检索结果-南通市图书馆

The integrative roles of chemokines at the maternal-feta interface in early pregnancy

Cellular & Molecular Immunology 2014年第5期11卷 438-448页

作者： Mei-Rong Du song-cun wang Da-Jin Li M-RD and S-CW contributed equally to this work. Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China

Embryos express paternal antigens that are foreign to the mother, but the mother provides a special immune milieu at the fetal-maternal interface to permit rather than reject the embryo growth in the uterus until parturition by establishing precise crosstalk between the mother and the fetus. There are unanswered questions in the maintenance of pregnancy, including the poorly understood phenomenon of maternal tolerance to the allogeneic conceptus, and the remarkable biological roles of placental trophoblasts that invade the uterine wall. Chemokines are multifunctional molecules initially described as having a role in leukocyte trafficking and later found to participate in developmental processes such as differentiation and directed migration. It is increasingly evident that the gestational uterine microenvironment is characterized, at least in part, by the differential expression and secretion of chemokines that induce selective trafficking of leukocyte subsets to the maternal-fetal interface and regulate multiple events that are closely associated with normal pregnancy. Here, we review the expression and function of chemokines and their receptors at the maternal-fetal interface, with a special focus on chemokine as a key component in trophoblast invasiveness and placental angiogenesis, recruitment and instruction of immune cells so as to form a fetus-supporting milieu during pregnancy. The chemokine network is also involved in pregnancy complications.

关键词： chemokine decidua pregnancy pregnant complications trophoblast

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light People:Professor Manijeh Razeghi

引用

Light(Science & Applications) 2024年第8期13卷 1451-1462页

作者： Hui wang cun Yu Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

The sense of light is the first sensation the human body *** importance of light is ***,we all know that the light we can see and perceive covers only a small section of the ***,for Light People,we feature a researcher who is committed to exploring different spectral bands of light ranging from deep ultraviolet to terahertz waves and working on quantum semiconductor technology,*** Razeghi of the Northwestern University in the United *** for her quick thinking and witty remarks,*** is passionate about life and always kind to *** a scientist,she does not limit her research to a single focus,instead,she works on the entire process from material selection,device design,processing,and manufacturing,all the way to product *** has a strong passion for education,a commitment unwavered by fame or *** her students,she is both a reliable source of knowledge and a motherly figure with a caring *** firmly believes that all things in nature can give her energy and *** science,she is a true“pioneer”in research and a“miner”of scientific *** advises young scientists to enjoy and love what they do,and turn their research into their *** a female scientist,she calls on all women to realize their true value and ***,let’s hear from Professor Manijeh Razeghi,a true star who radiates energy and light.

关键词： mother instead passion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light People:Professor Laura Na Liu

引用

Light(Science & Applications) 2024年第2期13卷 184-189页

作者： Hui wang cun Yu Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences130033ChangchunChina

Editorial The DNA nanotechnology outlines a new chapter in biological sciences,opening a new era of scientific and technological advancements.A pioneer of DNA nanotechnology,Professor Liu from the University of Stuttgart in Germany,our latest Light People,has been working at the interface,where nanophotonics meets biology and *** the path of scientific explorations.

关键词： chemistry. advancement pioneer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy

引用

Cellular & Molecular Immunology 2012年第5期9卷 423-430页

作者： Hai-Lan Piao Yu Tao Rui Zhu song-cun wang Chuan-Ling Tang Qiang Fu Mei-Rong Du Da-Jin Li Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and GynecologyFudan University Shanghai Medical CollegeShanghai 200011China Department of Obstetrics and Gynecology The First Affiliated Hospital of Sochow UniversitySuzhou 215006China Department of Immunology Binzhou Medical UniversityYantai 264003China

The regulatory mechanism of Th2 bias at the maternal/fetal interface remains unclear. In this study, we characterized cytokine production in decidual stromal cells （DSCs）, decidual immune cells （DICs） and embryo-derived trophoblast cells, and investigated the regulation of CXCL12/CXCR4 interaction on Th2 bias at the maternal/fetal interface in early human pregnancy. We found differential production of Th 1-type and Th2-type cytoki nes by trophoblasts, DSCs and DICs. The secretion of these cytokines varied in different cell cocultures, conduced to Th2 bias. Flow cytometry showed that coculture of trophoblasts with DSCs and DICs significantly increased IL-4 and IL-IO production in trophoblasts, and IL-IO production in DSCs. However, the coculture of trophoblasts with DSCs and DICs significantly increased interferon （IFN）-7 expression in DSCs, and tumor-necrosis factor （TNF）-a expression in DICs. No change was seen in Thl-type cytokine production in trophoblasts, and in Th2-type cytokine production in DICs in all cocultures. Furthermore, pre-treatment with anti-CXCR4 neutralizing antibody upregulated the production of the Thl-type cytokines IFN-y and TNF-a, and downregulated the production of the Th2-type cytokines IL-4 and IL-IO, in trophoblasts, DSCs, DICs or their cocultures. Interestingly, rhCXCL12 inhibited production of the Thl-type cytokine TNF-a and enhanced the expression of the Th2-type cytokines such as IL-4 and IL-IO in DICs; this effect was abrogated by anti-CXCR4 antibody. Our present study has elucidated the individual contributions of component cells to the shaping of Th2 bias, and uncovered a complicated cross-talk viathe CXCL12/CXCR4 signal at the maternal/fetal interface in early human pregnancy.

关键词： CXCL12/CXCR4 maternal/fetal interface Thl/Th2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Altered Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/T-Cell Immunoglobulin Mucin-3 Signaling Causes the Dysregulation of Decidual CD8+T Cells in the Third Trimester during Preeclamptic Pregnancies

引用

Reproductive and Developmental Medicine 2021年第4期5卷 206-212页

作者： Chun-Qin Chen song-cun wang Feng-Run Sun Meng-Die Li Mei-Rong Du Ying Zhang Laboratory for Reproductive Immunology NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research)Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesHospital of Obstetrics and GynecologyFudan University Shanghai Medical CollegeShanghai 200011China Department of Obstetrics Obstetrics and GynecologyHospital of Fudan UniversityShanghai 200090China

Objective:To investigate the frequency and function of Tim-3^(+)CD8^(+)T cells in the third trimester of normal pregnancies(NPs)and preeclamptic(PE)***:T-cell immunoglobulin mucin-3(Tim-3)expression levels of CD8^(+)T cells in the decidua,peripheral blood,and umbilical cord blood obtained from women showing NPs and PE pregnancies were analyzed using flow *** CD8^(+)T cells were cultured in the presence of recombinant human carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1)protein and/or Tim-3-specific neutralizing antibodies for analyzing CD107a and intracellular cytokine *** placental CEACAM1 protein expression was analyzed using ***:Tim-3^(+)CD8^(+)T cells were more abundant in the decidua than in the peripheral ***-3 expression in the decidual CD8^(+)T cells was significantly lower in PE *** Tim-3^(+)CD8^(+)T cells from PE patients expressed higher levels of CD107a and the Th1-type cytokine IFN-γ,but lower levels of the Th2-type cytokine ***1 altered the CD107a,IFN-γ,and IL-4 levels;this was reversed by anti-Tim-3 *** CEACAM1 protein levels were lower in the placental tissues of women with PE pregnancies than in those of women with ***:Abnormal CEACAM1/Tim-3 regulation may participate in the development of PE,accompanied by disturbed Th2 cell predominance and higher cytotoxicity of decidual CD8^(+)T cells.

关键词： 3rd-trimester Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 CD8^(+)T Cells Preeclampsia Tim-3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Galectin-9 Promotes Human Trophoblast Cell Invasion through Matrix Metalloproteinase-2 and p38 Signaling Pathway

引用

Reproductive and Developmental Medicine 2018年第1期2卷 1-7页

作者： Feng-Run Sun Chun-Qing Chen Min Yu song-cun wang Da-Jin Li Mei-Rong Du Laboratory for Reproductive Immunology Hospital of Obstetrics and GynecologyFudan University Shanghai Medical CollegeShanghai 200011China Key Lab of Reproduction Regulation of NPFPC SIPPRIRDFudan UniversityShanghai 200032China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China IVF-ET Center Hospital of Obstetrics and GynecologyFudan University Shanghai Medical CollegeShanghai 200011China

Objective:Adequate extravillous trophoblast(EVT)invasion plays a crucial role in the establishment of successful *** trophoblast migration and invasion can result in defective placentation,which is associated with a number of clinical pathological conditions of pregnancy including spontaneous abortion and ***-9(Gal-9)has a wide variety of regulatory functions in innate and adaptive immunity during infection,tumor growth,and organ ***:We utilized immortalized human first-trimester EVT cells(HTR8/SVneo)for our functional *** examined the effects of Gal-9 on viability,proliferation,and invasion of HTR8/SVneo cells,as well as on matrix metalloproteinase-2(MMP-2)production in HTR8/SVneo ***,we observed the effects of different MAPK-signaling pathway inhibitors on the stimulatory functions of Gal-9 on HTR8/SVneo cells’***:We verified the secretion of Gal-9 by trophoblasts and detected a correlation between low levels of Gal-9 and spontaneous ***-9 promoted the invasion of HTR8/SVneo cells through its interaction with Tim-3,not CD44,and subsequently increased MMP-2 *** of p38 signaling pathway inhibited Gal-9 activities in HTR8/SVneo ***:Gal-9 promotes human trophoblast cell invasion through MMP-2 and p38 signaling pathway in a Tim-3-dependent manner.

关键词： Galectin‑9 Invasion Matrix Metalloproteinase‑2 p38 Signaling Pathway Trophoblast Cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy

引用

Cellular & Molecular Immunology 2016年第1期13卷 73-81页

作者： Yan-Hong Li Wen-Hui Zhou Yu Tao song-cun wang Yun-Lan Jiang Di Zhang Hai-Lan Piao Qiang Fu Da-Jin Li Mei-Rong Du Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China Medical Center for Human Reproduction Beijing Chaoyang HospitalCapital Medical University Beijing China Maternal and Child Care Hospital Of Huangpu District Shanghai China These authors contributed equally to this work

Decidual natural killer （dNK） cells actively participate in the establishment and maintenance of maternal-fetal immune tolerance and act as local guardians against infection. However, how dNK cells maintain the immune balance between tolerance and anti-infection immune responses during pregnancy remains unknown. Here, we demonstrated that the inhibitory molecule T-cell immunoglobulin domain and mucin domain-containing molecule-3 （Tim-3） are expressed on over 60% of dNK cells. Tim-3^＋ dNK cells display higher interleukin （IL）-4 and lower tumor necrosis factor （TNF）-α and perforin production. Human trophoblast cells can induce the transformation of peripheral NK cells into a dNK-like phenotype via the secretion of galectin-9 （Gal-9） and the interaction between Gal-9 and Tim-3. In addition, trophoblasts inhibit lipopolysaccharide （LPS）-induced pro-inflammatory cytokine and perforin production by dNK cells, which can be attenuated by Tim-3 neutralizing antibodies. Interestingly, a decreased percentage of Tim-3-expressing dNK cells were observed in human miscarriages and murine abortion-prone models. Moreover, T helper （Th）2-type cytokines were decreased and Thl-type cytokines were increased in Tim-3^＋ but not Tim-3- dNK cells from human and mouse miscarriages. Therefore, our results suggest that the Gal-9/Tim-3 signal is important for the regulation of dNK cell function, which is beneficial for the maintenance of a normal pregnancy.

关键词： cytotoxicity galectin-9/Tim-3 NK cells pregnancy Th2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Organic near-infrared optoelectronic materials and devices:an overview

引用

Advanced Photonics 2024年第1期6卷 17-42页

作者： Zong-Lu Che Chang-cun Yan Xue-Dong wang Liang-Sheng Liao Soochow University Institute of Functional Nano and Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSuzhouChina Soochow University College of ChemistryChemical Engineering and Materials ScienceJiangsu Engineering Laboratory of Novel Functional Polymeric MaterialsSuzhouChina Macao University of Science and Technology Macao Institute of Materials Science and EngineeringMacaoChina

Near-infrared(NIR)light has shown great potential for military and civilian applications owing to its advantages in the composition of sunlight,invisibility to human eyes,deeper penetration into biological tissues,and low optical loss in optical ***,organic optoelectronic materials that can absorb or emit NIR light have aroused great scientific interest in basic science and practical *** on these NIR organic optoelectronic materials,NIR optoelectronic devices have been greatly improved in performance and *** this review,the representative NIR organic optoelectronic materials used in organic solar cells,organic photodetectors,organic light-emitting diodes,organic lasers,and organic optical waveguide devices are briefly introduced,and the potential applications of each kind of device are briefly ***,we summarize and take up the development of NIR organic optoelectronic materials and devices.

关键词： near-infrared organic optoelectronic materials organic solar cells organic light-emitting devices organic optical waveguides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tim-3 and CTLA-4 pathways help to regulate decidual CD8+T cells function in early pregnancy

Tim-3 and CTLA-4 pathways help to regulate decidual CD8+T ce...

引用

第十三届全国免疫学学术大会

作者： song cun wang Meirong Du Da jin Li Hospital of Obstetrics and Gynecology Fudan University

Maternal decidual CD8+T(dCD8+T) cells must integrate the antithetical demands of maternal-fetal tolerance and anti-viral immunity to establish a successful pregnancy. Tim-3 and CTLA-4 are two important co-inhibitory molecules that regulating CD8+T cells responses during infection and tumor. In the present study, we examined the co-expression of Tim-3 and CTLA-4 on CD8+T cells during pregnancy and found the higher frequency of Tim-3+PD-1+dCD8+T cells in response to trophoblasts. This Tim-3+PD-1+dCD8+T cells subset showed an active status and produced more anti-inflammatory cytokines. Furthermore, the decreased number and altered function of Tim-3+PD-1+dCD8+T cells correlated to miscarriage. Combined targeting Tim-3 and CTLA-4 pathways were highly effective in inhibiting the production of anti-inflammatory cytokines and were detrimental to the maintenance of pregnancy. Together, these findings supported that Tim-3 and CTLA-4 pathways might play positive roles in the establishment and/or maintenance of maternal-fetal tolerance so to promote the maintenance of normal pregnancy.

关键词： Pregnancy miscarriage Tim-3 CTLA-4 decidual CD8+T cells maternal-fetal interface

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Experimental study on combustion characteristics of supersonic combustor based on alternating-wedge strut

引用

Chinese Journal of Aeronautics 2024年第5期37卷 214-227页

作者： Jie LI Wenyan song Yuhang wang School of Power Energy Northwestern Polytechnical UniversityXi’an 710129China

Acetone Planar Lase-Induced Fluorescence(PLIF)and OH-PLIF were employed to capture the fuel distribution and OH distribution downstream for the supersonic combustor based on the alternating-wedge *** combustion establishment process and combustion mode in the combustor under different fuel injection methods and different equivalence ratios were *** with the kerosene-PLIF and OH-PLIF results in the cavity combustor,a comparative analysis was conducted to understand the combustion characteristics and combustion modes between the alternating-wedge strut-based combustor and the cavity-based *** results show that the combustor is in weak combustion mode in the case of low equivalence ratio,and the combustor is in intensive combustion mode in the case of high equivalence *** lower limit of the equivalence ratio of the combustor to maintain the intensive combustion mode varies based on different fuel injection *** OH distribution under reacting condition has a strong correlation with the fuel distribution under non-reacting *** OH fluorescence signal near the injector is weaker when the fuel distribution is more *** injector position located at the base of the strut rear has better mixing performance,enabling the combustor to be in intensive combustion mode at a lower equivalence *** combustion reaction in the alternating-wedge strut-based combustor is not necessarily dominated by mass transfer due to the mixing enhancement and premixed zone downstream of strut,while the combustion reaction process in the cavity-based combustor is mainly influenced by mass transfer.

关键词： Supersonic combustor Alternating-wedge strut Cavity PLIF Fuel injection Fuel distribution Combustion characteristics Combustion mode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：