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Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

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National Science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling Tang Yuhao Wang Wenhao Zhang Heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng song-mei liu Hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of Hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

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Beyond surgery:Overcoming postoperative depression in cancer patients

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World Journal of Psychiatry 2024年第7期14卷 1140-1142页

作者： Shao-Ming song Xiao Wang Hong-mei Yue Rong liu The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Faculty of Hepato-pancreato-biliary Surgery The First Medical Center of PLA General HospitalBeijing 100853China

Depression is a common occurrence among cancer patients,and it significantly impacts their clinical outcomes and quality of life,with a high incidence during anti-tumor treatment or after *** association between surgery and depression is the result of the interaction of various factors,including physio-logical,psychological,and social factors,all of which are intertwined and make patients susceptible to depression after surgical *** depression has a significant negative impact on many aspects of cancer patients,and it requires timely identification and intervention to improve the overall outcome.

关键词： Depression Surgery Tumor Anti-tumor therapy

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Effect of succinic acid on morphology transformation of the anhydrous magnesium carbonate particles prepared by magnesium chloride hexahydrate and urea

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Particuology 2024年第7期90卷 209-217页

作者： song liu Guojun Cheng Zhongfeng Tang School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Anhui Province Key Laboratory of Environment-friendly Polymer Materials Anhui UniversityHefei230601China

The homogeneous and controllable morphology of anhydrous magnesium carbonate(MgCO_(3))particles with excellent properties is difficult to obtain because of a variety of synthetic *** effect of succinic acid as a crystal modifier on the particle morphology transformation of anhydrous MgCO_(3)was investigated by the hydrothermal *** effect of the addition of succinic acid on the particles was similar to that of temperature *** morphology of particles with a folded diamond-like shape was gradually uniform,and the particle size was between 3.3 and 7.5μ*** MgCO_(3)particles prepared at pH 9 could easily agglomerate,and the average particle size increased from diamond-like to cube-like as the reaction time *** interaction between succinic acid and magnesium ions at different concentrations was the main factor responsible for the morphological *** pH,temperature,and time affected the molecular motion rate and crystal growth.

关键词： MgCO_(3) MgCl_(2)·6H_(2)O Urea Succinic acid Morphology

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Network selection policy in multi-radio access environment using stochastic control theory

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The Journal of China Universities of Posts and Telecommunications 2011年第4期18卷 98-103页

作者： WEI Yi-fei song mei ZHANG Yong liu Ning-ning School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Network selection is crucial in improving the performance of heterogeneous wireless access systems. Most of previous work on network selection or radio resource allocation concentrates on the capability of each available network and ignores the time-varying nature of wireless media due to channel fading. However, the channel condition determines the state of each wireless network and plays a vital role in ensuring quality of service in multi-radio access environment. In this article, we propose a network selection policy using stochastic control theory considering the time-varying and stochastic character of wireless channels. The proposed scheme selects one network among different alternatives in each decision epoch according to the channel state of each network, which is modeled as finite-state Markov channel, with the objectives of increasing the data-rate, decreasing the bit error rate and minishing the delay. The procedure of network selection is formulated as a stochastic control problem, which can be solved using linear programming and primal-dual index heuristic algorithm. Simulation results are presented to show that network selection has great impact on the system performance, and the proposed scheme can improve the performance significantly.

关键词： network selection multi-radio finite-state Markov channel stochastic control

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A credible traffic prediction method based on self-supervised causal discovery

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Science China(Information Sciences) 2024年第5期67卷 244-258页

作者： Dan WANG Yingjie liu Bin song State Key Laboratory of Integrated Services Networks Xidian University

Next-generation wireless network aims to support low-latency, high-speed data transmission services by incorporating artificial intelligence(AI) technologies. To fulfill this promise, AI-based network traffic prediction is essential for pre-allocating resources, such as bandwidth and computing power. This can help reduce network congestion and improve the quality of service(QoS) for users. Most studies achieve future traffic prediction by exploiting deep learning and reinforcement learning, to mine spatio-temporal correlated variables. Nevertheless, the prediction results obtained only by the spatio-temporal correlated variables cannot reflect real traffic changes. This phenomenon prevents the true prediction variables from being inferred, making the prediction algorithm perform poorly. Inspired by causal science, we propose a novel network traffic prediction method based on self-supervised spatio-temporal causal discovery(SSTCD). We first introduce the Granger causal discovery algorithm to build a causal graph among prediction variables and obtain spatio-temporal causality in the observed data, which reflects the real reasons affecting traffic ***, a graph neural network(GNN) is adopted to incorporate causality for traffic prediction. Furthermore,we propose a self-supervised method to implement causal discovery to to address the challenge of lacking ground-truth causal graphs in the observed data. Experimental results demonstrate the effectiveness of the SSTCD method.

关键词： wireless network traffic prediction causal discovery self-supervised

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Effect of surfactant frequently used in soil flushing on oxygen mass transfer in micro-nano-bubble aeration system

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Chinese Journal of Chemical Engineering 2024年第3期67卷 174-181页

作者： mei Bai Zhibin liu Zhu liu Chenfei He Zhanhuang Fan Miaoxin Yuan Jiangsu Key Laboratory of Urban Underground Engineering and Environmental Safety Southeast UniversityNanjing 211189China CECEP DADI(Hangzhou)Environmental Remediation Co. Ltd.Hangzhou 310020China

In-site soil flushing and aeration are the typical synergetic remediation technology for contaminated *** surfactant present in flushing solutions is bound to affect the aeration *** purpose of this study is to evaluate the effect of surfactant frequently used in soil flushing on the oxygen mass transfer in micro-nano-bubble(MNB)aeration ***,bio-surfactants and chemical surfactants were used to investigate their effects on Sauter mean diameter of bubble(dBS),gas holdup(ε),volumetric mass-transfer coefficient(kLa)and liquid-side mass-transfer coefficient(kL)in the MNB aeration ***,based upon the experimental results,the Sardeing's and Frossling's models were modified to describe the effect of surfactant on kL in the MNB *** results showed that,for the twenty aqueous surfactant solutions,with the increase in surfactant concentration,the value of dBS,kLa and kL decreased,while the value ofεand gas-liquid interfacial area(a)*** phenomena were mainly attributed to the synergistic effects of immobile bubble surface and the suppression of coalescence in the surfactant *** addition,with the presence of electric charge,MNBs in anionic surfactant solutions were smaller and higher in number than in non-ionic surfactant ***,the accumulation of surfactant on the gas-liquid interface was more conspicuous for small MNB,so the reduction of kL in anionic surfactant solutions was larger than that in non-ionic surfactant ***,the modified Frossling's model predicted the effect of surfactant on kL in MNB aeration system with reasonable accuracy.

关键词： Soil flushing Micro-nano-bubble aeration Bio-surfactant Mass transfer coefficient

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Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model

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Neural Regeneration Research 2024年第3期19卷 687-696页

作者： Longqing Zhang Xi Tan Fanhe song Danyang Li Jiayi Wu Shaojie Gao Jia Sun Daiqiang liu Yaqun Zhou Wei mei Department of Anesthesiology Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Healthand Wuhan Clinical Research Center for Geriatric AnesthesiaTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Activated G-protein-coupled receptor 39(GPR39)has been shown to attenuate inflammation by interacting with sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α).However,whether GPR39 attenuates neuropathic pain remains *** this study,we established a Sprague-Dawley rat model of spared nerve injury-induced neuropathic pain and found that GPR39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated *** injection of TC-G 1008,a specific agonist of GPR39,significantly alleviated mechanical allodynia in the rats with spared nerve injury,improved spinal cord mitochondrial biogenesis,and alleviated *** changes were abolished by GPR39 small interfering RNA(siRNA),Ex-527(SIRT1 inhibitor),and PGC-1α*** together,these findings show that GPR39 activation ameliorates mechanical allodynia by activating the SIRT1/PGC-1αpathway in rats with spared nerve injury.

关键词： G-protein-coupled receptor 39(GPR39) neuroinflammation neuropathic pain nuclear respiratory factor 1(NRF1) peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) sirtuin 1(SIRT1) spinal cord mitochondrial transcription factor A(TFAM)

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Experimental and numerical study on ignition and combustion characteristics of boron-magnesium composite powders

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Particuology 2024年第1期84卷 12-29页

作者： Shuyuan liu Luyang Han Hongmei liu Yingkai song Linlin liu songqi Hu Science and Technology on Combustion Internal Flow and Thermo-Structure LaboratoryNorthwestern Polytechnical UniversityXi'an710072China School of Mechanical Engineering and Rail Transit Changzhou UniversityChangzhou213164China Shanghai Institute of Space Propulsion Shanghai201112China Shanghai Engineering Research Center of Space Engine Shanghai201112China

A high-pressure laser ignition and combustion system with adjustable oxidizer gas atmosphere is established to investigate the ignition and combustion characteristics of boron-magnesium(BM)com-posite *** ignition and combustion model of BM powders is established and validated in the present *** results show that increasing water content,O_(2) content and Mg content all result in shorter ignition delay time of BM powders,among which the effect of water content is the most ***,ignition delay time increases as pressure *** combustion time decreases with increasing Mg content and ambient pressure but increases with water *** the increase of O_(2) content,combustion time of BM powders first increases and then decreases,which means a critical O_(2) content exists above which combustion time *** results show that there exists a trade-off between ignition and combustion performance of BM composite powders.

关键词： Boron magnesium powder Laser ignition Ignition and combustion model Reaction mechanism Numerical model

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Pregnancy and the disease recurrence of patients previously treated for differentiated thyroid cancer:A systematic review and meta analysis

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Chinese Medical Journal 2024年第5期137卷 547-555页

作者： Rui Shan Xin Li Ming Tao Wucai Xiao Jing Chen Fang mei Shibing song Bangkai Sun Chunhui Yuan Zheng liu Department of Maternal and Child Health School of Public HealthPeking UniversityBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Pathology Peking University Third HospitalSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Information Management and Big Data Center Peking University Third HospitalBeijing 100191China

Background:Differentiated thyroid cancer(DTC)is commonly diagnosed in women of child-bearing age,but whether pregnancy influences the prognosis of DTC remains *** study aimed to summarize existing evidence regarding the association of pregnancy with recurrence risk in patients previously treated for ***:We searched PubMed,Embase,Web of Science,Cochrane,and Scopus based on the prespecified protocol registered at PROSPERO(CRD42022367896).After study selection,two researchers independently extracted data from the included *** quantitative data synthesis,we used random-effects meta-analysis models to pool the proportion of recurrence(for pregnant women only)and odds ratio(OR;comparing the risk of recurrence between the pregnancy group and the nonpregnancy group),*** we conducted subgroup analyses to explore whether risk of recurrence differed by response to therapy status or duration of follow-up *** also assessed quality of the included ***:A total of ten studies were *** sample size ranged from 8 to 235,with participants’age at pregnancy or delivery ranging from 28 to 35 *** follow-up time varied from 0.1 to 36.0 *** pooled proportion of recurrence in all pregnant patients was 0.13(95%confidence intervals[CI]:0.06-0.25;I^(2):0.58).Among six included studies reporting response to therapy status before pregnancy,we observed a trend for increasingly higher risk of recurrence from excellent,indeterminate,and biochemically incomplete to structurally incomplete response to therapy(P trend0.05)or the OR of recurrence in studies with a comparison group(P>0.05).Two included studies t

关键词： Thyroid cancer Pregnancy Recurrence Women Systematic review Meta-analysis

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Differential Evolution Hemivariational Inequalities with Anti-periodic Conditions

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1143-1160页

作者： Jing ZHAO Chun mei GAN Zhen Hai liu School of Mathematics and Quantitative Economics Guangxi University of Finance and EconomicsNanning 530003P.R.China Guangxi Colleges and Universities Key Laboratory of Optimization Control and Engineering Calculation Guangxi Minzu UniversityNanning 530006P.R.China

The goal of this paper is to deal with a new dynamic system called a differential evolution hemivariational inequality(DEHVI)which couples an abstract parabolic evolution hemivariational inequality and a nonlinear differential equation in a Banach ***,by apply ing surjectivity result for pseudomonotone multivalued mappins and the properties of Clarke's subgradient,we show the nonempty of the solution set for the parabolic hemivariational ***,some topological properties of the solution set are established such as boundedness,closedness and ***,we explore the upper semicontinuity of the solution ***,we prove the solution set of the system(DEHVI)is nonempty and the set of all trajectories of(DEHVI)is weakly compact in C(I,X).

关键词： Differential parabolic hemivariational inequality Clarke subdifferential hyperbolicparabolic system parabolic-parabolic system existence result

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