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Chemotherapy predictors and a time-dependent chemotherapy effect in metastatic esophageal cancer

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 511-524页

作者： Lauren Midthun Sungjin Kim Andrew Hendifar Arsen Osipov Samuel J Klempner Joseph Chao May Cho Michelle Guan Veronica R Placencio-Hickok Alexandra Gangi Miguel Burch De-Chen lin Kevin Waters Katelyn Atkins Mitchell Kamrava Jun gong Department of Medicine Division of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesCA 90048United States Biostatistics and Bioinformatics Research Center Cedars Sinai Medical CenterLos AngelesCA 90048United States Samuel Oschin Cancer Center Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Medicine Beth Israel Deaconess Medical Center/Harvard Medical SchoolBrigham and Women's Hospital/Harvard Medical SchoolBostonMA 02114United States Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer CenterDuarteCA 91010United States Division of Hematology and Oncology Department of MedicineUniversity of CaliforniaIrvineCA 92697United States Department of Medicine Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Pathology and Laboratory Medicine Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Radiation Oncology Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Radiation Oncology Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Chemotherapy has long been shown to confer a survival benefit in patients with metastatic esophageal ***,not all patients with metastatic disease receive *** To evaluate a large cancer database of metastatic esophageal cancer cases to identify predictors of receipt to chemotherapy and *** We interrogated the National Cancer Database(NCDB)between 2004-2015 and included patients with M1 disease who had received or did not receive chemotherapy.A logistic regression model was used to examine the associations between chemotherapy and potential confounders and a Cox proportional hazards model was employed to examine the effect of chemotherapy on overall survival(OS).Propensity score analyses were further performed to balance measurable confounders between patients treated with and without *** A total of 29182 patients met criteria for inclusion in this analysis,with 21911(75%)receiving chemotherapy and 7271(25%)not receiving *** median follow-up was 69.45 *** median OS for patients receiving chemotherapy was 9.53 mo(9.33-9.72)vs 2.43 mo(2.27-2.60)with no *** of diagnosis 2010-2014[odds ratio(OR):1.29,95%confidence interval(CI):1.17-1.43,P value$46000(OR:1.49,95%CI:1.27-1.75,P value<0.001),and node-positivity(OR:1.35,95%CI:1.20-1.52,P<0.001)were independent predictors of receiving chemotherapy,while female gender(OR:0.86,95%CI:0.76-0.98,P=0.019),black race(OR:0.76,95%CI:0.67-0.93,P=0.005),uninsured status(OR:0.41,95%CI:0.33-0.52,P<0.001),and high Charlson Comorbidity Index(CCI)(OR for CCI≥2:0.61,95%CI:0.50-0.74,P<0.001)predicted for lower odds of receiving *** the effect of chemotherapy on OS using a time-dependent coefficient showed that chemotherapy was associated with improved OS up to 10 mo,after which there is no significant effect on ***,uninsured status[hazard ratio(HR):1.20,95%CI:1.09-1.31,P<0.001],being from the geographic

关键词： Esophageal cancer Metastatic Chemotherapy Predictors Survival

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铝合金轮毂铸件裂纹成因分析及对策

铸造技术 2007年第10期28卷 1395-1397页

作者：刘利华宫林松吕朔戴卡轮毂制造有限公司河北秦皇岛066000

图1为符合A356.2材料标准的铝合金轿车轮毂铸件热处理前后,在装饰面表面个别轮毂出现可见裂纹的产品结构照片,裂纹深度一般小于1 mm,长度一般小于10 mm.该件采用低压铸造,T6热处理.图2为裂纹位置放大图.

关键词：铝合金轮毂铸件裂纹成因分析 T6热处理轿车轮毂材料标准 A356 产品结构

Vertical variations and associated ecological function of bacterial communities from Sphagnum to underlying sediments in Dajiuhu Peatland

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Science China Earth Sciences 2014年第6期57卷 1013-1020页

作者： XIANG Xing WANG HongMei gong linFeng LIU Qiao State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences

To investigate vertical changes of bacterial communities from living plants to the associated sediments and bacterial biogeo- chemical roles in peatland ecosystem, samples of different part of individual Sphagnum palustre and the different layers of the underlying sediments were collected from Dajiuhu Peatland in central China. All samples were subject to 16S rRNA gene clone libraries and quantitative PCR analysis. Even though bacteria vary in abundance at the same order of magnitude in all samples, they show great profile difference in composition from the top part of S. palustre to the low layer of the sediments. Cyanobacteria and alpha-Proteobacteria dominate at the top part whereas Acidobacteria at the middle part of S. palustre. A1- pha-Proteobacteria and Acidobacteria are the dominant phyla at the bottom part of S. palustre and in the surface peat sediment. In contrast, bacterial communities in the subsurface sediments are dominated by Acidobacteria. These profile distributions of different bacterial communities are closely related to their ecological functions in the peatland ecosystem. Specifically, most Cyanobacteria were observed at the top green part of S. palustre, a horizon where the active photosynthesis of the moss occurs, which infers their endosymbiosis. In contrast, Acidobacteria, dominant in the subsurface sediments, are able to decompose the specific compounds on the cell wall of Sphagnum moss and thus might play an important role in the formation of the peatland, including the acidic condition. Methane oxidizing process might have been underestimated in Sphagnum peatland due to the identification of Methylocystaceae in all parts of the moss investigated here. The vertical difference in bacterial composition and bacterial ecological functions presented here sheds light on the understanding of biogeochemical processes, in particular the CH4 flux, in peat ecosystems.

关键词： Dajiuhu Peatland Sphagnum peat sediment bacterial communities CH4 cycle

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The role of water in methane adsorption and diffusion within nanoporous silica investigated by hyperpolarized 129Xe and 1H PFG NMR spectroscopy

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Nano Research 2018年第1期11卷 360-369页

作者： Yuanli Hu Mingrun Li Guangjin Hou Shutao Xu Ke gong Xianchun Liu Xiuwen Han Xiulian Pan Xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China National Engineering Laboratory for Methanol to Olefins Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China University of Chinese Academy of Sciences Beijing 100049 China

Understanding the properties and behavior of water molecules in restricted geometries, such as the nanopores of rocks, is of interest for shale gas exploitation. We present herein ex situ and in situ nuclear magnetic resonance （NMR） studies on the effects of water on the adsorption and diffusion of methane in nanopores. Silica materials with one-dimensional pores of ZSM-22, MCM-41, and SBA-15, with pore sizes ranging from 0.5 to 6 nm, were chosen as models. Hyperpolarized （HP） 129Xe NMR results show that water adsorption does not affect the pore sizes of ZSM-22 and MCM-41 but reduces that of SBA-15. The presence of water suppresses methane adsorption; this suppression effect is stronger in smaller pores. The self-diffusion coefficients of methane within ZSM-22 and MCM-41 are not significantly influenced by the presence of water, as measured by ~H pulsed field gradient （PFG） NMR. However, within SBA-15, which has a pore size of 6 nm, the diffusion coefficient of methane increases as the amount of water adsorption increases, peaks, and then decreases to a constant value with further water adsorption. These experiments reveal the effects of the pore size and the presence of water on methane adsorption and diffusion in constrained spaces, which could have important implications for flow simulations of methane in shales.

关键词： water adsorption nanopores diffusion hyperpolarized 129Xe nuclear magnetic resonance

DNA/银纳米簇荧光探针在检测Pb^(2+)中的应用

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化学学报 2014年第6期72卷 704-708页

作者：蔺超宫贺范楼珍李晓宏北京师范大学化学学院北京100875

基于DNA/银纳米簇的荧光特性报道了一种简单、灵敏、高选择性的荧光方法检测Pb2+.以茎部为富G结构,环状部分为聚C结构的发夹型DNA为模板合成具有稳定荧光的银纳米簇.当加入Pb2+后,发夹型DNA在Pb2+诱导下形成G-四链体结构,破坏了发夹型DN... 详细信息

基于DNA/银纳米簇的荧光特性报道了一种简单、灵敏、高选择性的荧光方法检测Pb2+.以茎部为富G结构,环状部分为聚C结构的发夹型DNA为模板合成具有稳定荧光的银纳米簇.当加入Pb2+后,发夹型DNA在Pb2+诱导下形成G-四链体结构,破坏了发夹型DNA的构型,极大地影响了合成银纳米簇的模板结构,导致银纳米簇的荧光强度降低.Pb2+存在和不存在时所产生荧光强度的差异与发夹型DNA的碱基序列和茎部配对碱基数有关.依据这一现象,在优化DNA碱基序列和茎部配对碱基数的基础上,可实现100μmol/L至100 nmol/L范围内对Pb2+的定量检测,检出限为10 nmol/L.该方法对Pb2+的检测具有较好的选择性,并可应用于实际水样中Pb2+的检测.检测结果与原子吸收光谱进行比对,显示出较好的一致性.

关键词：发夹型DNA 银纳米簇 G-四联体 Pb2+

A novel treatment of refractory coronary embolism:thrombus aspiration catheter-assisted twisting wire technique

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Journal of Geriatric Cardiology 2020年第2期17卷 110-115页

作者： Yi-Lun ZOU Jian-Qiang LI Yong-Tai gong Dang-Hui SUN Yue LI Department of Cardiology the First Affiliated Hospital of Harbin Medical University

Coronary embolism caused by the thrombus from guiding catheters is a rare and challenging complication,which may result in serious and fatal consequences due to the loss of blood flow of the coronary artery during percutaneous coronary intervention(PCI).Current strategies for the reduction of thrombus burden include pharmacological agents(typically glycoprotein IIb/IIIa platelet inhibitors),embolic protection devices(filters and distal balloon occlusion with aspiration),mechanical thrombectomy and manual or aspiration thrombectomy devices.[1]The above strategies are widely used as the first-line treatments,but have limitations for some refractory thrombus.A few techniques have been invented before to address this issue,[2–6]but they are not always effective or unavailable in some medical centers.

关键词： Complication Percutaneous coronary intervention Refractory thrombus embolism Thrombectomy

Detector performance of the Gamma-ray Transient Monitor onboard DRO-A satellite

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 75-90页

作者： Pei-Yi Feng Zheng-Hua An Da-Li Zhang Chen-Wei Wang Chao Zheng Sheng Yang Shao-lin Xiong Jia-Cong Liu Xin-Qiao Li Ke gong Xiao-Jing Liu Min Gao Xiang-Yang Wen Ya-Qing Liu Xiao-Yun Zhao Fan Zhang Xi-Lei Sun Hong Lu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The Gamma-ray Transient Monitor(GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A(DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 20 ke V to 1 MeV. The GTM was equipped with five Gamma-ray Transient Probe(GTP) detector modules utilizing a NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP uses a dedicated dual-channel coincident readout design. In this work, we first studied the impact of different coincidence times on the detection efficiency and ultimately selected a 0.5 μs time coincidence window for offline data processing. To test the performance of the GTPs and validate the Monte-Carlo-simulated energy response, we conducted comprehensive ground calibration tests using the Hard X-ray Calibration Facility(HXCF) and radioactive sources, including the energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively present the ground calibration results and validate the design and mass model of the GTP detector, thus providing the foundation for in-flight observations and scientific data analysis.

关键词： NaI(Tl)detector energy response ground calibration gamma-ray detector DRO-A satellite

Dynamic-statistics combined forecast scheme based on the abrupt decadal change component of summer precipitation in East Asia

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Science China Earth Sciences 2015年第2期58卷 404-419页

作者： gong ZhiQiang ZHAO JunHu FENG Guolin CHOU JiFan Laboratory for Climate Studies National Climate Research Center CMA College of Atmospheric Science Lanzhou University

Based on the 1983~2011 CMAP data,the precipitation anomaly in East Asia and its nearby sea regions（hereafter called East Asia for short） demonstrates the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterwards; this decadal change is contained principally in the corresponding EOF3 ***,the NCC_CGCM forecast results are quite different,which reveal the ＂＋-＋-＂ pattern before 1999 and the ＂-＋-＋＂ pattern ***,the probability of improving NCC_CGCM＇s forecast accuracy based on these key SST areas is discussed,and the dynamic-statistics combined forecast scheme is constructed for increasing the information of decadal change contained in the summer precipitation in East *** independent sample forecast results indicate that this forecasting scheme can effectively modify the NCC_CGCM＇s decadal change information contained in the summer precipitation in East Asia（especially in the area of 30°N–55°N）.The ACC is 0.25 and ACR is 61% for the forecasting result based on the V SST area,and the mean ACC is 0.03 and ACR is 51% for the seven key areas,which are better than NCC_CGCM＇s system error correction results（ACC is -0.01 and ACR is 49%）.Besides,the modified forecast results also provide the information that the precipitation anomaly in East Asia mainly shows the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterwards.

关键词： abrupt decadal change dynamic-statistics combined forecast scheme summer precipitation East Asia sea surface temperature

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Photometric Monitoring of Blazar 3C 66A with the Yunnan University Astronomical Observatory 1 m Telescope

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Research in Astronomy and Astrophysics 2023年第4期23卷 148-163页

作者： Wei Zeng Tao Wen Zhen-Lu gong Shi Chen Fan Wu Hao-Yang Zhang Ben-Zhong Dai School of Physics&Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Astroparticle Physics Yunnan ProvinceKunming 650091China Astronomical Observatory Yunnan UniversityKunming 650500China

3C 66A is one of our first batches of photometric monitoring objects with the 1 m optical telescope at Yunnan University Astronomical *** the present work,the observational campaign was performed from 2021 November 1 to 2022 February 27 in the Johnson-Morgan system V and R *** average magnitudes in each band were■=15.52±0.18 mag and■=15.07±0.17 *** overall variability amplitudes wereΔV=■,Amp=70.27%andΔR=■,Amp=68.56%,*** of the intraday variabilities(IDVs)occurred in 2021 December and 2022 *** minimal rise/decay timescale was about 6 minutes(5.82±2.74 minutes and 6.18±2.81 minutes on 2022 February 11,6.99±3.70 minutes and 6.17±2.91 minutes on 2022 February 12).Durations of these rapid variabilities were from 11.99 to 179.67 *** discrete correlation function analyses between V and R bands showed significantly correlated *** index analysis of ID Vs showed that the spectrums do not change with variabilities.

关键词： (galaxies:)BL Lacertae objects individual(3C 66A)-galaxies photometry-galaxies active