检索结果-南通市图书馆

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian Hu Siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin han Lanxin Luo Caiyan Wei Yaru qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Imidazolium-based ionic polymers for fast and efficient anion-exchange driven capture of Cr2O72-

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Yishou Wang Xiaonan Yuan Xingxing Gou Xiatian song Xiaogang Wang Ling Guo Yanfeng Liu Chengfang qiao Chunsheng Zhou Yingfeng han Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources Shaanxi Engineering Research Center for Mineral Resources Clean & Efficient Conversion and New Materials College of Chemical Engineering and Modern Materials Shangluo University Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi'an Key Laboratory of Functional Supramolecular Structure and Materials College of Chemistry and Materials Science Northwest University

The pervasive issue of chromium（VI） contamination,particularly in dichromate (Cr2O2-7),resulting from unchecked industrial growth and inadequate waste management,remains a pressing concern that demands immediate and dedicated ***,we present two novel imidazolium-based ionic polymers （ImIPs）.The ImIPs boast a highly cationic structure rich in bromide（Br-） ions and exhibit remarkable porosity,facilitating the easy exchange of these ions for chromate (Cr2O2-7) through anion *** unique combination leads to exceptional performance,including a high adsorption capacity （423 mg/g）,rapid adsorption rate (75 mg g-1min-1),and a broad operational pH range （2–12）.Moreover,our material demonstrates remarkable reusability,maintaining its efficacy even after 10 cycles without significant loss of *** mechanistic studies underscore the role of ion-exchange chemistry in effectively removing dichromate by the presented ImIPs,providing strong evidence for their suitability as a robust solution to address the ongoing challenges in water *** findings represent a crucial step in developing advanced materials for tackling chromium（VI） pollution.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

甲醛对DNA损伤的彗星实验研究

实验生物学报 2004年第4期37卷 262-268页

作者：李睿鲁志松乔琰姚汉超于非非杨旭华中师范大学生命科学学院武汉430079

甲醛是一种遗传毒性物质。国内外学者的大量研究证实,甲醛可以引起DNA-DNA、DNA-蛋白质分子交联,但对于甲醛是否能够引起DNA 分子的断裂,学界却存在分歧。本实验以颊黏膜细胞作为实验材料,通过彗星实验对甲醛的遗传毒性——尤其是DNA ... 详细信息

甲醛是一种遗传毒性物质。国内外学者的大量研究证实,甲醛可以引起DNA-DNA、DNA-蛋白质分子交联,但对于甲醛是否能够引起DNA 分子的断裂,学界却存在分歧。本实验以颊黏膜细胞作为实验材料,通过彗星实验对甲醛的遗传毒性——尤其是DNA 分子断裂作用进行了系统的研究。结果显示甲醛在较低浓度(5μmol/L,7.5μmol/L,10μmol/L)时具有断裂作用,在较高浓度(15μmol/L,30μmol/L,50μmol/L)时则具有交联作用。根据本实验的结果,本文还首次论证了甲醛断裂作用的断裂峰值(7.5μmol/L)。

关键词：甲醛 DNA损伤彗星实验断裂峰值颊黏膜细胞遗传毒性

Far-field sonic boom prediction considering atmospheric turbulence effects: An improved approach

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2022年第9期35卷 208-225页

作者： Jianling qiao Zhonghua han Liwen ZhanG Wenping song Bifeng song Institute of Aerodynamic and Multidisciplinary Design Optimization School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710071China National Key Laboratory of Science and Technology on Aerodynamic Design and Research School of AeronauticsNorthwestern Polytechnical UniversityXi'an710071China

Accurate prediction of sonic boom is one of key challenges for the design of a low-boom supersonic aircraft. For most of available far-field prediction methods, the effect of atmospheric turbulence appearing in the planetary boundary layer cannot be considered, which results in remarkable inaccuracy of predicting ground-level sonic boom waveform. Although some efforts have been made to overcome the shortcoming, the turbulence effects are not yet well described so far. This article proposes an improved method by extending the two-dimensional Heterogeneous One-Way Approximation for the Resolution of Diffraction(HOWARD) equation to account for the axial and transverse convections of wind fluctuation as well as the effect of temperature fluctuation. The proposed method is validated by comparing the predictions with the flight-test data of JAXA D-SEND#1 LBM, which shows that the result of the proposed method is in better agreement with the flight-test data than that of the method without considering atmospheric turbulence ***, distortion mechanism of sonic boom waveforms caused by atmospheric turbulence is analyzed by using the proposed method. It is indicated that the effect of turbulent convection makes uniform sonic-boom wavefronts irregular, which creates the condition of diffraction effect to perturb waveforms. Finally, the proposed method is applied to investigate the behavior of two types of waveforms given by the sonic boom minimization theory. Results show that a far-field waveform with a weaker initial shock is more beneficial for low-boom design of a supersonic aircraft.

关键词： Atmospheric turbulence Augmented Burgers equation HOWARD equation Sonic boom Supersonic transport

An Empirical Investigation on the Risk-Return Relationship of Carbon Future Market

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2016年第4期29卷 1057-1070页

作者： LI Ziran qiao han song Nan ZU Lei Collaborative Innovation Center for the Innovation and Regulation of Internet-Based Finance Southwestern University of Finance and EconomicsChengdu 611130China CFFEX Institute for Financial Derivatives Beijing 100033China School of Management University of Chinese Academy of SciencesBeijing 100190China Directors'Office Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Management Sciences and Engineering Central University of Finance and EconomicsBeijing 100081China

This paper examines the risk-return relationship for the carbon future market during Phases I, II and III of the European Union Emission Trading Scheme(EU ETS). The risk factors derived from the newly developed LSW model, are embedded into a GARCH framework. This new specification is compared with several GARCH-M type models analyzing the risk-return relationship in the carbon market. The results show that the new specification consistently achieves a good fit and possesses superior explanatory power for the European Union Allowance(EUA) data. Some policy suggestions regarding market efficiency are also provided.

关键词： Carbon price GARCH information diffusion risk-return.

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2024年第6期15卷 403-418页

作者： song Xue Yuru han Fan Wu qiao Wang Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecurityShanghai Frontiers Science Center of Pathogenic Microorganisms and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation *** mutations,particularly those within the receptor binding domain(RBD)of SARS-CoV-2 spike(S)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)***,we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune *** single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding ***,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major *** predominant direction of SARS-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two ***,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.

关键词： ACE2 affinity maintained

Effect of longitudinal lift distribution on sonic boom of a canard-wing-stabilator-body configuration

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第6期36卷 92-108页

作者： Liwen ZhanG Zhonghua han Jianling qiao Wenping song Yulin DING Xuehe WANG Institute of Aerodynamic and Multidisciplinary Design Optimization School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710072China National Key Laboratory of Science and Technology on Aerodynamic Design and Research School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710072China Research Center for Environment-friendly Supersonic Civil Transport Northwestern Polytechnical UniversityXi'an 710072China

After the last flight of the Concorde in 2003,sonic boom has been one of the obstacles to the return of a supersonic transport aircraft to *** reduce the sonic boom intensity to an acceptable level,it is of great significance to study the effect of lift distribution on far-field sonic boom,since lift is one of the most important contributors to an intense sonic *** studies on the longitudinal lift distribution used low-fidelity methods,such as Whitham theory,and in turn,only preliminary conclusions were obtained,such as that extending the lift distribution can reduce sonic *** paper uses a newly developed high-fidelity prediction method to quantitatively study the effect of longitudinal lift distribution on the sonic boom of a Canard-Wing-Stabilator-Body(CWSB)*** high-fidelity prediction method combines near-feld CFD simulation with far-field propagation by solving the augmented Burgers equation.A multipole analysis method is employed for the extraction of near-field waveform in order to reduce computational *** configurations with the same total lift but different distributions are studied,and the quantitative relationship between the longitudinal lift distribution and far-field sonic boom intensity is *** is observed that a small lift generated by the stabilator can prevent aft-stabilator and aft-fuselage shocks from merging,while the balanced lift generated by the canard and wing can effectively keep the corresponding shocks further apart,which is beneficial for reducing both the on-track and off-track sonic *** turn,the acoustic level perceived at the ground can be reduced by 5.9 PLdB on-track and 5.4 PLdB off-track,on average.

关键词： Computational fluid dynamics Longitudinal lift distribution Sonic boom Sonic boom reduction Supersonic transport

Strong Time-Consistent Core for a Class of Linear-State Games

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2020年第4期33卷 1080-1107页

作者： SEDAKOV Artem qiao han Saint Petersburg State University 7/9 Universitetskaya nab.Saint Petersburg 199034Russia School of Mathematics and Statistics Qingdao UniversityQingdao 266071China Institute of Applied Mathematics of Shandong Qingdao 266071China School of Economics and Management University of the Chinese Academy of SciencesBeijing 100190China

Time consistency is an important property of any solution to a cooperative dynamic *** the solution satisfies this property,players do not need to revise it and break a cooperative *** time consistency is a stricter property which is applicable to cooperative set *** this paper,the authors examine a class of linear-state games which come into use in many applications of dynamic *** the core as the solution of the game,the authors provide sufficient conditions for its strong time *** case of its inconsistency,the authors show how core elements can be realized using a strong time-consistent imputation distribution procedure.

关键词： property consistency dynamic