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Experimental study of drag reduction characteristics related to the multifactor coupling of a bionic jet surface

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Journal of Hydrodynamics 2019年第1期31卷 186-194页

作者： yun-qing Gu song-wei yu Jie-gang Mou Tian-xing Fan Shui-hua Zheng Gang Zhao College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310014China College of Mechanical and Electrical Engineering Harbin Engineering UniversityHarbin 150001China

To study the drag reduction of a jet surface,an experiment is conducted with a gyrorotor *** aim of this study is to analyze the influence of the jet aperture,the jet angle and the rotational velocity coupled with the jet velocity on the friction torque acting on a jet surface model by using a jet surface drag reduction testing experimental *** drag reduction characteristics of the jet surface are also *** results show that the maximum drag reduction rate is attained when the jet diameter is 5 mm and the jet velocity is 1.2 m/*** influence of the jet velocity on the drag reduction rate decreases as the diameter ***,the maximum drag reduction rate can be attained when the angle of the jet is 30° and the velocity of the jet is 1.0 m/*** the jet diameter is small,the influence of the jet velocity on the drag reduction rate is small,whereas the maximum drag reduction rate is attained when the jet angle is 30° and the jet velocity is 1.0 m/*** the jet angle is 15°,the drag reduction rate fluctuation is *** maximum drag reduction rate is attained when the rotational velocity is 2 100 r/min and the jet velocity is 1.0 m/*** results show that the best scheme is A2B2D3 A maximum drag reduction rate of 8.57% can be *** effective control of the jet effect on the separation of the boundary layer demonstrates the drag reduction principle of a bionic jet surface.

关键词： Drag reduction bionic jet surface friction torque coupling experiment

Protective effect of cyclophilin A against Alzheimer＇s amyloid beta-peptide （25-35）-induced oxidative stress in PC12 cells

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Chinese Medical Journal 2009年第6期122卷 716-724页

作者： GE yu-song TENG wei-yu ZHANG Chao-dong Department of Neurology First Affiliated Hospital China Medical University Shenyang Liaoning 110001 China

Background β-amyloid peptide （Aβ） is considered responsible for the pathogenesis of Alzheimer＇s disease （AD）. Possible mechanisms underlying Aβ-induced neuronal cytotoxicity include excessive production of reactive oxidative species （ROS） and apoptosis. Cyclophilin A （CypA）, exhibits antioxidant properties and protects neurons against oxidative stress induced injury. This study was conducted to demonstrate whether CyPA added to cultured PC12 cells could alleviate Aβ-induced oxidative stress and protect them from apoptosis.Methods PC12 cells were pre-incubated for 30 minutes with recombinant human cyclophilin A （rhCyPA） in 0.1 nmol/L, 1.0 nmol/L, 10 nmol/L and 100 nmol/L and then incubated with 10 μmol/L Aβ25-35. In every group, cell viability, apoptotic morphology, apoptotic rate, intracellular ROS accumulation, the activities of superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px） of PC12 cells and mitochondrial transmembrane potential were detected. Subsequently, the expression of the active form of caspase-3 was determined by Western blotting.Results It was shown that cultures treated with 1.0 nmol/L, 1U nmol/L or 100 nmol/L rnL, rhCyPA＋Aβ25-35 had significantly higher cell viability and a lower rate of apoptosis compared with the cultures exposed only to Aβ25-35. In addition, rhCyPA attenuated Aβ25-35-induced overproduction of intracellular ROS and Aβ25.35-induced a decrease in activity of the key antioxidant enzymes SOD and GSH-Px. Furthermore, rhCyPA also attenuated Aβ25.35-induced mitochondrial dysfunction and the activation of caspase-3.Conclusion CyPA may act as an ROS scavenger, and prevent Aβ25-35-induced neurotoxicity through attenuating oxidative stress induced by Aβ25-35.

关键词： Alzheimer's disease cyclophilin A β-amyloid oxidative stress apoptosis

Notes on soil dematiaceous hyphomycetes from Mount Taibai and its surrounding area, China Ⅰ

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菌物学报 2008年第1期27卷 16-28页

作者： song wei yu Jin-Feng ZHANG Tian-yu Department of Plant Pathology Shandong Agricultural University Tai ＇an 271018 China

A total of 103 isolates of soil dematiaceous hyphomycetes belonging to 27 species in 15 genera were obtained from soil samples of Mount Taibai and its surrounding area, Shaanxi Province, China. Among them Eladia pachyphialis and Gliomastix pallescens are new species, while Acremoniula sarcinellae, Allescheriella crocea, Chrysosporium merdarium, Chrysosporium pannorum are new records to China. The main distinction between E. pachyphialis and its similar species E. saccula is that the phialide of the former is wider and the conidia are smaller than those of the latter. Gliomastix pallescens is characterized by having light colored, long and unbranched conidiophores by which it can be separated from its similar species, G. cerealis. Latin descriptions are given for the new species. Brief descriptions and illustrations of the new records are also provided based on Chinese isolates. The other 21 species being previously known from China in several genera are also listed. All specimens (dried cultures and slides) and living cultures studied have been deposited in the Herbarium of Shandong Agricultural University: Plant Pathology (HSAUP).

关键词：土壤真菌中国新种新记录生物学特征太行山暗色丝孢菌

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-yu Zhao Guo-wei Si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

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拟南芥H_2O_2突变体的筛选及特性分析

西北植物学报 2009年第5期29卷 888-893页

作者：宋玉伟宋纯鹏南阳师范学院生命科学与技术学院河南南阳473061 河南大学生命科学学院河南开封475001

通过化学诱变剂甲基磺酸乙酯(EMS)诱变模式植物拟南芥(Arabidopsis thaliana)获得突变体筛选群体.在5mmol/LH2O2胁迫下,以叶片温度差异为筛选指标,利用远红外成像技术进行突变体的筛选,获得了对H2O2不敏感突变体hpi1(hydrogen peroxide-... 详细信息

通过化学诱变剂甲基磺酸乙酯(EMS)诱变模式植物拟南芥(Arabidopsis thaliana)获得突变体筛选群体.在5mmol/LH2O2胁迫下,以叶片温度差异为筛选指标,利用远红外成像技术进行突变体的筛选,获得了对H2O2不敏感突变体hpi1(hydrogen peroxide-insensitive1)和敏感突变体hps1(hydrogen peroxide-sensitive1).进一步研究发现,两种突变均为单基因隐性突变,气孔密度同野生型一样,而叶片温度、气孔开度和叶片失水率则有明显的差异.种子萌发实验表明,hpi1对甘露醇(Man)和NaCl不敏感而对ABA敏感,hps1则对3种胁迫都表现出敏感特性.

关键词：拟南芥远红外热像仪 H2O2 突变体筛选

Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 268-271页

作者： Shuai Liu Yong-wei yu Department of Cardiology The First People’s Hospital of JiashanJiaxing 314100Zhejiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of *** is a new choice and hot spot in the field of cancer *** have also previously published studies on TCM and network *** this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.

关键词： Network pharmacology Cancer Multicomponent Multitarget Therapy

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免疫衰老与心血管疾病

中国免疫学杂志 2021年第22期37卷 2779-2785页

作者：宋雨薇冯娟(指导) 北京大学基础医学院生理学与病理生理学系北京100191 北京大学医学部中西医结合研究院北京100191

衰老是机体复杂的生理过程。机体衰老往往伴随着免疫系统功能的失调,即免疫衰老。免疫衰老作为免疫系统与年龄相关变化的总称,受内在和外在因素的影响,主要有两个特征表现,即整体免疫反应缺陷和系统性慢性炎症。免疫衰老发生机制较为复... 详细信息

衰老是机体复杂的生理过程。机体衰老往往伴随着免疫系统功能的失调,即免疫衰老。免疫衰老作为免疫系统与年龄相关变化的总称,受内在和外在因素的影响,主要有两个特征表现,即整体免疫反应缺陷和系统性慢性炎症。免疫衰老发生机制较为复杂,包括固有免疫和适应性免疫的变化,以及两者的失衡。研究认为,机体内的这种炎症反应与多种老年性疾病有关,特别是心血管疾病。目前,随着对免疫衰老的深入研究,与之相关的心血管疾病的发病机理也得到了较为深入的研究,为疾病的预防及治疗提供了更多的新思路。

关键词：免疫衰老炎症衰老心血管疾病

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao yu yuhang song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

异金属铜-氧MAZ分子筛催化甲烷部分氧化反应DFT研究

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分子催化 2021年第5期35卷 404-414,I0001页

作者：宋卫余杨敏王林哲中国石油大学(北京)重质油国家重点实验室北京昌平102249

已有研究证明了 Cu-MAZ分子筛催化甲烷部分氧化的优异性且实验表征得出其活性结构含有三核铜结构.为进一步提高部分氧化活性,采用MAZ分子筛作为载体体系,用于[Cu_(3)(μ-O)_(3)]^(2+)结构,分别掺杂Pd、Pt、Fe、Co、Ni、Au和Ag,构建[Cu_(... 详细信息

已有研究证明了 Cu-MAZ分子筛催化甲烷部分氧化的优异性且实验表征得出其活性结构含有三核铜结构.为进一步提高部分氧化活性,采用MAZ分子筛作为载体体系,用于[Cu_(3)(μ-O)_(3)]^(2+)结构,分别掺杂Pd、Pt、Fe、Co、Ni、Au和Ag,构建[Cu_(2)MO_(3)]^(2+)异金属活性位.通过密度泛函理论(DFT)研究不同金属对Cu-MAZ催化甲烷部分氧化反应的能量变化和反应活性的影响,并分析了活性位、反应中间体、过渡态等结构的几何和电子结构性质,根据以上结果进一步得到描述符.

关键词：甲烷部分氧化铜交换分子筛 MAZ分子筛异金属描述符