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Expert consensus on irrigation and intracanal medication in root canal therapy

International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao song shen Xuedong Zhou Lin Yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

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Regulation and application of supramolecular gel with circularly polarized luminescence

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Science China Chemistry 2024年第6期67卷 1865-1880页

作者： shen song Yulong Shi Liangliang Zhu Bingbing Yue School of Materials and Chemistry&Institute of Bismuth and Rhenium University of Shanghai for Science and TechnologyShanghai200093China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200438China

Supermolecular gel is a three-dimensional network structure assembled by small molecules or polymers in solvents through noncovalent interaction.The emergence of system complexity occurs spontaneously during the molecular self-assembly process.A multitude of chiral molecular self-assembly systems have been engineered,facilitating the achievement of circularly polarized luminescence(CPL)through the amalgamation of chiral entities with fluorophores.Hydrogen bonding,π-πstacking,and noncovalent forces,such as host-guest interactions and Van der Waals'forces,confer upon supramolecular gels the capacity to react to diverse stimuli.Due to the flexibility of supramolecular assembly,the CPL properties of supramolecular gels have rich controllability and can be used in various applications.In this review,we summarized the examples of CPL-active supramolecular gel assembly,and further summarized the assembly environment factors and external stimuli.Furthermore,the versatility of CPL applications in supramolecular gels is demonstrated,ranging from optical devices,information encryption,biosensing and chemical sensing,and other practical applications.In conclusion,the study provides insights into the multicultural factors influencing CPL in supramolecular gels,describes their applications in various domains,and presents future perspectives in the field.

关键词： supramolecular gels circularly polarized luminescence self-assembly chirality stimuli-response

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Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs

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International Journal of Oral Science 2023年第1期15卷 113-126页

作者： Yushang Wang Lihua Wang Tianyong Sun song shen Zixuan Li Xiaomei Ma Xiufeng Gu Xiumei Zhang Ai Peng Xin Xu Qiang Feng Department of Implantology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanChina Department of Human Microbiome School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanChina Department of Orthodontics School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanChina State key laboratory of microbial technology Shandong UniversityQingdaoChina

Fusobacterium nucleatum(F.nucleatum)is an early pathogenic colonizer in periodontitis,but the host response to infection with this pathogen remains unclear.In this study,we built an F.nucleatum infectious model with human periodontal ligament stem cells(PDLSCs)and showed that F.nucleatum could inhibit proliferation,and facilitate apoptosis,ferroptosis,and inflammatory cytokine production in a dose-dependent manner.The F.nucleatum adhesin Fad A acted as a proinflammatory virulence factor and increased the expression of interleukin(IL)-1β,IL-6 and IL-8.Further study showed that Fad A could bind with PEBP1 to activate the Raf1-MAPK and IKK-NF-κB signaling pathways.Time-course RNA-sequencing analyses showed the cascade of gene activation process in PDLSCs with increasing durations of F.nucleatum infection.NFκB1 and NFκB2 upregulated after 3 h of F.nucleatum-infection,and the inflammatory-related genes in the NF-κB signaling pathway were serially elevated with time.Using computational drug repositioning analysis,we predicted and validated that two potential drugs(piperlongumine and fisetin)could attenuate the negative effects of F.nucleatum-infection.Collectively,this study unveils the potential pathogenic mechanisms of F.nucleatum and the host inflammatory response at the early stage of F.nucleatum infection.

关键词： inflammatory drugs PDL

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Progress in nanoparticle-based regulation of immune cells

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Medical Review 2023年第2期3卷 152-179页

作者： Ya-Nan Fan Gui Zhao Yue Zhang Qian-Ni Ye Yi-Qun Sun song shen Yang Liu Cong-Fei Xu Jun Wang School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong ProvinceChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouGuangdong ProvinceChina Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouGuangdong ProvinceChina Department of Biomedical Engineering Wake Forest School of MedicineWinston-SalemNCUSA School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442Guangdong ProvinceChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina

Immune cells are indispensable defenders of the human body,clearing exogenous pathogens and toxicities or endogenous malignant and aging cells.Immune cell dysfunction can cause an inability to recognize,react,and remove these hazards,resulting in cancers,inflammatory diseases,autoimmune diseases,and infections.Immune cells regulation has shown great promise in treating disease,and immune agonists are usually used to treat cancers and infections caused by immune suppression.In contrast,immunosuppressants are used to treat inflammatory and autoimmune diseases.However,the key to maintaining health is to restore balance to the immune system,as excessive activation or inhibition of immune cells is a common complication of immunotherapy.Nanoparticles are efficient drug delivery systems widely used to deliver small molecule inhibitors,nucleic acid,and proteins.Using nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell function.In this review,we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy.

关键词： biomaterial drug delivery immune cell immunotherapy nanoparticle

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焦作市城区居民共享高校公共资源的可达性研究——以地理信息系统为基础

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中国资源综合利用 2024年第1期42卷 38-40页

作者：沈松焦作师范高等专科学校河南焦作454000

高校拥有完善的基础设施,公共资源丰富,它具有公益属性,能为民众提供学习、休闲和娱乐的场所。一个城市高校数量有限,居民小区呈散点布局,城市交通网络便利度不一,因此不同居民点到达高校的路径存在差异。本文以焦作市城区高校、居民小... 详细信息

高校拥有完善的基础设施,公共资源丰富,它具有公益属性,能为民众提供学习、休闲和娱乐的场所。一个城市高校数量有限,居民小区呈散点布局,城市交通网络便利度不一,因此不同居民点到达高校的路径存在差异。本文以焦作市城区高校、居民小区为研究对象,依托ArcGIS软件构建数据模型,通过数据分析得出焦作市城区高校分布和居民小区的关系,然后提出对策,以提高高校公共资源的可达性,使城区居民共享高校公共资源。

关键词：高校公共资源可达性城区居民共享焦作市

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Nanomedicine-mediated ubiquitination inhibition boosts antitumor immune response via activation of dendritic cells

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Nano Research 2021年第11期14卷 3900-3906页

作者： Jilong Wang Mengwen Huang Senbiao Chen Yingli Luo song shen Xiaojiao Du School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou510006China Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou510006China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou510006China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou510005China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China Innovation Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China

Tumor immunotherapy as a promising method for tumor treatment received tremendous attention. However, the problem of low clinical response rate still needs to be solved, especially in the poorly immunogenic tumors. The enhancement of tumor antigens presentation can effectively activate dendritic cells (DCs) and improve the tumor immunotherapy. In this work, TAK-243 as an inhibitor of the ubiquitin activating enzyme (UAE), was fabricated into cationic lipid-assisted nanoparticle (CLANTAK-243). The obtained CLANTAK-243 could act as an effective tumor immunotherapy enhancer to promote the maturation of DCs as well as antigen presentation, which obviously stimulated the T cells activation and proliferation. Such CLANTAK-243 injected intravenously could well trigger immune response to tumor cells in vivo. Importantly, mice treated with CLANTAK-243 could obtain a long immune memory effect to protect themselves from re-challenged tumor cells. Therefore, this work presented an effective immunotherapy strategy for poorly immunogenic tumor.

关键词： drug delivery cancer immunotherapy ubiquitin activating enzyme(UAE) inhibitor antigen presentation dendritic cell(DC)maturation

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Simultaneous elimination of cancer stem cells and bulk cancer cells by cationic-lipid-assisted nanoparticles for cancer therapy

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Nano Research 2018年第8期11卷 4183-4198页

作者： Kaige Chen song shen Gui Zhao Zhiting Cao Xianzhu Yang Jun Wang School of Life Sciences University of Science and Technology of China Hefei 230027 China Institutes for Life Sciences and School of Medicine South China University of Technology Guangzhou S 10006 China Key Laboratory of Biomedical Materials of Ministry of Education South China University of Technology 6uangzhou S 1064 I China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou 510006 China Hefei National Laboratory for Physical Science at Microscale University of Science and Technology of China Hefei 230027 China Kaige Chen and song shen contributed equally to this work.

Convincing evidence indicates that the existence of cancer stem cells （CSCs） within malignant tumors is mostly responsible for the failure of chemotherapy. Therefore, instead of merely targeting bulk cancer cells, simultaneous elimin- ation of both CSCs and bulk cancer cells is necessary to improve therapeutic outcomes. Herein, we designed cationic-lipid-assisted nanopartides DTXLNPsRNA for simultaneous encapsulation of the conventional chemotherapeutic agent docetaxel （DTXL） and small interfering RNA （siRNA） targeting BMI-1 （siBMI-1）. We confirmed that nanopartides vrxLNPsiBMI-l effectively deliver both therapeutic agents into CSCs and bulk cancer cells. The bulk cancer cells were effectively killed by the DTXL encapsulated in DVXL NPsiBMI-1. In breast CSCs, BMI-1 expression was significantly downregulated by DVXLNpsiBMI-1; consequently, the sternness was reduced and chemosensitivity of CSCs to DTXL was enhanced, resulting in the elimination of CSCs. Therefore, via DTXLNPsiBMI-1, the combination of siBMI-1 and DTXL completely inhibited tumor growth and prevented a relapse by synergistic kiUing of CSCs and bulk cancer cells in a murine model of an MDA-MB-231 orthotropic tumor.

关键词： anti-cancer stem cells（CSCs） therap LBMI-1,combination therapy small interfering RNA（siRNA） therapy co-delivery

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基于残差网络模型的速溶全脂奶粉分散性与堆积密度检测方法

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食品科学 2024年第10期45卷 9-18页

作者：丁浩晗沈嵩谢祯奇崔晓晖王震宇江南大学未来食品科学中心江苏无锡214122 江南大学人工智能与计算机学院江苏无锡214122 武汉大学国家网络安全学院湖北武汉430072 嘉兴未来食品研究院浙江嘉兴314005

针对传统的奶粉品质国际标准检测方法中存在的主观性和滞后性等问题,本研究提出了一种基于残差网络(residual network,ResNet)的奶粉分散性和堆积密度的快速分类检测方法。在本研究中,使用的数据集包括499张在10倍光学显微镜下拍摄的速... 详细信息

针对传统的奶粉品质国际标准检测方法中存在的主观性和滞后性等问题,本研究提出了一种基于残差网络(residual network,ResNet)的奶粉分散性和堆积密度的快速分类检测方法。在本研究中,使用的数据集包括499张在10倍光学显微镜下拍摄的速溶全脂奶粉颗粒微观分布图像,这些图像来自10个不同的样本组。首先,按照国际标准方法检测这10组样本的分散性和堆积密度,进而基于测试结果划分不同的分散性和堆积密度级别。随后,利用这些微观图像对ResNet模型进行训练,以实现对不同样本的有效分类。最终,通过分类结果预测速溶全脂奶粉的分散性、松散密度和振实密度。此外,本研究还对比了ResNet、EfficientNetV2和SwinTransformer等不同深度学习模型的预测效果。结果表明,基于ResNet152的深度学习模型在预测速溶全脂奶粉的分散性、松散密度和振实密度方面表现最佳,其在测试集上的准确率分别达到97.50%、98.75%和95.00%。这些深度学习模型在奶粉品质检测中的出色性能不仅证明了该方法能够实时、准确地预测奶粉的分散性和堆积密度,同时也为奶粉品质的在线检测提供了新的技术途径。

关键词：速溶全脂奶粉分散性堆积密度深度学习残差网络

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Electrochemical Regulation of Antibacterial Activity Using Ferrocene-Containing Antibiotics

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CCS Chemistry 2021年第11期3卷 129-135页

作者： song shen Yiming Huang Anran Yuan Fengting Lv Libing Liu Shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 College of Pharmaceutical Sciences Jiangsu UniversityZhenjiangJiangsu 212013

The widespread use of antibiotics causes the accumulation of a large amount of antibiotics in the environment.Excessively active antibiotics in the environment results in the emergence of bacterial resistance.Building smart antibiotics capable of reversible regulation between active and inactive states on demand is a promising approach to address this issue.Herein,a ferrocene-containing quaternary ammonium compound has been developed for electrochemical redox-controlled bacterial inhibition.The reversible switch of the reduced and oxidized ferrocene groups between hydrophobic and hydrophilic states triggers the assembly and disassembly of the micelles while modulating the interactions of antibiotic molecules with the bacteria membrane,providing a new way to regulate antibacterial activity.In addition,the alternate use of reduced and oxidized antibiotics exhibits a favorable effect in preventing bacterial resistance.Thus,an unconventional strategy is offered to prevent the build-up of active bactericide in the environment and decrease bacterial resistance.

关键词： antibacterial regulation antibiotics bacterial resistance electrochemical redox molecular switches

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可穿戴超声系统的研究进展

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应用声学 2024年第3期43卷 678-688页

作者：宋珅衡佳鸣王宁浩崔崤峣简小华中国科学技术大学生物医学工程学院(苏州) 合肥230022 中国科学院苏州生物医学工程技术研究所苏州215163

近年来伴随着移动医疗的兴起,以及新材料、集成电路、人工智能领域的不断进步,可穿戴设备在医疗领域得到了迅猛的发展。超声技术作为一种快速、简便和安全的诊疗工具,自诞生之日起就在医疗领域有着众多应用。可穿戴超声系统综合了可穿... 详细信息

近年来伴随着移动医疗的兴起,以及新材料、集成电路、人工智能领域的不断进步,可穿戴设备在医疗领域得到了迅猛的发展。超声技术作为一种快速、简便和安全的诊疗工具,自诞生之日起就在医疗领域有着众多应用。可穿戴超声系统综合了可穿戴设备和超声技术的优点,有着巨大的发展空间。该文概述了可穿戴超声系统的发展背景和系统组成,着重介绍了近些年来可穿戴超声系统在医疗监测和治疗领域的应用成果,并对可穿戴超声系统的发展前景进行了展望。

关键词：可穿戴设备超声技术超声监测超声治疗

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