检索结果-南通市图书馆

OsMPK4 promotes phosphorylation and degradation of IPA1 in response to salt stress to confer salt tolerance in rice

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2022年第8期49卷 766-775页

作者： Meiru Jia Nan Luo Xiangbing Meng Xiaoguang song Yanhui Jing Liquan kou Guifu Liu Xiahe Huang Yingchun Wang Jiayang Li Bing Wang Hong Yu State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China

Salt stress adversely affects plant growth,development,and crop ***(Oryza sativa L.)is one of the most salt-sensitive cereal crops,especially at the early seedling ***-activated protein kinase(MAPK/MPK)cascades have been shown to play critical roles in salt response in ***,the roles of the MPK cascade signaling in rice salt response and substrates of Os MPK remain largely ***,we report that the salt-induced Os MPK4-Ideal Plant Architecture 1(IPA1)signaling pathway regulates the salt tolerance in *** salt stress,Os MPK4 could interact with IPA1 and phosphorylate IPA1 at Thr180,leading to degradation of *** evidence shows that IPA1 is a negative regulator of salt tolerance in rice,whereas Os MPK4 promotes salt response in an IPA1-dependent *** together,our results uncover an Os MPK4-IPA1 signal cascade that modulates the salt stress response in rice and sheds new light on the breeding of salt-tolerant rice varieties.

关键词： Oryza sativa MPK OsMPK4 IPA1 Salt tolerance

Intraoperative single administration of neutrophil peptide 1 accelerates the early functional recovery of peripheral nerves after crush injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第11期15卷 2108-2115页

作者： Yu-song Yuan Su-Ping Niu Fei Yu Ya-Jun Zhang Na Han Hao Lu Xiao-Feng Yin Hai-Lin Xu Yu-Hui kou Department of Trauma and Orthopedics Peking University People’s HospitalPeking UniversityBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Office of Academic Research Peking University People’s HospitalBeijingChina National and Local Joint Engineering Research Center of Orthopaedic Biomaterials Department of Bone&Joint SurgeryPeking University Shenzhen HospitalShenzhenGuangdong ProvinceChina National Center for Trauma Medicine BeijingChina Diabetic Foot Treatment Center Peking University People’s HospitalPeking UniversityBeijingChina

Neutrophil peptide 1 belongs to a family of peptides involved in innate immunity. Continuous intramuscular injection of neutrophil peptide 1 can promote the regeneration of peripheral nerves, but clinical application in this manner is not convenient. To this end, the effects of a single intraoperative administration of neutrophil peptide 1 on peripheral nerve regeneration were experimentally observed. A rat model of sciatic nerve crush injury was established using the clamp method. After model establishment, a normal saline group and a neutrophil peptide 1 group were injected with a single dose of normal saline or 10 μg/mL neutrophil peptide 1, respectively. A sham group, without sciatic nerve crush was also prepared as a control. Sciatic nerve function tests, neuroelectrophysiological tests, and hematoxylin-eosin staining showed that the nerve conduction velocity, sciatic functional index, and tibialis anterior muscle fiber cross-sectional area were better in the neutrophil peptide 1 group than in the normal saline group at 4 weeks after surgery. At 4 and 8 weeks after surgery, there were no differences in the wet weight of the tibialis anterior muscle between the neutrophil peptide 1 and saline groups. Histological staining of the sciatic nerve showed no significant differences in the number of myelinated nerve fibers or the axon cross-sectional area between the neutrophil peptide 1 and normal saline groups. The above data confirmed that a single dose of neutrophil peptide 1 during surgery can promote the recovery of neurological function 4 weeks after sciatic nerve injury. All the experiments were approved by the Medical Ethics Committee of Peking University People's Hospital, China(approval No. 2015-50) on December 9, 2015.

关键词： crush injury defensin 1 gait analysis intraoperative administration nerve conduction velocity nervous system neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration sciatic nerve tibialis anterior muscle trauma

Paleogene-Neogene stratigraphic realm and sedimentary sequence of the Qinghai-Tibet Plateau and their response to uplift of the plateau

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2010年第9期53卷 1271-1294页

作者： ZHANG KeXin WANG GuoCan JI JunLiang LUO ManSheng kou XiaoHu WANG YueMing XU YaDong CHEN FenNing CHEN RuiMing song BoWen ZHANG JianYu LIANG YinPing Key Laboratory of Biogeology and Environmental Geology of Ministry of Education China University of GeosciencesWuhan 430074China Faulty of Earth Sciences China University of GeosciencesWuhan 430074China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China Geological Survey of China University of Geosciences Wuhan 430074China Gansu Province Bureau of Geo-exploration and Mineral Development Lanzhou 730000China Xi’an Institute of Geology and Mineral Xi’an 710054China

Based on the data of 1:250000 geological mapping completed by CGS and the previous literature of the Cenozoic strata, 98 remnant basins and 5 stratigraphic realms with 13 stratigraphic subrealms have been recognized on the Qinghai-Tibet Plateau and its adjacent area. Through the research of the types of remnant basins, tectonic setting, stratigraphic sequence and sedimentary characteristics, contact relationship between the strata, the formation time and evolution history of sediments, we divided the uplift process and sedimentary response of the Qinghai-Tibet Plateau into 3 stages and 8 sub-stages, namely, subduction-collision uplift stage (65-34 Ma) with three sub-stages, intercontinental convergence and compressive uplift stage (34-13 Ma) with three sub-stages, and intercontinental isostatic adjustment uplift stage (since 13 Ma) with two sub-stages.

关键词： Paleogene-Neogene remnant basin stratigraphic realm sedimentary evolution Qinghai-Tibet Plateau

Endovascular treatment vs drug therapy alone in patients with mild ischemic stroke and large infarct cores

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第28期10卷 10077-10084页

作者： Wen-Hui kou Xiao-Qin Wang Jin-Shui Yang Nan Qiao Xiao-Hui Nie Ai-Mei Yu Ai-Xia song Qian Xue Department of Neurology First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina

BACKGROUND Treatment decision making is strictly associated with the outcomes in patients with ischemic stroke who show a large core *** care alone may result in suboptimal treatment efficacy,and endovascular treatment may be accompanied by safety *** endovascular treatment is superior to medical care is not well investigated in the clinical *** To investigate the efficacy of endovascular treatment and drug therapy alone in mild ischemic stroke patients with large infarct *** Fifty patients with mild ischemic stroke and 50 patients with acute ischemic stroke caused by anterior large vessel occlusion were selected at the First Affiliated Hospital of Hebei North University between January 2021 and December *** were divided into an endovascular therapy group and a drug therapy group according to different treatment *** the endovascular therapy group,there were 28 patients with minor stroke and 22 patients with large infarct *** drug therapy group had 22 patients with minor stroke and 28 patients with large infarct *** National Institutes of Health Stroke Scale(NIHSS) scores were collected and compared between the two groups immediately after the operation and 24 h and 7 d after the *** modified Rankin scale(m RS) and/or activity of daily living were assessed at hospital *** There was no significant difference in NIHSS scores between the two groups before the operation(P > 0.05).NIHSS scores were lower in the endovascular therapy group than in the drug therapy group at 24 h and 7 d after the operation and at hospital discharge(all P < 0.05).The incidence of early neurologic deterioration was significantly lower in the endovascular therapy group than in the drug therapy group(P < 0.05).At hospital discharge,the m RS score was lower in the endovascular treatment group than in the drug therapy group,and the activity of daily living score was better in the endovascular treatment gr

关键词： Ischemic stroke Large infarct cores Endovascular therapy Drug therapy Efficacy

肝硬化病人衰弱对不良健康结局影响的研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

循证护理 2024年第3期10卷 433-437页

作者：沈赛娅靳艳高飞张贤贤王菲左仲琪宋杰寇洁河南大学护理与健康学院河南475004 河南省人民医院河南省护理医学重点实验室郑州大学人民医院

综述肝硬化病人衰弱对不良健康结局的影响,为早期预防和识别肝硬化病人不良健康结局提供新的思路和启示。

关键词：肝硬化衰弱不良健康结局综述

维普期刊数据库博看期刊

济南社区卫生服务中心流感疫苗接种人群特征分析

在线全文

学校读者我要写书评

暂无评论

国际病毒学杂志 2024年第4期31卷 342-346页

作者：董祯孙林宋绍霞李敏李伟何玉洁张淑孙文魁吴巨龙李忠王显军寇增强刘倜山东省疾病预防控制中心传染病防制所济南250013 济南市历城区疾病预防控制中心传染病防制科 250199 济南市槐荫区疾病预防控制中心传染病防制科 250022

目的了解济南市流感疫苗接种人群的基本特征,为疫苗接种策略提供参考。方法在社区卫生服务中心对接种人群开展问卷调查,使用χ2检验对接种人群基本特征进行分析,使用多元logistic回归分析对流感疫苗预防作用、疫苗推荐意愿和接种效果进... 详细信息

目的了解济南市流感疫苗接种人群的基本特征,为疫苗接种策略提供参考。方法在社区卫生服务中心对接种人群开展问卷调查,使用χ2检验对接种人群基本特征进行分析,使用多元logistic回归分析对流感疫苗预防作用、疫苗推荐意愿和接种效果进行分析。结果调查共获得1736份有效问卷,接种人群以中老年人为主,94.8%的接种者认为疫苗能有效预防流感,87.8%会向周围人群推荐流感疫苗。多因素分析显示,非常了解流感疫苗(OR=24.326,95%CI:10.128~58.426)和第2年接种疫苗者(OR=8.781,95%CI:3.693~20.877)更加认可疫苗的预防作用;农民(OR=4.906,95%CI:1.519~15.847)和接种疫苗5次以上者(OR=7.435,95%CI:2.187~25.276)更愿意向周围人推荐流感疫苗。结论本次调查人群基本了解并认可疫苗的保护作用,接种及推荐接种意愿较高,疫苗宣传需要提高针对性。

关键词：流感疫苗接种人群影响因素

Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第4期14卷 706-712页

作者： Yu-Hui kou You-Lai Yu Ya-Jun Zhang Na Han Xiao-Feng Yin Yu-song Yuan Fei Yu Dian-Ying Zhang Pei-Xun Zhang Bao-Guo Jiang Peking University People's Hospital The Affiliated Hospital of Xuzhou Medical University

During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve suture. We investigated whether a small gap bio-sleeve suture with different inner diameters at both ends can be used to repair a 2-mm tibial nerve defect by proximal transposition of the common peroneal nerve in rats and compared the results with the repair seen after epineurial neurorrhaphy. Three months after surgery, neurological function, nerve regeneration, and recovery of nerve innervation muscle were assessed using the tibial nerve function index, neuroelectrophysiological testing, muscle biomechanics and wet weight measurement, osmic acid staining, and hematoxylin-eosin staining. There was no obvious inflammatory reaction and neuroma formation in the tibial nerve after repair by the small gap bio-sleeve suture with different inner diameters at both ends. The conduction velocity, muscle strength, wet muscle weight, cross-sectional area of muscle fibers, and the number of new myelinated nerve fibers in the biosleeve suture group were similar to those in the epineurial neurorrhaphy group. Our findings indicate that small gap bio-sleeve suture with different inner diameters at both ends can achieve surgical suture between nerves of different diameters and promote regeneration and functional recovery of injured peripheral nerves.

关键词： nerve regeneration bio-sleeve small gap sleeve suture nerve transposition nerve defect nerve conduit nerve reinnervation peripheral nerve neural regeneration

Deterministic Pattern Classifier Based on Genetic Programming

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2001年第2期13卷 129-136页

作者： LI Jian\|wu,\ LI Min\|qiang,\ kou Ji\|song Institute of Systems Engineering, Tianjin University, Tianjin 300072, China Institute of Systems Engineering Tianjin University Tianjin 300072 China

This paper proposes a supervised training\|test method with Genetic Programming (GP) for pattern classification. Compared and contrasted with traditional methods with regard to deterministic pattern classifiers, this method is true for both linear separable problems and linear non\|separable problems. For specific training samples, it can formulate the expression of discriminate function well without any prior knowledge. At last, an experiment is conducted, and the result reveals that this system is effective and practical.

关键词： genetic programming pattern classifiers discriminate function

o-C8 Carbon: a New Allotrope of Superhard Carbon

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2019年第3期32卷 357-364,I0002页

作者： Jun-ru kou Ai-hua Cao song-li Liu Li-hua Gan School of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China College of Materials Science and Engineering Yangtze Normal UniversityChongqing 408100China

An orthonormal crystal of carbon with PMMA space group(o-C8)was found to be a stable superhard carbon allotrope by particle swarm optimization algorithm and density functional *** phonon spectrum calculations demonstrate that the o-C8 carbon phase is dynamically *** volume compression calculations show that it is highly incompressible,with bulk modulus of 298.6 *** calculations demonstrate that it is a low-density superhard material with density of 2.993 g/cm^3 and Vickers hardness of 82.4 GPa.

关键词： Carbon Hardness Stability Structures