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Establishment of an animal model of ischemic type intrahepatic biliary lesion in rabbits

World Journal of Gastroenterology 2009年第6期15卷 732-736页

作者： Qin-song Sheng da-Zhi chen Ren Lang Qiang He Yong-Jiu Yang Zhao-Wei Qu De-Fang Zhao Xiao-Sheng Zhang Department of Hepatobiliary and Pancreatosplenic Surgery Beijing Chaoyang Hospital affiliated to the Capital Medical University Beijing 100020 China

AIM:To explore a method to establish an animal model of ischemic type intrahepatic biliary lesion in rabbits. METHODS:Forty Japanese white rabbits of clean grade were divided randomly into four groups(10 rabbits per group)including sham operation(SO) group,and artery-bile obstruction(ABO)-1 h group, ABO-2 h group and ABO-3 h *** the rabbits in this study underwent the same initial surgical procedure in which the liver was prepared as for graft removal during liver *** in the SO group,no additional vascular intervention was performed,while in groups ABO-1 h,ABO-2 h and ABO-3 h,the animals underwent combined clamping of the hepatic artery and common bile duct with microvascular clips for 1,2 and 3 h,*** the scheduled occlusion time,the clip was removed to recover blood *** animals were killed 4 wk after *** survival rate,liver function, cholangiography and histopathological manifestation of the rabbits in each group were observed. RESULTS:The survival rate was 100%in groups SO,ABO-1 h and ABO-2 h,while it was 60%in group ABO-3 *** each observation time,the change degree of the indexes of liver function was proportional to the clamping time(ABO-3 h>ABO-2 h>ABO-1 h> SO,P<0.05).Cholangiographical and histopathologic manifestations both showed that intrahepatic biliary lesion aggravated proportionally with the increase of the clamping time. CONCLUSION:An animal model of ischemic type intrahepatic biliary lesion in rabbits is successfully established,which may provide a reliable technique for basic and clinical research into the etiology, development and prophylaxis of ischemic type intrahepatic biliary lesion after liver transplantation.

关键词： Biliary complication Ischemic type biliary lesion Animal model Liver transplantation Intrahepatic biliary stricture Ischemic reperfusion injury

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Laparoscopic cystogastrostomy for the treatment of pancreatic pseudocysts: A case report

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World Journal of Gastroenterology 2008年第30期14卷 4841-4843页

作者： Qin-song Sheng da-Zhi chen Ren Lang Zhong-Kui Jin Dong-Dong Han Li-Xin Li Yong-Jiu Yang Ping Li Fei Pan Dong Zhang Zhao-Wei Qu Qiang He Department of Hepatobiliary and Pancreatospleenic Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China

Pancreatic pseudocysts （PPs） are collections of pancreatic secretions that are lined by fibrous tissues and may contain necrotic debris or blood. The interventions including percutaneous, endoscopic or surgical approaches are based on the size, location, symptoms and complications of a pseudocyst. With the availability of advanced imaging systems and cameras, better hemostatic equipments and excellent laparoscopic techniques, most pseudocysts can be found and managed by laparoscopy. We describe a case of a 30-year-old male patient with a pancreatic pseudocyst amenable to laparoscopic cystogastrostomy. An incision was made through the anterior gastric wall to expose the posterior gastric wall in close contact with the pseudocyst using an ultrasonically activated scalpel. Then, another incision was made for cystogastrostomy to obtain complete and unobstructed drainage. The patient recovered well after operation and was symptom-free during a 6-mo follow-up, suggesting that laparoscopic cystogastrostomy is a safe and effective alternative to open cystogastrostomy for minimally invasive management of PPs.

关键词： Pancreatic pseudocyst Laparoscopic cystogastrostomy Percutaneous drainage Endoscopic drainage Laparoscopy Pancreatitis

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人不是物:社会认知的稽古维新

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心理学报 2025年第1期57卷 173-189页

作者：董达陈巍绍兴文理学院心理学系大脑、心智与教育研究中心浙江绍兴312000 中国人民大学哲学与认知科学交叉平台北京100080

当代社会认知的理论版图可分为经典概念工具箱与正在与之对抗的新概念工具两部分。经考证,理论论和模拟论等经典概念工具集中诞生于1980年代的美国认知科学界,可以被视为1956认知革命蔓延至社会心理学领域的产物,而新概念工具可以被视... 详细信息

当代社会认知的理论版图可分为经典概念工具箱与正在与之对抗的新概念工具两部分。经考证,理论论和模拟论等经典概念工具集中诞生于1980年代的美国认知科学界,可以被视为1956认知革命蔓延至社会心理学领域的产物,而新概念工具可以被视为与第二代认知革命相适合的替代理论。历史上,社会心理学接受了认知主义的“物”的抽象认知原理,也全盘接受了它带来的理论负荷,即对“人”的感知被还原为对“物”的感知,并且隶属于后者。然而,基于“物”的抽象认知原理始终无法与社会认知的以“人”为本的实践经验相结合,也未能实现该领域的自治。事实上,这一理论困难并非一直存在于“社会认知”的历史路径中,至少在以Heider为标志性人物的1950年代早期社会认知中便不是这样。Heider“人不是物”理论体系在个体层面上包括知觉实在论、事件归因和生命性−非生命性范畴区分三个部分,但是第三个理论部件彼时囿于作者主题侧重、证据不足、技术匮乏等多种原因未能完成。结合当代来自演化和比较的、行为和发展的以及神经通路假设的新证据,通过重新发掘并最终完整构建了“人不是物”论题,尝试为当代社会认知理论困难提供一个建设性意见。

关键词：社会认知人的感知认知革命生命性主体间性

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三维数字化战场环境构建技术研究

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系统仿真学报 2009年第S1期21卷 91-94页

作者：吴玲达宋汉辰国防科技大学信息系统与管理学院长沙410073

考虑到数字化战场环境信息多维、多源、多尺度、多时态的特点,必须以建立可视化的战场信息环境为目的,对所有信息进行统一处理,建立规范的战场信息库和模型库,满足数字化战场环境实时绘制和浏览的需求。提出了一种三维数字化战场环境的... 详细信息

考虑到数字化战场环境信息多维、多源、多尺度、多时态的特点,必须以建立可视化的战场信息环境为目的,对所有信息进行统一处理,建立规范的战场信息库和模型库,满足数字化战场环境实时绘制和浏览的需求。提出了一种三维数字化战场环境的设计方案,对三维数字化战场环境中的地理环境、电磁环境、气象环境等信息可视化技术进行了研究,构建了一个典型的三维数字化战场环境。

关键词：三维数字化战场环境信息可视化地理环境电磁环境气象环境

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MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei Ming Longfu chen Tianliang song Moxi Yele Hao Zhang Long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao chen Xie Liu Changqing Xu da-Jian Wu Ying cheng Xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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Mutual-structure weighted guided image filtering for depth map restoration

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Optoelectronics Letters 2025年第1期21卷 51-56页

作者： LIU Zijian song Jian chen Quanmin XU Jiangtao Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology School of Microelectronics Tianjin University Spikesee Technology Co. Ltd.

Although guided image filtering(GIF) is known for preserving edges and fast computation, it may produce inaccurate outputs in depth map restoration. In this paper, a novel confidence-weighted GIF called mutual-structure weighted GIF(MSWGIF) is proposed, which replaces the mean filtering strategy in GIF during handling overlapping windows. The confidence value is composed of a depth term and a mutual-structure term, where the depth term is utilized to protect the edges of the output, and the mutual-structure term helps to select accurate windows during the structure characteristics of the guidance image are transferred to the output. Experimental results show that MSWGIF reduces the root mean square error(RMSE) by an average of 12.37%, and the average growth rate of correlation(CORR) is 0.07% on average. Additionally, the average growth rate of structure similarity index measure(SSIM) is 0.34%.

关键词： Wiener filtering

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng song Yuhang song Jingyu chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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LINC01614 expression in gastric cancer and its prognostic value based on bioinformatics analyses

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Journal of Hainan Medical University 2020年第10期26卷 42-46页

作者： Hui-Jie Wu Jing-Yuan Zhou song-da chen Ling-Yu Zhu Jia-Hao Liang Ai-QunLiu Department of Endoscopy Center Guangxi Medical University Cancer HospitalNanningGuangxi530021 Department of Hepatobiliary Surgery Guangxi Medical University Cancer HospitalNanningGuangxi530021

Objective:To identify the potential role and prognostic value of LINC01614 in gastric cancer. Methods: qRT-PCR was applied to analyze the LINC01614 expression in gastric cancer tissue and paired adjacent normal tissue, and gastric cell line. And the RNA-Seq data downloaded from the TCGA and GEO database was employed to analyze and validate the LINC01614 expression in gastric cancer tissue and adjacent normal tissue. And the analyses of relationship between LINC01614 expression level and clinical features was done to clarify the role of LINC01614 in gastric cancer. The survival analysis was used to identify the prognostic value of LINC01614. And the pathways that LINC01614 may enroll was ***: The qRT-PCR showed that LINC01614 was increased in gastric cancer tissue and gastric cancer cell line (P datasets analyses (P < 0.001). And it was found that LINC01614 expression was significantly correlated with histologic grade and residual tumor (P = 0.0177 and 0.0218, respectively). Survival analysis indicated that low expression of LINC01614 patients have longer overall survival than high expression one (HR = 1.520, 95% CI: 1.094 ~ 2.110). After all, enriched pathways showed that LINC01614 may act in carcinogenesis through various ***: LINC01614 is high expressed in gastric cancer and high expression of LINC01614 is related to poor prognosis. LINC01614 may be a potential prognostic biomarker for gastric cancer.

关键词： Stomach adenocarcinoma LINC01614 RNA Long Noncoding Bioinformatics

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun chen Heng Zhao Bin dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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