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The essential roles of m^(6)A modification in osteogenesis and common bone diseases

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Genes & Diseases 2024年第1期11卷 335-345页

作者： Yuxi gu Yidan song Yihua Pan Jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

N6-methyladenosine(m^(6)A)is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding RNAs.It affects the fate of the modified RNA,including its stability,splicing,and translation,and plays an important role in post-transcriptional regulation.Bones play a key role in supporting and pro-tecting muscles and other organs,facilitating the movement of the organism,ensuring blood production,etc.Bone diseases such as osteoarthritis,osteoporosis,and bone tumors are serious public health problems.The processes of bone development and osteogenic differen-tiation require the precise regulation of gene expression through epigenetic mechanisms including histone,DNA,and RNA modifications.As a reversible dynamic epigenetic mark,m^(6)A modifications affect nearly every important biological process,cellular component,and molecular function,including skeletal development and homeostasis.In recent years,studies have shown that m^(6)A modification is involved in osteogenesis and bone-related diseases.In this review,we summarized the proteins involved in RNA m^(6)A modification and the latest progress in elucidating the regulatory role of m^(6)A modification in bone formation and stem cell direc-tional differentiation.We also discussed the pathological roles and potential molecular mech-anisms of m^(6)A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone de-fects and bone diseases.

关键词： Bone diseases m^(6)A modification Osteogenesis Regulatory role Stem cells

The Current State and Progress of Mpox Vaccine Research

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China CDC weekly 2024年第7期6卷 118-125页

作者： Xinlong Wang Zhixia gu Shugui Sheng Rui song Ronghua Jin Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijingChina National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina

On July 23,2022,the World Health Organization(WHO)declared the monkeypox(mpox)outbreak a“Public Health Emergency of International Concern.”Since 2022,outbreaks of mpox in many countries around the world have primarily resulted in fatalities among immunocompromised individuals,such as untreated HIV/AIDS patients.Since the eradication of smallpox was declared by the WHO in 1980,the global vaccination against smallpox has been gradually discontinued.China also stopped routine smallpox vaccination in 1981.The protective effect of the smallpox vaccine has decreased over time due to aging and declining immunity in those who were vaccinated.For individuals,timely vaccination against smallpox is an effective means of protection against mpox.However,due to safety concerns with the smallpox vaccine and the limitations of current mpox vaccines,there is no vaccine that is safe,effective,and has low side effects applied in clinical settings.This article provides a comprehensive review of the development of mpox virus(MPXV)vaccines,their application in special populations,and the current state of vaccine research,considering the etiology,transmission,and prevention of the MPXV.Vaccination,as an effective method of epidemic prevention,can provide long-term immune protection and effectively reduce the severity of infection.However,as there is no licensed specific MPXV vaccine available globally,the vaccines currently used for mpox prevention are mostly smallpox vaccines.These smallpox vaccines can offer some degree of protection against mpox by activating cross-protection in the body.

关键词： prevention routine protective

Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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Genes & Diseases 2024年第1期11卷 283-293页

作者： Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun gu gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang Anhui University of Traditional Chinese Medicine HefeiAnhui 230000China Yangtze Delta Drug Advanced Research Institute Yangtze Delta Pharmaceutical CollegeNantongJiangsu226133China Shanghai Innostar Bio-Technology Co. LtdChina State Institute of Pharmaceutical IndustryShanghai 201203China Innostar Bio-tech Nantong Co. Ltd.NantongJiangsu 226133China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China

In recent years,significant breakthroughs have been made in the field of gene ther-apy.Adeno-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest.Among the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific tissues.Currently,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.

关键词： AAV8 Adeno-associated virus Gene therapy Primates

double-cone ignition;streaked optical pyrometer;velocity interferometer system for any reflector

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High Power Laser Science and Engineering 2024年第1期12卷 52-59页

作者： Dawei Yuan Shaojun Wang Huigang Wei Haochen gu Yu Dai Jiayong Zhong Yutong Li gang Zhao Jie Zhang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina Institute of Frontiers in Astronomy and Astrophysics of Beijing Normal University BeijingChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina Key Laboratory for Laser Plasmas(MOE)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Department of Astronomy Beijing Normal UniversityBeijingChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina School of Physical Sciences University of Chinese Academy of SciencesBeijingChina songshan Lake Materials Laboratory DongguanChina

The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of state and shock timing.To validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition(DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.

关键词： double-cone ignition streaked optical pyrometer velocity interferometer system for any reflector

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Knowledge,Attitude,and Practice Towards Mpox and Associated Factors Among HIV-Infected Individuals—Beijing Municipality,China,2023

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China CDC weekly 2024年第7期6卷 109-117,I0001,I0002页

作者： Yue gu Ruiqi Ren Jing Han Wenqing Bai Yuanyuan Zhang Haoliang Liu Zhaohe Li Chao Li Rui song Lei Zhou Chinese Center for Disease Control and Prevention BeijingChina National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijingChina Nanjing Medical University Nanjing CityJiangsu ProvinceChina

Summary What is already known about this topic?Approximately 50%of patients with mpox are human immunodeficiency virus(HIV)-infected globally.Studies have shown that individuals with advanced HIV infection tend to hav... 详细信息

关键词： mortality Infect clinical

Effects of long-term blood pressure variability on renal function in community population

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Chronic Diseases and Translational Medicine 2024年第2期10卷 149-152页

作者： Zhao Feng Zhiquan Jing Zeya Li gang Wang Shanshan Wu Dan Li Jing Hao Chunlei Yang Jiashu song Xianzhong gu Rongchong Huang Department of medical service Yongshun Community Health Service CenterYongshun TownBeijingChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Weihai Municipal HospitalWeihaiShandongChina National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijingChina

High blood pressure is a significant contributor to premature mortality,resulting in nearly 10 million deaths and over 200 million disabilities worldwide.1 In recent years,hypertension treatment has shifted focus not only to average blood pressure but also to blood pressure variability(BPV),categorized into very short-term,short-term,and long-term BPV based on the time period of occurrence.2,3 Long-term BPV has emerged as clinically significant,with studies demonstrating its superiority in predicting long-term cardiovascular events,stroke,and mortality compared to short-term variability.Given its association with pre-renal function decline,reducing blood pressure fluctuations is imperative.

关键词： mortality cardiovascular function

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Liquid-phase epitaxial layer by layer brushing fabrication of metalorganic frameworks films

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Nano Research 2024年第6期17卷 5698-5704页

作者： Li-Mei Chang Rui Zhai Zhi-Zhou Ma Jian-Dong Huang Zhi-gang gu Jian Zhang College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

Development of metal-organic framework(MOF)films is of great importance to expand their applications.Herein,we report a facile and universal method of liquid-phase epitaxial(LPE)layer by layer(LBL)brushing approach for fabricating MOF films on various substrates in a high-throughput fashion.This MOF films preparation method offers a great prospective to cost-effectively construct films with short preparation time and little reagent consumption.Moreover,this LBL brushing approach has been implemented successfully to assemble various MOF films,including HKUST-1,zeolitic imidazolate framework-8(ZIF-8),Cu(bdc),and Cu_(2)(L)_(2)P(L=bdc,ndc,and cam;P=dabco and bipy).Afterwards,the classic MOF HKUST-1 and ZIF-8 films were grown on sensor chip electrode and porous fiber support for good volatile organic compounds(VOCs)selective sensing and water purification applications.This study demonstrates that this LBL brushing preparation method can be employed to synthesize various MOF films with a variety of characteristics to realize their sensing and separation applications.

关键词： metal-organic framework porous materials layer by layer fabrication film

Zincophilic Ti_(3)C_(2)Cl_(2)MXene and anti-corrosive Cu NPs for synergistically regulated deposition of dendrite-free Zn metal anode

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Journal of Materials Science & Technology 2024年第2期169卷 137-147页

作者： Yunfei Shen Yi Liu Kaisheng Sun Tiantian gu gang Wang Yue Yang Jianxiang Pang Yang Zheng Xiaodong Yang Long Chen Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China Institute for Chemistry Chemnitz University of TechnologyChemnitz 09107Germany CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and DevicesCenter of Materials Science and Optoelectronics EngineeringXinjiang Technical Institute of Physics and Chemistry of CASUrumqi 830011China Key Laboratory of Ecophysics and Department of Physics College of ScienceShihezi UniversityShihezi 832003China

Dendrites growth,chemical corrosion,and hydrogen evolution reaction(HER)on zinc anodes are the main barriers for the development of aqueous zinc-ion batteries(AZIBs).Constructing interfacial protec-tive layer is an effective way to alleviate the side reactions on the anodes.Herein,Cu/Ti_(3)C_(2)Cl_(2)MXene(CMX)with high zincophilic and hydrophobic property is prepared by the lewis molten salts etching method,and the CMX interface protection layer is constructed by a simple spin coating.The CMX coat-ing layer can provide abundant nucleation sites and uniformize the charge distribution through the zin-cophilic Ti_(3)C_(2)Cl_(2)MXene matrix,leading to homogenous Zn deposition.In addition,the hydrophobic coat-ing contained anti-corrosive Cu nanoparticles can prevent the Zn anode from the electrolyte,beneficial for suppressing the chemical corrosion and HER.Therefore,the stable and reversible Zn plating/stripping is achieved for the Zn anode coated by the CMX,which exhibits the lifespan of over 1400 h at 0.5 mA cm^(−2),and even can steadily run for 700 h with 65 mV at 10 mA cm^(−2).Furthermore,CMX@Zn shows a high coulombic efficiency of over 100%for 3800 cycles,which indicates that the CMX@Zn electrode has excellent stability and reversibility of Zn stripping/plating.The full batteries assembled with ZnCoMnO/C(ZCM)cathodes also exhibits higher capacity(450.6 mAh g^(−1)at 0.1 A g^(−1))and cycle stability(capacity retention of 70%after 1500 cycles).This work enhanced the lifespan of AZIBs and broaden the research of multifunctional coating layer to other secondary batteries based on metal anodes.

关键词： Zinc anode Spin coating Zincophilic MXene Anti-corrosive Cu NPs Multifunctional coating

Multispectral point cloud superpoint segmentation

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Science China(Technological Sciences) 2024年第4期67卷 1270-1281页

作者： WANG QingWang WANG MingYe ZHANG ZiFeng song Jian ZENG Kai SHEN Tao gu YanFeng Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Computer Technologies Application Kunming 650500China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China

The multitude of airborne point clouds limits the point cloud processing efficiency.Superpoints are grouped based on similar points,which can effectively alleviate the demand for computing resources and improve processing efficiency.However,existing superpoint segmentation methods focus only on local geometric structures,resulting in inconsistent spectral features of points within a superpoint.Such feature inconsistencies degrade the performance of subsequent tasks.Thus,this study proposes a novel Superpoint Segmentation method that jointly utilizes spatial Geometric and Spectral Information for multispectral point cloud superpoint segmentation(GSI-SS).Specifically,a similarity metric that combines spatial geometry and spectral information is proposed to facilitate the consistency of geometric structures and object attributes within segmented superpoints.Following the formation of the primary superpoints,an intersuperpoint pointexchange mechanism that maximizes feature consistency within the final superpoints is proposed.Experiments are conducted on two real multispectral point cloud datasets,and the proposed method achieved higher recall,precision,F score,and lower global consistency and feature classification errors.The experimental results demonstrate the superiority of the proposed GSI-SS over several state-of-the-art methods.

关键词： multispectral point cloud superpoint segmentation over-segmentation spatial-spectral joint metric

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