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Energy-Aware Traffic Routing with Named Data Networking

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China Communications 2012年第6期9卷 71-81页

作者： song yunlong Liu Min Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 P. R. China Graduate University of Chinese Academy of Sciences Beijing 100190 P. R. China

Greening Internet is an important issue now, which studies the way to reduce the increas- ing energy expenditure. Our work focuses on the network infrastructure and considers its energy awareness in traffic routing. We formulate the model by traffic engineering to achieve link rate a- daption, and also predict traffic matrices to pre- serve network stability. However, we realize that there is a tradeoff between network performance and energy efficiency, which is an obvious issue as Internet grows larger and larger. An essential cause is the huge traffic, and thus we try to fred its so- lution from a novel architecture called Named Data Networking （NDN） which tent in edge routers and can flexibly cache con- decrease the backbone traffic. We combine our methods with NDN, and finally improve both the network performance and the energy efficiency. Our work shows that it is effective, necessary and feasible to consider green- ing idea in the design of future Internet.

关键词： Greening Internet energy-aware traf-fic routing Named Data Networking traffic matri-ces prediction link stability

SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA

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Cellular & Molecular Immunology 2021年第4期18卷 1032-1044页

作者： Yuze Wang Xinrui Fan yunlong song Yifei Liu Ruixin Liu Jianfeng Wu Xiaoling Li Quan Yuan Guo Fu Ningshao Xia Jiahuai Han State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamenFujian 361102China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Public HealthXiamen UniversityXiamenFujian 361005China Cancer Research Center of Xiamen University Xianmen Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian 361102China

HBV infection initiates hepatitis B and promotes liver cirrhosis and hepatocellular ***-α is commonly used in hepatitis B therapy,but how it inhibits HBV is not fully *** screened 285 human interferon-stimulated genes(ISGs)for anti-HBV activity using a cell-based assay,which revealed several anti-HBV *** these ISGs,SAMD4A was the strongest suppressor of HBV *** found the binding site of SAMD4A in HBV RNA,which was a previously unidentified Smaug recognition region(SRE)sequence conserved in HBV ***4A binds to the SRE site in viral RNA to trigger its *** SAM domain in SAMD4A is critical for RNA binding and the C-terminal domain of SAMD4A is required for SAMD4A anti-HBV *** SAMD4B is a homolog of human SAMD4A but is not an ISG,and the murine genome encodes *** these SAMD4 proteins suppressed HBV replication when overexpressed in vitro and in *** also showed that knocking out the Samd4 gene in hepatocytes led to a higher level of HBV replication in mice and AAV-delivered SAMD4A expression reduced the virus titer in HBVproducing transgenic *** addition,a database analysis revealed a negative correlation between the levels of SAMD4A/B and HBV in *** data suggest that SAMD4A is an important anti-HBV ISG for use in IFN therapy of hepatitis B and that the levels of SAMD4A/B expression are related to HBV sensitivity in humans.

关键词： ISG Hepatitis B virus SAMD4 family proteins RNA degradation

Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily:Identification of novel antitumor drug binding site

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Science China(Life Sciences) 2005年第4期48卷 375-384页

作者： song yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U)Jiaguo Department of Medicinal Chemistry School of PharmacySecond Military Medical UniversityShanghai 200433China

The studies of novel inhibitors of DNA topoisomerase I(Topo I)have already be-come very promising in cancer *** the new drug-binding residues is playing an important role in the design and optimization of Topo I *** designed com-pounds may have novel scaffolds,thus will be helpful to overcome the toxicities of current camptothecin(CPT)drugs and may provide a solution to cross resistance with these ***-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was *** Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo *** has been demonstrated that class-specific hydrophobic residues Ala351,Met428,Pro431 are located around the 7,9-position of CPT,indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor *** conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such *** has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily,whose mutation will render CPT *** our molecular docking studies demonstrated they did not make any direct interaction with CPT,they are important drug-binding site residues for future design of novel non-camptothecin lead *** work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds.

关键词： topoisomerase I binding site evolutionary trace camptothecin antineoplastic drugs.

基于Ontology的网上咨询专家系统的研究

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现代图书情报技术 2006年第3期 27-30页

作者：宋云龙山东大学威海分校图书馆威海264209

在分析了FAQ和非实时与实时咨询系统的优缺点的基础上,探讨了基于Ontology的网上咨询专家系统的概念、关键技术及实现方案。

关键词： Ontology 网上咨询专家系统文本生成

Homology modeling three-dimensional structure of AnxB1 and reducing its immunogenicity by sequence-deleted mutagenesis

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Science China(Life Sciences) 2004年第4期47卷 359-367页

作者： YAN Hongli1, song yunlong2, LIU Fan1, HE Yan1 & SUN Shuhan1 1. Department of Medical Genetics, Second Military Medical University, Shanghai 200433, China 2. Department of Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China Department of Medical Genetics Second Military Medical University Shanghai China Department of Medicinal Chemistry Second Military Medical University Shanghai China

AnxB1, a novel annexin previously isolated from Cysticercus cellulose, shows high thrombi affinity and anticoagulant activity in vivo. In order to investigate the relationship between structure and biological function, a predicted three-dimensional (3D) model of AnxB1 was gen-erated by homology modeling. This model contains four homologous internal-domains and the Ca trace of domain I, II and IV shows high similarity. Based on the structure characterization, four sequence-deleted mutants were constructed and expressed as GST fusion proteins in E. coli. Two of the mutants, GST-M3 and GST-M4 reserved high anticoagulant activity (p<0.01 vs. GST). Furthermore, compared with the wild type GST-AnxB1, the immunogenicity of GST-M3 and GST-M4 was reduced significantly (p<0.01) and the molecular weight was lowered to 27 kD and 34 kD, respectively. These observations laid a solid foundation for further study on developing new thrombolytic agents with higher efficiency and lower side effect.

关键词： annexin,homology modeling,sequence-deleted mutant,anticoagulant,immunogenicity.

功能化多孔有机聚合物(POPs)的应用研究

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化工新型材料 2024年第S1期52卷 454-462页

作者：宋云龙盖登宇哈尔滨工程大学材料科学与化学工程学院哈尔滨150001

多孔有机聚合物(POPs)由共价键连接的有机构筑单元组成,具有高比表面积、可定制的结构、可调节的孔隙大小等特点。这使POPs被开发并广泛应用于气体的吸附与分离、能量转换、荧光传感等领域。综述了POPs聚合法、模板法等合成方法,研究了... 详细信息

多孔有机聚合物(POPs)由共价键连接的有机构筑单元组成,具有高比表面积、可定制的结构、可调节的孔隙大小等特点。这使POPs被开发并广泛应用于气体的吸附与分离、能量转换、荧光传感等领域。综述了POPs聚合法、模板法等合成方法,研究了引入功能基团、催化剂等手段,并深入探讨了POPs在吸附、膜分离和能量转换等方面的研究进展,介绍了它们具体的应用领域,并展望了多孔有机聚合物研究的前沿和未来发展方向。

关键词：多孔有机聚合物合成方法功能化应用领域

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高校图书馆数据存储系统扩容解决方案探讨

现代图书情报技术 2005年第7期 81-82,91页

作者：宋云龙阚洪海山东大学威海分校威海264209

图书馆电子资源量的急剧扩大,使得作为其载体的数据存储系统也需要不断地进行扩容。构建双塔式SAN方案是存储设备扩容的一种行之有效的方法。本文就此方法做一探讨。

关键词：数据存储系统扩容电子资源高校图书馆

OPAC查询结果中图形化显示馆藏位置的研究

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现代图书情报技术 2008年第5期 81-84页

作者：阚洪海宋云龙山东大学威海分校图书馆威海264209

对现有图书馆管理系统的OPAC子系统进行分析,指出现有OPAC系统的不足,并提出改进的方法:图形化显示馆藏位置。随后以江苏汇文公司OPAC系统为例,分析实现的可行性,分别对数据库构建、后台书架管理、前台馆藏书架显示3部分给出了具体的实... 详细信息

对现有图书馆管理系统的OPAC子系统进行分析,指出现有OPAC系统的不足,并提出改进的方法:图形化显示馆藏位置。随后以江苏汇文公司OPAC系统为例,分析实现的可行性,分别对数据库构建、后台书架管理、前台馆藏书架显示3部分给出了具体的实现方法,并对用到的关键技术做详细的说明。

关键词： OPAC 图形化馆藏位置

640层容积CT 4D-CTA技术在脑血管病成像中的应用

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中国医学影像技术 2016年第4期32卷 492-495页

作者：冯瑞宋云龙毕永民刘洪亮中国人民解放军空军总医院磁共振科北京100142

目的探讨640层容积CT 4D-CTA技术在缺血性脑血管病成像中的临床应用价值。方法对45例拟诊为缺血性脑血管病的患者进行640层CT扫描,经Toshiba Aqulilion One 320工作站获得4D-CTA、3D-MIP、VR、4D-CTP图像;观察分析图像质量、血管狭窄程... 详细信息

目的探讨640层容积CT 4D-CTA技术在缺血性脑血管病成像中的临床应用价值。方法对45例拟诊为缺血性脑血管病的患者进行640层CT扫描,经Toshiba Aqulilion One 320工作站获得4D-CTA、3D-MIP、VR、4D-CTP图像;观察分析图像质量、血管狭窄程度及CTP参数特点。结果 45例中41例均获得高质量的4D-CTA图像,优良率为91.11%(41/45)。36例患者脑血管狭窄或闭塞、2例为大脑中动脉支架术后、1例为动脉瘤术后、1例为烟雾病患者,5例患者正常。4D-CTA显示8例患者的侧支循环较3D-MIP多。10例CTP未见异常,35例异常灌注主要分3类:第Ⅰ类(n=11)为延迟时间(DLY)、达峰时间(TTP)、通过时间(MTT)均升高,脑血流量(CBF)、脑血容量(CBV)正常或轻度升高;第Ⅱ类(n=9)为DLY、TTP、MTT升高,CBF、CBV轻度降低;第Ⅲ类(n=15)为DLY、TTP、MTT升高,CBF、CBV明显降低。结论 640层容积4D-CTA可动态观察颅内血管形态、评价脑组织血流灌注情况,可为缺血性脑血管病变诊断与治疗提供有价值的信息。

关键词：脑血管血管造影术体层摄影术,X线计算机