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A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement

Acta Pharmaceutica Sinica B 2024年第3期14卷 1457-1466页

作者： Yaqin Wei Xiangqing Xu Qiang Guo song zhao Yinli Qiu Dongli Wang Wenwen Yu Yani Liu KeWei Wang School of Pharmacy Xuzhou Medical UniversityXuzhou 221004China Institute of Pharmaceutical Research Jiangsu Nhwa Pharmaceutical Co.Ltd.&Jiangsu Key Laboratory of Central Nervous System Drug Research and DevelopmentXuzhou 221116China Department of Pharmacology School of PharmacyQingdao University Medical CollegeQingdao 266073China Institute of Innovative Drug Qingdao UniversityQingdao 266021China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510515China

Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving cognition.In this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in cognition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on locomotion.Intragastric administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like behavior.Additionally,D01 dose-dependently improves the cognitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or scopolamine-induced cognitive deficits in mice,but not fluoxetine.Furthermore,D01 reverses the long-term potentiation(LTP)inhibition induced by scopolamine.Taken together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and cognitive deficits,thus holding potential for development as therapy of depression with cognitive deficits.

关键词： SERT 5-HT Kv7/KCNQ/M current D01 Depression Cognition

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A Magnetic-Driven Multi-motion Robot with Position/Orientation Sensing Capability

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Research 2024年第1期2023卷 675-685页

作者： Liwen Zhang song zhao Xinzhao Zhou Xueshan Jing Yu Zhou Yan Wang Yantong Zhu Xiaolin Liu Zehui zhao Deyuan Zhang Lin Feng Huawei Chen School of Mechanical Engineering and Automation Beihang UniversityBeijingChina Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina

Miniature magnetic-driven robots with multimode motions and high-precision pose sensing capacity(position and orientation)are greatly demanded in in situ manipulation in narrow opaque enclosed spaces.Various magnetic robots have been carried out,whereas their deformations normally remain in single mode,and the lack of the robot’s real-time status leads to its beyond-sight remagnetization and manipulation being impossible.The function integration of pose sensing and multimode motion is still of challenge.Here,a multimotion thin-film robot is created in a novel multilayer structure with a magneticdriven layer covered by a heating-sensing conductive layer.Such a heating-sensing layer not only can segmentally and on-demand heat the magnetic-driven layer for in situ magnetization reprogramming and multimode motions but also can precisely detect the robot’s pose(position and orientation)from its electrical-resistance effect by creating a small deformation under preset magnetic fields.

关键词： robot Robot motion

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Association between prolactin/testosterone ratio and breast cancer in Chinese women

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Chinese Medical Journal 2024年第3期137卷 368-370页

作者： Qian Cai Xiaohan Tian Yuyi Tang Han Cong Jie Liu song zhao Rong Ma Jianli Wang Jiang Zhu Department of Geriatric Medicine Qilu Hospital of Shandong UniversityJinanShandong 250012China Key Laboratory of Cardiovascular Proteomics of Shandong Province Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Pharmacology School of Basic Medical SciencesShandong UniversityJinanShandong 250012China Department of Breast Surgery General SurgeryQilu Hospital of Shandong UniversityJinanShandong 250012China Department of Thyroid and Breast Surgery Guangdong Second Provincial General HospitalGuangzhouGuangdong 510310China Department of Toxicology and Cancer Biology Collage of MedicineUniversity of KentuckyLexingtonKY 40536USA Department of Immunology School of Basic Medical ScienceShandong UniversityJinanShandong 250012China Department of Gynaecology and Obstetrics Qilu Hospital of Shandong UniversityJinanShandong 250012China

To the Editor:Breast cancer is a prevalent malignant tumor and ranks as the second leading cause of cancer-related deaths globally.^([1])The breast is the target organ of some endocrine hormones,which regulate its growth and development.Aside from estrogen and progesterone,the relationship among prolactin,androgen,and breast cancer has recently garnered increasing attention.

关键词： breast cancer prolactin

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Observation of maximal intrinsic chirality empowered by dual quasi-bound states in the continuum in a planar metasurface

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Photonics Research 2024年第2期12卷 244-252页

作者： XIN QI JIAJU WU FENG WU song zhao CHAO WU YUEYANG MIN MINA REN YUFEI WANG HAITAO JIANG YUNHUI LI ZHIWEI GUO YAPING YANG WANHUA ZHENG HONG CHEN YONG SUN MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China l3 Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Electrical Engineering Tongji UniversityShanghai 201804China State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Metasurfaces with spin-selective transmission play an increasingly critical role in realizing optical chiral responses,especially for strong intrinsic chirality,which is limited to complex three-dimensional geometry.In this paper,we propose a planar metasurface capable of generating maximal intrinsic chirality and achieving dual-band spinselective transmission utilizing dual quasi-bound states in the continuum(quasi-BICs)caused by the structural symmetry breaking.Interestingly,the value of circular dichroism(CD)and the transmittance of two kinds of circular polarization states can be arbitrarily controlled by tuning the asymmetry parameter.Remarkable CD approaching unity with the maximum transmittance up to 0.95 is experimentally achieved in the dual band.Furthermore,assisted by chiral BICs,the application in polarization multiplexed near-field image display is also exhibited.Our work provides a new avenue to flexibly control intrinsic chirality in planar structure and offers an alternative strategy to develop chiral sensing,multiband spin-selective transmission,and high-performance circularly polarized wave detection.The basic principle and design method of our experiments in the microwave regime can be extended to other bands,such as the terahertz and infrared wavelengths.

关键词： planar intrinsic quasi

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Integrability and solutions of a nonsymmetric discrete Korteweg-de Vries equation

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Communications in Theoretical Physics 2024年第2期76卷 45-50页

作者： Maebel Mesfun Da-jun Zhang song-lin zhao Department of Mathematics Shanghai UniversityShanghai 200444China Newtouch Center for Mathematics of Shanghai University Shanghai 200444China Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310023China

In this paper,we present Lax pairs and solutions for a nonsymmetric lattice equation,which is a torqued version of the lattice potential Korteweg-de Vries equation.This nonsymmetric equation is special in the sense that it contains only one spacing parameter but consists of two consistent cubes with other integrable lattice equations.Using such a multidimensionally consistent property we are able to derive its two Lax pairs and also construct solutions using B?cklund transformations.

关键词： discrete Korteweg-de Vries equation nonsymmetric multi-dimensional consistency Backlund transformation solution

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Liquid lens based holographic camera for real 3D scene hologram acquisition using end-to-end physical model-driven network

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Light(Science & Applications) 2024年第3期13卷 488-497页

作者： Di Wang zhao-song Li Yi Zheng You-Ran zhao Chao Liu Jin-Bo Xu Yi-Wei Zheng Qian Huang Chen-Liang Chang Da-Wei Zhang song-Lin Zhuang Qiong-Hua Wang School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China

With the development of artificial intelligence,neural network provides unique opportunities for holography,such as high fidelity and dynamic calculation.How to obtain real 3D scene and generate high fidelity hologram in real time is an urgent problem.Here,we propose a liquid lens based holographic camera for real 3D scene hologram acquisition using an end-to-end physical model-driven network(EEPMD-Net).As the core component of the liquid camera,the first 10 mm large aperture electrowetting-based liquid lens is proposed by using specially fabricated solution.The design of the liquid camera ensures that the multi-layers of the real 3D scene can be obtained quickly and with great imaging performance.The EEPMD-Net takes the information of real 3D scene as the input,and uses two new structures of encoder and decoder networks to realize low-noise phase generation.By comparing the intensity information between the reconstructed image after depth fusion and the target scene,the composite loss function is constructed for phase optimization,and the high-fidelity training of hologram with true depth of the 3D scene is realized for the first time.The holographic camera achieves the high-fidelity and fast generation of the hologram of the real 3D scene,and the reconstructed experiment proves that the holographic image has the advantage of low noise.The proposed holographic camera is unique and can be used in 3D display,measurement,encryption and other fields.

关键词： calculation solution holographic

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Hepatomegaly and jaundice as the presenting symptoms of systemic light-chain amyloidosis: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 550-556页

作者： Xu Zhang Fei Tang Yan-Ying Gao De-zhao song Jing Liang Department of Gastroenterology and Hepatology The Third Central Hospital of TianjinTianjin 300170China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Artificial Cell Engineering Technology Research CenterTianjin Institute of Hepatobiliary DiseaseTianjin 300170China Department of Interventional Radiology The Third Central Hospital of TianjinTianjin 300170China

BACKGROUND Light chain(AL)amyloidosis is a plasma cell dyscrasia characterized by the pathologic production and extracellular tissue deposition of fibrillar proteins derived from immunoglobulin AL fragments secreted by a clone of plasma cells,which leads to progressive dysfunction of the affected organs.The two most commonly affected organs are the heart and kidneys,and liver is rarely the dominant affected organ with only 3.9%of cases,making them prone to misdia-gnosis and missed diagnosis.CASE SUMMARY A 65-year-old woman was admitted with a 3-mo history of progressive jaundice and marked hepatomegaly.Initially,based on enhanced computed tomography scan and angiography,Budd-Chiari syndrome was considered and balloon dilatation of significant hepatic vein stenoses was performed.However,addi-tional diagnostic procedures,including liver biopsy and bone marrow-exami-nation,revealed immunoglobulin kapa AL amyloidosis with extensive liver involvement and hepatic vascular compression.The disease course was progre-ssive and fatal,and the patient eventually died 5 mo after initial presentation of symptoms.CONCLUSION AL amyloidosis with isolated liver involvement is very rare,and can be easily misdiagnosed as a vascular disease.

关键词： Jaundice Hepatomegaly Liver amyloidosis Kappa light chain Pseudo-Budd-Chiari syndrome Case report

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Quantum nonlocality evolution for two entangled mesoscopic fields under decoherence

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Communications in Theoretical Physics 2024年第1期76卷 24-28页

作者： zhao-song Tan Shou-Bang Yang Zhen-Biao Yang Shi-Biao Zheng Fujian Key Laboratory of Quantum Information and Quantum Optics Fuzhou UniversityFuzhouFujian 350116China

Investigation of the nonlocality evolution of entangled mesoscopic fields under decoherence not only is important for understanding the quantum–classical transition,but also has relevance to quantum communication and quantum computation protocols based on continuous variables.According to previous formulations of Bell inequalities,the system loses nonlocal features far before the disappearance of entanglement.We here construct a new version of Bell signal based on rotated and displaced on–off correlations,with which the Bell inequality is violated as long as there remains entanglement and the field state components keep quasiorthogonal.Consequently,the nonlocal character revealed by our formulation decays much slower compared with those based on previous ones.More importantly,there exists a wide regime where the Bell inequality is restored with previous formulations but remains to be violated based on our correlation operators.

关键词： entangled mesoscopic fields rotated and displaced on-off correlations Bell inequality nonlocality evolution

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Low Surface Brightness Galaxies Selected by Different Model Fitting

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Research in Astronomy and Astrophysics 2024年第1期24卷 223-236页

作者： Bing-Qing Zhang Hong Wu Wei Du Pin-song zhao Min He Feng-Jie Lei Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We present a study of low surface brightness galaxies(LSBGs) selected by fitting the images for all the galaxies inα.40 SDSS DR7 sample with two kinds of single-component models and two kinds of two-component models(disk+bulge):single exponential,single sersic,exponential+deVaucular(exp+deV),and exponential+sérsic(exp+ser).Under the criteria of the B band disk central surface brightness μ_(0,disk)(B)≥22.5 mag arcsec^(-2) and the axis ratio b/a> 0.3,we selected four none-edge-on LSBG samples from each of the models which contain 1105,1038,207,and 75 galaxies,respectively.There are 756 galaxies in common between LSBGs selected by exponential and sersic models,corresponding to 68.42% of LSBGs selected by the exponential model and 72.83% of LSBGs selected by the sersic model,the rest of the discrepancy is due to the difference in obtaining μ_(0) between the exponential and sersic models.Based on the fitting,in the range of 0.5≤n≤1.5,the relation of μ_(0) from two models can be written as μ_(0,sérsic)-μ_(0,exp)=-1.34(n-1).The LSBGs selected by disk+bulge models(LSBG_(2)comps) are more massive than LSBGs selected by single-component models(LSBG_1comp),and also show a larger disk component.Though the bulges in the majority of our LSBG_(2)comps are not prominent,more than 60% of our LSBG_(2)comps will not be selected if we adopt a single-component model only.We also identified 31 giant low surface brightness galaxies(gLSBGs) from LSBG_(2)comps.They are located at the same region in the color-magnitude diagram as other gLSBGs.After we compared different criteria of gLSBGs selection,we find that for gas-rich LSBGs,M_(*)> 10^(10)M_⊙ is the best to distinguish between gLSBGs and normal LSBGs with bulge.

关键词： catalogs galaxies:spiral galaxies:bulges methods:data analysis methods:statistical

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Classification of anatomical morphology of cystic duct and its association with gallstone

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 307-317页

作者： Jia-Hai Zhu song-Ling zhao Qiang Kang Ya Zhu Li-Xin Liu Hao Zou Department of Hepatobiliary Pancreatic Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650106Yunnan ProvinceChina Department of Hepatobiliary Surgery The Second Affiliated HospitalKunming Medical UniversityKunming 650106Yunnan ProvinceChina

BACKGROUND Gallstones are common lesions that often require surgical intervention.Laparo-scopic cholecystectomy is the treatment of choice for symptomatic gallstones.Preoperatively,the anatomical morphology of the cystic duct(CD),needs to be accurately recognized,especially when anatomical variations occur in the CD,which is otherwise prone to bile duct injury.However,at present,there is no optimal classification system for CD morphology applicable in clinical practice,and the relationship between anatomical variations in CDs and gallstones remains to be explored.AIM To create a more comprehensive clinically applicable classification of the morphology of CD and to explore the correlations between anatomic variants of CD and gallstones.METHODS A total of 300 patients were retrospectively enrolled from October 2021 to January 2022.The patients were divided into two groups:The gallstone group and the nongallstone group.Relevant clinical data and anatomical data of the CD based on magnetic resonance cholangiopancreatography(MRCP)were collected and analyzed to propose a morphological classification system of the CD and to explore its relationship with gallstones.Multivariate analysis was performed using logistic regression analyses to identify the independent risk factors using variables that were significant in the univariate analysis.RESULTS Of the 300 patients enrolled in this study,200(66.7%)had gallstones.The mean age was 48.10±13.30 years,142(47.3%)were male,and 158(52.7%)were female.A total of 55.7%of the patients had a body mass index(BMI)≥24 kg/m2.Based on the MRCP,the CD anatomical typology is divided into four types:Type I:Linear,type II:n-shaped,type III:S-shaped,and type IV:W-shaped.Univariate analysis revealed differences between the gallstone and nongallstone groups in relation to sex,BMI,cholesterol,triglycerides,morphology of CD,site of CD insertion into the extrahepatic bile duct,length of CD,and angle between the common hepatic duct and CD.According to the multivariate analysis,female,BMI(≥24 kg/m2)

关键词： Cystic duct Gallstone Classification Anatomy Magnetic resonance cholangiopancreatography Risk factor

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