN-I-related genes,such as IFN-regulatory factor 5 and tyrosine kinase 2,are linked to SLE susceptibility in pediatric *** addition,type I interferonopathies,characterized by sustained IFN-I activation,can mimic SLE symptoms and are thus important to *** on interferonopathies also contribute to exploring the pathogenesis of *** IFN-I activation is crucial for SLE diagnosis and *** IFNstimulated gene expression and serum IFN-α2 levels are common *** cytometry markers such as CD169 and galectin-9 are promising ***-IFN therapies,such as sifalimumab and anifrolumab,show promise in adult patients with SLE,but their efficacy in pediatric patients requires further *** kinase inhibitors are another treatment option for severe pediatric SLE *** This review presents an overview of the IFN-I pathway in pediatric *** the intricate relationship between IFN-I and pediatric SLE may help to identify potential diagnostic markers and targeted therapies,paving the way for improved patient care and outcomes.

关键词： Interferonopathies Pediatric systemic lupus erythematosus Type I interferon

Atomic-scale mechanism of effect of co-separation of elements at interface of ferrite and austenite on Cr-depleted zone of duplex stainless steel

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Journal of Iron and Steel Research International 2024年第3期31卷 710-718页

作者： Yan-hui Hou ze-kun Xu Shi-long zhou Guang-qiang Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Three-dimensional atom-probe tomography and first-principles calculation combined with density functional theory were used to study the effect of the co-segregation of different elements formed during the solidification process of S32205 duplex stainless steel on the Cr-depleted zone at the interface between ferrite and *** was found that the co-segregation of different elements formed during the solidification process of duplex stainless steel can also form Cr-depleted zone at the interface between ferrite and ***,Mo,Si,B,C and P atoms promote co-segregation with Cr atoms,which promotes the formation of Cr-depleted zone at the interface between ferrite and austenite in duplex stainless *** and Si strongly promote the segregation of Cr at the interface between ferrite and austenite,thereby promoting the formation of Cr-depleted zone.B,C and P elements also promote the segregation of Cr element at the interface between ferrite and austenite and the formation of Cr-depleted zone,but their effect is weaker than that of Mo and Si *** conclusions provide a new theoretical basis for improving the intergranular corrosion performance of duplex stainless steel.

关键词： Duplex stainless steel Cr-depleted zone Intergranular corrosion Co-segregation First-principles calculation

Quantitative characterization of fusion state of virgin and aged asphalt using nano-ferrous ferric oxide tracer

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 467-480页

作者： Qiang Li song Liu Huameng Wen zhou zhou College of Civil Engineering Nanjing Forestry UniversityNanjing 210037China School of Transportation Southeast UniversityNanjing 211189China

The exact evaluation of the fusion rate of virgin and aged asphalt is essential to optimize the performance of the recycled asphalt *** fusion rate index was developed by tracing the distribution of tracer asphalt,which contains nano-ferrous ferric oxide(nano-Fe_(3)O_(4))*** fusion simulation tests were performed on three types of asphalt to obtain different fusion states,and fatigue tests were performed to evaluate the influence of the fusion rate on the fatigue life of the recycled *** was found that the tracer asphalt containing 4%nano-Fe_(3)O_(4)shows the optimal trace effect,and the developed fusion rate index can quantitatively characterize the influence of different factors on the fusion state of the recycled *** fusion state is closely related to the fatigue performance of recycled asphalt,and the fusion rate index can fairly evaluate its fatigue *** relationship between the fusion rate and the fatigue life of recycled asphalt depends on the factors that cause the fusion rate *** the influence of the amount of rejuvenator,the fatigue life of recycled asphalt grows exponentially with increasing fusion rate due to enhancement of molecular motion as well as a supplement of lightweight *** the influence of heat preservation treatment,fatigue life increases linearly with increasing fusion *** proposed fusion rate index can be utilized to quantitatively characterize the fusion state of virgin and aged asphalt,thus providing a simple way to guide the practical application of recycled asphalt.

关键词： Recycled asphalt Rejuvenator Tracing technique Fusion rate Fatigue

BSTFNet:An Encrypted Malicious Traffic Classification Method Integrating Global Semantic and Spatiotemporal Features

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Computers, Materials & Continua 2024年第3期78卷 3929-3951页

作者： Hong Huang Xingxing Zhang Ye Lu ze Li Shaohua zhou School of Computer Science and Engineering Sichuan University of Science&EngineeringYibin644002China School of Mathematics and Statistics Sichuan University of Science&EngineeringYibin644002China

While encryption technology safeguards the security of network communications,malicious traffic also uses encryption protocols to obscure its malicious *** address the issues of traditional machine learning methods relying on expert experience and the insufficient representation capabilities of existing deep learning methods for encrypted malicious traffic,we propose an encrypted malicious traffic classification method that integrates global semantic features with local spatiotemporal features,called BERT-based Spatio-Temporal Features Network(BSTFNet).At the packet-level granularity,the model captures the global semantic features of packets through the attention mechanism of the Bidirectional Encoder Representations from Transformers(BERT)*** the byte-level granularity,we initially employ the Bidirectional Gated Recurrent Unit(BiGRU)model to extract temporal features from bytes,followed by the utilization of the Text Convolutional Neural Network(TextCNN)model with multi-sized convolution kernels to extract local multi-receptive field spatial *** fusion of features from both granularities serves as the ultimate multidimensional representation of malicious *** approach achieves accuracy and F1-score of 99.39%and 99.40%,respectively,on the publicly available USTC-TFC2016 dataset,and effectively reduces sample confusion within the Neris and Virut *** experimental results demonstrate that our method has outstanding representation and classification capabilities for encrypted malicious traffic.

关键词： Encrypted malicious traffic classification bidirectional encoder representations from transformers text convolutional neural network bidirectional gated recurrent unit

Effect of dynamic loading orientation on fracture properties of surrounding rocks in twin tunnels

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 393-409页

作者： ze Deng Zheming Zhu Lei zhou Leijun Ma Jianwei Huang Yao Zhang Key Laboratory of Deep Earth and Engineering(Ministry of Education) College of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province College of Architecture and EnvironmentSichuan UniversityChengdu610065China Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610065China

For expedited transportation,vehicular tunnels are often designed as two adjacent tunnels,which frequently experience dynamic stress waves from various orientations during blasting *** analyze the impact of dynamic loading orientation on the stability of the twin-tunnel,a split Hopkinson pressure bar(SHPB)apparatus was used to conduct a dynamic test on the twin-tunnel *** two tunnels were rotated around the specimen’s center to consider the effect of dynamic loading ***-DYNA software was used for numerical simulation to reveal the failure properties and stress wave propagation law of the twin-tunnel *** findings indicate that,for a twin-tunnel exposed to a dynamic load from different orientations,the crack initiation position appears most often at the tunnel corner,tunnel spandrel,and tunnel *** the impact direction is created by a certain angle(30°,45°,60°,120°,135°,and 150°),the fractures are produced in the middle of the line between the left tunnel corner and the right tunnel *** the impact loading angle(a)is 90°,the tunnel sustains minimal damage,and only tensile fractures form in the surrounding *** orientation of the impact load could change the stress distribution in the twin-tunnel,and major fractures are more likely to form in areas where the tensile stress is concentrated.

关键词： Twin-tunnel Dynamic load Split Hopkinson pressure bar(SHPB) Fracture mode Stress distribution Displacement field distribution

Preface to the special topic on metals and their compounds for lithium ion/metal batteries

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Tungsten 2024年第1期6卷 162-163页

作者： Ying-ze song Wen-Long Cai Gao-Ran Li State Key Laboratory of Environment-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

The fast development of electronics and electric devices has inspired the practical application of lithium ion/metal *** this line,the metals and their compounds as electrode materials as well as the corresponding mechanism for energy storage have gained extensive international *** as-organized special topic focuses on W,Mo,Co,Zr,Hf,Re,Ta,Nb,V-based metals and their compounds for lithium ion/metal *** special topic involves four reviews and four research papers totally,providing the latest advances of transition metals and their related compounds for rechargeable lithium ion/metal batteries.

关键词： lithium metals gained