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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping Liang yu Li Liyong Wu Zhe Wang weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

盐胁迫对玉米幼苗叶片光合荧光和抗氧化酶活性的影响

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现代农业科技 2014年第24期 36-36,40页

作者：侯楠宋玉伟南阳师范学院生命科学与技术学院河南南阳473061

以玉米品种B73幼苗为试验材料,研究盐胁迫对其光合荧光和抗氧化酶活性的影响。结果表明:低浓度的盐胁迫(100 mmol/L)对玉米幼苗叶片的光合效率影响不大,但是高浓度的盐胁迫(200 mmol/L以上)对玉米幼苗叶片的光合效率影响明显,且随着时... 详细信息

以玉米品种B73幼苗为试验材料,研究盐胁迫对其光合荧光和抗氧化酶活性的影响。结果表明:低浓度的盐胁迫(100 mmol/L)对玉米幼苗叶片的光合效率影响不大,但是高浓度的盐胁迫(200 mmol/L以上)对玉米幼苗叶片的光合效率影响明显,且随着时间的延长不断加剧。同时,体内叶片抗氧化酶的活性变化同光合作用成正相关,说明在盐胁迫情况下,玉米幼苗可以通过启动抗氧化酶的活性来应答盐胁迫。此外,在应答盐胁迫时,玉米幼苗体内抗氧化保护酶系统(SOD、POD、CAT)活性会呈现出先升高后降低的趋势。

关键词：玉米盐胁迫光合作用抗氧化酶

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song Qian-Qian Wan yu-Ming Wang Han-Zhou Li wei-Quan Xu Jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

肺恶性肿瘤64层螺旋CT灌注成像参数与强化峰值的相关性

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中国医学影像技术 2009年第5期25卷 771-773页

作者：魏松宇储成凤杨明刘圣华李苏宜东南大学附属中大医院放射科江苏南京210009

目的探讨CT灌注参数评价肺恶性肿瘤血管功能状态的价值。方法对23例肺恶性肿瘤患者行64层螺旋CT灌注扫描,以CT灌注成像处理软件进行处理。感兴趣区的选择采用高灌注区均值和最大层面全肿瘤区域两种方式,分别获得血流量(BF)、血容量(BV)... 详细信息

目的探讨CT灌注参数评价肺恶性肿瘤血管功能状态的价值。方法对23例肺恶性肿瘤患者行64层螺旋CT灌注扫描,以CT灌注成像处理软件进行处理。感兴趣区的选择采用高灌注区均值和最大层面全肿瘤区域两种方式,分别获得血流量(BF)、血容量(BV)、表面渗透性(PS)等灌注参数,绘制时间-密度曲线,并测量肿瘤的CT强化峰值(PH),对各灌注参数值及PH进行相关性分析。结果①肺恶性肿瘤的PH与CT灌注成像BV的高灌注区均值、全肿瘤均值及BF的全肿瘤均值均呈显著的正相关;②肺恶性肿瘤的PH与BF的高灌注区均值及PS无显著相关性。结论肺恶性肿瘤多层螺旋CT灌注成像大部分灌注参数与PH有共同的组织学基础,呈显著的正相关,在评价肺恶性肿瘤的血管功能状态方面有重要价值。

关键词：肺肿瘤体层摄影术,X线计算机灌注强化峰值

GPS天线对近水面航行AUV操纵性的影响分析

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系统仿真学报 2008年第22期20卷 6106-6108,6113页

作者：杜晓旭宋保维罗钰胡海豹李家旺西北工业大学航海学院西安710072

在基于一定假设的条件下,建立了计算GPS天线流体动力的数学模型,并建立了GPS天线升出后对GPS导航定位精度影响的数学模型。对鱼雷形AUV通过GPS天线实现导航定位的典型操纵运动进行了仿真研究。结果显示,天线升出后对AUV的操纵性有明显... 详细信息

在基于一定假设的条件下,建立了计算GPS天线流体动力的数学模型,并建立了GPS天线升出后对GPS导航定位精度影响的数学模型。对鱼雷形AUV通过GPS天线实现导航定位的典型操纵运动进行了仿真研究。结果显示,天线升出后对AUV的操纵性有明显的影响,但对GPS导航精度的影响很小,说明鱼雷形AUV仍然可以通过操纵运动稳定的完成在近水面的导航定位运动。

关键词：操纵性自主水下航行器 GPS天线导航

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-yuan Hu Ding Ding yu song Ya-Feng Deng Cheng-Ming Zhang Tao yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi yu Xi Zheng Xiao-Sheng Li Qian-Jie Xu wei Zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

作图法分析光波在两个单轴晶体分界面上的双反射和双折射

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大学物理 2017年第10期36卷 16-20,56页

作者：宋哲于伟行张琳李琳吴晶丁一辽宁师范大学物理与电子技术学院辽宁大连116029 中国科学院空间激光通信及检验技术重点实验室上海201800

通过几何作图法,分析了光轴取向任意时,光波在两个单轴晶体分界面上的双反射和双折射.考虑到入射光波、反射光波、折射光波在界面上相位相等和晶体折射率面的定义,采用斯涅尔作图法,直接在图上得到了两条反射光波和两条折射光波.根据晶... 详细信息

通过几何作图法,分析了光轴取向任意时,光波在两个单轴晶体分界面上的双反射和双折射.考虑到入射光波、反射光波、折射光波在界面上相位相等和晶体折射率面的定义,采用斯涅尔作图法,直接在图上得到了两条反射光波和两条折射光波.根据晶体的光学各向异性,进一步讨论了各光波对应的光线方向和振动方向,并通过几何分析,给出了各反射光波、折射光波、反射光线和折射光线位置的一般表达式.斯涅尔作图法简单直观,可以直接获得光波的方向,结果具有普遍性.

关键词：晶体光学双反射双折射折射率面相位