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Enhanced interfacial charge transfer on Bi metal@defective Bi_(2)Sn_(2)O_(7) quantum dots towards improved full-spectrum photocatalysis:A combined experimental and theoretical investigation

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Chinese Chemical Letters 2024年第6期35卷 507-514页

作者： Huizhong Wu Ruiheng Liang ge song Zhongzheng Hu Xuyang Zhang Minghua Zhou Tianjin Key Laboratory of Environmental Technology for Complex Trans-Media Pollution College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Key Laboratory of Pollution Process and Environmental Criteria Ministry of EducationCollege of Environmental Science and EngineeringNankai UniversityTianjin 300350China

To mitigate the water pollution problem by photocatalytic degradation of typical antibiotics of tetracycline(TC),we prepared defective Bi_(2)Sn_(2)O_7(BSO)quantum dots(QDs)with a full spectral response due to Bi metal deposition,using a one-pot hydrothermal method,labeled as Bi@*** optimized Bi@BSOOV showed 73.4% removal of TC in 1 h under irradiation with a 50 W LED lamp in the wavelength band in the visible-near-infrared(vis-NIR)light,a rate that is substantially greater than that of pure BSO(14.7%).The synergistic interaction of Bi metal and oxygen vacancies(OVs)is crucial to boosting photocatalytic *** near-infrared region of the photo-response is extended by the surface plasmon resonance(SPR)effect of Bi metal,enhancing the photocatalytic performance and dramatically raising the efficiency of solar energy *** addition to inducing defect levels in BSO,the OVs also activate the surface adsorbed O_(2) to promote the production of·O_(2)^(-)and ^(1)O_(2).DFT calculations reveal that Bi metal and OVs can mutually tune the charge transfer *** the one hand,Bi metal can act as both a charge transfer bridge and an electron donor to assist charge *** the other hand,OVs-induced defect levels allow electrons that leap to the conduction band(CB)to first leap from the valence band(VB)to the defect levels,notably improving interfacial charge separation and *** concept of design executed in this study for altering the catalyst by introducing both OVs and Bi metal can provide a rational design idea and potential insight for improving the photocatalytic activity for environmental applications.

关键词： Bi metal Bi_(2)Sn_(2)O_7 quantum dots Surface plasmon resonance Oxygen vacancies

Tinea of Vellus Hair Caused by Trichophyton violaceum in a Child:A Case Report

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International Journal of Dermatology and Venereology 2024年第1期7卷 58-59页

作者： ge song Guan-Zhao Liang Wei-Da Liu Department of Medical Mycology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical College&Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIsNanjingJiangsu 210042China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

Introduction:Tinea of vellus hair is a rare dermatophytosis,caused by dermatophyte infection in the vellus *** clinical symptoms of tinea of vellus hair are more serious and the conventional topical treatment are often ***,we report a case of tinea of vellus hair caused by Trichophyton violaceum in a *** presentation:A 7-year-old boy presented with a localized,scaly,and itchy erythema on his left cheek for two *** once used a topical corticosteroid but without any clinical improvement,the erythema was progressively enlarging and spread to the left *** denied any contact with *** microscopy found abundant spores and hyphae on the vellus hair;*** was identified by culture and PCR *** patient was diagnosed with tinea of vellus hair and cured after treating with oral terbinafine 125 mg/day and topical treatment for two *** was no recurrence during the follow-up ***:The clinical symptoms of tinea of vellus hair are often atypical and easy to be *** fungal examination is necessary for suspicious patients and confirmed patients should be treated with oral antifungal ***:The diagnosis and treatment of tinea of vellus hair need to be paid more attention in clinical works.

关键词： tinea vellus hair case report

Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules

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Acta Pharmaceutica Sinica B 2024年第2期14卷 836-853页

作者： ge song Minghui Li Shumin Fan Mengmeng Qin Bin Shao Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Medical Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijing 100142China

Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted *** is critical to inspire new potential to remodel the value of this classical therapeutic ***,we fabricate bisphosphonate coordination lipid nanogranules(BC-LNPs)and load paclitaxel(PTX)to boost the chemo-and immuno-therapeutic synergism of cytotoxic *** in BC-LNPs@PTX,a bisphosphonate to block mevalonate metabolism,works as both the structure and drug constituent in nanogranules,where alendronate coordinated with calcium ions to form the particle *** synergy of alendronate enhances the efficacy of paclitaxel,suppresses tumor metastasis,and alters the cytotoxic *** from the paclitaxel-induced apoptosis,the involvement of alendronate inhibits the mevalonate metabolism,changes the mitochondrial morphology,disturbs the redox homeostasis,and causes theaccumulation of mitochondrial ROS and lethal lipid peroxides(LPO).These factors finally trigger the ferroptosis of tumor cells,an immunogenic cell death mode,which remodels the suppressive tumor immune microenvironment and synergizes with ***,by switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis,BC-LNPs@PTX provides new insight into the development of cytotoxic drugs and highlights the potential of metabolism regulation in cancer therapy.

关键词： Bisphosphonate coordinationlipid nanogranules Ferroptosis Mevalonatemetabolism Mitochondrial metabolism Nano-systematic biology

Mortality from cerebrovascular diseases in China:Exploration of recent and future trends

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Chinese Medical Journal 2024年第5期137卷 588-595页

作者： Bin Lv ge song Feng Jing Mingyu Li Hua Zhou Wanjun Li Jiacai Lin Shengyuan Yu Jun Wang Xiangyu Cao Chenglin Tian Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Neurology the 305 Hospital of Chinese PLABeijing 100017China Department of Internal Medicine Gucheng County Hospital of Traditional Chinese MedicineHengshuiHebei 253800China Department of Neurology Tangshan Hospital of Traditional Chinese MedicineTangshanHebei 063000China Department of Neurology Hainan Hospital of Chinese PLA General HospitalSanyaHainan 572013China

Background:Cerebrovascular disease(CVD)ranks among the foremost factors responsible for mortality on a global *** mortality patterns of CVDs and temporal trends in China need to be well-illustrated and ***:We collected mortality data on patients with CVD from Chinese Center for Disease Control and Prevention’s Disease Surveillance Points(CDC-DSP)*** mortality of CVD in 2020 was described by age,sex,residence,and *** temporal trend from 2013 to 2019 was evaluated using joinpoint regression,and estimated rates of decline were extrapolated until 2030 using time series ***:In 2019,the age-standardized mortality in China(ASMRC)per 100,000 individuals was *** ASMRC for males(137.7/10^(5))and rural areas(123.0/10^(5))were both higher when stratified by gender and urban/rural *** central region had the highest mortality(126.5/10^(5)),the western region had a slightly lower mortality(123.5/10^(5)),and the eastern region had the lowest mortality(97.3/10^(5)).The age-specific mortality showed an accelerated upward trend from aged 55-59 years,with maximum mortality observed in individuals over 85 years of *** age-standardized mortality of CVD decreased by 2.43%(95%confidence interval,1.02-3.81%)annually from 2013 to ***,the age-specific mortality of CVD increased from 2013 to 2019 for the age group of over 85 *** 2020,both the absolute number of CVD cases and the crude mortality of CVD have increased compared to their values in *** estimated total deaths due to CVD were estimated to reach 2.3 million in 2025 and 2.4 million in ***:The heightened focus on the burden of CVD among males,rural areas,the central and western of China,and individuals aged 75 years and above has emerged as a pivotal determinant in further decreasing mortalities,consequently presenting novel challenges to strategies for disease prevention and control.

关键词： Cerebrovascular diseases Mortality Epidemiology Global Burden of Disease China COVID-19 pandemic

丙酮盐酸混合液提取土壤腐殖质组分的光谱学特征

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光谱学与光谱分析 2024年第2期44卷 474-479页

作者：宋鸽孔祥仕黑龙江大学中俄学院黑龙江哈尔滨150080 Institute of Earth Sciences St.Petersburg State UniversitySt.Petersburg 199034Russia 吉首大学旅游学院湖南吉首416000

采用丙酮盐酸混合液提取土壤胡敏酸(HA)和胡敏素(HU)组分,利用元素分析、紫外-可见漫反射光谱和红外光谱进行结构表征。元素分析表明,HA中C、H、N和S含量均高于HU,O含量低于HU。原子比分析表明HA的缩合度相对较高,分子结构相对复杂,HU... 详细信息

采用丙酮盐酸混合液提取土壤胡敏酸(HA)和胡敏素(HU)组分,利用元素分析、紫外-可见漫反射光谱和红外光谱进行结构表征。元素分析表明,HA中C、H、N和S含量均高于HU,O含量低于HU。原子比分析表明HA的缩合度相对较高,分子结构相对复杂,HU的缩合度相对较低,分子结构相对简单。紫外-可见漫反射光谱分析表明,由于腐殖质(HS)的组成复杂,多种官能团互相干扰,HA和HU紫外-可见漫反射光谱无明显特征峰,吸光度值随着波长的增加呈下降趋势,且HA包含的吸光有机成分较多,化学组成较复杂。HA和HU紫外特征参数SUV254和E4/E6比较分析表明,与HU相比,HA芳香性较大,腐殖化程度较高。红外光谱分析表明,HA和HU具有相似的红外光谱,各研究对象特征吸收峰的吸收强度不同,其中开垦黑土20~40 cm和未开垦灰土18~37 cm土层HA的振动幅度较大,说明其包含的酚类化合物、含羟基化合物、脂肪族化合物和羧酸,以及含羰基的醛、酮、醚等化合物的含量较多。开垦黑土10~20 cm土层和未开垦灰土18~37 cm土层HU在各特征吸收峰振动幅度较大,说明其包含的酚类化合物、羧酸、脂肪烃和糖类化合物含量较多。红外光谱各吸收峰强度比较分析表明,开垦后黑土HA和HU酚类化合物、羟基官能团和脂肪族化合物等含量增加,而开垦后灰土HA和HU酚类化合物、羧酸和脂肪族化合物含量下降,表明开垦对黑土土壤有机质影响相对较小,并且在一定程度上增加了土壤有机质含量,而促进了灰土土壤有机质的分解。综上所述,丙酮盐酸混合液提取法为HS生物化学和生理活性的研究提供了新的技术手段,为合理利用土壤资源提供理论依据。

关键词：胡敏酸胡敏素元素分析紫外-可见漫反射光谱近红外光谱

如何实现可持续、可扩展的跨学科学习——国际学习科学领域的研究框架与思路

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比较教育研究 2024年第8期46卷 45-56页

作者：宋歌河南师范大学教育学部河南新乡453007 美国纽约州立大学奥尔巴尼分校纽约奥尔巴尼12203

如若实现在更广泛的体系中影响教育变革,跨学科学习必须从研究型干预走向普遍适用的教学常规。这需要借助学习科学研究,明确“整合”和“创新”的具体机制,从而实现可持续、可扩展的跨学科学习。学习科学家主张运用生态视角,从个体活动... 详细信息

如若实现在更广泛的体系中影响教育变革,跨学科学习必须从研究型干预走向普遍适用的教学常规。这需要借助学习科学研究,明确“整合”和“创新”的具体机制,从而实现可持续、可扩展的跨学科学习。学习科学家主张运用生态视角,从个体活动、集体协作、学校课程及社会中的教育系统四层相互关联的嵌套结构入手,打开跨学科学习黑箱。具体而言:一是发展适切的认识论,促进个体自主地深度参与整合;二是发挥认知主体性,实现集体持续地协作创新;三是面向参与者、知识人造物与媒介环境的多元交互,设计整体的跨学科课程活动系统;四是基于批判研究,审视社会政治背景如何影响跨学科教育实践。

关键词：跨学科学习学习科学知识创造学习生态

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数据可携带权的解读与践行路径研究

大连理工大学学报（社会科学版） 2024年第2期45卷 85-92页

作者：宋歌中南财经政法大学知识产权研究中心湖北武汉430073 南京财经大学法学院江苏南京210023

数据可携带权是产生于数据流通环节的一项新兴权利,对加强个人数据保护和释放竞争活力具有重要意义,我国《个人信息保护法》仅对数据可携带权作出了原则性规定,有必要对其本土化完善进行研究。欧盟、美国在数据可携带权实施过程中积累... 详细信息

数据可携带权是产生于数据流通环节的一项新兴权利,对加强个人数据保护和释放竞争活力具有重要意义,我国《个人信息保护法》仅对数据可携带权作出了原则性规定,有必要对其本土化完善进行研究。欧盟、美国在数据可携带权实施过程中积累了一定经验,能够为我国数据可携带权的后续运行提供参考。我国数据可携带权的践行路径应当秉持谦抑的原则,从具体规则和适用场域两个方面着手,为促进数据流通和个人信息保护提供保障。

关键词：数据可携带权个人数据个人信息保护法

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Fructose aggravating colon barrier dysfunction by decreasing gut bacteria metabolites indole-3-carboxaldehyde and inhibiting activation of aryl hydrocarbon receptor in vivo and in vitro

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Food Science and Human Wellness 2024年

作者： ge song Shaojie Pang Wenting Peng Wei Fang Yong Wang Rui Liu Qianyun Gan Wentao Qi Academy of National Food and Strategic Reserves Administration Department of Nutrition and Food Hygiene School of Public Health Peking University School of Health Science and Engineering University of Shanghai for Science and Technology

Background: Fructose may induce non-alcoholic fatty acids (NAFLD) due to the gut-liver axis interactions. The mechanism of fructose impairing colon barrier is unrevealed. Methods: Normal and DSS-induced Sprague-Dawley rats fed by 35% fructose diets were used to evaluate colon barrier functions. Microbiome and metabolome were applied to screen potential biomarker bacteria and metabolites induced by fructose. HT-29 cells were applied to validate metabolite biomarker indoleacrylic acid (IAA) and indole-3-carboxaldehyde (I3A) function in colon barrier which impaired by fructose. Results: Fructose induced colon barrier dysfunction， aggravated colon impairment in DSS-induced rats. With fructose intake， the colon length shortened， goblet numbers declined， inflammation infiltration induced， inflammatory cytokines increased， and apoptosis signals upregulated in colon tissue. Moreover， fructose induced dysbiosis of microbiota and their metabolites. Adlercreutzia， Holdemania were screened out as potential bacteria biomarkers， IAA and I3A as tryptophan metabolites were selected as metabolite biomarkers inhibited by fructose. IAA and I3A treatment alleviated the impairment induced by fructose by increasing trans epithelial electric resistance (TEER) value， tight junction proteins (TJPs)， and AhR activity in HT-29 cell. Conclusion: Fructose stimulated inflammation， apoptosis， gut bacteria alteration， and induced the reduction of IAA and I3A. Since fructose inhibited production of IAA and I3A， AhR remained inactivated and consequently induced colon barrier dysfunction.

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构建多层次金融服务体系提升普惠金融服务水平

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新金融 2024年第2期 32-38页

作者：宋歌交通银行吉林省分行

构建多层次金融服务体系,对于提升金融服务的质量和效率,加快中国普惠金融的发展进程,进一步激发地方经济发展潜力等都具有重大意义。本文通过因素分析法分析中国金融服务体系现状,以及金融供给方为构建多层次金融服务体系、提升普惠金... 详细信息

构建多层次金融服务体系,对于提升金融服务的质量和效率,加快中国普惠金融的发展进程,进一步激发地方经济发展潜力等都具有重大意义。本文通过因素分析法分析中国金融服务体系现状,以及金融供给方为构建多层次金融服务体系、提升普惠金融服务水平进行的部分有益尝试;进一步梳理多层次金融服务推动普惠金融发展过程中存在的一系列问题及其产生的根源;借助地方金融的成功实践,得出了提高金融资源利用率、重视金融体系建设、加大金融创新力度的探索启示;提出了搭建产融合作平台、完善数据共享平台及创新产品服务模式的三大优化路径,以期为构建多层次金融服务体系提供参考。

关键词：金融服务体系普惠金融经济高质量发展