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Targeting IL-2:an unexpected effect in treating immunological diseases

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Signal Transduction and Targeted Therapy 2018年第1期3卷 312-321页

作者： Congxiu Ye David Brand song G.zheng Department of Clinical Immunology Third Affiliated Hospital at Sun Yat-sen UniversityGuangzhouChina Research Service Memphis VA Medical CenterMemphisTNUSA Division of Rheumatology Penn State Milton S.Hershey Medical CenterHersheyPAUSA

Regulatory T cells(Treg)play a crucial role in maintaining immune homeostasis since Treg dysfunction in both animals and humans is associated with multi-organ autoimmune and inflammatory *** IL-2 is generally considered to promote Tcell proliferation and enhance effector T-cell function,recent studies have demonstrated that treatments that utilize low-dose IL-2 unexpectedly induce immune tolerance and promote Treg development resulting in the suppression of unwanted immune responses and eventually leading to treatment of some autoimmune *** the present review,we discuss the biology of IL-2 and its signaling to help define the key role played by IL-2 in the development and function of Treg *** also summarize proof-of-concept clinical trials which have shown that low-dose IL-2 can control autoimmune diseases safely and effectively by specifically expanding and activating ***,future studies will be needed to validate a better and safer dosing strategy for low-dose IL-2 treatments utilizing well-controlled clinical *** studies will also be needed to validate the appropriate dose of IL-2/anti-cytokine or IL-2/anti-IL-2 complex in the experimental animal models before moving to the clinic.

关键词： diseases treatment utilize

Effects of leaf removal and cluster thinning on berry quality of Vitis vinifera cultivars in the region of Weibei Dryland in China

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Journal of Integrative Agriculture 2018年第7期17卷 1620-1630页

作者： song Chang-zheng WANG Chao XIE Sha ZHANG Zhen-wen College of Enology Northwest A&F UniversityYangling 712100P.R.China Shaanxi Engineering Research Center for Viti-Viniculture Yangling 712100P.R.China

Leaf removal and cluster thinning were carried out prior to veraison to evaluate the effects on berry quality of two Vitis vinifera cultivars（Cabernet Sauvignon and Ugni Blanc） in the Weibei Dryland of China in 2013 and 2014, and comprehensive analysis of the chemical and volatile composition in berries was performed. The results showed that content of reducing sugar in both varieties was not affected while total acid was generally decreased by leaf removal and cluster thinning. The pH of berry juice was correspondingly higher in most treatment groups. Meanwhile, promoting effects on accumulation of total phenols, tannin in both varieties and total anthocyanins in Cabernet Sauvignon were found. As for monomeric anthocyanins, percentage of malvidin and its derivatives was decreased by leaf removal and cluster thinning. Besides, cinnamylated anthocyanins decreased with the intensity of cluster thinning. The accumulation of non-anthocyanin phenolics was similarly affected in the two varieties. Notably, cluster thinning was more effective on enhancing the phenolics content than leaf removal. The combination of middle level of leaf removal and cluster thinning was the most favor to the accumulation of phenolic acids. Furthermore, cluster thinning could also significantly enhance the synthesis of flavanols and stilbenes. Lastly, content and variety of aroma compounds in both grape varieties were also significantly affected by the treatments. The results provided a theoretical basis for a combination of leaf removal and cluster thinning to improve quality of grapes and wines.

关键词： leaf removal cluster thinning wine grape quality comprehensive analysis

An Inherent Chiral Calix[4]arene Bearing Chiral Groups without Forming Sub-ring

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Chinese Chemical Letters 2006年第9期17卷 1169-1172页

作者： Xian Xian LIU Yan song zheng Wan Ling MO Departmentof Chemistry Huazhong University of Science and Technology Wuhan 430074 Department of Chemistry Guilin Normal College Guilin 541001 不详

The NMR spectra revealed that the calixarene frame of 1, 3-disubstituted calix[4]arenes beating optically active groups is asymmetric, even without the formation of a sub-ring. This inherent chirality arises from the interaction of the two chiral groups, which hinder the substituents＇ free rotation. Thus, these chiral calix[4]arenes display good chiral recognition ability.

关键词： Calixarene inherent chirality chiral recognition.

Tetraphenylethylene dicycle helicates: circularly polarized luminescence and chiral recognition based on emission wavelength change

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Science China Chemistry 2024年第11期67卷 3817-3824页

作者： Zhi-Rong Xu Miao-Li Gao Ming Hu Wei Yu Yan-song zheng Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Chiral tetraphenylethylene(TPE) dicycle tetraaldehyde and TPE dicycle tetraacids bearing optically pure groups on the cycles were designed and synthesized. Due to the propeller-like conformation immobilization of TPE unit, this new class of TPE dicycle was resolved into M-and P-enantiomers, which could emit strong circular polarized luminescence(CPL). Interestingly,these TPE helicates displayed exceptional ability of molecule recognition. While the TPE dicycle tetraaldehyde could detect the microscale water in anhydrous tetrahydrofuran, the chiral TPE dicycle tetraacid could display different fluorescent color after interacting with two enantiomers of a wide variety of chiral amines including monoamines, diamines, and aminols, which could be applied to chiral recognition of these chiral amines. Furthermore, the emission wavelength of TPE dicycle tetraacid was found to change linearly with the enantiomer purity of chiral amine from enantiomer excess(ee) percent-100% to +100%, for the first time showing the potential for quantitative chiral analysis of chiral amines based on emission wavelength change. The emission wavelength was affected less by environmental factors than fluorescence intensity, which would enable the chiral analysis based on wavelength change with higher accuracy and repeatability.

关键词： TPE dicycle helicate CPL chiral recognition enantiomer excess analysis emission wavelength change

On the Study of Multi-Gas Data Acquisition System Based on PCI1711 Card

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稀有金属材料与工程 2006年第A03期35卷 180-181页

作者： He Wang Dongxiang Zhou Xinmin Zhou Weiyuan song zheng Wu Department of Electronic Science ＆ Technology Huazhong University of Science ＆ Technology Wuhan 430074 China

A data acquisition system for testing gas sensor array response to multi-gas is *** testing system is based on the character of the gas response of metal oxide semiconductor gas sensor *** data acquisition is realized automatically through the real time controlling of the data acquisition card *** system is highly attractive for electronic nose,which is a powerful tool for the discrimination of gases.

关键词： gas sensor array data acquisition multi-gas test PCI1711 card

Chemiluminescent carbon nanodots for dynamic and guided antibacteria

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Light(Science & Applications) 2023年第5期12卷 915-927页

作者： Jiang-Fan Han Qing Lou Zhong-zheng Ding Guang-song zheng Qing-Chao Ni Run-Wei song Kai-Kai Liu Jin-Hao Zang Lin Dong Cheng-Long Shen Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China

Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant *** therapy is one of the most promising strategies for efficiently and accurately curing bacterial ***,a chemiluminescence(CL)-dynamic/guided antibacteria(CDGA)with multiple reactive oxygen species(ROS)generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots(CDs)and peroxalate as CL ***,hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate,enabling bacterial induced inflammation ***,type Ⅰ/Ⅱ photochemical ROS production and type Ⅲ ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation *** potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma *** self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria,and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance,whose sterilizing rate is up to 99.99%.

关键词： dynamic illumination initiated

Hydrogen storage properties of MgH2 co-catalyzed by LaH3 and NbH

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1183-1191页

作者： Jian-zheng song Zi-yang Zhao Xin Zhao Rui-dong Fu Shu-min Han State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China

To improve the hydrogen storage properties of Mg-based alloys, a composite material of MgH_2 + 10wt%LaH_3 + 10wt%NbH was prepared by a mechanical milling method. The composite exhibited favorable hydrogen desorption properties, releasing 0.67wt% H2 within 20 min at 548 K, which was ascribed to the co-catalytic effect of LaH_3 and NbH upon dehydriding of MgH_2. By contrast, pure MgH_2, an MgH_2 + 20wt%LaH_3 composite, and an MgH_2 + 20wt%NbH composite only released 0.1wt%, 0.28wt%, and 0.57wt% H2, respectively, under the same conditions. Analyses by X-ray diffraction and scanning electron microscopy showed that the composite particle size was small. Energy-dispersive X-ray spectroscopic mapping demonstrated that La and Nb were distributed homogeneously in the matrix. Differential thermal analysis revealed that the dehydriding peak temperature of the MgH_2 + 10wt%LaH_3 + 10wt%NbH composite was 595.03 K, which was 94.26 K lower than that of pure MgH_2. The introduction of LaH_3 and NbH was beneficial to the hydrogen storage performance of MgH_2.

关键词： energy storage materials hydrogen absorbing materials mechanical milling phase transformation activation analysis

Chromosomal Location of the Genes Associated with Photosynthesis of Lophopyrum elongatum (Host) A.Lve in Chinese Spring Background

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Agricultural Sciences in China 2006年第8期5卷 579-586页

作者： PENG Yuan-ying PENG zheng-song song Hui-xing XU Jia-shao College of Life Science China West Normal University Nanchong 637002 P.R.China College of Life Science Qufu Normal University Qufu 273165 P.R.China College English Department Qufu Normal University Qufu 273165 P.R.China

Researches on the relationship between photosynthesis and wheat yield have equally attracted the attention of both domestic and overseas scholars. No report has existed so far on the study of the effects of exogenous chromosomes on photosynthesis using the substitution series as materials. In this research, Triticum aestivum cv. Chinese Spring-Lophopyrum elongatum （Host） *** disomic substitution series were used as materials and flag leaves as the measuring position. And the CI-310 Portable Photosynthesis System made by CID Co. in USA was used to measure the net rate of photosynthesis of flag leaves in different developing stages and also to correlate photosynthesis with yield. Results showed that, out of the whole developing stages, at the anthesis stage the line of DS2Ee （2A） had the highest photosynthetic rate, therefore it could be used in improving process of the character of kernel number. The flag leaves of DS4Ee （4A, 4B, 4D） lines demonstrated certain high net photosynthetic rate from heading to grain filling stage, so it is valuable in the researh of promoting the yield index like 1 000-grain weight through improvement of the photosynthetic rate at grain filling stage.

关键词： wheat Lophopyrum elongatum substitution photosynthetic rate gene location

Stability of the Barrett True-K formula for intraocular lens power calculation after SMILE in Chinese myopic eyes

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 560-566页

作者： Wei Zhu Feng-Ju Zhang Yu Li Yan-zheng song Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology&Visual Sciences Key LabCapital Medical UniversityBeijing 100730China The Center of Refractive Surgery Shijiazhuang Aier Eye HospitalShijiazhuang 050000Hebei ProvinceChina Aier School of Ophthalmology Central South UniversityChangsha 410000Hunan ProvinceChina

AIM: To compare the Barrett True-K formula with other formulas integrated in Lenstar 900 to predict intraocular lens(IOL) power after small-incision lenticule extraction(SMILE).METHODS: A theoretical prospective study was performed to predict the ratio of equivalent IOL power before and after SMILE using the SRK/T(Sanders, Retzlaff, Kraff/theoretical), Holladay 1, Haigis, and Barrett True-K formulas and compare the stability of their predictions. The study included 54 eyes(54 cases) with a manifest refraction spherical equivalent(MRSE) of-4.99±1.45 D. They were divided into two groups: 27 eyes with axial length of 24-26 mm in Group A, and 27 eyes with axial length >26 mm in Group B. All subjects enrolled in this study were examined with the Lenstar 900 before and 6 mo after SMILE including measurements of axial length, corneal curvature, and anterior chamber depth(ACD). RESULTS: The prediction of equivalent IOL power of the two groups was more stable for the Barrett True-K formula, especially in long axial length eyes(Group B). The respective percentages for the SRK/T, Holladay 1, Haigis, and Barrett True-K formulas were 7.4%, 7.4%, 85.19%, and 88.89% for a margin of error within 0.5 D;25.92%, 51.84%, 100%, and 100% for a margin of error within 1.0 D in Group A;33.33%, 40.74%, 44.44%, and 81.48% for a margin of error within 0.5 D;and 44.44%, 59.26%, 66.66%, and 92.59% for a margin of error within 1.0 D in Group B. The respective percentages for Barrett True-K formulas were 100% for a margin of error within 2.0 D in Group ***: Theoretically, the Barrett True-K formula provides more stable predictions than other formulas for cataract eyes after SMILE.

关键词： intraocular lens IOL power calculation formula SMILE equivalent IOL power Lenstar 900